CN110721189A - Skin disinfectant - Google Patents
Skin disinfectant Download PDFInfo
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- CN110721189A CN110721189A CN201911137271.0A CN201911137271A CN110721189A CN 110721189 A CN110721189 A CN 110721189A CN 201911137271 A CN201911137271 A CN 201911137271A CN 110721189 A CN110721189 A CN 110721189A
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- Prior art keywords
- disinfectant
- benzalkonium chloride
- skin
- water
- menthol
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- Pending
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 53
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960004335 azelastine hydrochloride Drugs 0.000 claims abstract description 20
- YEJAJYAHJQIWNU-UHFFFAOYSA-N azelastine hydrochloride Chemical compound Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 YEJAJYAHJQIWNU-UHFFFAOYSA-N 0.000 claims abstract description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 19
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 18
- 229940041616 menthol Drugs 0.000 claims abstract description 18
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract 4
- 238000003756 stirring Methods 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 6
- 239000012982 microporous membrane Substances 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000013589 supplement Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 14
- 230000001954 sterilising effect Effects 0.000 abstract description 11
- 201000004624 Dermatitis Diseases 0.000 abstract description 9
- 208000003251 Pruritus Diseases 0.000 abstract description 9
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 208000006877 Insect Bites and Stings Diseases 0.000 abstract description 3
- 208000002193 Pain Diseases 0.000 abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 230000007803 itching Effects 0.000 abstract description 3
- 241000256059 Culex pipiens Species 0.000 abstract description 2
- 238000004140 cleaning Methods 0.000 abstract description 2
- 230000007794 irritation Effects 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 30
- 239000000243 solution Substances 0.000 description 21
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 17
- 238000005303 weighing Methods 0.000 description 11
- -1 quaternary ammonium salt compound Chemical class 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 9
- 238000011049 filling Methods 0.000 description 9
- 239000007921 spray Substances 0.000 description 9
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- 239000010935 stainless steel Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 5
- 206010013786 Dry skin Diseases 0.000 description 4
- 230000037336 dry skin Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 239000004570 mortar (masonry) Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 206010003399 Arthropod bite Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 206010034754 petechiae Diseases 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000255925 Diptera Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a skin disinfectant, which is characterized in that: the disinfectant comprises the following components in percentage by mass: 0.05-0.14% of benzalkonium chloride, 0.05-0.1% of azelastine hydrochloride, 0.04-0.06% of menthol and the balance of water, and can be widely used for sterilization, wound cleaning, skin allergy, dermatitis and pain and pruritus caused by common mosquito and insect bites. After being sprayed, the disinfectant can be quickly absorbed, sterilized and disinfected, and can quickly diminish inflammation and relieve itching without causing bad irritation.
Description
Technical Field
The invention relates to a skin disinfectant, in particular to a skin disinfectant with the functions of diminishing inflammation, sterilizing and the like.
Background
Skin(s)The total weight accounts for 5-15% of the body weight, and the total area is 1.5-2 m2The skin covers the whole body and protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microbial attacks. In daily life, skin is often easily damaged (such as abrasion, scald, mosquito bite, allergy caused inflammation and the like), and the wound surface needs to be cleaned and disinfected in time in the process.
At present, most of the disinfectant sprays sold in the market are single components, such as 75% ethanol, 0.12% -0.14% benzalkonium chloride, hydrogen peroxide, methyl violet, iodophor disinfectant and the like, and are mainly used for skin spray disinfection.
In addition, the prior art indicates that the novel disinfectant is formed by mixing the quaternary ammonium salt compound and the alcohol disinfectant, so that the aim of quickly disinfecting the alcohol disinfectant is kept, and the aim of persistently inhibiting bacteria of the quaternary ammonium salt compound disinfectant can be fulfilled. However, the alcohol disinfectant still exists in the disinfectant, although the content of the alcohol disinfectant is in the range specified in GB26373-2010 ethanol disinfectant sanitary Standard, the problems of dry skin, pruritus and the like caused by rapid dehydration of the alcohol disinfectant on the skin after use cannot be avoided, so that the application range of the mixed disinfectant of the quaternary ammonium salt compound and the alcohol disinfectant is limited.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: provides a skin disinfectant, which solves the problems of dry skin, pruritus and the like caused by disinfectant liquid to skin in the prior art.
The technical scheme of the invention is as follows: the skin disinfectant comprises the following components in percentage by mass: 0.05-0.14% of benzalkonium chloride, 0.05-0.1% of azelastine hydrochloride, 0.04-0.06% of menthol and the balance of water.
The disinfectant comprises the following components in percentage by mass: 0.08-0.12% of benzalkonium chloride, 0.08-0.1% of azelastine hydrochloride, 0.04% of menthol and the balance of water.
A skin disinfectant is prepared by preparing 0.1-0.4% water solution of azelastine hydrochloride, preparing 0.1-0.4% benzalkonium chloride solution, mixing the two solutions, adding prepared Mentholum solution, mixing, adding purified water to the prescription amount, stirring, and filtering with 0.45 μm microporous membrane.
The invention has the beneficial effects that:
(1) the invention removes the advantage that ethanol which is a single or partial component in the prior art can be quickly disinfected, but the problems of dry skin, pruritus and the like caused by the alcohol disinfectant serving as the main component of the skin disinfectant are not quite different, the disinfectant is prepared by mixing benzalkonium chloride, azelastine hydrochloride, menthol and water, the alcohol disinfectant is not used, the problems caused by the alcohol disinfectant are solved, meanwhile, the azelastine hydrochloride and the menthol are not conventional replacements of the alcohol disinfectant in the prior art, the menthol has the effects of promoting drug absorption, cooling and relieving itching, and the azelastine hydrochloride is a third-generation antihistamine medicine and is mainly used for anti-allergic reaction and has an anti-inflammatory effect. Has good effect on skin allergy and dermatitis caused by daily mosquito and insect bites (such as pimple, wheal, edematous erythema, blister, herpes simplex, petechia petechiae and the like at the bite part, accompanied with skin pruritus and stabbing pain of different degrees).
In combination with the above, the compound benzalkonium chloride disinfectant spray can be widely used for sterilization, disinfection, wound cleaning treatment, skin allergy, dermatitis, pain, pruritus and other symptoms caused by common mosquito and insect bites. After being sprayed, the disinfectant can be quickly absorbed, sterilized and disinfected, and can quickly diminish inflammation and relieve itching without causing bad irritation.
Detailed Description
Example 1
(1) Preparing benzalkonium chloride water solution
Precisely weighing 1.2g of benzalkonium chloride, placing the benzalkonium chloride in a stainless steel barrel, adding a small amount of water, stirring and dissolving to prepare 0.1-0.4 mass percent aqueous solution for later use.
(2) Preparing aqueous solution of azelastine hydrochloride
Accurately weighing 0.8g of azelastine hydrochloride, placing in a stainless steel barrel, adding a small amount of water, stirring to dissolve (heating to 50 deg.C, stirring to dissolve), and making into 0.1-0.4% water solution.
(3) Dissolving menthol
Accurately weighing 0.4g of menthol, grinding with a mortar, and dissolving with a small amount of ethanol for later use;
(4) preparation of compound benzalkonium chloride disinfectant spray
Adding the azelastine hydrochloride solution into the prepared benzalkonium chloride aqueous solution, and stirring while adding to fully dissolve. Then slowly adding the menthol solution into the mixed solution while stirring. Weighing, and adding purified water to make up to the prescription amount. The stirring was continued for 10 minutes and the mixture was filtered through a 0.45 μm microporous membrane.
(5) Filling
Filling the compound benzalkonium chloride disinfectant spray solution into a plastic bottle, wherein the filling amount is carried out according to the product specification, screwing a quantitative valve, and covering a dustproof cap.
Example 2
(1) Preparing benzalkonium chloride water solution
Precisely weighing 1.3g of benzalkonium chloride, placing the benzalkonium chloride in a stainless steel barrel, adding a small amount of water, stirring and dissolving to prepare 0.1-0.4 mass percent aqueous solution for later use.
(2) Preparing aqueous solution of azelastine hydrochloride
Precisely weighing 1g of azelastine hydrochloride, placing in a stainless steel barrel, adding a small amount of water, stirring to dissolve (heating to 50 deg.C, stirring to dissolve), and preparing into 0.1-0.4% water solution.
(3) Dissolving menthol
Accurately weighing 0.4g of menthol, grinding with a mortar, and dissolving with a small amount of ethanol for later use;
(4) preparation of compound benzalkonium chloride disinfectant spray
The azelastine hydrochloride solution is added into the prepared benzalkonium chloride aqueous solution, and stirring is carried out while adding so as to fully dissolve the mixture. Then slowly adding the menthol solution into the mixed solution while stirring. Weighing, and adding purified water to make up to the prescription amount. The stirring was continued for 10 minutes and the mixture was filtered through a 0.45 μm microporous membrane.
(5) Filling
Filling the compound benzalkonium chloride disinfectant spray solution into a plastic bottle, wherein the filling amount is carried out according to the product specification, screwing a quantitative valve, and covering a dustproof cap.
Example 3
(1) Preparing benzalkonium chloride water solution
0.8g of benzalkonium chloride is precisely weighed, placed in a stainless steel barrel, and a small amount of water is added to be stirred and dissolved to prepare 0.1-0.4 percent aqueous solution for later use.
(2) Preparing aqueous solution of azelastine hydrochloride
Precisely weighing 1g of azelastine hydrochloride, placing in a stainless steel barrel, adding a small amount of water, stirring to dissolve (heating to 50 deg.C, stirring to dissolve), and preparing into 0.1-0.4% water solution.
(3) Dissolving menthol
Accurately weighing 0.4g of menthol, grinding with a mortar, and dissolving with a small amount of ethanol for later use;
(4) preparation of compound benzalkonium chloride disinfectant spray
The azelastine hydrochloride solution is added into the prepared benzalkonium chloride aqueous solution, and stirring is carried out while adding so as to fully dissolve the azelastine hydrochloride solution. Then slowly adding the menthol solution into the mixed solution while stirring. Weighing, and adding purified water to make up to the prescription amount. The stirring was continued for 10 minutes and the mixture was filtered through a 0.45 μm microporous membrane.
(5) Filling
Filling the compound benzalkonium chloride disinfectant spray solution into a plastic bottle, wherein the filling amount is carried out according to the product specification, screwing a quantitative valve, and covering a dustproof cap.
Stability testing of disinfectants
The disinfectant prepared in the embodiment is stored in a constant temperature box at 37 ℃ for 90 days, and the appearance of the disinfectant is unchanged and is colorless and transparent.
TABLE 1 content variation (mass%) of active ingredients in disinfectant
The experimental result shows that the product is stored for 90 days at 37 ℃, the reduction rate of the main components is lower than 4 percent, and the product meets the standard that the effective period is 2 years.
Sterilization effect detection
The disinfectant prepared in the examples was subjected to a quantitative sterilization test using a suspension according to the requirements of the test method "technical specification for disinfection" (2002 edition), and the test results are shown in table 2.
TABLE 2 germicidal Effect
TABLE 3 product quality index
As can be seen from the table 2, the product can kill common bacteria at a rate of 100% in a short time (1min), so that the effect of rapid sterilization is achieved.
Comparison and verification of sterilization effect
The disinfectant prepared in the embodiment is compared with a single ethanol, an ethanol and quaternary ammonium salt mixed disinfectant and a quaternary ammonium salt disinfectant, and is carried out according to the requirement of an experimental method 'disinfection technical specification' (2002 edition), and indexes such as sterilization speed, efficiency, dry skin, skin allergy and the like are examined by adopting a suspension quantitative sterilization experiment.
The results are shown in Table 4.
TABLE 4 comparison of the disinfecting effects of the disinfecting solutions (Escherichia coli 8099)
Through the experimental data, the product has the effects of no stimulation and no drying to skin of the single quaternary ammonium salt disinfectant, overcomes the defects of low sterilization rate and long action time of the quaternary ammonium salt disinfectant, solves the problems of skin allergy and dryness of the ethanol, ethanol and quaternary ammonium salt mixed disinfectant, and also overcomes the defects of low sterilization rate, long action time and skin allergy of the benzalkonium chloride disinfectant.
Claims (3)
1. A skin sanitizer, characterized by: the disinfectant comprises the following components in percentage by mass: 0.05-0.14% of benzalkonium chloride, 0.05-0.1% of azelastine hydrochloride, 0.04-0.06% of menthol and the balance of water.
2. A skin sanitizer according to claim 1, wherein: the disinfectant comprises the following components in percentage by mass: 0.08-0.12% of benzalkonium chloride, 0.08-0.1% of azelastine hydrochloride, 0.04% of menthol and the balance of water.
3. A method of preparing a skin sanitizer according to claim 1 wherein: preparing 0.1-0.4% by mass of water solution of azelastine hydrochloride, preparing 0.1-0.4% by mass of benzalkonium chloride solution, mixing the two solutions, adding prepared menthol solution, mixing, adding purified water to supplement the amount of the prescription, stirring circularly, and filtering with 0.45 μm microporous membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911137271.0A CN110721189A (en) | 2019-11-19 | 2019-11-19 | Skin disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911137271.0A CN110721189A (en) | 2019-11-19 | 2019-11-19 | Skin disinfectant |
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| Publication Number | Publication Date |
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| CN110721189A true CN110721189A (en) | 2020-01-24 |
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| CN201911137271.0A Pending CN110721189A (en) | 2019-11-19 | 2019-11-19 | Skin disinfectant |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318047A (en) * | 2021-06-10 | 2021-08-31 | 山东省润荷卫生材料有限公司 | Mosquito-repellent wet tissue and production method thereof |
| CN114129592A (en) * | 2021-12-06 | 2022-03-04 | 郑州大学第一附属医院 | Disinfection gel for obstetrics and gynecology department and preparation method thereof |
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| CN113318047A (en) * | 2021-06-10 | 2021-08-31 | 山东省润荷卫生材料有限公司 | Mosquito-repellent wet tissue and production method thereof |
| CN114129592A (en) * | 2021-12-06 | 2022-03-04 | 郑州大学第一附属医院 | Disinfection gel for obstetrics and gynecology department and preparation method thereof |
| CN114129592B (en) * | 2021-12-06 | 2023-03-10 | 郑州大学第一附属医院 | A kind of disinfection gel for obstetrics and gynecology and its preparation method |
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