CN110404153B

CN110404153B - Magnet and wheat-mango bionic dual-drive reverse intestinal flora transplanting device

Info

Publication number: CN110404153B
Application number: CN201810389428.8A
Authority: CN
Inventors: 马锋; 吕毅; 杜妍莹; 单丽宇; 吴荣谦; 袁力蓉
Original assignee: First Affiliated Hospital of Xian Jiaotong University
Current assignee: Chonghao Technology Co ltd
Priority date: 2018-04-27
Filing date: 2018-04-27
Publication date: 2021-10-26
Anticipated expiration: 2038-04-27
Also published as: CN110404153A

Abstract

A magnet and Maiman bionic dual-drive reverse intestinal flora transplantation device, comprising a pipeline body with open ends at both ends, a sliding jacket and an internal magnet are arranged at the head end of the pipeline body, and the internal magnet is arranged on the pipeline body The upper end of the sliding jacket is closed, and it is wrapped and attached to the inner wall of the pipeline body and the outer surface of the magnet in the body. The tail end of the body is provided with a velcro, the velcro is distributed on the inner and outer walls of the pipeline body, the pulling wires are all connected and fixed on the velcro, and the side wall at the head end of the pipeline body is provided with a side hole. The invention can obviously shorten the intubation time, can inject bacteria-containing liquid after being inserted into a deep part, ensure the curative effect, eliminate the discomfort brought by the traditional oral intestinal flora transplantation to the patient, and at the same time can avoid the effect of gastric juice on the flora activity. Influence, to achieve the purpose of injecting the liquid containing the intestinal flora to be transplanted through the lower gastrointestinal tract.

Description

Magnet and wheat-mango bionic dual-drive reverse intestinal flora transplanting device

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a magnet and wheat-mango bionic dual-drive reverse intestinal flora transplanting device.

Background

The intestinal flora is not only huge in quantity but also important in function, and not only participates in energy metabolism of human bodies, but also plays an important role in the regulation mechanism of an immune system. However, in the past years, due to the application of broad-spectrum antibiotics and the reasons of old age, long hospitalization time, taking immunosuppressive drugs or past infection history, the normal structure of intestinal flora is destroyed, the dynamic balance of the self-regulation of the intestinal flora is broken, various intestinal diseases are caused, such as constipation, irritable bowel syndrome and inflammatory bowel disease, particularly clostridium difficile infection is more and more common, and enteritis caused by the antibiotics is the most typical example of intestinal flora disorder caused by excessive use of antibiotics. The resistance of the flora to antibiotics is also enhanced, even surpassing that of methicillin-resistant staphylococcus aureus, which becomes the main cause of hospital-acquired infection. After antibiotic treatment, a repeated chronic process is easily formed, and the cure is difficult.

In recent years, with the high incidence of intestinal dysbiosis diseases and the defects of the existing treatment measures, the intestinal flora transplantation is gradually emphasized to be applied to various clinical researches and treatments. The intestinal flora transplantation is a new treatment method for changing intestinal flora and resisting 'super bacteria', and is a treatment method for inputting the excrement of a healthy person into small intestine or colon of a patient through a nasal-intestinal tube or enema and the like and helping the patient to recover normal flora by using some beneficial flora in the excrement of the healthy person. Intestinal flora transplantation has been demonstrated to permanently alter the intestinal microbiota of the recipient and to be effective against recurrent clostridium difficile infections. The intestinal flora transplantation is mainly realized through three ways of an upper digestive tract, a middle digestive tract and a lower digestive tract. Oral fecal bacteria capsule is the main route of upper digestive tract; administration via nasogastric, nasojejunal or gastroscope is the main route to the alimentary canal; colonoscopic, enema administration is the primary route of the lower digestive tract. Some medical literature indicates that fecal microbes transplanted through the lower digestive tract may have a higher cure rate.

Although a plurality of intestinal flora transplantation ways exist at present, no medical instrument specially aiming at intestinal flora transplantation exists, and the above methods have obvious defects. Although the oral fecal freezing capsule is convenient, the capsule needs to be unfrozen when being taken, the cost is high, and digestive juice influences the quantity and the richness of flora and influences the curative effect. At present, the research and experiments of adopting oral coprinus comatus capsules are very few, and the curative effect of the coprinus comatus capsules needs to be further verified. The naso-intestinal tube is much thinner than the colonoscope, and is a tube that is inserted into the intestine through the mouth, and the naso-intestinal tube administration has two obvious defects: the patient can be difficult to accept in sense and vision when the liquid dung is input, and great psychological burden is caused to the patient; the tube placing speed is slow, and the treatment process is seriously influenced. Enema is the transrectal insertion of a catheter into the colon from the anus to perfuse the liquid, but the insertion depth can only reach around 20cm, presumably in the sigmoid colon. The lesion parts are located in the ileocecal part or the ileum, and the insertion depth of the enema method can not meet the treatment requirements. In addition, the shallow depth of insertion can cause the patient to feel defecation and diarrhea after the liquid dung is filled, and the treatment is affected or even interrupted after the liquid dung is filled. Colonoscopy is used in the research and experiment of intestinal flora transplantation at present, and although the colonoscope can be inserted into a deeper part, the treatment effect is guaranteed, but patients can obviously feel abdominal pain and abdominal distension. And the potential safety hazard is large, and the risk of perforation, hemorrhage and cardiopulmonary related complications is high. The enteroscope is very clumsy, inconvenient to operate and time-consuming and labor-consuming.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide a magnet and awn bionic double-drive reverse intestinal flora transplanting device.

In order to achieve the purpose, the invention adopts the technical scheme that:

a bionic double-drive reverse intestinal flora transplanting device with magnets and awn comprises a pipeline body 6 with both open ends, a sliding outer sleeve 1 and an internal magnet 3 are arranged at the head end of the pipeline body 6, an external abdominal wall magnet 4 matched with the internal magnet 3 is arranged outside the body, wherein the internal magnet 3 is arranged on the outer wall of the pipeline body 6, the upper end of the sliding outer sleeve 1 is closed and wraps the inner wall attached to the pipeline body 6 and the outer surface of the internal magnet 3, the outer wall of the sliding outer sleeve 1 is provided with an awn-imitating structure 2, the inner wall and the outer wall tail part of the sliding outer sleeve 1 are respectively and correspondingly connected with a plurality of pulling wires 7, the tail end of the pipeline body 6 is provided with thread gluing 9, the thread gluing 9 is distributed on the inner wall and the outer wall of the pipeline body 6, the pulling wires 7 connected with the inner wall of the sliding outer sleeve 1 are arranged in the pipeline body 6, the pulling wires 7 connected with the outer wall of the sliding outer sleeve 1 are arranged outside the pipeline body 6, are all connected and fixed on the thread gluing 9, a side hole 5 as a liquid outflow channel is arranged on the side wall of the head end position of the pipeline body 6.

The length of the pipeline body 6 is 145-250cm, and the pipeline body is provided with scale marks 8 which can be developed under X-ray.

The sliding outer sleeve 1 is made of a high polymer material with good biocompatibility.

And lubricating liquid is arranged between the sliding outer sleeve 1 and the magnet 3 in the body.

The awn-like structure 2 is composed of a plurality of thin whiskers, each thin whisker takes the length direction of the sliding outer sleeve 1 as an axis to form a gathering effect, the gathering head end faces the head end of the sliding outer sleeve 1, and the diverging tail end faces the tail end of the sliding outer sleeve 1, so that resistance is formed in the opposite direction of traction.

The fine hair is made of materials with certain flexibility, acid and alkali corrosion resistance, such as natural wheat awn, bristles, horsehair and the like, the head of the fine hair is blunt and round, the length of the fine hair is 3.5-5 mm, the diameter of the head end of the fine hair is 0.5mm, and the diameter of the tail end of the fine hair is 1mm, and the fine hair and the head end of the fine hair are arranged alternately.

The tail end of the pipeline body 6 is provided with graduation marks 8 of 145cm, 155cm, 165cm, 175cm, 185cm, 195cm and 215cm and the like, so as to assist in judging the approximate position of the pipeline inserted into the body.

Compared with the prior art, the invention has the beneficial effects that:

1. obviously shortens the tube placing time and relieves the pain of patients.

2. Can be inserted into deeper part for injection to ensure therapeutic effect.

3. Can eliminate discomfort and refusal of patients caused by traditional oral intestinal flora transplantation.

4. Avoid the influence of digestive juice such as gastric juice and the like on the activity of flora and realize the purpose of injecting liquid through the lower digestive tract.

Drawings

FIG. 1 is a schematic diagram of the present invention.

Fig. 2 is a cross-sectional view AA of fig. 1.

Detailed Description

The embodiments of the present invention will be described in detail below with reference to the drawings and examples.

As shown in fig. 1 and 2, a magnet and mcfart bionic dual-drive reverse intestinal flora transplanting device comprises a pipeline body 6, wherein the length of the pipeline body 6 is 175cm, the pipeline body is a penetration tube with both open ends, a sliding outer sleeve 1 and an in-vivo magnet 3 are arranged at the head end of the pipeline body 6, and an abdominal wall outer magnet 4 matched with the in-vivo magnet 3 is arranged outside the body. Be provided with side opening 5 as liquid outflow passageway on the lateral wall of the head end position of pipeline body 6, side opening 5 can be located different axes (have a plurality of side openings 5 that do not communicate in week promptly) in order to guarantee the outflow effect, and side opening 5 can not be wrapped up by slip overcoat 1. The end of the line body 6 has 145cm and 155cm graduations 8 to assist in determining the approximate location of the line when inserted into the body.

Wherein, internal magnet 3 sets up the outer wall at pipeline body 6, and the closure of slip overcoat 1 upper end is wrapped up and is attached to the inner wall of pipeline body 6 and the surface of internal magnet 3, has lubricating liquid between slip overcoat 1 and the internal magnet 3.

The sliding outer sleeve 1 is made of rubber or other high polymer materials with good biocompatibility, the outer wall of the sliding outer sleeve is provided with a wheat-mango-like structure 2, the wheat-mango-like structure 2 is composed of a plurality of thin whiskers, the thin whiskers are made of materials with certain flexibility, acid and alkali corrosion resistance, such as natural wheat awns, bristles and horsehairs, the head of the sliding outer sleeve is blunt and round, the length of the thin whiskers ranges from 3.5 mm to 5mm, the diameter of the head of the sliding outer sleeve is 0.5mm, and the diameter of the tail of the sliding outer sleeve is 1 mm. Each thin hair takes the length direction of the sliding outer sleeve 1 as an axis to form a gathering effect, the gathering head end faces the head end of the sliding outer sleeve 1, and the diverging tail end faces the tail end of the sliding outer sleeve 1, so that resistance is formed in the opposite direction of traction.

The tail parts of the inner wall and the outer wall of the sliding outer sleeve 1 are respectively and correspondingly connected with two pulling wires 7, and the number of the pulling wires 7 is four, and the pulling wires are divided into two groups. The thread gluing 9 is arranged at the tail end of the pipeline body 6, the thread gluing 9 is distributed on the inner wall and the outer wall of the pipeline body 6, two traction wires 7 connected with the inner wall of the sliding sleeve 1 are arranged in the pipeline body 6, two traction wires 7 connected with the outer wall of the sliding sleeve 1 are arranged outside the pipeline body 6 and are both connected and fixed on the thread gluing 9,

according to the above structure, the working process of the invention is as follows:

the invention is suitable for intestinal flora transplantation, when in operation, a patient adopts a lateral position and backs on to an operator, and the operator inserts the pipeline body 6 into the body through the anus beside a bed. The outer magnet 4 of the abdominal wall moves, and provides combined power for the retrograde motion of the pipeline body 6 with the wheat-mango-like structure 2 under the intestinal peristalsis, so that the pipeline body 6 can be driven to rapidly crawl retrograde and upwards to reach the ileocecal part. After relevant inspection confirms that the pipeline reaches the corresponding position, the four pulling wires 7 below the thread gluing 9 are cut off, an operator slowly migrates the two pulling wires 7 on the inner wall of the pipeline body 6, and the whole sliding outer sleeve 1 can easily and completely slide into the pipe along with the pulling wires 7 under the action of the lubricating liquid. At this time, liquid is supplied to the tube body 6 to transplant the intestinal flora, and the tube body 6 is pulled out after the transplantation is finished.

Claims

1. a magnet and a Maimang bionic dual-drive reverse intestinal flora transplantation device, comprising a pipeline body (6) open at both ends of the head and tail, it is characterized in that, the head end of the pipeline body (6) is provided with sliding The outer casing (1) and the internal magnet (3) are provided with an external abdominal wall magnet (4) which is used in conjunction with the internal magnet (3), wherein the internal magnet (3) is arranged on the outer wall of the pipeline body (6), and the outer casing slides (1) The upper end is closed, wrapped and attached to the inner wall of the pipeline body (6) and the outer surface of the internal magnet (3), the outer wall of the sliding jacket (1) is provided with an imitation wheat awn structure (2), and the imitation wheat awn structure (2) It consists of a number of thin whiskers, each of which takes the length direction of the sliding jacket (1) as the axis to form a gathering effect, the gathering head end faces the head end of the sliding jacket (1), and the divergent tail end faces the sliding jacket (1). The rear end, thereby forming resistance in the opposite direction of traction; the inner wall and outer wall tail of the sliding jacket (1) are respectively connected with a number of pulling wires (7), and the rear end of the pipeline body (6) is provided with a hook and loop fastener (9). ), the hook and loop fasteners (9) are distributed on the inner and outer walls of the pipeline body (6). The pulling wire (7) is connected and fixed to the velcro (9) from the outside of the pipeline body (6), and the side wall of the head end of the pipeline body (6) is provided with a liquid outflow channel side hole (5).

2. The magnet and Maimang bionic dual-drive reverse intestinal flora transplantation device according to claim 1, characterized in that, the pipeline body (6) is 145-250cm long, has a scale line (8), and can be placed in X Offline development.

3 . The magnet and Maimang bionic dual-drive reverse intestinal flora transplantation device according to claim 1 , wherein the sliding jacket ( 1 ) is made of a polymer material with good biocompatibility. 4 .

4 . The magnet and Maimang bionic dual-drive reverse intestinal flora transplantation device according to claim 1 , wherein there is lubricating fluid between the sliding outer jacket ( 1 ) and the in-vivo magnet ( 3 ). 5 .

5. according to the described magnet of claim 1 and the bionic dual-drive reverse intestinal flora transplantation device, it is characterized in that, described fine whiskers are made of natural wheat awn, bristle or horsehair, and the head is blunt and round, and the length is 3.5～5mm, and the head is 3.5-5mm long. The diameter of the end is 0.5mm, and the diameter of the tail is 1mm, which are arranged alternately.

6. The magnet and Maimang bionic dual-drive reverse intestinal flora transplantation device according to claim 1, wherein the tail end of the pipeline body (6) has 145cm, 155cm, 165cm, 175cm, 185cm, 195cm, The 215cm isometric line (8) is used to assist in judging the approximate position of the tube inserted into the body.