CN110064130A - A kind of gall-bladder pacemaker - Google Patents

Abstract

The invention discloses a gallbladder pacemaker, comprising an internal stimulator, an external controller and a PC terminal; the PC terminal is connected with a serial port of the external controller, and is used for transmitting preset control instruction parameters to In the external controller; the external controller adopts wireless communication with the internal stimulator, which inputs control instructions for the internal stimulator and is used for storage and display of in-vivo detection data; the internal stimulator is implanted. Into the patient's body, to provide a certain current stimulation for the patient's gallbladder. The gallbladder pacemaker provided by the present invention achieves the effect of stimulating and contracting by stimulating the gallbladder wall with electric current, thereby realizing the treatment of gallbladder stones, avoiding postoperative complications caused by the treatment of gallbladder removal, and is the best solution for gallbladder treatment. It provides a new way, has a relatively broad market prospect, and is easy to promote.

Description

a gallbladder pacemaker

technical field

The invention relates to the technical field of electronic medical products, in particular to a gallbladder pacemaker.

Background technique

Cholecystolithiasis is a common disease, the incidence of which has reached 10%-12% in economically developed areas of our country. The treatment of cholecystolithiasis has been extended to cholecystectomy, but the complications after cholecystectomy include indigestion, abdominal distension, diarrhea, reflux of duodenal and gastric juices, post-cholecystectomy syndrome, intraoperative bile duct injury, etc. , its incidence is 10%-15%, and once bile duct injury occurs, the consequences are very serious.

In recent years, the research on the causes of gallbladder stones has paid more and more attention to the significance of gallbladder contraction function. Clinical and experimental studies have shown that the formation of gallstones does not completely depend on the physical and chemical changes of bile. It plays an important role. However, in the treatment of gallbladder contractile dysfunction at home and abroad, clinicians are helpless except for some traditional Chinese medicines that promote gallbladder and dissolve stones.

SUMMARY OF THE INVENTION

In view of the problems existing in the background art, the present invention provides a gallbladder pacemaker.

In order to achieve the above purpose, the present invention provides the following technical solutions: a gallbladder pacemaker, including an internal stimulator, an external controller and a PC terminal;

The PC terminal is connected with the external controller serial port, which is used to transmit the preset control command parameters to the external controller;

The in-vitro controller and the in-vivo stimulator use wireless communication, which inputs control instructions for the in-vivo stimulator, and is simultaneously used for storage and display of in-vivo detection data;

The in vivo stimulator is implanted in the patient's body to provide a certain current stimulation to the patient's gallbladder.

As a preferred technical solution of the present invention, the in vivo stimulator includes a first microprocessor, a first radio frequency module, a first power supply module, a clock control module, a pulse generating module and a stimulation electrode, the first power supply module, The first radio frequency module, the clock control module and the pulse generation module are all electrically connected to the first microprocessor, and the pulse generation module is connected to the stimulation electrode through an extension wire.

As a preferred technical solution of the present invention, the external controller includes a second microprocessor, a second radio frequency module, a liquid crystal display module, a second power supply module and an input button, the second radio frequency module, the liquid crystal display module, Both the second power module and the input key are electrically connected to the second microprocessor.

As a preferred technical solution of the present invention, the pulse generating module generates a biphasic stimulation waveform.

As a preferred technical solution of the present invention, the first power module adopts a kangpo battery.

As a preferred technical solution of the present invention, the first microprocessor, the first radio frequency module, the first power supply module, the clock control module and the pulse generating module of the in-vivo stimulator are sealed in an encapsulating shell, and this part is implanted in the lower abdomen. In the skin of the region, the stimulating electrode is implanted in the muscular layer of the gallbladder wall.

As a preferred technical solution of the present invention, the packaging shell of the in vivo stimulator is made of silica gel.

Compared with the prior art, the beneficial effects of the present invention are: the gallbladder pacemaker provided by the present invention achieves the effect of stimulating and contracting by stimulating the gallbladder wall with electric current, thereby realizing the treatment of gallbladder stones and avoiding the need to remove the gallbladder. The postoperative complications brought about by the treatment method provide a new way for the treatment of gallbladder, which has a relatively broad market prospect and is easy to popularize.

Description of drawings

1 is a schematic diagram of the overall structure of a gallbladder pacemaker provided by the present invention;

2 is a schematic structural diagram of an in vivo stimulator of a gallbladder pacemaker provided by the present invention;

3 is a schematic structural diagram of an external controller of a gallbladder pacemaker provided by the present invention;

4 is a schematic diagram of the external structure of the in vivo stimulator of a gallbladder pacemaker provided by the present invention;

5 is a schematic diagram of the external structure of the external controller of a gallbladder pacemaker provided by the present invention;

In the figure: 1-in vivo stimulator; 101-first microprocessor; 102-first radio frequency module; 103-first power supply module; 104-clock control module; 105-pulse generation module; 106-stimulation electrode; 107- Encapsulation shell; 2-external controller; 201-second microprocessor; 202-second radio frequency module; 203-liquid crystal display module; 204-second power module; 205-input button; 3-PC terminal.

Detailed ways

The basic principle of gallbladder pacing is based on the fact that the electrical activity of the human gallbladder pacing point can be "driven" by the external current stimulation, and the best gallbladder bioelectric information generated by electronic technology is similar to the basic electrical rhythm of the human gallbladder. The frequency and amplitude of the treatment act on the pacemaker at the bottom of the gallbladder through the body or the body surface, so that the electrical activity of the gallbladder produces a "following effect", which can restore the normal rhythm and amplitude of the gallbladder electricity, thereby reducing or eliminating the gallbladder contractile dysfunction disease. Symptoms, to achieve the purpose of prevention and treatment of gallstones.

The points that need to be paid attention to in gallbladder pacing are as follows: 1. According to the position of the stimulating electrode: the electrical stimulation of the gallbladder is divided into serous stimulation, mucosal stimulation and body surface stimulation. The serosa stimulation refers to the stimulation method in which the stimulating electrode is placed on the serosa surface of the gallbladder without penetrating the mucosal layer, and directly acts on the smooth muscle of the gallbladder. Mucosal stimulation refers to a kind of stimulation method in which the stimulating electrode is placed on the mucosal surface of the gallbladder, and exogenous electrical stimulation is transmitted through the mucosa through the adsorption electrode to the smooth muscle layer, thereby controlling the electromyographic activity. Body surface stimulation, including body surface pacemaker stimulation and body surface acupuncture point stimulation. The stimulation of the body surface pacemaker is to input stimulation signals from the projection of the bottom of the gallbladder on the abdominal surface to drive the movement of the gallbladder.

2. The number of stimulating electrodes; Gallbladder electrical stimulation methods are divided into single-lead stimulation and multi-lead stimulation. Single-lead stimulation refers to electrical stimulation of the gallbladder with a pair of electrodes in the physiological gallbladder pacemaker region (bottom). Multi-lead stimulation refers to electrical stimulation of the gallbladder with multiple pairs of electrodes in the pacemaker area, and the main purpose is to simulate the propagation and characteristics of normal gallbladder slow waves.

3. According to the frequency of electrical stimulation, gallbladder electrical stimulation methods are divided into high-frequency stimulation, low-frequency stimulation and pulse train stimulation. Among them, high-frequency stimulation refers to electrical stimulation with 2-10 times the inherent slow-wave rhythm, but its pulse width is mostly hundreds of microseconds. Low-frequency stimulation refers to electrical stimulation that is similar to or slightly higher than the inherent slow-wave rhythm of the gallbladder. The wave type is pulse wave, and the pulse width is generally millisecond. Burst stimulation consists of repeated bursts and is based on a combination of low-frequency stimulation and high-frequency stimulation.

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Please refer to FIG. 1, the present invention provides a gallbladder pacemaker, including an in vivo stimulator 1, an in vitro controller 2 and a PC terminal 3;

The PC terminal 3 is connected with the in vitro controller 2 serial port, which is used to transmit the preset control instruction parameters to the in vitro controller 2;

The external controller 2 uses wireless communication with the internal stimulator 1, which inputs control instructions for the internal stimulator 1, and is used for storage and display of in-vivo detection data;

The in vivo stimulator 1 is implanted in the patient's body to provide a certain current stimulation to the patient's gallbladder.

As shown in FIG. 2 and FIG. 4 , the in vivo stimulator 1 includes a first microprocessor 101 , a first radio frequency module 102 , a first power supply module 103 , a clock control module 104 , a pulse generation module 105 and a stimulation electrode 106 . The first power supply module 103 , the first radio frequency module 102 , the clock control module 104 and the pulse generation module 105 are all electrically connected to the first microprocessor 101 , and the pulse generation module 105 is connected to the stimulation electrode 106 through an extension wire. connect.

As shown in FIG. 3 and FIG. 5 , the external controller 2 includes a second microprocessor 201, a second radio frequency module 202, a liquid crystal display module 203, a second power supply module 204 and an input button 205. The second radio frequency module 202 , the liquid crystal display module 203 , the second power module 204 and the input button 205 are all electrically connected to the second microprocessor 201 .

When the present invention is working, the software of the PC terminal 3 is connected with the serial port of the external controller 2, and the preset control command parameters are downloaded to the external controller 2, and then the control signal is transmitted to the internal stimulator 1 through radio frequency. , the in-vivo stimulator 1 generates corresponding actions after receiving the command signal, and acts on the smooth muscle cells at the bottom of the gallbladder through the stimulating electrode 106 to achieve electrical stimulation of the gallbladder wall. The command signals mainly include start stimulation, end stimulation, start detection, end detection, current detection, system sleep and system reset.

In the specific implementation process, since the stimulation pulse directly acts on the biological tissue through the stimulation electrode, it is necessary to consider both the stimulation effect and its biological safety, and select the stimulation waveform with the least harm to the biological tissue. The inventors found that the biphasic stimulation waveform had the least effect on electrode corrosion and tissue damage, so it was selected as the basic waveform of the stimulation pulse in the gallbladder. The stimulation mode was selected as the main stimulation mode with higher biological safety and more mature constant pressure stimulation mode.

In the specific implementation process, the first power module 103 adopts a keng battery, and the keng battery uses a solid electrolyte, which can be fully sealed, has high energy, high reliability and small self-discharge amount. Keng-ion rechargeable batteries are considered to be the battery system with the best comprehensive performance at present due to their excellent properties such as high working voltage, high cycle life and high energy density. The gallbladder pacemaker has been used for 2 years, 3 times a day, 30 minutes each time. The design life of this active battery is 5 years, which fully meets the needs.

As shown in FIG. 4 , in the specific implementation process, the first microprocessor 101 , the first radio frequency module 102 , the first power supply module 103 , the clock control module 104 and the pulse generation module 105 of the in vivo stimulator 1 are sealed in a package In the shell 107, this part is implanted in the skin of the lower abdominal area, and the stimulating electrode 106 is implanted in the muscular layer of the gallbladder wall.

In the specific implementation process, since the intra-gallbladder stimulator designed by the inventor is an implantable therapeutic device, its biocompatibility is also a problem that must be considered. Considering the rejection reaction produced by the implantable gallbladder in vivo electrical stimulator, the present invention adopts a non-toxic and harmless medical safety silicone material with good biocompatibility as the encapsulation shell 107 of the in vivo stimulator.

Based on the above, the present invention has the advantage that: the gallbladder pacemaker provided by the present invention achieves the effect of stimulating contraction by stimulating the gallbladder wall with electric current, thereby realizing the treatment of gallbladder stones and avoiding the treatment of gallbladder removal. It provides a new way for the treatment of gallbladder, has a relatively broad market prospect, and is easy to promote.

The above descriptions are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included in the protection of the present invention. within the range.

Claims (7)

1. a kind of gall-bladder pacemaker, it is characterised in that: including internal stimulator, external controller and the end PC；

The end PC is connect with the external controller serial ports, is used to pre-set control instruction parameter being transmitted to institute It states in external controller；

The external controller and the internal stimulator are referred to using wirelessly communicating for the internal stimulator input control It enables, while being used for the storage and display of vivo detection data；

In the internal stimulator implantation patient, certain electric current stimulation is provided for sufferer gall-bladder.

2. a kind of gall-bladder pacemaker according to claim 1, it is characterised in that: the internal stimulator includes first micro- place Reason device, the first radio-frequency module, the first power module, clock control module, pulse generating module and stimulating electrode, described first Power module, the first radio-frequency module, clock control module and pulse generating module are electrically connected with the first microprocessor, The pulse generating module is connect by extension lead with the stimulating electrode.

3. a kind of gall-bladder pacemaker according to claim 2, it is characterised in that: the external controller includes second micro- place Manage device, the second radio-frequency module, LCD MODULE, second power supply module and input key, second radio-frequency module, liquid crystal Display module, second power supply module and input key are electrically connected with second microprocessor.

4. a kind of gall-bladder pacemaker according to claim 2, it is characterised in that: the pulse generating module generation is double Phase stimulus waveform.

5. a kind of gall-bladder pacemaker according to claim 2, it is characterised in that: first power module is using clang electricity Pond.

6. a kind of gall-bladder pacemaker according to claim 2, it is characterised in that: the first micro process of the internal stimulator Device, the first radio-frequency module, the first power module, clock control module and pulse generating module are sealed in package casing, should Part is planted in the skin of lower abdominal region, and the stimulating electrode is planted in gallbladder wall muscle layer.

7. a kind of gall-bladder pacemaker according to claim 6, it is characterised in that: the package casing of the internal stimulator is adopted Use silica gel material.