CN118599651B - A method and system for transmitting ultrasonic waves into a sterile container - Google Patents
A method and system for transmitting ultrasonic waves into a sterile container Download PDFInfo
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- CN118599651B CN118599651B CN202410637264.1A CN202410637264A CN118599651B CN 118599651 B CN118599651 B CN 118599651B CN 202410637264 A CN202410637264 A CN 202410637264A CN 118599651 B CN118599651 B CN 118599651B
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
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Abstract
The invention discloses a method and a system for transmitting ultrasonic waves into an aseptic container, which belong to the technical field of ultrasonic treatment, and the method comprises the steps of S1, converting an ultrasonic electric signal generated by an ultrasonic driver into ultrasonic waves by an ultrasonic transducer and transmitting the ultrasonic waves to an amplitude transformer, S2, receiving and enhancing the ultrasonic waves by the amplitude transformer and transmitting the enhanced ultrasonic waves to an ultrasonic tool head, S3, receiving the ultrasonic waves by the ultrasonic tool head and transmitting the ultrasonic waves upwards, S4, fixing the aseptic container and pressing the aseptic container, enabling at least one part of the bottom of the aseptic container to be in contact with the ultrasonic tool head and keeping the pressure, and S5, receiving the ultrasonic waves from the ultrasonic tool head by the aseptic container and acting on liquid or biological tissues in the aseptic container, so that the liquid or the biological tissues generate ultrasonic oscillation. The invention can realize full aseptic sealing operation, omits complicated operations such as cleaning and sterilizing of the container and the ultrasonic probe, avoids pollution of overflow of metal materials to treatment solution, and improves ultrasonic transmission efficiency.
Description
Technical Field
The invention relates to the technical field of ultrasonic treatment, in particular to a method and a system for transmitting ultrasonic waves into a sterile container.
Background
Ultrasonic waves are used in common methods for biological tissue treatment, such as comminution, emulsification and homogenization. One commonly used method is to insert an ultrasonic tool head into the tissue mixture to be treated to generate ultrasonic oscillations that cause physical changes in the tissue such as comminution, emulsification and homogenization.
However, the biological tissue treatment generally has aseptic requirements, the traditional method for transmitting ultrasonic into the container needs to permanently fix an ultrasonic transducer to the container wall by using glue and screws, so that the container cannot be replaced, the other method for transmitting ultrasonic by inserting an ultrasonic tool head into the container from the outside has the aseptic requirements of strictly sterilizing the interior of the container and the ultrasonic tool head, has troublesome process and hidden trouble, further, the metal materials of the inner wall of the container and the probe have trace overflow under the oscillation action of ultrasonic wavelength time to generate trace pollution to the biological tissue, and the water bath isolation ultrasonic method can cause extremely low energy penetration efficiency due to the absorption of ultrasonic energy by water, so that the ultrasonic action efficiency is reduced.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides the method and the system for transmitting the ultrasonic waves into the sterile container, which can solve the problem of difficult control of the sterile environment, save tedious operations such as cleaning and sterilizing the inside of the sterile container and an ultrasonic probe, ensure that the metal materials overflow extremely slightly under the oscillation action of ultrasonic wavelength time, improve the ultrasonic transmission efficiency and realize the ultrasonic action effect equivalent to that of the insertion type ultrasonic probe.
To achieve the above object, in one aspect, the present invention provides a method for transmitting ultrasonic waves into a sterile container, comprising the steps of:
S1, an ultrasonic driver generates an ultrasonic electric signal, and an ultrasonic transducer converts the ultrasonic electric signal into ultrasonic waves and transmits the ultrasonic waves to an amplitude transformer;
s2, receiving and enhancing ultrasonic waves from the ultrasonic transducer by the amplitude transformer, and transmitting the enhanced ultrasonic waves to an ultrasonic tool head;
s3, the ultrasonic tool head receives ultrasonic waves from the amplitude transformer and transmits the ultrasonic waves upwards;
S4, fixing the sterile container and pressing the sterile container, so that at least one part of the bottom of the sterile container contacts the ultrasonic tool head and keeps pressure;
S5, the sterile container receives ultrasonic waves from the ultrasonic tool head and acts on liquid or biological tissues in the container to enable the liquid or the biological tissues to generate ultrasonic oscillation.
Further, in step S4, the aseptic container is pressurized by a fixing and pressurizing device which can move up and down and can adjust the magnitude of the applied pressure.
Further, the range in which the pressure is kept to be present is not less than 5kg.
Further, in step S4, the bottom of the aseptic container is provided with a partial protrusion structure, and the fixing and pressing device pushes the aseptic container to move downward so that the partial protrusion structure of the bottom of the aseptic container contacts with the ultrasonic tool head.
In another aspect, the present invention provides a system for transmitting ultrasonic waves into a sterile container, comprising a fixing and pressurizing device, a sterile container and an ultrasonic wave generating device;
The fixing and pressing device is movably arranged above the sterile container and used for transmitting controllable pressure to the sterile container;
The ultrasonic wave generating device is arranged below the sterile container and is in contact with the lower part of the sterile container, and is used for transmitting ultrasonic waves to the sterile container.
Further, the ultrasonic generating device comprises an ultrasonic tool head, a luffing rod, an ultrasonic transducer and an ultrasonic driver which are sequentially connected, wherein the ultrasonic tool head is used for being in contact with the bottom of the sterile container, the luffing rod is used for receiving and enhancing ultrasonic waves from the ultrasonic transducer, the ultrasonic tool head transmits the ultrasonic waves from the luffing rod to the sterile container, the ultrasonic driver is used for generating ultrasonic electric signals, and the ultrasonic transducer is used for converting the ultrasonic electric signals into ultrasonic waves.
Further, the joint of the bottom of the sterile container and the side wall of the sterile container is of an arc-shaped structure, and the diameter of the ultrasonic tool head is larger than or equal to the diameter of the sterile container.
Further, the bottom of the sterile container is a part of a protruding structure for contacting the ultrasonic tool head.
Further, the protruding structure is an annular protruding structure.
Further, the fixing and pressing device comprises a sliding pressure adjusting device and a pressure measuring device, wherein the pressure measuring device is arranged on the top of the sliding pressure adjusting device, and the sliding pressure adjusting device is arranged between the sterile container and the pressure measuring device.
Further, the device also comprises a fixing frame, wherein a track is arranged on the fixing frame, and the sliding pressure adjusting device is connected with the track in a sliding manner.
Further, the sterile container is made of hard materials.
The method and the system for transmitting ultrasonic waves into the sterile container have the beneficial effects that:
the ultrasonic tool head is arranged outside the sterile container, so that the sterile container is contacted with the ultrasonic tool head to transmit ultrasonic output energy into the sterile container, the full sterile sealing operation is realized, the problem of difficult control of a sterile environment is solved, complicated operations such as cleaning and disinfection of the interior of the sterile container and an ultrasonic probe are omitted, and pollution of overflow of metal materials to a treatment solution is avoided;
The bottom of the sterile container is provided with a specific annular bulge structure, or the joint of the bottom of the sterile container and the side wall of the sterile container is designed into an arc structure, so that the ultrasonic transmission efficiency can be improved, and the ultrasonic action effect equivalent to that of the insertion type sterile container is realized.
Drawings
FIG. 1 is a schematic diagram of the forces exerted by the ultrasonic tool head in compressive contact with the bottom of the sterile container when the diameter of the sterile container is less than or equal to the diameter of the ultrasonic tool head;
FIG. 2 is a schematic force diagram of the ultrasonic tool head in pressure contact with the bottom of the sterile container when the diameter of the sterile container is larger than that of the ultrasonic tool head;
FIG. 3 is a force-bearing schematic view of an ultrasonic tool head of a system for delivering ultrasonic waves into a sterile container in pressure contact with the bottom of the sterile container according to one embodiment of the present invention;
FIG. 4 is a schematic view of the overall structure of a system for delivering ultrasound into a sterile container in accordance with the present invention;
FIG. 5 is a force-bearing schematic view of an ultrasonic tool head of a system for delivering ultrasonic waves into a sterile container in pressure contact with the bottom of the sterile container in accordance with another embodiment of the present invention;
FIG. 6 is a flow chart of a method of delivering ultrasound into a sterile container in accordance with the present invention;
Reference numeral 1, a fixing and pressing device, 2, an aseptic container, 3, an annular bulge structure, 4, an ultrasonic tool head, 5, an amplitude transformer, 6, an ultrasonic transducer, 7, an ultrasonic driver, 8, a pressure measuring device, 9, an arc-shaped structure and 10, and the middle part of the bottom of the aseptic container.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, based on the embodiments of the invention, which are apparent to those of ordinary skill in the art without inventive faculty, are intended to be within the scope of the invention.
Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, based on the embodiments of the invention, which are apparent to those of ordinary skill in the art without inventive faculty, are intended to be within the scope of the invention.
It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed, directly connected, indirectly connected via an intermediate medium, or in communication with each other between two elements or in an interaction relationship between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
For a better understanding of the objects, structure and function of the invention, a method and system for delivering ultrasound into a sterile container in accordance with the present invention will be described in further detail with reference to the accompanying drawings.
Example 1:
as shown in fig. 3 to 6, a method of transmitting ultrasonic waves into a sterile container includes the steps of:
s1, an ultrasonic driver 7 generates an ultrasonic electric signal, and an ultrasonic transducer 6 converts the ultrasonic electric signal into ultrasonic waves and transmits the ultrasonic waves to an amplitude transformer 5;
S2, the amplitude transformer 5 receives and enhances the ultrasonic wave from the ultrasonic transducer 6 and transmits the enhanced ultrasonic wave to the ultrasonic tool head 4;
S3, the ultrasonic tool head 4 receives ultrasonic waves from the amplitude transformer 5 and transmits the ultrasonic waves upwards;
S4, fixing the sterile container 2 and pressing the sterile container, so that at least one part of the bottom of the sterile container 2 contacts the ultrasonic tool head 4 and keeps the pressure;
s5, the sterile container 2 receives ultrasonic waves from the ultrasonic tool head and acts on liquid or biological tissues in the container to enable the liquid or the biological tissues to generate ultrasonic oscillation.
As shown in fig. 3 and 4, in step S4, the aseptic container 2 is pressurized by the fixing and pressurizing device 1, which can move up and down and can adjust the magnitude of the applied pressure, and the range of the existing pressure is kept to be not less than 5kg, specifically, the pressure range is not less than 5kg and not more than 30kg, and the ultrasonic output power is 5 w-1 kw;
In step S4, a part of the protruding structure is provided at the bottom of the aseptic container 2, the fixing and pressing device pushes the aseptic container to move downward to make the part of the protruding structure at the bottom of the aseptic container contact with the ultrasonic tool head 4, and the aseptic container 2 is continuously pressed downward to make the central part of the ultrasonic tool head 4 contact with the middle part 10 at the bottom of the aseptic container 2, because the amplitude of the central part of the ultrasonic tool head 4 is greater than the edge amplitude of the ultrasonic tool head 4, the solution in the aseptic container 2 can obtain higher ultrasonic coupling transmission efficiency;
Or in step S4, the bottom of the aseptic container 2 is connected to the side wall of the aseptic container by an arc-shaped structure 9, the diameter of the ultrasonic tool head is larger than or equal to that of the aseptic container, when the aseptic container 2 is subjected to the pressure applied by the fixing and pressing device 1, the aseptic container 2 moves downwards until the bottom of the aseptic container contacts with the ultrasonic tool head 4, and the stress area is not transferred to the side wall of the aseptic container 2, so that the central part of the ultrasonic tool head 4 can contact with the middle part 10 of the bottom of the aseptic container 2;
the ultrasonic output energy is transferred into the sterile container 2 and acts upon the liquid within the sterile container.
Example 2:
as shown in fig. 3 to 4, a system for transmitting ultrasonic waves into a sterile container includes a fixing and pressurizing device, a sterile container, and an ultrasonic wave generating device;
the fixing and pressing device 1 is movably arranged above the sterile container 2 and is used for transmitting controllable pressure to the sterile container;
the ultrasonic wave generating device is arranged below the sterile container 2 and is in contact with the lower part of the sterile container for transmitting ultrasonic waves to the sterile container 2.
As shown in fig. 4, the ultrasonic generating device comprises an ultrasonic tool head 4, a horn 5, an ultrasonic transducer 6 and an ultrasonic driver 7 which are sequentially connected, wherein the ultrasonic tool head 4 is used for being in contact with the bottom of the sterile container 2, the horn 5 is used for receiving and enhancing ultrasonic waves from the ultrasonic transducer 6, the ultrasonic tool head 4 is used for transmitting the ultrasonic waves from the horn 5 to the sterile container 2, the ultrasonic driver 7 is used for generating ultrasonic electric signals, and the ultrasonic transducer 6 is used for converting the ultrasonic electric signals into ultrasonic waves;
In order to achieve good ultrasonic propagation effect, according to the ultrasonic transmission principle, the length of the ultrasonic tool head along the ultrasonic transmission direction is odd times of half wavelength, the thickness of the bottom of the sterile container 2 is odd times of half wavelength of ultrasonic wave, or the thickness of the bottom of the sterile container 2 is designed to be very thin, so that after the bottom of the sterile container 2 is coupled with the ultrasonic tool head 4, the bottom of the sterile container 2 has little influence on the geometric dimension of the ultrasonic tool head, and therefore, the thickness of the bottom of the sterile container 2 is designed to be very thin from the aspect of cost;
the following qualitative analysis was performed on the stress condition and the ultrasonic coupling transfer condition between the three groups of ultrasonic tool heads and the bottom of the sterile container as follows:
a) As shown in fig. 1, the diameter of the ultrasonic tool head 4 is larger than or equal to that of the sterile container 2, the sterile container 2 is flat bottom, the actual stress area of the sterile container 2 is the side wall of the sterile container under pressure, and the middle part of the sterile container 2 is extremely small in stress due to material deformation;
b) As shown in fig. 2, the diameter of the ultrasonic tool head 4 is smaller than that of the aseptic container 2, the aseptic container 2 is flat-bottomed, the bottom of the aseptic container 2 is deformed under pressure, only the edge ring area of the ultrasonic tool head 4 is in actual contact with the aseptic container 2, ultrasonic energy can only be transmitted to the bottom of the aseptic container 2 through edge coupling of the ultrasonic tool head 4 and into solution in the aseptic container, the coupling efficiency is greatly improved compared with a) condition, but the solution in the aseptic container still cannot obtain higher ultrasonic coupling transmission efficiency due to the fact that the edge amplitude of the ultrasonic tool head 4 is smaller than that of the central area of the tool head, and the maximum pressure born by the aseptic container cannot be very high due to the influence of the strength of the material of the aseptic container;
therefore, in the invention, the bottom of the sterile container 2 is a part of a bulge structure, the bulge structure is used for contacting the ultrasonic tool head 4, in particular, as shown in fig. 3 and 4, the bottom of the sterile container 2 is an annular bulge structure 3, the annular bulge structure 3 is connected with the side wall of the sterile container 2 by adopting an arc surface, the annular bulge structure 3 is connected with the non-bulge bottom surface of the sterile container by adopting an arc surface, the annular bulge structure 3 is used for contacting the top of the ultrasonic tool head 4, and the annular bulge structure 3 is made of an elastic material;
In this way, when the sterile container 2 is contacted with the top of the ultrasonic tool head 4 under pressure, the force applied by the side wall of the sterile container 2 is transferred to the ultrasonic tool head 4 through the annular bulge structure 3, and as the contact part of the annular bulge structure 3 at the bottom of the sterile container 2 and the ultrasonic tool head 4 is circular arc and the annular bulge structure 3 is made of elastic materials, when the sterile container 2 is contacted with the ultrasonic tool head and the bottom of the sterile container 2 is stressed, the circular arc shape can maintain the contact surface to be circular arc all the time when deformed, and the central part of the ultrasonic tool head 4 can be contacted with the middle part 10 at the bottom of the sterile container 2, so that ultrasonic energy is coupled to the bottom of the sterile container 2 and is acted into the solution through the bottom, good coupling of ultrasonic waves can be ensured, and thus the ultrasonic coupling transmission efficiency of the ultrasonic tool head 4 into the solution of the sterile container is realized.
The results of experiments performed with different sterile containers (the experimental conditions were identical except for the different sterile containers) are shown in table 1:
table 1 comparative table of ultrasonic homogenization effects of different sterile containers
It can be seen that the aseptic container provided with the annular bulge structure at the bottom has the best ultrasonic homogenization effect on the fat solution under the condition of the same contact pressure.
Example 3:
As shown in fig. 3 to 4, a system for transmitting ultrasound into a sterile container, for use in the above method for transmitting ultrasound into a sterile container, comprises a fixing and pressurizing device, a sterile container, and an ultrasound generating device;
The fixing and pressing device is movably arranged above the sterile container 2 and is used for transmitting controllable pressure to the sterile container;
the ultrasonic wave generating device is arranged below the sterile container 2 and is in contact with the lower part of the sterile container for transmitting ultrasonic waves to the sterile container 2.
This embodiment differs from embodiment 2 in that:
as shown in fig. 4, the fixing and pressing device 1 comprises a sliding pressure adjusting device and a pressure measuring device 8, wherein the pressure measuring device 8 is arranged at the top of the sliding pressure adjusting device, the sliding pressure adjusting device is arranged between the sterile container 2 and the pressure measuring device 8, the system for transmitting ultrasonic waves into the sterile container further comprises a fixing frame, a track is arranged on the fixing frame, the sliding pressure adjusting device and the sterile container can move up and down along the track, so that the sterile container 2 is pushed to move downwards, the annular bulge structure 3 at the bottom of the sterile container 2 is tightly contacted with the top of the ultrasonic tool head 4, the applied pressure can be adjusted through up and down sliding, the up and down movement and the pressure control are connected to a controller and a pressure setting device through a pressure sensor to form a feedback loop, and after the pressure reaches a set value, the pressure is stopped to be continuously pressurized, automatic control is realized, and a manual control mode can also be adopted;
Or as shown in fig. 5, the connection part between the bottom of the sterile container 2 and the side wall of the sterile container is provided with an arc-shaped structure 9, and the diameter of the ultrasonic tool head 4 is larger than or equal to the diameter of the sterile container 2; when the sterile container 2 is subjected to the pressure applied by the sliding pressure regulating device, the sterile container 2 moves downwards until the bottom of the sterile container is in contact with the top of the ultrasonic tool head 4, and the stress area is not transferred to the side wall of the sterile container 2, so that the middle part of the ultrasonic tool head 4 can be in contact with the bottom of the sterile container 2, and the ultrasonic coupling transmission efficiency of the ultrasonic tool head 4 in the sterile container solution is realized;
In particular, the pressure measuring device 8 is a pressure sensor for measuring the pressure exerted on the sterile container 2, and the sterile container 2 is brought into pressure contact with the ultrasonic tool head 4, so that the sterile container 2 is preferably made of a hard material.
Since the bottom of the sterile container 2 is brought into close contact with the ultrasonic tool head 4 by applying pressure, the amount of pressure in contact directly affects the efficiency of ultrasonic energy transmission. In practical applications, the greater the pressure, the greater the output power achievable by the ultrasonic transducer 6, see the following experimental data:
TABLE 2 pressure and ultrasonic transducer output Power relationship Table between ultrasonic transducer and sterile Container
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
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| CN202410637264.1A CN118599651B (en) | 2024-05-22 | 2024-05-22 | A method and system for transmitting ultrasonic waves into a sterile container |
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| CN202410637264.1A CN118599651B (en) | 2024-05-22 | 2024-05-22 | A method and system for transmitting ultrasonic waves into a sterile container |
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| CN118599651B true CN118599651B (en) | 2025-05-09 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044442A2 (en) * | 1999-01-28 | 2000-08-03 | Ultra Cure Ltd. | An ultrasound system and methods utilizing same |
| IL144638A (en) * | 2001-07-30 | 2005-12-18 | Nano Size Ltd | High power ultrasound reactor for the production of nano-powder materials |
| GB2425974A (en) * | 2005-05-09 | 2006-11-15 | Orion Diagnostica Oy | Sonication of a medium |
| US20120330194A1 (en) * | 2011-05-19 | 2012-12-27 | Alexander Britva | Apparatus and method for treating tissue with ultrasound |
| US9359632B2 (en) * | 2013-03-15 | 2016-06-07 | Theranos, Inc. | Devices, systems and methods for sample preparation |
| US10196611B2 (en) * | 2015-02-07 | 2019-02-05 | Julian HENLEY | Device and surgical system for rapid aseptic isolation and concentration of autologous fat derived stem cells |
| CN207138242U (en) * | 2017-04-21 | 2018-03-27 | 浙江源熙生物科技有限公司 | A kind of tank outer ultrasonic ripple shaking device of the fermentation tank for preparing probiotics |
| CN113731326B (en) * | 2021-08-19 | 2023-11-03 | 墨格微流科技(汕头)有限公司 | Large-volume ultrasonic tube reactor |
| CN116078240A (en) * | 2023-03-06 | 2023-05-09 | 博颐(上海)科学仪器设备有限公司 | Ultrasonic oscillation processing device, system and method |
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