CN119632504A - Laser detection and treatment integrated machine and laser output control method - Google Patents

Abstract

The embodiment of the disclosure discloses a laser detection and treatment integrated machine and a laser output control method. The specific implementation mode of the laser detection and treatment integrated machine comprises a Raman detection information acquisition device, a semiconductor laser output treatment device and a touch screen processing device, wherein the Raman detection information acquisition device comprises a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pump light narrow-band pass filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable double-color sheet, a second replaceable double-color sheet, a third replaceable double-color sheet, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, an upper computer connecting wire and an analog-to-digital converter, the Raman detection information acquisition device is used for acquiring Raman spectrum data of an object to be detected, and the touch screen processing device is configured to execute the steps of tissue abnormality detection and laser output. This embodiment improves the laser treatment effect and reduces the surgical treatment time.

Description

Laser detection and treatment integrated machine and laser output control method

Technical Field

The embodiment of the disclosure relates to the technical field of lasers, in particular to a laser detection and treatment integrated machine and a laser output control method.

Background

With the aggravation of the aging society and the change of life style, the incidence of human tissue lesions or cancerations (such as skin tumors and oral cancers) is gradually increased worldwide. The application of laser output devices in the treatment of various types of tissue lesions and cancers (e.g., skin tumors, oral cancers) has driven the growth of market demand. Currently, existing laser output devices for laser therapy are typically conventional laser output devices.

However, the above-mentioned conventional laser output apparatus often has the following technical problems:

The conventional laser output apparatus has a function of destroying or resecting diseased and cancerous human tissue and does not have a function of performing abnormality detection (e.g., disease detection, cancerous detection) of human tissue. When the traditional laser output equipment is used for cutting abnormal tissues, the laser output equipment without detection function is only limited to laser emission, and cannot detect target tissues in real time or in real time, so that damage to normal tissues is increased, and the laser treatment effect is poor. In order to accurately and completely ablate abnormal tissue, multiple abnormal detections of abnormal tissue are required, and in the case of using other detection devices (such as a Computed Tomography (CT) device), the abnormal detection of tissue requires more time to prepare the device and position the patient, and the detection operation steps are numerous, which increases the surgical treatment time.

The above information disclosed in this background section is only for enhancement of understanding of the background of the inventive concept and, therefore, may contain information that does not form the prior art that is already known to a person of ordinary skill in the art.

Disclosure of Invention

The disclosure is in part intended to introduce concepts in a simplified form that are further described below in the detailed description. The disclosure is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter.

Some embodiments of the present disclosure propose a laser detection therapy integrated machine and a laser output control method to solve one or more of the technical problems mentioned in the background section above.

According to the first aspect, some embodiments of the disclosure provide a laser detection and treatment integrated machine, which comprises a raman detection information acquisition device, a semiconductor laser output treatment device and a touch screen processing device, wherein the raman detection information acquisition device comprises a raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a raman pump light narrow-band pass filter, a replaceable focusing mirror, a reflecting mirror, a raman signal light transmission optical fiber, a first replaceable bicolor sheet, a second replaceable bicolor sheet, a third replaceable bicolor sheet, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, an upper computer connecting wire and an analog-to-digital converter, the raman excitation light output device is connected with the excitation light transmission optical fiber through a coaxial radio frequency connector, the raman detection information acquisition device is used for acquiring raman spectrum data of an object to be detected, and transmitting the acquired raman spectrum data to the touch screen processing device, the raman spectrum data comprise raman spectrum sub-data, the raman sub-data comprise the first raman spectrum data, the second raman sub-data and the raman spectrum sub-data comprise the first raman spectrum data, the third raman sub-data are arranged to be detected by the laser detection information acquisition device and the upper computer connecting wire, the raman detection information acquisition device is used for carrying out abnormal tissue detection on the raman spectrum data of the object to be detected by the laser detection device.

Optionally, the raman pump light narrow band pass filter is replaced by a pluggable slot.

Alternatively, the replaceable focusing lens is replaced by a pluggable replacement or a threaded replacement.

Optionally, the excitation light output by the raman excitation light output device reaches the collimating mirror through the excitation light transmission optical fiber, then the excitation light is collimated through the collimating mirror, then the collimated excitation light reaches the object to be measured through the replaceable focusing mirror, wherein the replaceable focusing mirror focuses the collimated excitation light to a region where the object to be measured is located, the object to be measured emits raman scattered light under the action of the excitation light, the replaceable focusing mirror focuses the raman scattered light to the raman pump light narrowband bandpass filter, and enters the raman signal light transmission optical fiber through the reflection of the raman pump light narrowband bandpass filter and the reflecting mirror, then the raman scattered light reaches the first replaceable dichroic sheet through the raman signal light transmission optical fiber, the raman scattered light in a first preset wavelength range is separated and reflected from the raman scattered light in the first raman light to the first charge-coupled device camera through the first replaceable dichroic sheet, a raman scattered light in a first preset wavelength range is obtained, a raman scattered light in a first analog electric signal corresponding to the first preset wavelength range is obtained, the raman scattered light is separated and reflected to the first charge-coupled device through the raman scattered light in the first preset wavelength range through the first replaceable dichroic sheet, obtaining a second analog electrical signal corresponding to the raman scattered light in the second preset wavelength range; the raman scattered light of the first preset wavelength range and the raman scattered light of the second preset wavelength range in the raman scattered light are separated by the first replaceable double-color plate and the second replaceable double-color plate, and reflecting the Raman scattered light in a third preset wavelength range to the third CCD camera through the third replaceable double-color chip to obtain a third analog electric signal corresponding to the Raman scattered light applied to the third preset wavelength range.

Optionally, the first analog electric signal, the second analog electric signal and the third analog electric signal are transmitted to the analog-to-digital converter through the upper computer connection line, the analog-to-digital converter is used for converting the first analog electric signal into first raman spectrum data, the analog-to-digital converter is used for converting the second analog electric signal into second raman spectrum data, and the analog-to-digital converter is used for converting the third analog electric signal into third raman spectrum data.

Optionally, the touch screen processing device is further configured to perform tissue anomaly detection on the object to be detected based on the raman spectrum data by controlling the semiconductor laser output treatment device to output laser light corresponding to the raman spectrum data to a region where the object to be detected is located, including obtaining incident wavelength information of excitation light corresponding to the raman spectrum data, performing raman detection processing for each of the raman spectrum sub-data included in the raman spectrum data, generating a raman spectrum data point information set corresponding to the raman spectrum sub-data based on the incident wavelength information and the raman spectrum sub-data, generating a raman spectrum map corresponding to the raman spectrum sub-data based on the raman spectrum data point information set, performing a spectrogram resolution processing on the raman spectrum map to obtain raman tissue detection information corresponding to the object to be detected, displaying the obtained respective raman tissue detection information on a preset detection page, characterizing at least one of the respective raman tissue detection information in response to detecting the raman spectrum sub-data, determining that the input is a frame input is started in response to the detection page, determining that the input is started to the frame input is started in response to the detection window, ending the frame input is started in response to the detection window input time, determining that the input frame input is ended in response to the input frame input is started in response to the detection time, and controlling the semiconductor laser output treatment device to output laser corresponding to the at least one piece of raman tissue detection information representing the abnormality to the region where the object to be measured is located in a period of time corresponding to the start time information and the end time information.

In a second aspect, some embodiments of the present disclosure provide a laser output control method applied to a touch screen processing device included in the laser detection and treatment integrated machine, where the method includes receiving raman spectrum data transmitted by the raman detection information collecting device, and performing tissue abnormality detection on the object to be detected based on the raman spectrum data, so as to control the semiconductor laser output treatment device to output laser corresponding to the raman spectrum data to an area where the object to be detected is located.

The laser detection treatment all-in-one machine has the advantages that the laser treatment effect is improved and the operation treatment time is shortened through the laser detection treatment all-in-one machine of some embodiments of the present disclosure. Specifically, the reason why the laser treatment effect is poor and the surgical treatment time is long is that the conventional laser output apparatus has a function of destroying or resecting diseased and cancerous human tissue and does not have a function of detecting abnormality (e.g., disease detection, cancerous detection) of human tissue. When the traditional laser output equipment is used for cutting abnormal tissues, the laser output equipment without detection function is only limited to laser emission, and cannot detect target tissues in real time or in real time, so that damage to normal tissues is increased, and the laser treatment effect is poor. In order to accurately and completely ablate abnormal tissue, multiple abnormal detections of abnormal tissue are required, and in the case of using other detection devices (such as a Computed Tomography (CT) device), the abnormal detection of tissue requires more time to prepare the device and position the patient, and the detection operation steps are numerous, which increases the surgical treatment time. the laser detection and treatment integrated machine comprises a Raman detection information acquisition device, a semiconductor laser output treatment device and a touch screen processing device, wherein the Raman detection information acquisition device comprises a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pumping light narrow-band pass filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable double-color sheet, a second replaceable double-color sheet, a third replaceable double-color sheet, a first CCD camera, a second CCD camera, a third CCD camera, an upper computer connecting wire and an analog-to-digital converter, and the Raman excitation light output device is connected with the excitation light transmission optical fiber through a coaxial radio frequency connector, so that Raman spectrum data of an object to be detected can be acquired in real time through the Raman detection information acquisition device. The Raman detection information acquisition device is used for acquiring Raman spectrum data of an object to be detected and transmitting the acquired Raman spectrum data to the touch screen processing device, wherein the Raman spectrum data comprise all Raman spectrum sub-data, the all Raman spectrum sub-data comprise first Raman spectrum data, second Raman spectrum data and third Raman spectrum data, the touch screen processing device is configured to execute the steps of detecting abnormal tissues and outputting lasers, namely receiving the Raman spectrum data transmitted by the Raman detection information acquisition device, detecting abnormal tissues of the object to be detected based on the Raman spectrum data, and controlling the semiconductor laser output treatment device to output lasers corresponding to the Raman spectrum data to a region where the object to be detected is located. Therefore, the Raman spectrum data can be analyzed in real time through the touch screen processing equipment included in the laser detection and treatment integrated machine so as to control the semiconductor laser output treatment equipment to output laser. The laser detection and treatment integrated machine can acquire Raman spectrum data of an object to be detected (such as human tissue) in real time through the Raman detection information acquisition equipment to detect tissue abnormality. The device can also detect tissue abnormality through the touch screen processing device according to the Raman detection information acquired in real time, so as to control the semiconductor laser output treatment device to output laser corresponding to Raman spectrum data, reduce damage to normal tissues, improve laser treatment effect, and meanwhile, the device and the patient are not required to be prepared and positioned in more time, so that the detection operation steps are simplified, and the operation treatment time is shortened.

Drawings

The above and other features, advantages, and aspects of embodiments of the present disclosure will become more apparent by reference to the following detailed description when taken in conjunction with the accompanying drawings. The same or similar reference numbers will be used throughout the drawings to refer to the same or like elements. It should be understood that the figures are schematic and that elements and components are not necessarily drawn to scale.

FIG. 1 is a schematic structural diagram of some embodiments of a Raman detection information acquisition device according to the present disclosure;

fig. 2 is a schematic structural view of some embodiments of a semiconductor laser output therapy apparatus according to the present disclosure;

FIG. 3 is a flow chart of some embodiments of a laser output control method suitable for use in implementing the present disclosure;

FIG. 4 is a schematic structural view of some embodiments of a laser detection and treatment all-in-one machine according to the present disclosure;

Fig. 5 is a physical diagram of an internal test product of a laser detection and treatment all-in-one machine according to the present disclosure.

Detailed Description

Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While certain embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete. It should be understood that the drawings and embodiments of the present disclosure are for illustration purposes only and are not intended to limit the scope of the present disclosure.

It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings. Embodiments of the present disclosure and features of embodiments may be combined with each other without conflict.

It should be noted that the terms "first," "second," and the like in this disclosure are merely used to distinguish between different devices, modules, or units and are not used to define an order or interdependence of functions performed by the devices, modules, or units.

It should be noted that references to "one", "a plurality" and "a plurality" in this disclosure are intended to be illustrative rather than limiting, and those of ordinary skill in the art will appreciate that "one or more" is intended to be understood as "one or more" unless the context clearly indicates otherwise.

The names of messages or information interacted between the various devices in the embodiments of the present disclosure are for illustrative purposes only and are not intended to limit the scope of such messages or information.

The present disclosure will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

Referring first to fig. 1 and 4, fig. 4 illustrates a schematic structural diagram of some embodiments of a laser detection and treatment integrated machine of the present disclosure. The laser detection and treatment integrated machine comprises a Raman detection information acquisition device 401, a semiconductor laser output treatment device 403 and a touch screen processing device 402. Fig. 1 illustrates a structural schematic diagram of some embodiments of a raman detection information acquisition device 401 of the present disclosure. The raman detection information collecting device 401 comprises the raman detection information collecting device 401 comprising a raman excitation light output device 101, an excitation light transmission optical fiber 102, a collimator lens 103, a raman pump light narrow band pass filter 104, a replaceable focusing lens 105, a reflecting mirror 107, a raman signal light transmission optical fiber 108, a first replaceable double-color plate 109, a second replaceable double-color plate 110, a third replaceable double-color plate 111, a first charge-coupled device camera 1121, a second charge-coupled device camera 1122, a third charge-coupled device camera 1123, an upper computer connecting wire 112 and an analog-to-digital converter. The raman excitation light output device 101 is connected to the excitation light transmitting fiber 102 through a coaxial radio frequency connector.

The raman excitation light output device 101 may be a device for outputting raman excitation light. The raman excitation light may be light that excites an object to be measured (for example, human tissue) to generate a raman scattering signal. For example, the raman excitation light output device 101 may be a raman laser. The excitation light transmitting fiber 102 may be a fiber (e.g., a hand-held fiber) for transmitting raman excitation light. The raman pump light narrow bandpass filter 104 may be a reflective filter for transmitting raman excitation light and reflecting raman scattered light. The replaceable focusing mirror 105 may be a replaceable focusing mirror that focuses the raman excitation light onto the object to be measured 106. The raman signal light transmission optical fiber 108 may be an optical fiber for transmitting raman scattered light. The first replaceable two-color patch 109 may be a two-color patch that splits light satisfying a first predetermined wavelength band among raman scattered light to the first ccd camera 1121. The second replaceable two-color chip 110 may be a two-color chip that splits light satisfying a second preset wavelength band among raman scattered light to the second ccd camera 1122. The third replaceable two-color sheet 111 may be a two-color sheet that splits light satisfying a third predetermined wavelength band among raman scattered light to the third ccd camera 1123. The first CCD camera 1121, the second CCD camera 1122, and the third CCD camera 1123 are CCD cameras. For example, the first CCD camera 1121 may be an ultraviolet CCD camera. The second CCD camera 1122 may be a visible light CCD camera. The third CCD camera 1123 may be a near-infrared CCD camera.

The raman detection information collection apparatus 401 is configured to collect raman spectrum data of the object to be detected 106, and transmit the collected raman spectrum data to the touch screen processing apparatus 402. Wherein the raman spectral data comprises respective raman spectral sub-data comprising first raman spectral data, second raman spectral data and third raman spectral data. The touch screen processing device 402 is configured to perform the following steps of tissue abnormality detection and laser output, namely, receiving the raman spectrum data transmitted by the raman detection information acquisition device 401. Based on the raman spectrum data, the tissue abnormality detection is performed on the object to be measured 106, so as to control the semiconductor laser output treatment device 403 to output laser light corresponding to the raman spectrum data to the region 228 where the object to be measured 106 is located. The touch screen processing device 402 may control the raman detection information collecting device 401 to collect raman spectrum data in real time before or after the semiconductor laser output treatment device 403 outputs laser light through a timing task, so as to control the semiconductor laser output treatment device 403 to output or output laser light corresponding to the raman spectrum data to the region 228 where the object 106 to be measured is located.

Wherein the raman detection information collection device 401 may be connected to the touch screen processing device 402 (e.g., a computing device of a touch screen) through a USB cable or other high-speed data transmission line (e.g., an ethernet cable). The touch screen processing device 402 may communicate through a serial communication interface (such as RS-232, RS-485, etc.), an ethernet interface, or other high-speed communication interface, so as to control the semiconductor laser output treatment device 403 to output laser light corresponding to the raman spectrum data to the region 228 where the object 106 to be measured is located.

Optionally, the raman pump light narrow bandpass filter 104 is replaced by a pluggable slot.

Alternatively, the replaceable focusing mirror 105 is replaced by a pluggable replacement or a threaded replacement.

Alternatively, the excitation light output by the raman excitation light output device 101 reaches the collimator 103 through the excitation light transmission fiber 102, then the excitation light is collimated by the collimator 103, and then the collimated excitation light reaches the object to be measured 106 through the replaceable focusing mirror 105. Wherein the replaceable focusing mirror 105 focuses the collimated excitation light to the region 228 where the object to be measured 106 is located. The object to be measured 106 emits raman scattered light by the excitation light. The interchangeable focusing mirror 105 focuses the raman scattered light onto the raman pump light narrow band pass filter 104, and enters the raman signal light transmission fiber 108 through reflection by the raman pump light narrow band pass filter 104 and the reflecting mirror 107, and then reaches the first interchangeable dichroic plate 109 through the raman signal light transmission fiber 108, and the raman scattered light in a first predetermined wavelength range is separated from the raman scattered light by the first interchangeable dichroic plate 109 and reflected to the first ccd camera 1121, thereby obtaining a first analog electric signal corresponding to the raman scattered light in the first predetermined wavelength range. The raman scattered light having separated the raman scattered light in the first predetermined wavelength range from among the raman scattered light by the first replaceable two-color sheet 109 is separated and reflected to the second ccd camera 1122 by the second replaceable two-color sheet 110, thereby obtaining a second analog electric signal corresponding to the raman scattered light in the second predetermined wavelength range. The raman scattered light in the first preset wavelength range and the raman scattered light in the second preset wavelength range are separated by the first replaceable two-color chip 109 and the second replaceable two-color chip 110, and the raman scattered light in the third preset wavelength range is reflected to the third ccd camera 1123 by the third replaceable two-color chip 111, so as to obtain a third analog electrical signal corresponding to the raman scattered light in the third preset wavelength range.

Optionally, the first analog electrical signal, the second analog electrical signal, and the third analog electrical signal are transmitted to the analog-to-digital converter through the upper computer connection. The analog-to-digital converter is used for converting the first analog electric signal into first Raman spectrum data. The analog-to-digital converter is used for converting the second analog electric signal into second Raman spectrum data. The analog-to-digital converter is configured to convert the third analog electrical signal into third raman spectrum data.

In the process of solving the problems mentioned in the background art by adopting the technical scheme, the following problems are often accompanied:

Generally, most of the lasers output by the existing semiconductor laser output treatment equipment are single lasers, and when abnormal tissues (such as lesions or cancerations) are treated, the single lasers are generally fixed in wavelength due to the difference of the absorption characteristics of different tissues on the lasers, so that the application range of laser treatment is small. Meanwhile, the same tissue may face multiple pathological changes, and a single laser may not be capable of performing accurate treatment on the pathological changes of the tissue with multiple pathological changes at the same time, so that the laser treatment effect of the semiconductor laser output treatment device is poor.

In view of the above technical problems, the inventors decided to adopt the following solutions:

With further reference to fig. 2, fig. 2 shows a schematic structural diagram of some embodiments of a semiconductor laser output therapy apparatus 403 of the present disclosure. The semiconductor laser output treatment apparatus 403 includes a first laser diode 201, a second laser diode 202, a third laser diode 203, a fourth laser diode 204, a fifth laser diode 205, a sixth laser diode 206, a seventh laser diode 207, a first volume bragg grating 208, a second volume bragg grating 209, a third volume bragg grating 210, a first slow axis collimator mirror 211, a second slow axis collimator mirror 201, a third slow axis collimator mirror 213, a fourth slow axis collimator mirror 214, a fifth slow axis collimator mirror 215, a sixth slow axis collimator mirror 216, a seventh slow axis collimator mirror 217, a mirror 218, a first dichroic plate 219, a second dichroic plate 220, a third dichroic plate 221, a fourth dichroic plate 222, a fifth dichroic plate 223, a sixth dichroic plate 224, an aspheric focusing mirror 225, a laser output window 226, and a coupler dust window 227. Wherein each of the first laser diode 201, the second laser diode 202, the third laser diode 203, the fourth laser diode 204, the fifth laser diode 205, the sixth laser diode 206, and the seventh laser diode 207 may be a laser diode for generating a predetermined wavelength or a predetermined wavelength range. Each of the first bulk bragg grating 208, the second bulk bragg grating 209, and the third bulk bragg grating 210 may be used to stabilize the laser output wavelength and compress the narrow linewidth. Each of the first bragg grating 208, the second bragg grating 209, the third bragg grating 210, the first slow axis collimator 211, the second slow axis collimator 201, the third slow axis collimator 213, the fourth slow axis collimator 214, the fifth slow axis collimator 215, the sixth slow axis collimator 216, and the seventh slow axis collimator 217 may be a slow axis collimator located at a predetermined position of a corresponding one of the first laser diode 201, the second laser diode 202, the third laser diode 203, the fourth laser diode 204, the fifth laser diode 205, the sixth laser diode 206, and the seventh laser diode 207. For example, the first laser diode 201 corresponds to the first slow axis collimator mirror 211.

The laser beam of the first predetermined wavelength emitted from the first laser diode 201 passes through the first slow axis collimator 211, the reflection of the reflection mirror 218, and passes through the first dichroic plate 219, the second dichroic plate 220, the third dichroic plate 221, the fourth dichroic plate 222, the fifth dichroic plate 223, and the sixth dichroic plate 224 to reach the aspherical focusing mirror 225. The aspheric focusing lens 225 focuses the first laser beam onto the laser output window 226, and outputs the first laser beam to the laser treatment area 228 through the coupler dustproof window 227, wherein the laser treatment area 228 may be an area where the object 106 to be measured is located in fig. 1. The second laser beam with the second preset wavelength emitted from the second laser diode passes through the second slow axis collimator lens, is reflected by the first dichroic plate, passes through the second dichroic plate, the third dichroic plate, the fourth dichroic plate 222, the fifth dichroic plate, and the sixth dichroic plate 224, and reaches the aspheric focusing lens 225. The aspheric focusing mirror 225 focuses the second laser light to the laser light output window 226 and then outputs the second laser light to the laser treatment area 228 through the coupler dust window 227. The laser beam with the third preset wavelength emitted by the third laser diode passes through the first bragg grating and the third slow axis collimator, and passes through the third dichroic plate, the fourth dichroic plate 222, the fifth dichroic plate, and the sixth dichroic plate to reach the aspheric focusing mirror 225 by reflection of the second dichroic plate. The aspheric focusing mirror 225 focuses the third laser light to the laser light output window 226 and then outputs the third laser light to the laser treatment area 228 through the coupler dust window 227. The fourth laser beam with the fourth preset wavelength emitted by the fourth laser diode passes through the second volume bragg grating and the fourth slow axis collimator lens, and passes through the fourth dichroic plate 222, the fifth dichroic plate, and the sixth dichroic plate to reach the aspheric focusing lens 225 by reflection of the third dichroic plate. The aspheric focusing mirror 225 focuses the third laser light to the laser light output window 226 and then outputs the third laser light to the laser treatment area 228 through the coupler dust window 227. The fifth laser diode emits a fifth laser beam with a predetermined wavelength, which passes through the third bragg grating and the fifth slow axis collimator, and is reflected by the fourth dichroic plate 222, and passes through the fifth dichroic plate and the sixth dichroic plate to reach the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the fifth laser light to the laser light output window 226 and then outputs the fifth laser light to the laser treatment area 228 through the coupler dust window 227. The laser beam with the sixth preset wavelength emitted by the sixth laser diode passes through the sixth slow axis collimating mirror, and is reflected by the fifth dichroic plate, passes through the sixth dichroic plate, and reaches the aspheric focusing mirror 225. The aspheric focusing mirror 225 focuses the fifth laser light to the laser light output window 226 and then outputs the fifth laser light to the laser treatment area 228 through the coupler dust window 227. The seventh laser diode emits a seventh laser beam with a predetermined wavelength, which passes through the seventh slow axis collimator lens, and is reflected by the sixth dichroic plate, and reaches the aspheric focusing lens 225. The aspheric focusing mirror 225 focuses the seventh laser light to the laser light output window 226 and then outputs the laser light to the laser treatment area 228 through the coupler dust window 227.

The above-mentioned multi-laser diode configuration structure of the semiconductor laser output treatment apparatus 403 and the related content of the optical path design between the optical elements included therein, as an invention point of the embodiments of the present disclosure, solve the technical problem of "the application range of the laser treatment of the semiconductor laser output treatment apparatus is smaller and the laser treatment effect is worse". The factors causing the smaller application range and poorer laser treatment effect of the semiconductor laser output treatment device often include that the laser output by the conventional semiconductor laser output treatment device is mostly single laser, and when abnormal tissues (such as lesions or cancerations) are treated, the wavelength of the single laser is usually fixed due to the difference of the absorption characteristics of different tissues on the laser, so that the application range of the laser treatment is smaller. Meanwhile, the same tissue may face multiple pathological changes, and a single laser may not be capable of performing accurate treatment on the pathological changes of the tissue with multiple pathological changes at the same time, so that the laser treatment effect of the semiconductor laser output treatment device is poor. If the above factors are solved, the application range of the laser treatment of the semiconductor laser output treatment equipment can be widened and the laser treatment effect can be improved. To achieve this effect, the present disclosure employs a multiple laser diode configuration of a semiconductor laser output treatment device and an optical path design between individual optical elements included therein. In particular, the semiconductor laser output therapy apparatus of the present disclosure may incorporate a plurality of laser diodes in parallel at the time of production. Here, the first laser diode, the second laser diode, the third laser diode, the fourth laser diode, the fifth laser diode, the sixth laser diode, and the seventh laser diode are incorporated in the semiconductor laser output treatment apparatus. Therefore, multiband laser can be generated, so that the problem that different tissues have differences in the absorption characteristics of the laser is solved, and the application range of laser treatment is widened. Meanwhile, different laser diodes in the laser diodes can be designed to emit laser with different wavelengths, and by combining a plurality of laser diodes, on the basis of the optical path design among optical elements (such as Bragg gratings, slow-axis collimating mirrors, reflecting mirrors, bicolor plates and aspheric focusing mirrors) included in the semiconductor laser output treatment equipment, the multi-wavelength laser is simultaneously output to the area where lesion tissues with various lesions are located, the laser with various wavelengths is combined for carrying out accurate treatment on the tissues with various lesions, and the laser treatment effect of the semiconductor laser output treatment equipment is improved.

Optionally, in some embodiments, the touch screen processing device may be further configured to determine, based on the raman spectrum data, detecting the tissue abnormality of the object to be detected so as to control the semiconductor laser output treatment equipment to output laser corresponding to the Raman spectrum data to the area where the object to be detected is located:

first, the incident wavelength information of the excitation light corresponding to the raman spectrum data is acquired. In practice, the touch screen processing device may acquire the incident wavelength information of the excitation light corresponding to the raman spectrum data from a preset storage file (for example, a preset Word file). The incident wavelength information may characterize the wavelength of raman excitation light. For example, the incident wavelength information may be "532nm".

A second step of performing the following raman detection process for each of the respective raman spectrum sub-data included in the raman spectrum data:

a first sub-step of generating a raman spectrum data point information set corresponding to the raman spectrum sub-data based on the incident wavelength information and the raman spectrum sub-data. Wherein the raman spectral sub-data may include individual raman scattered light data point information. Each of the individual raman scattered light data point information described above includes a scattered light wavelength and an intensity. For example, the raman spectral sub-data may be "(wavelength: 600nm, intensity: 100), (wavelength: 700nm, intensity: 120), (wavelength: 800nm, intensity: 150)". In practice, for each raman scattered light data point information in the respective raman scattered light data point information included in the raman spectrum sub-data, the touch screen processing device may determine a ratio of a preset value to a wavelength emission corresponding to the incident wavelength information as the first value. The touch screen processing device may then determine a ratio of the predetermined value to the wavelength included in the raman scattered light data point information as a second value. The touch screen processing device may then determine a difference between the first value and the second value as a raman scattered light offset. Next, the touch screen processing apparatus may determine the raman scattered light offset and the intensity included in the raman scattered light data point information as raman spectrum data point information. Finally, the touch screen processing device may determine each of the generated raman spectrum data point information as a raman spectrum data point information set corresponding to the raman spectrum sub-data.

And a second sub-step of generating a raman spectrum map corresponding to the raman spectrum sub-data based on the raman spectrum data point information set. In practice, the touch screen processing device may invoke a drawing tool (e.g., matplotlib (Python library)) to generate a graph corresponding to the raman spectrum data point information set as a raman spectrum graph.

And a third sub-step, carrying out spectrogram analysis processing on the Raman spectrogram to obtain Raman tissue detection information corresponding to the object to be detected. In practice, the touch screen processing device may obtain each resolution similarity by using the similarity between the raman spectrogram and each pre-stored spectrogram in the pre-constructed spectrogram database. The pre-constructed spectrogram database may be a database for storing a spectrogram and anomaly information corresponding to the spectrogram. Each of the above-described individual resolution similarities may be represented by a cosine similarity. Then, in response to determining that at least one resolution similarity greater than a preset value exists in the resolution similarities, the touch screen processing device may determine the resolution similarity with the largest value among the resolution similarities as the target resolution similarity. Then, the touch screen processing device may determine the abnormal information corresponding to the target resolution similarity as raman tissue detection information. The raman tissue detection information may be text information, and for example, the raman tissue detection information may be "detection abnormality, change in frequency and intensity of amide I band and amide III band of protein compared to normal tissue". In response to determining that at least one resolution similarity greater than a preset value does not exist in the respective resolution similarities, the touch screen processing device may determine text information representing that detection is normal as raman tissue detection information.

And thirdly, displaying the obtained detection information of each Raman organization on a preset detection page. The preset detection page may be a page for displaying raman tissue detection information and controlling the semiconductor laser output treatment device to output laser light.

And fourthly, responding to detection of at least one piece of Raman tissue detection information in the pieces of Raman tissue detection information to represent detection abnormality, and displaying a laser output control, a start time input box and an end time input box on the detection page. The laser output control can be a page interaction element for controlling the semiconductor laser output treatment equipment to output laser. The start time input box may be a page interactive element for inputting a laser output start time. The end time input box may be a page interaction element for inputting a laser output end time.

And fifth, in response to detecting an input operation to the start time input box, determining input information corresponding to the output start time input box as start time information.

And a sixth step of determining, as end time information, an input corresponding to the end time input box in response to detection of an input operation acting on the end time input box.

And seventh, in response to detection of a selection operation acting on the laser output control, controlling the semiconductor laser output treatment device to output laser corresponding to the at least one piece of raman tissue detection information characterizing the abnormality to the region where the object to be measured is located in a period of time corresponding to the start time information and the end time information.

Referring now to fig. 3, fig. 3 illustrates a laser output control method applied to a laser detection and treatment all-in-one machine according to the present disclosure. The laser output control method comprises the following steps:

Step 301, receiving raman spectrum data transmitted by a raman detection information acquisition device.

In some embodiments, the execution subject (e.g., a touch screen processing device) of the laser output control method may receive the raman spectrum data transmitted by the raman detection information acquisition device described above.

Step 302, based on the raman spectrum data, performing tissue abnormality detection on the object to be detected, so as to control the semiconductor laser output treatment device to output laser corresponding to the raman spectrum data to the region where the object to be detected is located.

In some embodiments, the execution body may perform tissue abnormality detection on the object to be measured based on the raman spectrum data, so as to control the semiconductor laser output treatment apparatus to output laser light corresponding to the raman spectrum data to an area where the object to be measured is located.

The laser detection treatment all-in-one machine has the advantages that the laser treatment effect is improved and the operation treatment time is shortened through the laser detection treatment all-in-one machine of some embodiments of the present disclosure. Specifically, the reason why the laser treatment effect is poor and the surgical treatment time is long is that the conventional laser output apparatus has a function of destroying or resecting diseased and cancerous human tissue and does not have a function of detecting abnormality (e.g., disease detection, cancerous detection) of human tissue. When the traditional laser output equipment is used for cutting abnormal tissues, the laser output equipment without detection function is only limited to laser emission, and cannot detect target tissues in real time or in real time, so that damage to normal tissues is increased, and the laser treatment effect is poor. In order to accurately and completely ablate abnormal tissue, multiple abnormal detections of abnormal tissue are required, and in the case of using other detection devices (such as a Computed Tomography (CT) device), the abnormal detection of tissue requires more time to prepare the device and position the patient, and the detection operation steps are numerous, which increases the surgical treatment time. the laser detection and treatment integrated machine comprises a Raman detection information acquisition device, a semiconductor laser output treatment device and a touch screen processing device, wherein the Raman detection information acquisition device comprises a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pumping light narrow-band pass filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable double-color sheet, a second replaceable double-color sheet, a third replaceable double-color sheet, a first CCD camera, a second CCD camera, a third CCD camera, an upper computer connecting wire and an analog-to-digital converter, and the Raman excitation light output device is connected with the excitation light transmission optical fiber through a coaxial radio frequency connector, so that Raman spectrum data of an object to be detected can be acquired in real time through the Raman detection information acquisition device. The Raman detection information acquisition device is used for acquiring Raman spectrum data of an object to be detected and transmitting the acquired Raman spectrum data to the touch screen processing device, wherein the Raman spectrum data comprise all Raman spectrum sub-data, the all Raman spectrum sub-data comprise first Raman spectrum data, second Raman spectrum data and third Raman spectrum data, the touch screen processing device is configured to execute the steps of detecting abnormal tissues and outputting lasers, namely receiving the Raman spectrum data transmitted by the Raman detection information acquisition device, detecting abnormal tissues of the object to be detected based on the Raman spectrum data, and controlling the semiconductor laser output treatment device to output lasers corresponding to the Raman spectrum data to a region where the object to be detected is located. Therefore, the Raman spectrum data can be analyzed in real time through the touch screen processing equipment included in the laser detection and treatment integrated machine so as to control the semiconductor laser output treatment equipment to output treatment laser. The laser detection and treatment integrated machine can acquire Raman spectrum data of an object to be detected (such as human tissue) in real time through the Raman detection information acquisition equipment to detect tissue abnormality. The device can also detect tissue abnormality through the touch screen processing device according to the Raman detection information acquired in real time, so as to control the semiconductor laser output treatment device to output laser corresponding to Raman spectrum data, reduce damage to normal tissues, improve laser treatment effect, and meanwhile, the device and the patient are not required to be prepared and positioned in more time, so that the detection operation steps are simplified, and the operation treatment time is shortened.

The foregoing description is only of the preferred embodiments of the present disclosure and description of the principles of the technology being employed. It will be understood by those skilled in the art that the scope of the invention in the embodiments of the present disclosure is not limited to the specific combination of technical features, but encompasses other technical features formed by any combination of technical features or their equivalents without departing from the spirit of the invention. Such as a solution in which features and technical features having similar functions (but not limited to) disclosed in the embodiments of the present disclosure are replaced with each other.

Claims (7)

1. The laser detection and treatment integrated machine is characterized by comprising a Raman detection information acquisition device, a semiconductor laser output treatment device and a touch screen processing device;

The Raman detection information acquisition equipment comprises a Raman excitation light output device, an excitation light transmission optical fiber, a collimating mirror, a Raman pump light narrow-band pass filter, a replaceable focusing mirror, a reflecting mirror, a Raman signal light transmission optical fiber, a first replaceable double-color sheet, a second replaceable double-color sheet, a third replaceable double-color sheet, a first charge-coupled device camera, a second charge-coupled device camera, a third charge-coupled device camera, an upper computer connecting wire and an analog-to-digital converter;

the Raman excitation light output device is connected with the excitation light transmission optical fiber through a coaxial radio-frequency connector;

The Raman detection information acquisition device is used for acquiring Raman spectrum data of an object to be detected and transmitting the acquired Raman spectrum data to the touch screen processing device, wherein the Raman spectrum data comprise all Raman spectrum sub-data, and the all Raman spectrum sub-data comprise first Raman spectrum data, second Raman spectrum data and third Raman spectrum data;

The touch screen processing device is configured to perform the following tissue anomaly detection and laser output steps:

receiving Raman spectrum data transmitted by the Raman detection information acquisition equipment;

and based on the Raman spectrum data, carrying out tissue abnormality detection on the object to be detected so as to control the semiconductor laser output treatment equipment to output laser corresponding to the Raman spectrum data to the region where the object to be detected is located.

2. The laser detection and treatment integrated machine according to claim 1, comprising:

The Raman pump light narrow-band pass filter is replaced through a pluggable slot.

3. The laser detection and treatment integrated machine according to claim 1, comprising:

the replaceable focusing lens is replaced by a pluggable replacement mode or a threaded replacement mode.

4. The laser detection and treatment integrated machine according to claim 1, comprising:

The excitation light output by the Raman excitation light output device reaches the collimating lens through the excitation light transmission optical fiber, the excitation light is collimated through the collimating lens, and then the collimated excitation light reaches the object to be detected through the replaceable focusing lens, wherein the replaceable focusing lens focuses the collimated excitation light to the area where the object to be detected is located;

The object to be detected emits Raman scattered light under the action of the excitation light;

The replaceable focusing mirror focuses the Raman scattered light to the Raman pump light narrow-band pass filter, enters the Raman signal light transmission optical fiber after being reflected by the Raman pump light narrow-band pass filter and the reflecting mirror, then reaches the first replaceable bicolor plate through the Raman signal light transmission optical fiber, and separates and reflects the Raman scattered light in a first preset wavelength range from the Raman scattered light to the first charge-coupled device camera by the first replaceable bicolor plate to obtain a first analog electric signal corresponding to the Raman scattered light in the first preset wavelength range;

The raman scattered light in a first preset wavelength range in the raman scattered light is separated through the first replaceable double-color plate, the raman scattered light in a second preset wavelength range contained in the raman scattered light is separated and reflected to the second charge coupled device camera through the second replaceable double-color plate, and a second analog electric signal corresponding to the raman scattered light in the second preset wavelength range is obtained;

Separating the raman scattered light of the first preset wavelength range from the raman scattered light of the second preset wavelength range through the first replaceable double-color plate and the second replaceable double-color plate, and reflecting the Raman scattered light in a third preset wavelength range to the third CCD camera through the third replaceable double-color chip to obtain a third analog electric signal corresponding to the Raman scattered light applied to the third preset wavelength range.

5. The laser detection and treatment integrated machine according to claim 4, comprising:

The first analog electric signal, the second analog electric signal and the third analog electric signal are transmitted to the analog-to-digital converter through the upper computer connecting wire;

the analog-to-digital converter is used for converting the first analog electric signal into first Raman spectrum data;

the analog-to-digital converter is used for converting the second analog electric signal into second Raman spectrum data;

the analog-to-digital converter is used for converting the third analog electric signal into third Raman spectrum data.

6. The laser detection and treatment all-in-one machine according to claim 1, wherein the touch screen processing device is further configured to perform tissue abnormality detection on the object to be measured based on the raman spectrum data by controlling the semiconductor laser output treatment device to output laser light corresponding to the raman spectrum data to an area where the object to be measured is located, comprising:

Acquiring incident wavelength information of excitation light corresponding to the Raman spectrum data;

the following raman detection process is performed for each of the individual raman spectrum sub-data included in the raman spectrum data:

Generating a raman spectrum data point information set corresponding to the raman spectrum sub-data based on the incident wavelength information and the raman spectrum sub-data;

Generating a raman spectrum map corresponding to the raman spectrum sub-data based on the raman spectrum data point information set;

Carrying out spectrogram analysis processing on the Raman spectrogram to obtain Raman tissue detection information corresponding to the object to be detected;

Displaying the obtained detection information of each Raman organization on a preset detection page;

responsive to detecting that at least one of the individual raman tissue detection information characterizes a detection anomaly, displaying a laser output control, a start time input box, and an end time input box on the detection page;

In response to detecting an input operation acting on the start time input box, determining input information corresponding to the output start time input box as start time information;

in response to detecting an input operation acting on the end time input box, determining an input corresponding to the end time input box as end time information;

And in response to detection of the selection operation acting on the laser output control, controlling the semiconductor laser output treatment equipment to output laser corresponding to the at least one piece of Raman tissue detection information characterizing the abnormality to the region where the object to be detected is located in a time period corresponding to the start time information and the end time information.

7. A laser output control method applied to a touch screen processing device included in the laser detection and treatment integrated machine according to any one of claims 1 to 6, the method comprising:

receiving Raman spectrum data transmitted by the Raman detection information acquisition equipment;

and based on the Raman spectrum data, carrying out tissue abnormality detection on the object to be detected so as to control the semiconductor laser output treatment equipment to output laser corresponding to the Raman spectrum data to the region where the object to be detected is located.