CN118750473B - Alcohol disinfectant with color-changing indication function, preparation method and application - Google Patents
Alcohol disinfectant with color-changing indication function, preparation method and application Download PDFInfo
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Abstract
The invention discloses an alcohol disinfectant with a color-changing indication function, a preparation method and application thereof, and belongs to the technical field of disinfectant, wherein the alcohol disinfectant is characterized by comprising the following components, by weight, 0.1-0.3% (w/v) of a reducing agent, 0.05-0.07mol/L of an indicator, 0.08-0.12% (w/v) of a reaction auxiliary agent, 1.6-1.8% (w/v) of a skin care agent, 70% (v/v) of ethanol and water as solvents, wherein the alcohol disinfectant is in a colorless transparent state, and changes into red after the effect of oxygen in the air, and the color-changing time can be controlled by adjusting the ratio of the disinfectant to the colorless-red-colorless in the changing process, so that the disinfectant has a good flexible application effect.
Description
Technical Field
The invention belongs to the technical field of disinfectant, and particularly relates to an alcohol disinfectant with a color-changing indication function, a preparation method and application thereof.
Background
In the medical sensing field, alcohol disinfectants are commonly used skin disinfectant products. The skin disinfectant should have the characteristics of quick drying, broad sterilization spectrum, no stimulation, skin care and the like, and medical staff needs to strictly carry out according to the specifications. When the disinfection product is applied to skin disinfection, the problem that whether medical staff strictly meets the disinfection operation standard cannot be judged, and the disinfection liquid cannot be subjected to visual monitoring exists. Therefore, it is necessary to develop a disinfection solution with a color-changing indication function capable of monitoring whether the disinfection process can meet the standard requirements.
Disclosure of Invention
In order to solve the problems and overcome the defects in the prior art, the invention provides a skin disinfectant with a color-changing indication function and a preparation method thereof. The invention can be well applied to the skin disinfection process of medical staff, judges the standardization of disinfection operation through the change of color, and aims to develop the visual functional characteristics of disinfection. The prepared disinfectant can change color in the air, can achieve controllable color change process time by regulating and controlling the raw material proportion of the disinfectant, has good broad-spectrum sterilization capability, has the advantages of strong operability and strong indication effect, and can be applied to the field of medical sensing control.
The alcohol disinfectant with color change indication function is characterized by comprising the following components, by weight, 0.1-0.3% (w/v) of a reducing agent, 0.05-0.07mol/L of an indicator, 0.08-0.12% (w/v) of a reaction auxiliary agent, 1.6-1.8% (w/v) of a skin care agent, 70% (v/v) of ethanol and water as a solvent;
the reducing agent is glucose, the indicator is alkaline saffron, and the reaction auxiliary agent is fatty alcohol polyoxyethylene ether.
Further, the skin care agent is glycerin or allantoin or a mixture of the two.
Further, the alcohol disinfectant can have a bactericidal effect on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa or candida albicans.
Further, the color of the alcohol disinfectant is colorless, the time for changing from colorless to red after the alcohol disinfectant is contacted with oxygen in the air is 25s-2min, and the time for changing from red to colorless is 55s-5min.
The preparation method of the alcohol disinfectant with the color-changing indication function is characterized by comprising the following steps of:
(1) Mixing and diluting a reducing agent and deionized water according to a proportion;
(2) Under the condition of nitrogen protection, the indicator and the mixed liquid are taken and fully stirred and mixed;
(3) And under the condition of nitrogen protection, sequentially adding ethanol, a skin care agent and a reaction auxiliary agent into the mixed solution, and fully stirring and mixing to obtain the disinfectant with the color change indication function.
Further comprising the steps of:
(1) Mixing and diluting glucose solution with mass concentration of 20% (w/v) with deionized water according to a mass ratio of 1:67.7-200;
(2) Under the condition of nitrogen protection, taking 0.05-0.07 weight part of 1mol/L alkaline saffron solution and fully stirring and mixing the alkaline saffron solution with the mixed solution;
(3) Under the condition of nitrogen protection, 70% (v/v) ethanol, 0.08-1.0% (w/v) glycerol, 0.08-1.0% (w/v) allantoin and 0.08-0.12% (w/v) fatty alcohol-polyoxyethylene ether are sequentially added into the mixed solution, and the mixed solution is fully stirred and mixed to obtain the disinfectant with the color-changing indication function.
The application of the alcohol disinfectant with the color-changing indication function adopts the alcohol disinfectant, the alcohol disinfectant is applied to the skin sanitation disinfection process, after the alcohol disinfectant is contacted with air for a period of time, the color change process is colorless-red-colorless, and the visual indication of the disinfection operation time requirement of medical staff is realized through the color change of the alcohol disinfectant.
The beneficial effects of the invention are as follows:
The disinfectant prepared by the invention has the advantages that 1, the sterilizing effect of the disinfectant prepared by using alkaline saffron, glucose and fatty alcohol polyoxyethylene ether is not affected, 2, the initial liquid is in a colorless transparent state, turns red after being acted with oxygen in the air and turns colorless after a period of time, 3, the color changing time can be controlled by adjusting the proportion of the disinfectant in the process of changing the disinfectant from colorless to red to colorless, so that the disinfectant has better flexible application effect;
The color change indication principle of the prepared disinfectant is that under the action of the reaction auxiliary agent fatty alcohol polyoxyethylene ether, alkaline saffron and oxygen in the air undergo oxidation-reduction reaction to generate color change, and then are reduced to be colorless by glucose, so that the disinfectant is discolored;
Compared with the prior art, the invention has the obvious application effect that the alcohol disinfectant is applied to the skin sanitation disinfection process, the color change process of the alcohol disinfectant is colorless-red-colorless after the alcohol disinfectant contacts air for a period of time, and the visual indication is realized on the requirements of the disinfection operation process time nodes of medical staff through the color change of the alcohol disinfectant.
Drawings
FIG. 1 is a diagram showing the discoloration process of the alcohol disinfectant according to example 1 of the present invention;
FIG. 2 is a diagram showing the discoloration process of the alcohol disinfectant according to example 2 of the present invention;
FIG. 3 is a graph showing the discoloration process of the alcohol disinfectant according to example 3 of the present invention;
FIG. 4 is a graph showing the discoloration process of the alcohol disinfectant according to example 4 of the present invention;
FIG. 5 is a graph showing the discoloration process of the alcohol disinfectant according to example 5 of the present invention;
FIG. 6 is a graph showing the color development process of the alcohol disinfectant of comparative example 1 of the present invention;
FIG. 7 is a graph showing the color development process of the alcohol disinfectant of comparative example 2 of the present invention;
FIG. 8 is a graph showing the discoloration process of the alcohol disinfectant according to comparative example 3 of the present invention;
FIG. 9 is a diagram showing the usage state of the alcohol disinfectant with color change indication function according to the present invention;
Detailed Description
Specific details are set forth in the description of the invention in order to provide a thorough understanding of embodiments of the invention, it will be apparent to those skilled in the art that the invention is not limited to these details. In other instances, well-known structures and functions have not been shown or described in detail to avoid obscuring aspects of embodiments of the invention. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Specific embodiments of the invention:
for better understanding of the present invention, specific examples are given, and it should be emphasized that the effects of the examples are not substantially different from those of the various examples within the scope of the present invention, including the respective reagents and the content ratios of the reagents, and that other combinations are not described here;
example 1
The preparation method comprises the following steps of:
0.1% (w/v) glucose, 0.05mol/L alkaline saffron, 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin, 0.08% (w/v) fatty alcohol-polyoxyethylene ether, and water as the solvent.
Mixing glucose solution with the mass concentration of 20% (w/v) with deionized water according to the mass ratio of 1:200, taking 0.05 part by weight of 1mol/L alkaline saffron solution under the protection of nitrogen, fully stirring and mixing with the mixed solution, sequentially adding 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin and 0.08% (w/v) fatty alcohol polyoxyethylene ether into the mixed solution under the protection of nitrogen, and fully stirring and mixing to obtain the disinfectant with the color fading indication function.
The disinfectant prepared in example 1 was placed in a test tube to be in contact with oxygen in the air, the time for the disinfectant to change from colorless to red at room temperature was 2min, and the time for the disinfectant to change from red to colorless was 5min, as shown in FIG. 1;
Example 2
The preparation method comprises the following steps of:
0.2% (w/v) glucose, 0.06mol/L alkaline saffron, 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin, 0.10% (w/v) fatty alcohol-polyoxyethylene ether, and water as the solvent.
Mixing glucose solution with the mass concentration of 20% (w/v) with deionized water according to the mass ratio of 1:100, fully stirring and mixing 0.06 part by weight of 1mol/L alkaline saffron solution with the mixed solution under the protection of nitrogen, sequentially adding 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin and 0.10% (w/v) fatty alcohol polyoxyethylene ether into the mixed solution under the protection of nitrogen, and fully stirring and mixing to obtain the disinfectant with the color fading indication function.
The disinfectant prepared in example 2 was placed in a test tube to be in contact with oxygen in the air, the time for the disinfectant to change from colorless to red at room temperature was 1min, and the time for the disinfectant to change from red to colorless was 3min, as shown in FIG. 2;
Example 3
The preparation method comprises the following steps of:
0.3% (w/v) glucose, 0.06mol/L alkaline saffron, 70% (v/v) ethanol, 0.8% (w/v) glycerol, 0.8% (w/v) allantoin, 0.12% (w/v) fatty alcohol-polyoxyethylene ether, and water as the solvent.
Mixing glucose solution with the mass concentration of 20% (w/v) with deionized water according to the mass ratio of 1:66.7, fully stirring and mixing 0.06 part by weight of 1mol/L alkaline saffron solution with the mixed solution under the protection of nitrogen, sequentially adding 70% (v/v) ethanol, 0.8% (w/v) glycerol, 0.8% (w/v) allantoin and 0.12% (w/v) fatty alcohol-polyoxyethylene ether into the mixed solution under the protection of nitrogen, and fully stirring and mixing to obtain the disinfectant with the color fading indication function.
The disinfectant prepared in example 3 was placed in a test tube to be in contact with oxygen in the air, the time for changing the disinfectant from colorless to red at room temperature was 30s, and the time for changing the disinfectant from red to colorless was 1min, as shown in FIG. 3;
Example 4
The preparation method comprises the following steps of:
0.1% (w/v) glucose, 0.06mol/L alkaline saffron, 70% (v/v) ethanol, 0.8% (w/v) glycerol, 1.0% (w/v) allantoin, 0.09% (w/v) fatty alcohol-polyoxyethylene ether, and water as the solvent.
Mixing glucose solution with the mass concentration of 20% (w/v) with deionized water according to the mass ratio of 1:200, fully stirring and mixing 0.06 part by weight of 1mol/L alkaline saffron solution with the mixed solution under the protection of nitrogen, sequentially adding 70% (v/v) ethanol, 0.8% (w/v) glycerol, 1.0% (w/v) allantoin and 0.09% (w/v) fatty alcohol polyoxyethylene ether into the mixed solution under the protection of nitrogen, and fully stirring and mixing to obtain the hand disinfectant with the color fading indication function.
The hand sanitizer prepared in example 4 was placed in a test tube and contacted with oxygen in the air, the time for the sanitizer to change from colorless to red at room temperature was 45s, and the time for the sanitizer to change from red to colorless was 2.5min, as shown in fig. 4;
Example 5
The preparation method comprises the following steps of:
0.3% (w/v) glucose, 0.07mol/L alkaline saffron, 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin, 0.085% (w/v) fatty alcohol-polyoxyethylene ether, and water as the solvent.
Mixing glucose solution with the mass concentration of 20% (w/v) with deionized water according to the mass ratio of 1:66.7, fully stirring and mixing 0.07 part by weight of 1mol/L alkaline saffron solution with the mixed solution under the protection of nitrogen, and sequentially adding 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin and 0.085% (w/v) fatty alcohol-polyoxyethylene ether into the mixed solution under the protection of nitrogen to obtain the disinfectant with the color fading indication function.
The disinfectant prepared in example 5 was placed in a test tube to be in contact with oxygen in the air, the time for the disinfectant to change from colorless to red at room temperature was 25S, and the time for the disinfectant to change from red to colorless was 55S, as shown in fig. 5;
The disinfectant prepared in examples 1-5 was placed in a test tube to contact with oxygen in the air, and the disinfectant was observed in a room temperature environment by slightly shaking the test tube due to the limited contact area between the test tube and oxygen to increase the effect of the disinfectant on the oxygen and the frequency and time of shaking were fixed.
TABLE 1 results of different examples of color change time and sterilization effect
TABLE 2 different examples test for the sterilizing performance of different harmful bacteria
From the data analysis in tables 1 and 2, it can be seen that:
(1) The hand disinfectant bacteria prepared in examples 1-5 are tested for sterilization performance according to the sterilization technical Specification (2002 edition), and the test is carried out on strains such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like, and the detection results all accord with the specification of being qualified in sterilization in the sterilization technical Specification (2002 edition).
(2) The color change indication principle of the prepared disinfectant is that under the action of the reaction auxiliary agent fatty alcohol polyoxyethylene ether, alkaline saffron red and oxygen in air undergo oxidation-reduction reaction to generate color change, and then are reduced to be colorless by glucose, so that the disinfectant is discolored, the fatty alcohol polyoxyethylene ether not only serves as a stabilizer to enable the alcohol disinfectant to be in a more stable physical and chemical property, but also can realize controllable adjustment of a color change period, especially the color change time from red to colorless is 55S-5min, and can meet the requirement of realizing visual indication on the disinfection operation process time requirement of medical staff through the color change of the alcohol disinfectant, and the requirement of the disinfection operation process time node of the medical staff is realized through the color change of the alcohol disinfectant.
In order to more intuitively show the technological advantages of the invention, the invention adopts the alcohol disinfectant with the color-changing indication function to compare with the same technology by adopting an equivalent replacement method,
Comparative example 1
The preparation method is the same as the example, except that in the preparation process of the comparative example, the indicator is replaced by methyl red, methylene red, bromocresol green and thymol blue solution;
0.1% (w/v) glucose, 0.05mol/L indicator, 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin, 0.08% (w/v) fatty alcohol-polyoxyethylene ether, and water as the solvent. Wherein the indicator comprises methyl red, methylene red, bromocresol green and thymol blue solution.
Mixing glucose solution with the mass concentration of 20% (w/v) with deionized water according to the mass ratio of 1:200, stirring and mixing 0.05 part of 1mol/L indicator solution with the mixed solution under the protection of nitrogen, and sequentially adding 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin and 0.08% (w/v) fatty alcohol-polyoxyethylene ether into the mixed solution under the protection of nitrogen, and stirring and mixing fully to obtain the disinfectant. The color of the front and back disinfection solution is not changed as shown in figure 6. It can be seen that when the indicator is selected from the group consisting of methyl red, methylene red, bromocresol green, thymol blue solutions, the color of the disinfectant does not change.
Comparative example 2
The preparation method is the same as that of the example, except that no reducing agent, namely glucose, is added in the preparation process of the comparative example;
The preparation method of the ethanol hand disinfectant comprises the following steps of:
0.05mol/L of alkaline saffron, 70% (v/v) ethanol, 1.0% (w/v) glycerol, 0.8% (w/v) allantoin, 0.08% (w/v) fatty alcohol polyoxyethylene ether, and water as the solvent.
Under the condition of nitrogen protection, 0.05 part by weight of 1mol/L indicator solution is added into 70% (v/v) ethanol solution, and 1.0% (w/v) glycerol, 0.8% (w/v) allantoin and 0.08% (w/v) fatty alcohol-polyoxyethylene ether are sequentially added, and fully stirred and mixed to obtain the disinfectant. The color change of the front and rear sterilizing fluids is shown in fig. 7 below. It can be seen that the color of the disinfectant does not change when glucose is not added to the disinfectant.
Comparative example 3
The preparation method is the same as the example, except that no reaction auxiliary agent, namely fatty alcohol polyoxyethylene ether, is added in the preparation process of the comparative example;
the preparation method of the ethanol disinfectant comprises the following steps of:
0.1-0.3% (w/v) glucose, 0.05-0.07mol/L alkaline saffron, 70% (v/v) ethanol, 0.8-1.0% (w/v) glycerol, 0.8-1.0% (w/v) allantoin, and water as solvent.
Mixing glucose solution with mass concentration of 20% (w/v) with deionized water according to mass ratio of 1:200, diluting, adding 0.05 part by weight of 1mol/L indicator alkaline saffron solution into 70% (v/v) ethanol solution under the protection of nitrogen, sequentially adding 1.0% (w/v) glycerol and 0.8% (w/v) allantoin, and stirring thoroughly to obtain disinfectant.
Placing the disinfectant prepared in comparative examples 1-3 in a test tube to contact with oxygen in the air, and slightly shaking the test tube to increase the effect of the disinfectant and the oxygen due to the limited contact area between the test tube and the oxygen, wherein the shaking frequency and time are fixed;
TABLE 3 comparative color development effects of different examples and comparative examples
From the data analysis in tables 1 and 3, it can be seen that:
(1) The alcohol disinfectant prepared in examples 1-5 was colorless-red-colorless in the color change process after exposure to air for a period of time, and the requirements of the time node of the disinfection operation process of medical staff were visually indicated by the color change of the alcohol disinfectant.
(2) In the comparative examples 1 and 2, the fading effect cannot be obtained, and the requirement of the color change of the alcohol disinfectant on the time requirement of the disinfection operation process of medical staff cannot be met;
(3) In the comparative example 3, the color change indication function of the disinfectant is invalid, the solution turns yellow and cannot be recovered because the fatty alcohol polyoxyethylene ether is not added in the disinfectant, so that the requirement of realizing visual indication on the time requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant cannot be met, namely, the requirement of realizing visual indication on the time node of the disinfection operation process of the medical staff through the color change of the alcohol disinfectant;
In order to more intuitively show the technological advantages of the invention, the invention adopts the alcohol disinfectant with the color-changing indication function and also adopts the color-developing effect in the skin sanitation and disinfection process,
TABLE 4 comparative color development effects of different examples and comparative examples
From Table 4, it can be seen that the alcohol disinfectant of the invention can be applied to different skin colors, including black, yellow or white skin colors, has obvious color change effect, and can meet the requirement of medical staff on realizing visual indication in the disinfection operation process time;
According to practical results, the color change time simulating the color development effect in the skin sanitation and disinfection process is adopted to contact with oxygen in the air when the disinfection solution is placed in the test tube, the effect of the disinfection solution and the oxygen is increased in a slight vibration mode of the test tube, the vibration frequency is not greatly different from the color change time of the color development effect with fixed time, especially, the color change time from red to colorless is not different, and the requirement of realizing visual indication on the disinfection operation process time requirement of medical staff through the color change of the alcohol disinfection solution can be met, namely, the requirement of realizing visual indication on the disinfection operation process time node of the medical staff through the color change of the alcohol disinfection solution;
In order to more intuitively show the technological advantages of the invention, the invention adopts the alcohol disinfectant with the color-changing indication function to further study the suitability of the color-changing time and the disinfection operation time node of the examples and the comparative example 3,
Comparative example 3-1
The preparation method is the same as in example 1, except that no reaction auxiliary agent, namely fatty alcohol polyoxyethylene ether, is added in the preparation process of the comparative example;
Comparative example 3-2
The preparation method is the same as in example 2, except that no reaction auxiliary agent, namely fatty alcohol polyoxyethylene ether, is added in the preparation process of the comparative example;
comparative examples 3 to 3
The preparation method is the same as in example 3, except that no reaction auxiliary agent, namely fatty alcohol polyoxyethylene ether, is added in the preparation process of the comparative example;
Comparative examples 3 to 4
The preparation method is the same as in example 4, except that no reaction auxiliary agent, namely fatty alcohol polyoxyethylene ether, is added in the preparation process of the comparative example;
comparative examples 3 to 5
The preparation method is the same as in example 5, except that no reaction auxiliary agent, namely fatty alcohol polyoxyethylene ether, is added in the preparation process of the comparative example;
TABLE 5 comparative color development effects of different examples and comparative examples
From Table 5, it is known that the fatty alcohol-polyoxyethylene ether is creatively added in examples 1-5, and the fatty alcohol-polyoxyethylene ether not only serves as a stabilizer to enable the alcohol disinfectant to be in a more stable physical and chemical property, but also can realize controllable adjustment of a color-changing period, especially the color-changing time from red to colorless is 55S-5min, the controllable range of the color-changing time is wide, the requirement of the color change of the alcohol disinfectant on the disinfection operation process time requirement of medical staff can be met, and the requirement of the color change of the alcohol disinfectant on the disinfection operation process time node of the medical staff can be met.
While comparative examples 1 to 5 obtained no-red-yellow discoloration effect, but the color difference between yellow and skin color was small, and not easy to observe, and more importantly, from the data in table 5, it was found that the discoloration effect of no-red-yellow was also obtained without adding fatty alcohol polyoxyethylene ether, but the discoloration time from red to yellow was 18S to 30S, and the discoloration time could not be improved to a greater extent by adjustment, and the discoloration time was short, so that the requirement for realizing visual indication of the time requirement of the disinfection operation process of medical staff by the color change of the alcohol disinfectant could not be met, and the requirement for realizing visual indication of the time node of the disinfection operation process of medical staff by the color change of the alcohol disinfectant.
To sum up:
The disinfectant prepared by the invention has the advantages that 1, the sterilizing effect of the disinfectant prepared by using alkaline saffron, glucose and fatty alcohol polyoxyethylene ether is not affected, 2, the initial liquid is in a colorless transparent state, turns red after being acted with oxygen in the air and turns colorless after a period of time, 3, the color changing time can be controlled by adjusting the proportion of the disinfectant in the process of changing the disinfectant from colorless to red to colorless, so that the disinfectant has better flexible application effect;
The color change indication principle of the prepared disinfectant is that under the action of the reaction auxiliary agent fatty alcohol polyoxyethylene ether, alkaline saffron and oxygen in the air undergo oxidation-reduction reaction to generate color change, and then are reduced to be colorless by glucose, so that the disinfectant is discolored;
Compared with the prior art, the invention has the obvious application effect that the alcohol disinfectant is applied to the skin sanitation disinfection process, the color change process of the alcohol disinfectant is colorless-red-colorless after the alcohol disinfectant contacts air for a period of time, and the visual indication is realized on the requirements of the disinfection operation process time nodes of medical staff through the color change of the alcohol disinfectant.
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| CN108904315A (en) * | 2018-08-06 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | A kind of foam type hand sanitizing fluid and preparation method thereof |
| CN111150705A (en) * | 2020-02-28 | 2020-05-15 | 北京蒙博润生物科技有限公司 | Alcohol hyaluronic acid disinfectant and preparation method thereof |
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| CN1594463A (en) * | 2004-07-02 | 2005-03-16 | 林劲冬 | Light catalyzed oxidation reduction degradation decolorization writing ink used for blackboard and degradation promoter thereof |
| US9134285B2 (en) * | 2006-11-30 | 2015-09-15 | Sensor International, Llc | Apparatus with timed color change indication |
| SG11201702732UA (en) * | 2014-10-03 | 2017-04-27 | Agency Science Tech & Res | Oxidant-dependent time indicator |
| CN108410206A (en) * | 2018-02-28 | 2018-08-17 | 郁锡群 | A kind of novel soft and type dye |
| WO2020070014A1 (en) * | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition comprising anionic surfactant and a polypeptide having rnase activity |
| KR20210051328A (en) * | 2019-10-30 | 2021-05-10 | 인하대학교 산학협력단 | Disinfectant |
| CN112970750B (en) * | 2021-02-23 | 2022-06-24 | 浙江工业大学 | A kind of quaternary ammonium salt disinfectant with fading indicator function and preparation method thereof |
| WO2023021329A1 (en) * | 2021-08-17 | 2023-02-23 | Wiab Water Innovation Ab | Compositions and methods to disinfect, treat and prevent microbial infections |
| CN114632017A (en) * | 2022-04-27 | 2022-06-17 | 山东利尔康医疗科技股份有限公司 | Hand disinfectant for inactivating coronavirus and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904315A (en) * | 2018-08-06 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | A kind of foam type hand sanitizing fluid and preparation method thereof |
| CN111150705A (en) * | 2020-02-28 | 2020-05-15 | 北京蒙博润生物科技有限公司 | Alcohol hyaluronic acid disinfectant and preparation method thereof |
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