CN110403733B - Device for implanting an intraocular lens and method for preparing a device for implanting an intraocular lens - Google Patents
Device for implanting an intraocular lens and method for preparing a device for implanting an intraocular lens Download PDFInfo
- Publication number
- CN110403733B CN110403733B CN201811167935.3A CN201811167935A CN110403733B CN 110403733 B CN110403733 B CN 110403733B CN 201811167935 A CN201811167935 A CN 201811167935A CN 110403733 B CN110403733 B CN 110403733B
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- hollow tube
- elongated hollow
- axially elongated
- assembly
- artificial
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- 238000000034 method Methods 0.000 title claims description 14
- 239000013078 crystal Substances 0.000 claims abstract description 38
- 239000003190 viscoelastic substance Substances 0.000 claims abstract description 27
- 238000002347 injection Methods 0.000 claims abstract description 23
- 239000007924 injection Substances 0.000 claims abstract description 23
- 238000004891 communication Methods 0.000 claims abstract description 9
- 239000007943 implant Substances 0.000 claims description 85
- 238000003780 insertion Methods 0.000 claims description 34
- 230000037431 insertion Effects 0.000 claims description 34
- 230000009977 dual effect Effects 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 8
- 230000008878 coupling Effects 0.000 claims description 7
- 238000010168 coupling process Methods 0.000 claims description 7
- 238000005859 coupling reaction Methods 0.000 claims description 7
- 230000037361 pathway Effects 0.000 abstract description 2
- 238000002513 implantation Methods 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/1664—Instruments for inserting intraocular lenses into the eye for manual insertion during surgery, e.g. forceps-like instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/167—Instruments for inserting intraocular lenses into the eye with pushable plungers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/1675—Instruments for inserting intraocular lenses into the eye with a lubricated inner surface, e.g. the lubricant being coated on the inner surface or being injected through a port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/16902—Separable from intraocular lens
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
A device for implanting a plurality of artificial crystals, the device comprising an axially elongated hollow tube having a first end and a second end and defining an artificial crystal injection pathway extending along a longitudinal axis; the axially elongated hollow tube forming a syringe adapter at the first end, the syringe adapter defining a movable syringe mounting location, and a push assembly located within the axially elongated hollow tube between the syringe adapter and the second end; at least one of the axially elongated hollow tube and the push assembly is formed of a plurality of conduits in communication with each other that enable viscoelastic material to pass through the syringe adapter and the push assembly to a location between the push assembly and the second end of the axially elongated hollow tube.
Description
Reference to related applications
The disclosures of the following patents and patent applications of the assignee of the present application are hereby incorporated by reference:
U.S. patent publication number 5,354,335、5,391,202、5,814,103、5,876,442、 5,928,283、6,007,579、6,066,171、6,569,199、6,596,026、6,972,032、 7,001,427、7,101,397、7,736,390、7,727,277、7,776,087、7,842,086、 7,918,886、8,088,161、8,133,273 and 9,358,102 and
U.S. patent publication No. 2005/0065602、2005/0154457、2006/0004446、 2007/0027541、2010/0145445、2011/0054599、2012/0095554、2014/0371851、 2014/0371852、2016/0262877,2016/0278913.
Technical Field
The present invention relates generally to medical devices, and more particularly to a device for implanting a plurality of artificial crystals.
Background
Various types of artificial crystals (intraocular lenses) are known, examples of which are described in the patents and patent applications referenced above. Various tools for implanting a plurality of artificial crystals are also known.
Disclosure of Invention
The present invention aims to provide an improved device for implanting several artificial crystals.
Thus, in accordance with a preferred embodiment of the present invention, there is provided an apparatus for implanting a plurality of artificial crystals, the apparatus comprising: an axially elongated hollow tube (axial elongate hollow conduit) having a first end and a second end and defining an artificial crystal injection path extending along a longitudinal axis; the axially elongated hollow tube is formed with a syringe adapter (syringe connector) at the first end, the syringe adapter defining a movable syringe mount location (removable syringe mounting location); and a push assembly (pusher element) located within said axially elongated hollow tube between said syringe adapter and said second end; wherein at least one of the axially elongated hollow tube and the push assembly is formed of a plurality of conduits in communication with each other that enable viscoelastic material to pass through the syringe adapter and the push assembly to a location between the push assembly and the second end of the axially elongated hollow tube.
According to a preferred embodiment of the present invention, the apparatus for implanting a plurality of artificial crystals also comprises: a dual function elongate hollow tube (dual purpose elongate hollow tube) secured to the push assembly, the dual function elongate hollow tube having: a fluid inlet end (fluid inlet end) adjacent to the syringe adapter, and a fluid outlet end (fluid outlet end); the dual function elongated hollow tube defines a hollow pushrod (hollow pusher rod) and is movable within the axially elongated hollow tube along the longitudinal axis relative to the axially elongated hollow tube toward the second end to move the push assembly along the axis toward the second end. Additionally or alternatively, the axially elongated hollow tube comprises: a first relatively solid housing portion (FIRST RELATIVELY RIGID housing portion) defining the syringe connection; and a relatively flexible sleeve portion (flexible sleeve portion) mounted on the relatively rigid housing portion. In addition, the flexible sleeve portion defines a beveled edge (ANGLED EDGE) defining the second end of the axially elongated hollow tube.
According to a preferred embodiment of the present invention, the hollow pushrod is slidably and sealably disposed within the axially elongated hollow tube. In addition, the hollow pushrod is slidably and sealably disposed within the axially elongated hollow tube by coupling with an O-ring.
Preferably, the hollow pushrod forms a tapered opening (tapered opening) that communicates with a fully cylindrical bore (throughgoing cylindrical bore) that extends axially through the hollow pushrod. In addition, the full cylindrical bore communicates with a conduit (conduit) extending through the pushing assembly, thereby defining a portion of the plurality of conduits that communicate with each other; the interconnecting conduits enable viscoelastic material to pass through the syringe adapter and the push assembly to a location at the push assembly and the second end of the axially elongated hollow tube.
There is also provided in accordance with another preferred embodiment of the present invention a method of preparing an artificial crystal for injection, the method including the steps of: providing a device for implanting the artificial lens, the device comprising: an axially elongated hollow tube having a first end and a second end and defining an artificial crystal injection path extending along a longitudinal axis; a syringe adapter defining a movable syringe mounting location, said syringe adapter being located at a first end of said axially elongated hollow tube; and a push assembly located within said axially elongated hollow tube between said syringe adapter and said second end; wherein at least one of the axially elongated hollow tube and the push assembly is formed of a plurality of conduits in communication with each other that enable viscoelastic material to pass through the syringe adapter and the push assembly to a location at the second end of the push assembly and the axially elongated hollow tube; injecting a viscoelastic material through said interconnecting plurality of conduits to said location between said pushing assembly and said second end of said axially elongated hollow tube; and thereafter inserting an artificial crystal through the second end of the axially elongated hollow tube into the viscoelastic material at the location between the pushing assembly and the second end of the axially elongated hollow tube.
According to a preferred embodiment of the invention, said injection is performed at said first end through said syringe connector.
Preferably, the axially elongated hollow tube is mounted on an implant member (implantation assembly) prior to and during the injection of the viscoelastic material. Furthermore, the axially elongated hollow tube is mounted on an implant component prior to and during insertion of the intraocular lens into the viscoelastic material.
According to a preferred embodiment of the invention, in a first operating phase, the support feet (haptics) of an artificial crystal to be injected are located in the grooves (recesses); the plurality of grooves are formed in an azimuthally precise mounting assembly (azimuthally precise mounting element) that forms part of the implant component, and a rearward portion (rearward portion) of the intraocular lens seats within a hole formed in the azimuthally precise mounting assembly.
Preferably, the axially elongated hollow tube comprises: a first relatively rigid housing portion defining said syringe connector; and a relatively flexible sleeve portion mounted on said relatively solid housing portion and forming a beveled edge defining said second end of said axially elongated hollow tube; and in the first stage of operation, the beveled edge is proximate the intraocular lens. Furthermore, in a second stage of operation, the viscoelastic material is transferred to the interior of the flexible sleeve portion.
According to a preferred embodiment of the invention, in a third operating phase, the intraocular lens is moved axially into the flexible sleeve and the supporting feet are positioned in a folded-back and flipped-up direction while maintaining a precise predetermined azimuthal positioning with respect to the longitudinal axis.
According to a preferred embodiment of the invention, in a further operating phase, the axially elongated hollow tube is released from the implant component and connected to an implant syringe.
Drawings
The present invention will become more fully understood from the detailed description given below in conjunction with the accompanying drawings, wherein:
FIG. 1 is a simplified illustration of an apparatus for implanting a plurality of artificial crystals constructed and operative in accordance with a preferred embodiment of the present invention;
FIG. 2 is a simplified exploded view of an implant component forming part of the device of FIG. 1;
FIGS. 3A and 3B are simplified pictorial and sectional illustrations, respectively, showing a manually couplable axial displacer forming part of the implant component of FIG. 2, FIG. 3B being taken along line 3B-3B of FIG. 3A;
FIGS. 4A and 4B are, respectively, a simplified pictorial and sectional illustration of an internal cylindrical assembly forming part of the implant component of FIG. 2, FIG. 4B being taken along line 4B-4B of FIG. 4A;
FIGS. 5A, 5B, 5C and 5D are respectively a posteriorly and anteriorly facing illustration, a posteriorly facing plan view and a cross-sectional view of an axial displacement guide assembly forming part of the implant component of FIG. 2, FIG. 5D being taken along line 5D-5D in FIG. 5A;
FIGS. 6A, 6B, 6C and 6D are simplified exploded and rearwardly-facing assembled illustrations, rearwardly-facing planar and partial sectional views, respectively, showing an artificial lens and an azimuthal precision mounting, forming part of the implant component of FIG. 2, FIG. 6D being taken along line 6D-6D in FIG. 6A;
FIGS. 7A, 7B and 7C are simplified pictorial and sectional illustrations, respectively, of a posterior-facing and anterior-facing portion of an intraocular lens implant insertion assembly housing component, forming part of the implant component of FIG. 2, FIG. 7C being taken along line 7C-7C of FIG. 7A;
FIGS. 8A and 8B are simplified pictorial and sectional illustrations, respectively, of a main housing assembly forming a portion of the implant component of FIG. 2, FIG. 8B being taken along line 8B-8B of FIG. 8A;
FIGS. 9A, 9B and 9C are, respectively, a simplified pictorial illustration, a plan sectional illustration and an exploded view illustration of an intraocular lens implant insertion component, forming part of the implant component of FIG. 2, FIG. 9B being taken along line 9B-9B of FIG. 9A;
FIGS. 10A and 10B are simplified pictorial and sectional illustrations, respectively, of a portion of the intraocular lens implant insertion component of FIGS. 9A-9C, FIG. 10B being taken along line 10B-10B of FIG. 10A;
FIG. 11 is a simplified pictorial illustration and cross-sectional illustration of another portion of the intraocular lens implant insertion component of FIGS. 9A-9C;
FIG. 12 is a simplified plan side view of yet another portion of the intraocular lens implant insertion component of FIGS. 9A-9C;
FIGS. 13A and 13B are simplified assembled and exploded views, respectively, of an implant syringe forming a portion of the device of FIG. 1;
Fig. 14A, 14B, 14C and 14D are simplified pictorial, sectional and plan sectional views, respectively, of the implant component of fig. 2, both anteriorly and posteriorly facing in a first operational orientation.
FIGS. 15A and 15B are, respectively, a simplified pictorial illustration and a plan sectional illustration of the implant component of FIG. 2 in a second operational orientation after completion of an injection of viscoelastic material, FIG. 15B being taken along line 15B-15B of FIG. 15A;
FIGS. 16A and 16B are, respectively, a simplified cross-sectional view and a plan cross-sectional view of the implant component of FIG. 2 in a second operational orientation thereof, as shown in FIGS. 15A and 15B, with FIGS. 16A and 16B being taken partially along line 15B-15B of FIG. 15A after injection of the viscoelastic material and detachment of a viscoelastic material syringe is completed;
FIGS. 17A and 17B are simplified cross-sectional and plan cross-sectional views of the implant component of FIG. 2 in a second operational orientation thereof, as shown in FIGS. 15A-16B, with FIGS. 17A and 17B taken along line 15B-15B in FIG. 15A after coupling of an implant syringe;
fig. 18A and 18B are simplified cross-sectional and plan sectional views of the implant component of fig. 2 in a third operational orientation, fig. 18A and 18B being taken along the same plane as described in fig. 15A-17B;
FIGS. 19A and 19B are simplified cross-sectional and plan sectional views of the implant component of FIG. 2 in a fourth operational orientation, with FIG. 19B being taken along line 19B-19B of FIG. 19A after a safety catch has been removed from the implant component; and
Fig. 20 is a simplified pictorial illustration, partially enlarged sectional illustration of a portion of the intraocular lens implant insertion component in a fifth operational orientation ready for implantation of an intraocular lens.
Detailed Description
Referring now to fig. 1, fig. 1 is a simplified illustration of an apparatus for implanting a plurality of artificial crystals 100, constructed and operative in accordance with a preferred embodiment of the present invention.
As shown in fig. 1, the apparatus for implanting an intraocular lens 100 preferably comprises: an implant member 110, the implant member 110 partially surrounding an intraocular lens implant insertion member 120, a viscoelastic filling syringe 130 and an implant syringe 140. The implant member 110 is described in detail below with reference to fig. 2-8B. The implant insertion component 120 is described in detail below with reference to fig. 9A-12. An example of a commercially available viscoelastic material filled syringe 130 is available from Johnson & Johnson5。
Referring now to fig. 2, fig. 2 is a simplified exploded view of an implant component 110, the implant component 110 forming part of the device of fig. 1. As shown in FIG. 2, implant component 110 is generally disposed along a longitudinal axis 148 and preferably includes: a manually couplable axial displacer 150, a tip of the manually couplable axial displacer 150 is surrounded by a displacer assembly 151, preferably formed of silicone. Manually coupleable axial displacer 150 is fixedly coupled to an inner cylinder assembly 152.
Conversely, the inner cylinder assembly 152 is within a main housing assembly 154, the main housing assembly 154 having a removable safety catch 155 associated with the inner cylinder assembly 152. 1. Also located within the main housing assembly 154 is a coil spring 156 and an axial displacement guide assembly 158. Seated at a distal end of the main housing assembly 154 is a sleeve member 159, the sleeve member 159 having a rearwardly facing surface 160. Located forward of axial displacement guide assembly 158 is an intraocular lens 161 and an azimuthal precision mounting assembly 162 for the intraocular lens 161, the azimuthal precision mounting assembly 162 preferably being formed of silicone.
Initially, the intraocular lens 161 is preferably mounted on an azimuthally precise mounting assembly 162 and is located within an intraocular lens implant insertion assembly housing assembly 164, said intraocular lens implant insertion assembly 164 axially removably surrounding the intraocular lens implant insertion component 120. The intraocular lens implant insertion component 120 is initialized and removably mounted on the intraocular lens implant insertion assembly housing component 164. Referring to fig. 9A-12, as described in more detail below, the intraocular lens implant insertion component 120 includes: a housing assembly 170, a dual function elongated hollow tube in the form of a hollow pushrod 172, is slidably and sealingly disposed within the housing assembly 170 by means of an O-ring 174, a push assembly 176 secured to the pushrod 172 and a rearward end of a flexible sleeve 178, the flexible sleeve 178 having a forward portion, fitting over a rearward portion of the housing assembly 170.
The housing assembly 170 and flexible sleeve 178 define an axially elongated hollow tube defining an artificial crystal injection pathway extending along the longitudinal axis 148.
Referring now to fig. 3A and 3B, fig. 3A and 3B are simplified pictorial and sectional illustrations, respectively, of a manually couplable axial displacer 150 forming part of the implant component 110 of fig. 2, fig. 3B being taken along line 3B-3B of fig. 3A. As shown in fig. 3A and 3B, the manually coupleable axial displacer 150 is preferably an axisymmetric integral assembly and includes: a forward generally cylindrical pin portion 202 terminates rearwardly at a tapered portion 204, followed by a forward intermediate cylindrical portion 206, the forward intermediate cylindrical portion 206 having a radius greater than the radius of the forward generally cylindrical pin portion 202. The forward middle cylindrical portion 206 terminates rearwardly at a tapered portion 208, followed by a rearward middle cylindrical portion 210, the rearward middle cylindrical portion 210 having a larger radius than the forward middle cylindrical portion 206. The forward intermediate cylindrical portion 210 terminates in a forward facing annular surface 212 of a rearward knob portion 214.
Referring now to fig. 4A and 4B, fig. 4A and 4B are simplified pictorial and sectional illustrations, respectively, of an inner cylindrical member 152 forming a portion of the implant component 110 of fig. 2, and fig. 4B is taken along line 4B-4B of fig. 4A.
As shown in fig. 4A and 4B, the inner cylindrical member 152 is preferably an axisymmetric integral member and includes: a rearward generally cylindrical surface portion 222, the rearward generally cylindrical surface portion 222 terminating in a rearward facing annular surface 224. The rearwardly facing annular surface 224 extends radially outwardly to a rearwardly intermediate generally cylindrical surface portion 226, the rearwardly intermediate generally cylindrical surface portion 226 having a larger radius than the rearwardly intermediate generally cylindrical surface portion 222. The rearward intermediate generally cylindrical surface portion 226 extends forwardly to a forwardly facing annular surface 228, the forwardly facing annular surface 228 extending radially inwardly to a forward intermediate generally cylindrical surface portion 230, the forward intermediate generally cylindrical surface portion 230 having a generally same radius as the rearward generally cylindrical surface portion 222. The forward intermediate generally cylindrical surface portion 230 extends forward to a forward and inward sloping surface 232, the sloping surface 232 terminating forward at a forward generally cylindrical surface portion 234, the forward generally cylindrical surface portion 234 terminating at a forward annular surface 236.
The forward generally cylindrical surface portion 234 preferably forms four axial slots 240 having the same azimuthal distribution, the axial slots 240 extending through the forward generally cylindrical surface portion 234.
The inner cylindrical member 152 preferably defines a bore 242 having the same radius, the bore 242 extending from an open trailing edge 244 of the rearward generally cylindrical surface portion 222 to a rearward facing annular surface 246 adjacent a forward end of the forward generally cylindrical surface portion 234. The rearwardly facing annular surface 246 extends inwardly to a forwardly and outwardly sloping circular surface 248, which circular surface 248 terminates at the forward annular surface 236.
Referring now to fig. 5A, 5B, 5C and 5D, fig. 5A, 5B, 5C and 5D are simplified, posteriorly and anteriorly facing illustrations, posteriorly facing planes and cross-sectional views, respectively, of an axial displacer guide assembly 158 forming part of the implant component of fig. 2; fig. 5D is taken along line 5D-5D in fig. 5A.
As shown in fig. 5A-5D, the axial displacer guide assembly 158 is preferably an axisymmetric integral assembly having a uniform axial bore 250 and including: a rearwardly facing annular surface 260, the rearwardly facing annular surface 260 extending outwardly to a rearwardly generally forwardly and outwardly tapered circumferential surface 262. The rearwardly generally forwardly and outwardly tapered circumferential surface 262 terminates forwardly in a forwardly facing annular surface 264, the forwardly facing annular surface 264 extending radially inwardly and terminating at a rearwardly intermediate cylindrical surface 270
The rearward intermediate cylindrical surface 270 terminates in a rearward facing annular surface 272, which rearward facing annular surface 272 extends radially outwardly and terminates in an intermediate cylindrical surface 274. The intermediate cylindrical surface 274 terminates in a circumferentially stepped forward facing annular surface 276 extending radially inwardly and terminating at a forwardly and inwardly tapered surface 278. The tapered surface 278 extends radially inward and terminates at a forward cylindrical surface 280. The forward cylindrical surface 280 terminates in a forward facing annular surface 282.
The intermediate cylindrical surface 274 preferably forms a recess 284 having three identical azimuthal spacings. Each groove has an arcuate outer surface comprising: a rearward portion 286 of a first depth, an intermediate portion 288 of a second depth less than the first depth, and a forward portion 290 of a third depth greater than the first depth.
Referring now to fig. 6A, 6B, 6C and 6D, fig. 6A, 6B, 6C and 6D are simplified exploded and assembled rearward-facing illustrations, rearward-facing plan and partial cross-sectional views, respectively, showing a plurality of crystals 161 and azimuthally precise mounting assemblies 162 forming a portion of the implant component of fig. 2, fig. 6D being taken along line 6D-6D in fig. 6A.
As shown in FIG. 6A, the number of intraocular lenses 161 may be any suitable intraocular lens, and is preferably an intraocular lens PR00035-00 commercially available from vision care technologies, inc.
As shown in fig. 6A-6D, azimuthally accurate mounting assembly 162 is preferably an axisymmetric integral assembly and includes: a rearwardly facing annular surface 300, the rearwardly facing annular surface 300 surrounding a rearwardly facing central recess 302 and forming three evenly azimuthally spaced cutouts 304. The central recess 302 forms a rearwardly facing annular surface 306, the annular surface 306 surrounding an axial bore 308.
The azimuthally precise mounting assembly 162 defines a radially outwardly facing cylindrical surface 310, the radially outwardly facing cylindrical surface 310 terminating in a forwardly facing annular surface 312, the forwardly facing annular surface 314 extending inwardly to a rearwardly and inwardly tapered surface 314. Three uniformly azimuthally-spaced grooves 316 are formed in surfaces 310, 312 and 314, each groove 316 being defined by a pair of mutually parallel side surfaces 318, and a rearwardly and outwardly tapered planar surface 320 extending rearwardly to cylindrical surface 310. Each tapered planar surface 320 extends radially outwardly and rearwardly from a generally forward facing surface 322.
A central axial bore 324, the central axial bore 324 being narrower than the bore 308, extending rearwardly from the forwardly facing surface 322 to a rearwardly facing surface 326, parallel to the surface 322, the surface 322 defining a forward termination of the axial bore 308 and a junction of the bores 308 and 324.
As shown in fig. 6A and 6B, the intraocular lens 161 is preferably seated in an azimuthally precise mounting assembly 162, wherein a rearward portion 328 of the intraocular lens 161 is securely seated in the bore 324, and a plurality of support feet 330 of the intraocular lens 161 are positioned in the bore 324 but not seated in corresponding grooves 316.
Referring now to fig. 7A, 7B, and 7C, fig. 7A, 7B, and 7C are simplified pictorial and sectional illustrations, respectively, of a posteriorly and anteriorly facing version of an intraocular lens implant insertion assembly housing component 164 forming a portion of the implant component of fig. 2, and fig. 7C is taken along line 7C-7C of fig. 7A.
As shown in fig. 7A-7C, the intraocular lens implant insertion assembly housing component 164 is preferably an axially side-to-side symmetrical unitary component and includes: a rearwardly facing annular surface 350 extending radially outwardly to a hollow rearwardly cylindrical portion 352, wherein three uniformly azimuthally distributed axial slits 354 are formed, the cylindrical portion 352 terminating forwardly at a forwardly facing annular surface 355, the forwardly facing annular surface 355 extending radially inwardly to a forwardly and inwardly tapered surface 356, the forwardly and inwardly tapered surface 356 in turn terminating forwardly in a central cylindrical portion 358, the central cylindrical portion 358 defining a radially outwardly directed cylindrical surface 360 forming a pair of axial slots 361.
The cylindrical surface 360 terminates forwardly at a rearwardly directed annular surface 362, the rearwardly directed annular surface 362 extending radially outwardly to an outwardly directed cylindrical surface 362, the outwardly directed cylindrical surface 362 extending radially outwardly to an outwardly directed cylindrical surface 363 of a forwardly directed cylindrical portion 364, the forwardly directed cylindrical portion 364 having a forwardly facing planar surface 366. The front facing planar surface 366 defines a key hole type opening 372 comprising: a generally circular central portion 372 and a pair of generally rectangular side portions 374.
Extending rearwardly from the forward facing planar surface 366 at the generally circular central portion 372 is an axial bore 380 that includes: a first portion 382, the first portion 382 extending rearwardly from the shoulder 384 to a cylindrical portion 387, the cylindrical portion 387 being located in the hollow rearward cylindrical portion 352, a smooth rounded edge 388 being formed at a rearward end of the hollow rearward cylindrical portion 352. An angled inner shoulder 389 is formed forward of the edge 388.
Extending rearwardly from the forward facing planar surface 366 at the generally rectangular side 374 are a pair of generally planar rectangular recesses 390, each recess 390 being laterally displaced by a through-going aperture 392.
Referring now to fig. 8A and 8B, fig. 8A and 8B are simplified pictorial and sectional illustrations, respectively, of a main housing assembly 154 forming a portion of the implant component of fig. 2, and fig. 8B is taken along line 8A-8B of fig. 8A. As shown in fig. 8A and 8B, the main housing assembly 154 is preferably an axially side-to-side symmetrical unitary assembly and includes: a rearwardly facing annular surface 400, the rearwardly facing annular surface 400 extending radially outwardly to a cylindrical surface 402, wherein a pair of cutouts 404 are formed. The cylindrical surface 402 terminates forwardly at a forwardly and inwardly tapered surface 406, the forwardly and inwardly tapered surface 406 extending to an annular forwardly facing surface 408. A portion of circumferential groove 410 is located rearward of tapered surface 406. The main housing assembly 154 defines an axial bore 412, the axial bore 412 being interrupted by an inner radially inwardly extending ring 414, the inner radially inwardly extending ring 414 defining a forward facing annular surface 416 and a rearward facing annular surface 418.
Referring now to fig. 9A-9C, fig. 9A-9C are a simplified illustration, a plan cross-sectional illustration, and an exploded illustration, respectively, of an intraocular lens implant insertion component 120 forming part of the device of fig. 1; FIGS. 10A and 10B are simplified and cross-sectional views, respectively, of the intraocular lens implant insertion component 120 depicted in FIGS. 9A-9C; fig. 11 is a simplified pictorial illustration and cross-sectional illustration of another portion of the intraocular lens implant insertion component 120 depicted in fig. 9A-9C; and FIG. 12 is a simplified plan side view of another portion of the intraocular lens implant insertion component 120 depicted in FIGS. 9A-9C.
As above, in the description of fig. 2, the intraocular lens implant insertion component 120 includes: a relatively solid housing assembly 170, a hollow pushrod, slidably and sealably disposed within the housing assembly 170 by an O-ring 174, a pushing assembly 176 secured to a rearward end of the pushrod 172 and a relatively flexible sleeve 178, wherein a forward portion of the flexible sleeve 178 fits over a preferably ribbed rearward portion of the housing assembly 170.
As shown in fig. 9A-12, the housing assembly 170 is preferably an axially side-to-side symmetrical integral assembly and includes: a rearwardly facing annular surface 500, the rearwardly facing annular surface 500 extending radially outwardly to a cylindrical surface 502, including a ribbed rearward portion 504 and a generally smooth forward portion 506. Extending outwardly from the generally smooth forward portion 506 are a pair of generally flat wing portions 508, a surface 510 preferably having a formal name visible to a user, such as: "UP". The front portion 506 terminates at its front end in a conventional syringe connector, preferably a luer lock connector 512, adapted to be coupled thereto by a syringe having a conventional luer connector, such as: syringes 130 and 140 (fig. 1). Wings 508 are important to enable an implanter to easily and accurately secure the plurality of support feet 330 of the intraocular lens 161 during implantation.
The housing assembly 170 defines a slightly tapered bore 520 at its forward end, the slightly tapered bore 520 narrowing at a taper 522 toward a cylindrical bore 524, the cylindrical bore 524 terminating at a relatively narrow cylindrical bore 525.
The hollow pushrod 172 forms a fluid inlet end in the form of a tapered opening 526, the tapered opening 526 communicating with a cylindrical bore 528 therethrough. The hollow pushrod 172 is initially seated entirely within the cylindrical bore 524 and sealed against the cylindrical bore 524 by an O-ring 174. The hollow pushrod 172 slidingly extends through a cylindrical bore 525 and is secured to the pushrod assembly 176, the pushrod assembly 176 in turn defining a cylindrical bore 530, the cylindrical bore 530 being in communication with the bore 528 of the hollow pushrod 172.
A forward end of flexible sleeve 178 is snugly fitted over rib rearward portion 504 and flexible sleeve 178 extends rearward beyond rearward facing annular portion 500 and terminates in a tapered rearward facing edge 550. It will be appreciated that when the intraocular lens implant insertion component 164 is fully seated in its desired azimuthal orientation relative to the intraocular lens implant insertion assembly housing component 164, the mutual orientation of the plurality of wings 508 and the beveled edge 550 is as shown in fig. 9B, which causes the angular orientation of the beveled edge 550 to match the angular orientation of the tapered shoulder 389 of the intraocular lens implant insertion assembly 164.
It will be appreciated that the hollow pushrod 172 moves along the longitudinal axis 148 (fig. 2) relative to the housing assembly 170 and is operable to, when displaced rearwardly, displace the pushing assembly 176 rearwardly toward the tapered rearward facing edge 550.
Referring now to fig. 13A and 13B, fig. 13A and 13B illustrate an implanted syringe 140. It will be appreciated that any suitable implant injector may alternatively be employed, as shown in fig. 13A and 13B, and that implant injector 140 preferably comprises: a barrel portion 560, the barrel portion 560 having a narrow front opening 562 and a rear flange. A retaining portion 566 is optionally mounted to the rear flange 564 to assist in the desired proper orientation of the intraocular lens implant insertion device 120 during implantation.
Rearward of the barrel portion 560 is a movable stop assembly 568, the movable stop assembly 568 preventing unintentional axial movement of a push assembly 570 that causes manual axial movement, a push rod 572 being mounted forward of the push rod assembly 570, the push rod 572 being configured for selective axial movement through the narrow front opening 562. A notch-retaining ring clip 574 non-sealingly couples the push member 570 and the housing portion 568 to guide the push member 570 during axial movement of the push member 570 through the barrel portion 560.
Referring now to fig. 14A-14D, fig. 14A-14D illustrate the implant component of fig. 2 in a first operational orientation, which is generally an "out of box" operational orientation. As can be seen, the posterior portion 328 of the intraocular lens 161 seats in the aperture 324 (FIGS. 6A-6D) of the azimuthally precise mounting assembly 162. As shown in fig. 6B, it can also be seen that several support feet 330 of the intraocular lens 161 are located in but not seated in the recesses 316 (fig. 6A-6D) of the azimuthally accurate mounting assembly 162. In this orientation, the rearwardly facing tapered edge 550 of the flexible sleeve 178 is located adjacent the shoulder 389 of the intraocular lens implant insertion assembly housing assembly 164 and adjacent the intraocular lens 161. In this operational orientation, the rearwardly facing tapered edge 550 of the flexible sleeve 178 is located adjacent the shoulder 389 of the intraocular lens implant insertion assembly housing assembly 164 and adjacent the intraocular lens 161. In this operational orientation, the manually-couplable axial displacer 150 is maintained in a retracted orientation under the urging of the coil spring 156 such that the forward-facing annular surface 212 of the manually-couplable axial displacer 150 is spaced rearwardly from the rearward-facing surface 160 of the sleeve member 159. Flexible sleeve 178 is in fluid communication with hollow pushrod 172. The smooth rounded edge 388 is preferably not in contact coupling with the plurality of support feet 330 of the intraocular lens 161.
Referring now to fig. 15A and 15B, fig. 15A and 15B are a simplified pictorial illustration and a plan sectional view, respectively, of the implant component of fig. 2 in a second operational orientation upon completion of the connection of the viscoelastic material filled syringe 130 and injection of the viscoelastic material into the sleeve 178.
As shown in fig. 15A and 15B, the viscoelastic material filled syringe 130 connects to the luer lock connector 512 of the front 506 of the housing assembly 170. Therein, the contained viscoelastic material is transferred through the hollow pushrod 172 to the interior of the flexible sleeve 178 and into the portion of the hollow rearward cylindrical portion 352 in front of the azimuthally precise mounting assembly 162, thereby surrounding the intraocular lens 161. The smooth rounded edge 388 is preferably not in contact coupling with the several support feet of the intraocular lens 161.
Referring now to fig. 16A and 16B, as shown in fig. 15A and 15B, after completion of injection of the viscoelastic material 900 and detachment of a viscoelastic material filled syringe 130, fig. 16A and 16B are a simplified cross-sectional view and a plan cross-sectional view, respectively, of the implant component of fig. 2 in its second operational orientation.
Referring now to fig. 17A and 17B, as shown in fig. 16A and 1-6B, after coupling of an implant syringe 140, fig. 17A and 17B are a simplified cross-sectional view and a plan cross-sectional view, respectively, of the implant component of fig. 2 in its second operational orientation.
Referring now to fig. 18A and 18B, fig. 18A and 18B are simplified and plan sectional views, respectively, of the implant component of fig. 2 in a third operational orientation, with fig. 18A and 18B being taken along the same plane as in fig. 15B-17B.
18A and 18B, after engagement of the implant syringe 140, a user depresses the rearward knob portion 214 of the manually-couplable axial displacer 150, compressing the coil spring 156. Forward movement of the manually coupleable axial displacer 150 causes the displacer assembly 151 to couple to the rearward portion 328 of the intraocular lens 161 and move the intraocular lens 161 from the azimuthally precise mounting assembly 162 to the flexible sleeve portion 178. The forward movement of the intraocular lens 161 toward the flexible sleeve 178 causes the plurality of support feet 330 to couple with the smooth rounded edges 388, as shown in the enlarged view A of FIG. 18B, the coupling of the smooth rounded edges 388 gently folds the plurality of support feet back into a folded back direction.
Continued forward movement of the intraocular lens 161 past the edge 388 causes the intraocular lens 161 to pass over the shoulder 389 of the intraocular lens implant insertion assembly housing component 164 and past the edge 550 of the flexible sleeve 178 toward the pushing assembly 176 to a final loading position within the intraocular lens implant insertion component 120.
As shown in enlarged view B of FIG. 18B, forward facing annular surface 264 of axial displacement guide assembly 158 lockingly couples with rearward facing annular surface 246 of inner cylindrical assembly 152 to ensure accurate positioning of crystal 161 within flexible sleeve 178.
Referring now to fig. 19A and 19B, fig. 19A and 19B are a simplified pictorial and a plan sectional view, respectively, of the implant member of fig. 2 in a fourth operational orientation, after removal of a safety catch 155 from the implant member, and fig. 20 is a simplified pictorial and enlarged partially sectional view of a portion of the intraocular lens implant insertion member 120 in a fifth operational orientation ready for implantation of an intraocular lens.
As shown in fig. 19A and 19B, after positioning the intraocular lens 161 within the flexible sleeve 178, a user manually removes the safety catch 155 to release the implant syringe 140 from the main housing assembly 154 with the intraocular lens implant insertion component 120 attached to the implant syringe 140. As shown in fig. 20, an intraocular lens 161 and a plurality of support legs 330 are positioned within the intraocular lens implant insertion component 120 in a direction ready for implantation.
It will be appreciated by persons skilled in the art that the invention is not limited to what has been particularly shown and described hereinabove, and that the scope of the invention includes combinations and subcombinations of the various features described hereinabove and modifications thereof which would occur to persons reading the foregoing description and which do not in the prior art.
Claims (16)
1. An apparatus for implanting a plurality of artificial crystals, characterized by: the device comprises a ratio of
An axially elongated hollow tube having a first end and a second end and defining an artificial crystal injection path extending along a longitudinal axis; the axially elongated hollow tube is formed with a syringe adapter at the first end, the syringe adapter defining a movable syringe mounting location, the axially elongated hollow tube comprising: a first relatively rigid housing portion defining said syringe connector; and a relatively flexible sleeve portion mounted on said relatively rigid housing portion; and
A push assembly located within said axially elongated hollow tube between said syringe adapter and said second end;
Wherein at least one of the axially elongated hollow tube and the push assembly is formed of a plurality of conduits in communication with each other that enable viscoelastic material to pass through the syringe adapter and the push assembly to a location between the push assembly and the second end of the axially elongated hollow tube.
2. The apparatus for implanting a plurality of artificial crystals as claimed in claim 1, wherein: the apparatus also includes: a dual function elongate hollow tube secured to the push assembly, the dual function elongate hollow tube having: a fluid inlet end adjacent the syringe connector, and a fluid outlet end; the dual function elongated hollow tube defines a hollow pushrod and is movable within the axially elongated hollow tube along the longitudinal axis relative to the axially elongated hollow tube toward the second end to move the pushing assembly along the longitudinal axis toward the second end.
3. The apparatus for implanting a plurality of artificial crystals as claimed in claim 1, wherein: the flexible sleeve portion defines a beveled edge defining the second end of the axially elongated hollow tube.
4. The apparatus for implanting a plurality of artificial crystals as claimed in claim 2, wherein: the hollow pushrod is slidably and sealably disposed within the axially elongated hollow tube.
5. The apparatus for implanting a plurality of artificial crystals as set forth in claim 4, wherein: the hollow pushrod is slidably and sealably disposed within the axially elongated hollow tube by coupling with an O-ring.
6. The apparatus for implanting a plurality of artificial crystals as set forth in claim 5, wherein: the hollow pushrod forms a tapered opening in communication with a full cylindrical bore extending axially through the hollow pushrod.
7. The apparatus for implanting a plurality of artificial crystals as set forth in claim 6, wherein: the substantially cylindrical bore communicates with a conduit extending through the pushing assembly, thereby defining a portion of the plurality of conduits in communication with one another; the interconnecting conduits enable viscoelastic material to pass through the syringe adapter and the push assembly to a location at the push assembly and the second end of the axially elongated hollow tube.
8. A method of preparing an artificial crystal for injection, characterized by: the method comprises the following steps:
providing a device for implanting the artificial lens, the device comprising:
an axially elongated hollow tube having a first end and a second end and defining an artificial crystal injection path extending along a longitudinal axis;
A syringe adapter defining a movable syringe mounting location, said syringe adapter being located at a first end of said axially elongated hollow tube; and
A push assembly located within said axially elongated hollow tube between said syringe adapter and said second end;
wherein at least one of the axially elongated hollow tube and the push assembly is formed of a plurality of conduits in communication with each other that enable viscoelastic material to pass through the syringe adapter and the push assembly to a location at the second end of the push assembly and the axially elongated hollow tube, the axially elongated hollow tube comprising: a first relatively rigid housing portion defining said syringe connector; and a relatively flexible sleeve portion mounted on said relatively rigid housing portion;
Injecting a viscoelastic material through said interconnecting plurality of conduits to said location between said pushing assembly and said second end of said axially elongated hollow tube; after which
An artificial crystal is inserted through the second end of the axially elongated hollow tube into the viscoelastic material at the location between the pushing assembly and the second end of the axially elongated hollow tube.
9. A method of preparing an artificial crystal for injection according to claim 8, wherein: the injection is performed at the first end through the syringe adapter.
10. A method of preparing an artificial crystal for injection according to claim 8, wherein: the axially elongated hollow tube is mounted on an implant component prior to and during the injecting of the viscoelastic material.
11. A method of preparing an artificial crystal for injection according to claim 10, wherein: the axially elongated hollow tube is mounted on an implant component prior to and during insertion of the intraocular lens into the viscoelastic material.
12. A method of preparing an artificial crystal for injection according to claim 10, wherein: in a first operation stage, a plurality of supporting feet of an artificial crystal to be injected are positioned in a plurality of grooves; the plurality of grooves are formed in an azimuthally precise mounting assembly that forms a portion of the implant member, and a rearward portion of the intraocular lens seats within a hole formed in the azimuthally precise mounting assembly.
13. A method of preparing an artificial crystal for injection according to claim 12, wherein:
the flexible sleeve portion defining a beveled edge defining the second end of the axially elongated hollow tube; and
In the first stage of operation, the beveled edge is proximate the intraocular lens.
14. A method of preparing an artificial crystal for injection according to claim 13, wherein: in a second stage of operation, viscoelastic material is transferred to the interior of the flexible sleeve portion.
15. A method of preparing an artificial crystal for injection according to claim 13, wherein: in a third stage of operation, the intraocular lens is moved axially into the flexible sleeve and the plurality of support feet are positioned in a folded-back direction while maintaining precise predetermined azimuthal positioning relative to the longitudinal axis.
16. A method of preparing an artificial crystal for injection according to claim 13, wherein: in a further stage of operation, the axially elongated hollow tube is released from the implant component and connected to an implant syringe.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US15/963,309 US10925722B2 (en) | 2018-04-26 | 2018-04-26 | Apparatus for use in implanting intraocular lenses and method of preparing apparatus for use |
| US15/963,309 | 2018-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110403733A CN110403733A (en) | 2019-11-05 |
| CN110403733B true CN110403733B (en) | 2024-05-14 |
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| CN201811167935.3A Active CN110403733B (en) | 2018-04-26 | 2018-10-08 | Device for implanting an intraocular lens and method for preparing a device for implanting an intraocular lens |
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| JP2015510825A (en) * | 2012-03-21 | 2015-04-13 | パワーヴィジョン・インコーポレーテッド | Intraocular lens delivery system and method of use |
| DE102014221373A1 (en) * | 2014-10-21 | 2016-04-21 | Implandata Ophthalmic Products Gmbh | Combined eye implant |
Also Published As
| Publication number | Publication date |
|---|---|
| US11957571B2 (en) | 2024-04-16 |
| ES2943909T3 (en) | 2023-06-16 |
| CN110403733A (en) | 2019-11-05 |
| CA3041263A1 (en) | 2019-10-26 |
| US10925722B2 (en) | 2021-02-23 |
| US20190328510A1 (en) | 2019-10-31 |
| EP3560457B1 (en) | 2023-03-08 |
| JP7449044B2 (en) | 2024-03-13 |
| EP3560457A1 (en) | 2019-10-30 |
| JP2019213846A (en) | 2019-12-19 |
| US20210236271A1 (en) | 2021-08-05 |
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