CN119454082A - Ultrasound contrast imaging diagnostic method and system - Google Patents
Ultrasound contrast imaging diagnostic method and system Download PDFInfo
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Abstract
The invention discloses an ultrasonic contrast diagnosis method and system, which comprise the steps of determining an area of interest and an imaging section, performing ultrasonic scanning and synchronously generating a tissue gray level image and a contrast video, collecting contrast data in the contrast video within a selected time period, acquiring corresponding radio frequency data, acquiring perfusion characteristics based on the contrast data, extracting blood vessel blood flow parameters based on the radio frequency data, and comprehensively diagnosing the area of interest according to the perfusion characteristics and the blood vessel blood flow parameters. The invention combines the perfusion characteristics and blood vessel blood flow parameters, analyzes the perfusion condition of the blood vessel in the region of interest from a macroscopic angle, and analyzes the blood flow dynamics information and the morphological information of the blood vessel in the region of interest from a microscopic angle. And the perfusion characteristics and the blood vessel blood flow parameters are synchronously acquired based on the same time, so that the information synchronism of the perfusion characteristics and the blood vessel blood flow parameters is higher, the combinability is stronger, the analysis and judgment of the focus area are more accurate, and the medical staff can be helped to deeply understand the focus area.
Description
Technical Field
The invention relates to the technical field of ultrasonic contrast diagnosis, in particular to an ultrasonic contrast diagnosis method and system.
Background
In the field of modern medical image diagnosis, ultrasonic contrast imaging is an important tool for evaluating vascular distribution, blood flow perfusion, tissue focus characteristics and the like as a non-radiative, real-time and high-resolution technical means, and is widely applied to disease diagnosis of various organs such as heart, liver, kidney, thyroid and the like. Conventional ultrasound contrast imaging refers to the technique of imaging injected contrast agent enhanced echoes.
In one aspect of the prior art, contrast imaging techniques provide physicians with visual information about vascular structure, blood flow velocity, and blood flow perfusion volume by intravenous injection of contrast agent and observation of its perfusion characteristics in the lesion area. However, the method mainly depends on the macro perfusion process and distribution of the contrast agent, and the specific motion track, morphological change and detail capturing capability of dynamics characteristics of the contrast agent microbubble in blood vessels or tissues are insufficient, so that a diagnosis result can be rough and lack of basis for deep analysis.
With the continuous progress of medical imaging technology and the increasing clinical demands, the perfusion characteristics obtained by only relying on contrast imaging can reflect the blood flow condition of a lesion area, but the detailed tracking and analysis of the motion track of the contrast agent microbubbles on a microscopic level are often lacking, so that the morphological and hemodynamic information of the lesion area is not deeply understood, and more accurate diagnosis cannot be performed.
Disclosure of Invention
The invention aims to provide an ultrasonic contrast diagnosis method and an ultrasonic contrast diagnosis system, which are used for solving the problem that the contrast imaging technology in the prior art mainly depends on macroscopic distribution of contrast agent and has insufficient detail capturing capability on the microbubbles of the contrast agent in blood vessels or tissues.
In order to achieve one of the above objects, an embodiment of the present invention provides an ultrasound contrast diagnosis method, including determining a region of interest and an imaging section of an object, performing ultrasound scanning on the region of interest and generating a tissue gray image and a contrast video simultaneously;
acquiring contrast data in the contrast video within a selected time and acquiring corresponding radio frequency data, wherein the radio frequency data and the contrast data correspond to each other in a time dimension;
obtaining perfusion characteristics of a contrast agent within the region of interest based on the contrast data;
Obtaining morphological and hemodynamic information of a vascular network in the region of interest based on the radio frequency data analysis, and extracting vascular blood flow parameters in the morphological and hemodynamic information;
and comprehensively diagnosing the region of interest according to the perfusion characteristics and the blood vessel blood flow parameters.
As a further improvement of the present invention, the method further comprises the steps of ultrasonically scanning the region of interest and synchronously generating a tissue grayscale image and a contrast video, including:
transmitting an ultrasonic signal;
and receiving an echo signal of the ultrasonic wave, and generating a tissue gray level image and a contrast video according to the echo signal.
As a further improvement of the present invention, the method further includes the specific steps of acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video, including:
detecting and receiving a data acquisition instruction in an ultrasonic scanning process, wherein the data acquisition instruction is generated at least once according to the real-time conditions of the tissue gray level image and the contrast video;
and acquiring radio frequency data representing ultrasonic echo according to the data acquisition instruction and synchronously extracting contrast data in the contrast video.
As a further improvement of the invention, the method further comprises detecting and receiving an acquisition end instruction during the ultrasound scanning process:
detecting and receiving at least one data acquisition instruction in the ultrasonic scanning process;
and continuously acquiring the radio frequency data and the contrast data based on the received data acquisition instruction and ending the acquisition when the acquisition ending instruction is received, wherein the acquisition ending instruction is generated according to the real-time condition of the tissue gray level image and the contrast video.
As a further improvement of the invention, the method further comprises the steps of presetting the acquisition time length:
detecting and receiving at least one data acquisition instruction in the ultrasonic scanning process;
and acquiring the radio frequency data and the contrast data within the preset duration according to the data acquisition instruction.
As a further refinement of the invention the method further comprises the step of obtaining perfusion characteristics of a contrast agent in the region of interest based on the contrast data specifically comprises:
obtaining the average intensity of the contrast agent microbubbles when the contrast agent is perfused into the region of interest according to the contrast data and generating a change curve of the average intensity corresponding to time based on the perfusion time;
And extracting time parameters and intensity parameters in the change curve, and determining the perfusion characteristics.
As a further improvement of the invention, the method further comprises the steps of obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting vascular blood flow parameters from the morphological and hemodynamic information specifically comprises:
filtering the radio frequency data and continuously positioning the positions of the contrast agent microbubbles according to the radio frequency data;
Tracking the motion trail of the contrast agent microbubbles to obtain density information and speed information of the contrast agent microbubbles;
mapping the density information and the speed information in a vascular network space, and carrying out morphological imaging and kinetic imaging to obtain morphological and hemodynamic information;
the vessel blood flow parameters are extracted from the morphological and hemodynamic information.
As a further improvement of the invention, the method further comprises the following steps when acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video:
And monitoring the tissue gray level image in the ultrasonic scanning process, and guiding and adjusting the imaging section according to the tissue gray level image so that the acquisition process of the radio frequency data and the contrast data is based on the same imaging section.
As a further improvement of the invention, the method further comprises the steps of obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting vascular blood flow parameters from the morphological and hemodynamic information specifically comprises:
Acquiring and storing multi-frame tissue gray level images corresponding to the contrast video along the time dimension, and performing correlation analysis on the stored multi-frame tissue gray level images to obtain a motion difference curve of the tissue;
Acquiring partial data frames in the radio frequency data based on the motion difference curve indication, wherein the data frames are characterized as partial data of which the motion difference of a scanning section in the radio frequency data accords with a preset condition;
filtering the data frame and continuously positioning the positions of the contrast agent microbubbles according to the data frame;
Tracking the motion trail of the contrast agent microbubbles to obtain density information and speed information of the contrast agent microbubbles;
mapping the density information and the speed information in a vascular network space, and carrying out morphological imaging and kinetic imaging to obtain morphological and hemodynamic information;
the vessel blood flow parameters are extracted from the morphological and hemodynamic information.
The invention also provides an ultrasonic contrast diagnosis system, which comprises an ultrasonic probe, a detection module and a control module, wherein the ultrasonic probe is used for performing ultrasonic scanning on ultrasonic waves emitted by a region of interest;
The ultrasonic diagnostic apparatus transceiver control module is electrically connected with the ultrasonic probe and used for controlling the ultrasonic probe to emit ultrasonic waves and receiving echo signals of the ultrasonic waves;
The ultrasonic diagnostic apparatus imaging and processing analysis module is electrically connected with the ultrasonic diagnostic apparatus transceiver control module and is configured to diagnose a region of interest of a subject by adopting the ultrasonic contrast diagnosis method as set forth in any one of the above.
Compared with the prior art, the invention has the beneficial effects that the perfusion characteristics and the blood vessel blood flow parameters are combined, so that on one hand, the perfusion condition of the blood vessel in the region of interest can be analyzed from a macroscopic angle, and on the other hand, the dynamic information and the morphological information of the blood vessel in the region of interest can be analyzed from a microscopic angle. And the perfusion characteristics and the blood vessel blood flow parameters are synchronously acquired based on the same time, so that the information synchronism of the perfusion characteristics and the blood vessel blood flow parameters is higher, the combinability is stronger, the analysis and judgment of the focus area are more accurate, and the medical staff can be helped to deeply understand the focus area.
Drawings
FIG. 1 is a flow chart of a diagnostic ultrasound contrast method in an embodiment of the present invention.
Fig. 2 is a flowchart of acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video according to an embodiment of the present invention.
Fig. 3 is a specific flowchart of obtaining perfusion characteristics of a contrast agent in a region of interest based on contrast data in an embodiment of the present invention.
FIG. 4 is a flowchart of a method for obtaining morphology and hemodynamic information of a vascular network in a region of interest and extracting blood flow parameters based on RF data analysis, in accordance with one embodiment of the present invention.
Fig. 5 is a flowchart showing a method for obtaining morphology and hemodynamic information of a vascular network in a region of interest and extracting blood flow parameters based on radio frequency data analysis, according to another embodiment of the present invention.
Fig. 6 is a block diagram of an ultrasound contrast diagnostic system in an embodiment of the invention.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments shown in the drawings. These embodiments are not intended to limit the invention and structural, methodological, or functional modifications of these embodiments that may be made by one of ordinary skill in the art are included within the scope of the invention.
The imaging diagnosis of the present invention includes diagnosis of two-dimensional imaging as well as diagnosis of three-dimensional imaging.
In one embodiment of the present invention, an ultrasound contrast diagnosis method is provided, which can integrate multiple types of data (ultrasound radio frequency data, ultrasound tissue gray scale image, ultrasound contrast video) to form a multi-scale ultrasound contrast image for diagnosing a potential lesion area.
In the field of the invention, imaging slices are an important concept in medical imaging for acquiring and analyzing images. The imaging section can clearly show the structure, shape and distribution of each tissue and organ in the human body. By analyzing the image presented by the imaging section, it is possible to determine whether a lesion, such as a tumor, cyst, inflammation, etc., is present and to preliminarily determine the nature, size, location and relationship with surrounding tissue of the lesion. Imaging slices include transverse, longitudinal, coronal, and sagittal planes. In the invention, an ultrasonic probe is adopted to emit a section scanned by sound beams, and the probe array element direction and the depth direction form an x-z section. Where the x-axis generally represents the array element direction of the probe (i.e., the scan range across the width of the probe), and the z-axis represents the depth direction of the acoustic beam (i.e., the direction of penetration of the acoustic wave through the tissue).
In the present field, a region of interest (Region of Interest, ROI) refers to a region or object of particular interest in an image, which typically contains critical information to be identified, analyzed or processed, in the medical field, specifically a potential lesion area.
In one embodiment of the present invention, the imaging section may be selected by the medical staff according to the actual situation.
Specifically, medical staff judges whether the current section of the tissue gray level image contains a region of interest, namely a suspicious focal region, and then starts contrast injection contrast agent. The region of interest may be further manually framed when analyzing the radio frequency data to extract the vascular blood flow parameters therein. The region of interest may be further manually framed when obtaining perfusion characteristics of the contrast agent within the region of interest based on the contrast data.
As shown in fig. 1, in one embodiment of the present invention, an ultrasound contrast diagnostic method includes at least the steps of:
and S1, determining an interested region and an imaging section of an object, performing ultrasonic scanning on the interested region, and synchronously generating a tissue gray level image and a contrast video.
The contrast video comprises a plurality of contrast images that are consecutive in a time dimension.
Before the region of interest is scanned ultrasonically and tissue grey scale images and contrast videos are generated synchronously, contrast agents are required to be injected, the ultrasonic contrast agents are usually substances capable of absorbing or reflecting sound waves with specific wavelengths, after the contrast agents are injected into a body, signals returned by scanning are processed through ultrasonic scanning, microbubble signals of the contrast agents are extracted, at the moment, signals of surrounding tissues are restrained, only the microbubble signals are reserved, and the microbubble signals in the body are analyzed, so that doctors can be helped to identify pathological parts more accurately. Ultrasound scanning is the emission of ultrasound waves to a region of interest.
In the present invention, the tissue gray scale image generally refers to a gray scale image generated after scanning the tissue structure inside the human body by the B mode of ultrasound, that is, the gray scale imaging mode.
In the present invention, a contrast video generated by ultrasound contrast is a medical image, and a back scattering signal flowing through a tissue or an organ is enhanced by injecting a contrast agent into a body, so that the back scattering signal is more prominent in the image.
And generating a tissue gray image and a contrast video of the region of interest by scanning the region of interest by ultrasonic waves, wherein the flow of the contrast agent in the blood vessel causes dynamic change of the contrast video, and when the contrast agent starts to be injected into the region of interest, the contrast video dynamically changes in real time according to the flow of the contrast agent.
And S2, acquiring contrast data in the contrast video in a selected time and acquiring corresponding radio frequency data, wherein the radio frequency data and the contrast data correspond in a time dimension.
And acquiring radio frequency data of the ultrasonic echo based on the data acquisition instruction, wherein the radio frequency data comprises multi-frame data. The radio frequency data is acquired while the contrast data in the contrast video is acquired. The contrast data is a continuous multi-frame contrast image collection in the contrast video. The radio frequency data characterizes echo signals generated when ultrasound scans contrast agent microbubbles in a slice. Wherein the scan plane includes a region of interest.
The correspondence of the radio frequency data and the contrast data in the time dimension may be understood as the simultaneous acquisition of radio frequency data and contrast data and the simultaneous end of acquisition.
In one embodiment, the radio frequency data and the contrast data may be acquired multiple times.
And step S3, obtaining perfusion characteristics of the contrast agent in the region of interest based on the contrast data.
The condition of the lesion in the region of interest may be analyzed by differences between perfusion characteristics of the contrast agent in the region of interest and perfusion characteristics in other regions.
In one embodiment, the perfusion feature comprises an enhanced amount of contrast agent perfusion. Based on analysis of the perfusion characteristics, a lesion of interest, such as a malignant or benign tumor, may be obtained.
And obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting vascular blood flow parameters in the morphological and hemodynamic information.
The contrast agent flows in the blood vessel in the region of interest, and morphological and hemodynamic information of the blood vessel is obtained from the flow detection of the contrast agent in the blood vessel. Among them, morphological information of blood vessels mainly focuses on the structure and morphological characteristics of blood vessels. Hemodynamic information of blood flow is mainly focused on the flow characteristics of blood in blood vessels.
In one embodiment, the vascular flow parameters include blood flow velocity in the blood vessel, blood vessel density, tortuosity, and complexity.
In this way, detection of blood flow parameters of the blood vessel helps to assess the severity of vascular lesions. For example, in cardiovascular angiography, the severity of coronary heart disease can be determined by parameters such as blood flow velocity in the blood vessel, vessel density, tortuosity, and complexity. Before interventional therapy (such as vascular embolism, chemoembolization and the like), the vascular condition of a focus area is known through radiography examination, so that an accurate interventional therapy scheme can be formulated, and complications are reduced.
And S4, comprehensively diagnosing the region of interest according to the perfusion characteristics and the blood vessel blood flow parameters.
Therefore, by combining the perfusion characteristics and the blood vessel blood flow parameters, on one hand, the perfusion condition of the blood vessel in the region of interest can be analyzed from a macroscopic angle, and on the other hand, the dynamic information and the morphological information of the blood vessel in the region of interest can be analyzed from a microscopic angle. And the radio frequency data and the contrast data are synchronously acquired based on the same time, so that the information synchronism of the perfusion characteristics and the blood flow parameters of the blood vessel is higher, the combinability is stronger, the analysis and judgment of the focus area are more accurate, and the medical staff can be helped to deeply understand the focus area.
In the invention, the perfusion characteristic is generated based on contrast data in a contrast video generated by ultrasonic detection of contrast agent, and the vascular blood flow parameter is generated based on radio frequency data in an echo signal of ultrasonic wave to the contrast agent. Perfusion characteristics and vascular blood flow parameters are based on the same imaging slice and both result from the detection of contrast agent by ultrasound. The perfusion characteristics are focused on perfusion information of the contrast agent in the region of interest from a macroscopic aspect in the invention, and the blood vessel blood flow parameters are focused on dynamic information and blood vessel morphology information of the metabolism of the intravascular contrast agent along with blood flow from a microscopic aspect in the invention. Both diagnose focal areas from a combination of macroscopic and microscopic dimensions.
In an embodiment of the present invention, the ultrasound scanning and synchronous generation of the tissue gray scale image and the contrast video for the region of interest includes:
transmitting an ultrasonic signal;
in some embodiments, the ultrasonic signals may be transmitted in a focused transmission, a weakly focused transmission, and an unfocused transmission (e.g., plane wave, divergent wave transmission).
And receiving an echo signal of the ultrasonic wave, and generating a tissue gray level image and a contrast video according to the echo signal.
As shown in fig. 2, in an embodiment of the present invention, the specific steps of acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video include:
And step S2.1, detecting and receiving a data acquisition instruction in the ultrasonic scanning process, wherein the data acquisition instruction is generated at least once according to the real-time condition of the tissue gray level image and the contrast video.
And step S2.2, acquiring radio frequency data representing ultrasonic echo according to the data acquisition instruction and synchronously extracting contrast data in the contrast video.
The process of contrast agent perfusion into the region of interest includes a contrast agent perfusion phase, contrast agent intensity peak display, and contrast agent gradual circulation metabolism exit elimination phase. In one embodiment, the data acquisition instructions are generated at any one time during the perfusion phase. In one embodiment, the data acquisition instructions are generated at any one of the time periods of contrast agent regression. In an embodiment, the data acquisition instructions are generated at any one time in the perfusion phase and at any one time in the contrast agent regression phase, i.e. once in the perfusion phase and once in the regression phase. It should be noted that, in other embodiments, the number of times the data acquisition instruction is generated is not limited.
In one embodiment, the generation of the data acquisition command is automatically generated according to a preset time. In one embodiment, the generation of the data acquisition instructions is manually generated based on the observations of the healthcare worker.
Wherein, the real-time status according to the tissue gray level image and the contrast video can be understood as that the data acquisition instruction is generated based on the steady state of the tissue gray level image and the flow of the display contrast agent in the contrast video (such as the contrast agent starts to enter the region of interest).
Based on the foregoing implementation manner, in an embodiment, the method further includes detecting and receiving an acquisition end instruction during the ultrasound scanning process:
detecting and receiving at least one data acquisition instruction in the ultrasonic scanning process;
and continuously acquiring the radio frequency data and the contrast data based on the received data acquisition instruction and ending the acquisition when the acquisition ending instruction is received, wherein the acquisition ending instruction is generated according to the real-time condition of the tissue gray level image and the contrast video.
Therefore, the acquisition time can be controlled by controlling the generation of the acquisition end instruction, the acquisition time can be further selectively prolonged or shortened according to the actual situation, the controllability is higher, and the flexible adjustment of medical staff can be facilitated.
In another embodiment, the method further includes the step of presetting the acquisition duration:
detecting and receiving at least one data acquisition instruction in the ultrasonic scanning process;
and acquiring the radio frequency data and the contrast data within the preset duration according to the data acquisition instruction.
Therefore, the system can automatically end the collection of radio frequency data and contrast data by setting the preset collection duration, and the collection duration can be preset in advance, so that the workload of medical staff is reduced.
As shown in fig. 3, in an embodiment of the present invention, the obtaining the perfusion characteristic of the contrast agent in the region of interest based on the contrast data specifically includes:
Step K3.1, obtaining the average intensity of the contrast agent microbubbles when the contrast agent is perfused into the region of interest according to the contrast data and generating a change curve of the average intensity corresponding to time based on the perfusion time;
and K3.2, extracting time parameters and intensity parameters in the change curve, and determining perfusion characteristics.
Wherein the intensity of the contrast agent microbubbles characterizes the brightness of the contrast agent microbubbles in the image. The average intensity of the contrast agent microbubbles can be obtained by summing the gray signals of all the contrast agent microbubbles in the region of interest and dividing by the number of the contrast agent microbubbles in the region of interest.
Based on the acquisition duration, continuously calculating the average intensity of the contrast agent microbubbles in the region of interest, and forming a variation curve of the average intensity according to the time relationship. Wherein the abscissa of the variation curve is a time variable and the ordinate of the variation curve is an average intensity variable.
In one embodiment, time parameters such as the arrival time of the average intensity, the peak halving time, and the like, and intensity parameters such as the peak intensity, the peak halving intensity, and the like are extracted from the variation curve. The arrival time of the average intensity is understood to be the time when the contrast agent microbubbles appear in the region of interest, the arrival peak time of the average intensity is understood to be the time when the average intensity of the contrast agent microbubbles is maximum in the region of interest, and the peak halving time is understood to be the time corresponding to half the average intensity of the contrast agent microbubbles in the region of interest.
And determining the perfusion characteristics of the contrast agent in the region of interest according to the time parameters such as the arrival time of the average intensity, the peak halving time and the like and the intensity parameters such as the peak intensity, the peak halving intensity and the like.
As shown in fig. 4, in an embodiment of the present invention, the obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting the vascular blood flow parameters therein specifically includes:
and step Z3.1, filtering the radio frequency data and continuously positioning the position of the contrast agent microbubbles according to the radio frequency data.
And step Z3.2, tracking the motion track of the contrast agent microbubbles to obtain density information and speed information of the contrast agent microbubbles.
And step Z3.3, mapping the density information and the speed information into a vascular network space, and carrying out morphological imaging and kinetic imaging to obtain morphological and hemodynamic information.
And step Z3.4, extracting the blood flow parameters of the blood vessel from the morphological and blood flow dynamics information.
In the above embodiment, the filtering, positioning and tracking operations of the contrast agent in the multi-frame radio frequency data are performed, so that the background noise and unnecessary interference signals are removed, the image quality is improved, and the motion trail of the microbubbles is obtained.
By counting the number of microbubbles per unit volume or per unit area, the density distribution of the microbubbles of the contrast agent within the blood vessel can be indirectly reflected.
Based on the duration of the acquired data and the motion trail of the contrast agent microbubbles, the rate of change of displacement of the contrast agent microbubbles with time, namely speed information, can be calculated.
Mapping the density information and the speed information into a blood vessel network space of an image to perform morphological imaging and dynamic imaging, and analyzing the morphological imaging and the dynamic imaging to obtain the morphological and blood flow dynamic information of the blood vessel.
In an embodiment of the present invention, when acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video, the method further includes:
And monitoring the tissue gray level image in the ultrasonic scanning process, and guiding and adjusting the imaging section according to the tissue gray level image so that the acquisition process of the radio frequency data and the contrast data is based on the same imaging section.
Therefore, the stability of an imaging section can be ensured, and the region corresponding to the data caused by the object deviation in the data acquisition process is prevented from being different from the region of interest.
In an embodiment of the present invention, as shown in fig. 5, the obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting the vascular blood flow parameters therein specifically includes:
And step T3.1, acquiring and storing multi-frame tissue gray images corresponding to the contrast video along the time dimension, and performing correlation analysis on the stored multi-frame tissue gray images to obtain a tissue motion difference curve.
The motion difference curve describes the difference in motion of a tissue over time. For showing the change in motion within a tissue or between different tissues over a specific period of time.
In one embodiment, the correlation analysis is to extract features for analysis, such as pixel positions, gray values, texture features, etc., from each frame of image of the rf data. And calculating the displacement of pixels or areas between adjacent frames by using an image processing technology (such as a characteristic point tracking technology), so as to obtain the motion information of the tissues, and calculating the motion difference degree between different tissues or inside the tissues within a specific time period based on the motion information.
And step T3.2, based on the motion difference curve indication, acquiring partial data frames in the radio frequency data, wherein the data frames are characterized in that the motion difference of the scanning section in the radio frequency data accords with the partial data of the preset condition.
The obtaining of the partial data frame in the radio frequency data may be understood as selecting a data frame corresponding to a segment with smaller motion difference in the motion difference curve.
In one embodiment, the degree of difference satisfies a predetermined condition, the predetermined condition representing a range.
In another embodiment, the degree of variability may be selected based on healthcare worker observations.
And step T3.3, filtering the data frame and continuously positioning the positions of the contrast agent microbubbles according to the data frame.
Specifically, the data frame is subjected to high-pass wall filtering.
And step T3.4, tracking the motion track of the contrast agent microbubbles, and obtaining the density information and the speed information of the contrast agent microbubbles.
And step T3.5, mapping the density information and the speed information into a vascular network space, and carrying out morphological imaging and kinetic imaging to obtain morphological and hemodynamic information.
And step T3.6, extracting the blood flow parameters of the blood vessel from the morphological and blood flow dynamics information.
Therefore, the accuracy of the data can be ensured by selecting the data frame corresponding to the section of curve with smaller difference.
In one embodiment of the invention, when the motion track of the contrast agent microbubbles is analyzed and processed based on the radio frequency data, the speed information of the contrast agent microbubbles is calculated through the constraint of acceleration, so that the calculated information is more accurate and reliable.
As shown in FIG. 6, in one embodiment of the present invention, an ultrasound contrast diagnostic system is also provided for performing ultrasound scanning diagnosis on a patient and analyzing the condition of the incorporated lesion area for reference by medical personnel. The ultrasonic contrast diagnosis system comprises an ultrasonic probe 1, an ultrasonic diagnostic apparatus receiving and transmitting control module 2 and an ultrasonic diagnostic apparatus imaging and processing analysis module 3.
The ultrasound probe 1 is used for ultrasound scanning of ultrasound emitted by a region of interest.
The ultrasonic diagnostic apparatus transceiver control module 2 is electrically connected with the ultrasonic probe and is used for controlling the ultrasonic probe 1 to emit ultrasonic waves and receive echo signals of the ultrasonic waves.
The diagnostic ultrasound imaging and processing analysis module 3 is electrically connected to the diagnostic ultrasound transceiver control module 2 and is configured to diagnose a region of interest (lesion area) of a subject (patient) using the diagnostic ultrasound imaging method as described in any of the embodiments above.
In one embodiment of the invention, the transceiver control module of the ultrasonic diagnostic apparatus controls the ultrasonic probe to perform scanning of tissue imaging and contrast imaging, so that the time duty ratio of the ultrasonic probe and the contrast imaging can be changed according to the requirement, and the emission modes (focusing scanning lines, weak focusing wide beams, unfocused plane waves and diffusion waves) of the ultrasonic probe and the contrast imaging can be selected.
In summary, an embodiment of the present invention provides an ultrasound contrast diagnostic method for solving the problem that the contrast imaging technique in the prior art mainly depends on the macroscopic distribution of the contrast agent, and the capturing capability of the contrast agent microbubbles in blood vessels or tissues is insufficient. The method mainly comprises the steps of generating a tissue gray image and a contrast video by ultrasonic scanning based on injection of contrast agent, synchronously acquiring radio frequency data and contrast data, analyzing the radio frequency data and the contrast data to obtain perfusion characteristics and blood vessel blood flow parameters, and analyzing and diagnosing the condition of a focus area by combining the perfusion characteristics and the blood vessel blood flow parameters.
In order to further improve the accuracy of data, the consistency of an imaging section is ensured by using the tissue gray level image, and meanwhile, a section with smaller motion difference degree is obtained by carrying out correlation processing on the tissue gray level image before the analysis of the radio frequency data, so that a corresponding partial frame in the radio frequency data is intercepted, and further, the partial data frame is analyzed to obtain blood vessel blood flow parameters, thereby improving the accuracy of data analysis.
Another embodiment of the invention provides an ultrasonic contrast diagnosis system based on multi-scale data, which comprises an ultrasonic probe, an ultrasonic diagnostic apparatus receiving and transmitting control module and an ultrasonic diagnostic apparatus imaging and processing analysis module. The method is used for scanning diagnosis by adopting the ultrasonic contrast diagnosis method.
It will be clear to those skilled in the art that, for convenience and brevity of description, specific working procedures of the above-described system, system and module may refer to corresponding procedures in the foregoing method embodiments, which are not described herein again.
In the several embodiments provided herein, it should be understood that the disclosed systems, and methods may be implemented in other ways. For example, the system embodiments described above are merely illustrative, e.g., the division of the modules is merely a logical function division, and there may be additional divisions when actually implemented, e.g., multiple modules or components may be combined or integrated into another system, or some features may be omitted or not performed. Alternatively, the coupling or direct coupling or communication connection shown or discussed with respect to each other may be through some interface, indirect coupling or communication connection of systems or modules, electrical, mechanical, or other form. The modules described as separate components may or may not be physically separate, and components shown as modules may or may not be physical modules, i.e., may be located in one place, or may be distributed over a plurality of network modules. Some or all of the modules may be selected according to actual needs to achieve the purpose of the embodiment.
In addition, each functional module in each embodiment of the present application may be integrated into one processing module, or each module may exist alone physically, or 2 or more modules may be integrated into one module. The integrated modules may be implemented in hardware or in hardware plus software functional modules. The integrated modules, which are implemented in the form of software functional modules, may be stored in a computer readable storage medium. The software functional modules described above are stored in a storage medium and include instructions for causing a computer system (which may be a personal computer, a server, or a network system, etc.) or a processor (processor) to perform some of the steps of the methods described in the embodiments of the present application. The storage medium includes a U disk, a removable hard disk, a Read-Only Memory (ROM), a random access Memory (Random Access Memory, RAM), a magnetic disk, an optical disk, or other various media capable of storing program codes.
It should be noted that the above-mentioned embodiments are merely for illustrating the technical solution of the present application, and not for limiting the same, and although the present application has been described in detail with reference to the above-mentioned embodiments, it should be understood by those skilled in the art that the technical solution described in the above-mentioned embodiments may be modified or some technical features may be equivalently replaced, and these modifications or substitutions do not make the essence of the corresponding technical solution deviate from the spirit and scope of the technical solution of the embodiments of the present application.
Claims (10)
1. An ultrasound contrast diagnostic method comprising:
Determining an interested region and an imaging section of an object, and performing ultrasonic scanning on the interested region and synchronously generating a tissue gray level image and a contrast video;
acquiring contrast data in the contrast video within a selected time and acquiring corresponding radio frequency data, wherein the radio frequency data and the contrast data correspond to each other in a time dimension;
obtaining perfusion characteristics of a contrast agent within the region of interest based on the contrast data;
Obtaining morphological and hemodynamic information of a vascular network in the region of interest based on the radio frequency data analysis, and extracting vascular blood flow parameters in the morphological and hemodynamic information;
and comprehensively diagnosing the region of interest according to the perfusion characteristics and the blood vessel blood flow parameters.
2. The ultrasound contrast diagnostic method according to claim 1, wherein the ultrasound scanning of the region of interest and the simultaneous generation of tissue grayscale images and contrast video comprises:
transmitting an ultrasonic signal;
and receiving an echo signal of the ultrasonic wave, and generating a tissue gray level image and a contrast video according to the echo signal.
3. The ultrasound contrast diagnostic method according to claim 1, wherein the specific step of acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video comprises:
detecting and receiving a data acquisition instruction in an ultrasonic scanning process, wherein the data acquisition instruction is generated at least once according to the real-time conditions of the tissue gray level image and the contrast video;
and acquiring radio frequency data representing ultrasonic echo according to the data acquisition instruction and synchronously extracting contrast data in the contrast video.
4. The ultrasound contrast diagnostic method of claim 3, further comprising detecting and receiving an end of acquisition instruction during an ultrasound scan:
detecting and receiving at least one data acquisition instruction in the ultrasonic scanning process;
and continuously acquiring the radio frequency data and the contrast data based on the received data acquisition instruction and ending the acquisition when the acquisition ending instruction is received, wherein the acquisition ending instruction is generated according to the real-time condition of the tissue gray level image and the contrast video.
5. The ultrasound contrast diagnostic method according to claim 3, further comprising presetting an acquisition duration:
detecting and receiving at least one data acquisition instruction in the ultrasonic scanning process;
and acquiring the radio frequency data and the contrast data within the preset duration according to the data acquisition instruction.
6. The ultrasound contrast diagnostic method according to claim 1, wherein said obtaining perfusion characteristics of contrast agent within said region of interest based on said contrast data comprises in particular:
obtaining the average intensity of the contrast agent microbubbles when the contrast agent is perfused into the region of interest according to the contrast data and generating a change curve of the average intensity corresponding to time based on the perfusion time;
And extracting time parameters and intensity parameters in the change curve, and determining the perfusion characteristics.
7. The ultrasound contrast diagnostic method according to claim 1, wherein the obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting the vascular blood flow parameters therein specifically comprises:
filtering the radio frequency data and continuously positioning the positions of the contrast agent microbubbles according to the radio frequency data;
Tracking the motion trail of the contrast agent microbubbles to obtain density information and speed information of the contrast agent microbubbles;
mapping the density information and the speed information in a vascular network space, and carrying out morphological imaging and kinetic imaging to obtain morphological and hemodynamic information;
the vessel blood flow parameters are extracted from the morphological and hemodynamic information.
8. The ultrasound contrast diagnostic method of claim 1, wherein acquiring radio frequency data and correspondingly acquiring contrast data in the contrast video further comprises:
And monitoring the tissue gray level image in the ultrasonic scanning process, and guiding and adjusting the imaging section according to the tissue gray level image so that the acquisition process of the radio frequency data and the contrast data is based on the same imaging section.
9. The ultrasound contrast diagnostic method according to claim 1, wherein the obtaining morphological and hemodynamic information of the vascular network in the region of interest based on the radio frequency data analysis, and extracting the vascular blood flow parameters therein specifically comprises:
Acquiring and storing multi-frame tissue gray level images corresponding to the contrast video along the time dimension, and performing correlation analysis on the stored multi-frame tissue gray level images to obtain a motion difference curve of the tissue;
Acquiring partial data frames in the radio frequency data based on the motion difference curve indication, wherein the data frames are characterized as partial data of which the motion difference of a scanning section in the radio frequency data accords with a preset condition;
filtering the data frame and continuously positioning the positions of the contrast agent microbubbles according to the data frame;
Tracking the motion trail of the contrast agent microbubbles to obtain density information and speed information of the contrast agent microbubbles;
mapping the density information and the speed information in a vascular network space, and carrying out morphological imaging and kinetic imaging to obtain morphological and hemodynamic information;
the vessel blood flow parameters are extracted from the morphological and hemodynamic information.
10. An ultrasound contrast diagnostic system, comprising:
the ultrasonic probe is used for transmitting ultrasonic waves to the region of interest for ultrasonic scanning;
The ultrasonic diagnostic apparatus transceiver control module is electrically connected with the ultrasonic probe and used for controlling the ultrasonic probe to emit ultrasonic waves and receiving echo signals of the ultrasonic waves;
An ultrasonic diagnostic apparatus imaging and processing analysis module electrically connected to the ultrasonic diagnostic apparatus transceiver control module and configured to diagnose a region of interest of a subject using the ultrasonic contrast diagnostic method as set forth in any one of claims 1 to 9.
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