Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a drug balloon delivery catheter.
In order to achieve the aim, the invention adopts the following technical scheme that the drug balloon delivery catheter comprises a catheter main body, wherein the catheter main body is provided with a balloon main body, and drugs are uniformly distributed on the surface of the balloon main body;
The balloon body is of an olive-like structure, after reaching a target area, filling holes formed in the catheter body are filled with filling liquid into the balloon body so that the balloon body can be inflated, and the balloon body is fully attached to the inner wall of the target after being inflated.
As a further description of the above technical solution, the balloon body includes a middle inflation body portion and head end portions at both ends.
As a further description of the above technical solution, the diameter of the head end is not greater than 25mm and the diameter of the expansion body is not greater than 45mm at the initial stage of the balloon body.
As a further description of the above technical solution, the balloon body, after inflation, has a diameter of the head end portion of no more than 40mm and a maximum diameter of the inflation body portion of no more than 65mm.
As a further description of the above technical solution, the diameter of the head end portion is reduced by a larger amount than the diameter of the expansion body portion under the same pressure.
As a further description of the above technical solution, the central axis of the balloon body is collinear with the central axis of the catheter body.
As a further description of the above technical solution, the central axis of the balloon body is eccentrically disposed from the central axis of the catheter body.
As a further description of the above technical solution, at least one end of the catheter body is provided with a blocking balloon.
As a further description of the above technical solution, the material of the balloon body is a polyurethane material.
As a further description of the above technical solution, the balloon body is a preformed balloon, which, when preformed, immerses the balloon mold into the polyurethane solution;
Taking out the balloon mold and waiting for the polyurethane solution on the surface of the balloon mold to be cured;
and (5) after the curing is finished, obtaining the preformed balloon main body.
The invention has the following beneficial effects:
According to the invention, the preformed olive-like compliant balloon is adopted, the PGG medicine is adhered to the surface of the balloon, and after the balloon reaches a target area, the balloon is expanded, so that the balloon is in contact with the vessel wall of a treatment area to act, the olive-like balloon can have sufficient medicine carrying area, and the balloon is in contact with the vessel wall by a small amount of expanded balloon, so that the treatment effect is fully realized, and meanwhile, the risk of injury to the vessel wall of an aneurysm is reduced.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The embodiment of the application provides a drug balloon delivery catheter, which solves the problem that the drug is excessively ingested when the PGG liquid drug is utilized for drug infusion in the prior art, and meanwhile, under the action of gravity, the lower half part of a target treatment area contacts more drugs than the upper half part to cause uneven treatment. In order to solve the problem, the technical conception of the application is to provide the olive-like medicine balloon, PGG medicines are uniformly distributed on the surface of the medicine balloon, after the olive-like medicine balloon reaches the target area, namely the abdominal aneurysm 400 in the middle and early stage, the olive-like medicine balloon can be inflated, and a small amount of inflation can enable the medicine balloon to be in contact with the vessel wall, so that the effect of the PGG medicines can be fully exerted, and the treatment effect is more uniform. In the prior art, even though PGG drugs are distributed on the surface of the balloon, the adopted balloon is generally a compliant balloon, the compliant balloon is in a round ball shape after filling, and for the arc-shaped vessel wall, the maximum diameter of the balloon is firstly contacted with the vessel wall, and when other parts of the balloon are required to be fully contacted with the vessel wall, the pressure at the maximum diameter of the balloon is required to be larger or the extrusion of the vessel wall is more serious, but the vessel wall of the aneurysm 400 in the early and middle stages is relatively weak, and the risk of rupture of the aneurysm 400 exists.
In addition, the existing compliant balloons are mostly molded by a blow molding process, and the existing compliant balloons have the effect of being used for expanding a narrow channel such as a blood vessel, so that the wall thickness of the balloon is uneven, and during the expansion process, the part with the thinner wall thickness can be rapidly expanded, thereby realizing the rapid expansion of the narrow channel and then opening.
In the present application, the balloon is molded by adopting the dipping process, the wall thickness of the formed balloon main body 200 is uniform, and in the process of attaching to the lesion position such as an aneurysm, the expansion of the whole balloon main body 200 is uniform, so that the aneurysm which is the lesion position is not damaged due to the excessively high expansion speed of a part of the region, and meanwhile, the whole balloon main body 200 is attached to the aneurysm 400, so that the medicine on the balloon main body 200 is fully contacted with the aneurysm 400, and the treatment effect is improved.
Referring to fig. 1-3, in an embodiment of the present invention, a drug balloon catheter is provided, and the specific structure of the drug balloon catheter includes a catheter main body 100, wherein the catheter main body 100 can deliver a drug balloon to a target location, in this embodiment, a mid-early abdominal aneurysm 400 is formed, a filling hole 110 is formed in the catheter main body 100, and filling liquid can be poured or pumped into the drug balloon through the filling hole 110, so as to realize filling and shrinkage of the drug balloon.
The drug balloon, i.e. the balloon body 200 in this embodiment is connected to the outside of the catheter body 100, the balloon body 200 is preformed to be olive-like in vitro, it is understood that the preforming to be olive-like means that the balloon body 200 presents an olive-like shape when in a filled and unexpanded state, preferably, in this embodiment, the balloon body 200 includes two end head ends 210 and a middle expansion body, wherein the diameter of the head end 210 is not greater than 25mm in the initial state of being filled and unexpanded, the diameter of the expansion body is not greater than 45mm, and the diameter of the head end 210 is not greater than 40mm in the fully filled and expanded state, and the maximum diameter of the expansion body in the middle is not greater than 65mm, so that the balloon body 200 can have a larger drug carrying area, and can better fit the inner wall of the blood vessel of the aneurysm 400, so that the therapeutic effect is better and uniform, and at the same time, the risk of relatively easily breaking the inner wall of the aneurysm 400 can be effectively reduced.
The material selected for the balloon body 200 in the present application is polyurethane material, namely TPU, and the balloon body 200 using the polyurethane material has high elasticity and high strength, and also has excellent wear resistance and oil resistance. Meanwhile, the TPU also has excellent biocompatibility, so that the balloon main body 200 can keep stable in-vivo environment.
At least one blocking balloon 300 is arranged on the catheter main body 100, and before the balloon main body 200 is inflated, the blocking balloon 300 can be filled to block blood in a blood vessel, so that the control of high-flow blood flow is realized, the loss of PGG medicine on the surface of the balloon main body 200 under the scouring of the blood flow is reduced, and the treatment effect on abdominal aorta is reduced. In some other embodiments, the blocking balloon 300 is provided with two blocking balloons, which are respectively arranged at two ends of the balloon body 200, so that the area where the balloon body 200 is located is a closed area.
Further, since the diameter of the head end 210 of the balloon body 200 is increased by an amount smaller than that of the balloon body 220, it is understood that since the entire balloon body 200 is of a preformed olive-like shape, when the diameter of the balloon body 200 is increased by an amount larger than that of the head end 210, the balloon body 200 will be close to the inside of the aneurysm 400 first, whereas since the diameter of the head end 210 itself is relatively small and the diameters of both ends of the aneurysm 400 are relatively small, even though the diameter of the head end 210 is slightly smaller, both ends of the aneurysm 400 can be blocked by the head end 210, as shown in fig. 2, a closed region is formed between the balloon body 200 and the aneurysm 400, and when PGG drug acts on the vessel wall, the drug diffuses to a non-target position, affecting the therapeutic effect of the drug. It should be noted that, in fig. 2, by making the head end 210 closer to the vessel wall, it is characterized that a closed region may be formed between the balloon body 200 and the aneurysm 400.
Further, in the present embodiment, the central axis of the balloon body 200 is in the same line as the central axis of the catheter body 100, and in this case, the balloon body 200 has an axisymmetric structure, and the abdominal aneurysm 400 to which it is applied has a symmetric structure.
In some embodiments, the central axis of the balloon body 200 and the central axis of the catheter body 100 may also be non-coincident, specifically, the balloon body 200 is eccentrically disposed on the catheter (refer to fig. 3), which is applied to the abdominal aortic aneurysm 400 with a clinically practical asymmetric structure.
Further, as shown in fig. 4, through holes are formed in the catheter main body 100, and the through holes are provided in the catheter main body 100 at both ends of the balloon main body 200, respectively. Specifically, the blood flow inlet 500 is provided in the catheter body 100 at one end of the balloon body, the blood flow outlet 600 is provided in the catheter body 100 at the other end of the balloon body, and the direction from the blood flow inlet 500 to the blood flow outlet 600 is the direction of blood flow, and the blood flow inlet 500 and the blood flow outlet 600 constitute a blood flow channel in the catheter body 100.
For easier understanding, the present application also provides a method for preparing the preformed balloon body 200, specifically:
Preparing a polyurethane solution, and immersing a balloon mold into the polyurethane solution;
after a period of soaking, the mold is lifted out of the polyurethane solution, at this time, a layer of TPU solution is attached to the surface of the mold, and the polyurethane solution on the surface of the balloon mold is cured to obtain the preformed balloon body 200.
It should be noted that the foregoing description is only a preferred embodiment of the present invention, and although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood that modifications, equivalents, improvements and modifications to the technical solution described in the foregoing embodiments may occur to those skilled in the art, and all modifications, equivalents, and improvements are intended to be included within the spirit and principle of the present invention.