CN111134669A - Visual evoked potential acquisition method and device - Google Patents
Visual evoked potential acquisition method and device Download PDFInfo
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- CN111134669A CN111134669A CN202010267157.6A CN202010267157A CN111134669A CN 111134669 A CN111134669 A CN 111134669A CN 202010267157 A CN202010267157 A CN 202010267157A CN 111134669 A CN111134669 A CN 111134669A
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- 230000000763 evoking effect Effects 0.000 title claims abstract description 52
- 230000000007 visual effect Effects 0.000 title claims abstract description 30
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- 238000012360 testing method Methods 0.000 claims abstract description 68
- 238000012545 processing Methods 0.000 claims abstract description 31
- 230000000638 stimulation Effects 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 7
- 210000003128 head Anatomy 0.000 claims description 18
- 230000001360 synchronised effect Effects 0.000 claims description 17
- 210000001061 forehead Anatomy 0.000 claims description 9
- 230000006698 induction Effects 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 210000000103 occipital bone Anatomy 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 4
- 230000000630 rising effect Effects 0.000 claims description 3
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 210000000857 visual cortex Anatomy 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
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- 230000037361 pathway Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000037152 sensory function Effects 0.000 description 1
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- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
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Abstract
The invention discloses a method for acquiring visual evoked potentials, which comprises the following steps: when the potential acquisition device is well connected with the recording electrode, the synchronization device is assembled on the test display screen and connected with the acquisition device; according to the test requirement, a test subject wears a recording electrode, and the state of a test display screen is debugged and arranged at a proper position; the signal processing terminal sends an instruction to the acquisition device to control the test display screen to display the stimulation pattern; the acquisition device starts to record evoked potential signals when receiving the instruction, simultaneously receives square wave signals of the synchronization device, and uploads the two signals to the signal processing terminal; and keeping the process for a certain time, and calculating by adopting a superposition average method to obtain the final evoked potential after the signal processing terminal synchronously divides the two signals. The invention also provides a device for acquiring the visual evoked potential. By the scheme, the accuracy of the latency period and the amplitude of the evoked potential are improved, and the collection quality of the evoked potential is improved.
Description
Technical Field
The invention relates to the field of biomedical engineering and computer interaction, in particular to a method and a device for acquiring visual evoked potentials.
Background
Visual evoked potential (visual evoked potential) electrophysiological phenomena. In the visual field, the retina is stimulated with a flash of light or pattern of a certain intensity, and potential changes can be recorded in the visual cortex or occipital region outside the skull. Important means for studying human sensory functions, nervous system diseases, behaviors, psychological activities, and the like. Visual Evoked Potentials (VEPs) are tests that understand the functional integrity of the entire visual pathway from the retina to the visual cortex. The left and right eyes are stimulated to record evoked potentials (P100) in the visual cortex respectively through a specific checkerboard flip pattern. The levels of pathway damage in the retina, before or after the visual cross are analyzed according to the P100 latency and amplitude, and objective assessment is made on the damage degree, treatment effect and prognosis.
When the traditional evoked potential acquisition method is used for carrying out superposition averaging on potential signals, because the precision of a timer of a general computer is not high, and in a windows system, the precision is generally 1-10 ms, the precision can cause the front and back jitter of the superposition time, so that the superposition of the wave peak of each electroencephalogram evoked potential and the wave peak time cannot be carried out, namely, the peak is staggered, and the latent period is inaccurate or the amplitude value of the evoked potential is not large enough.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a method and a device for acquiring a visual evoked potential, which have high evoked potential signal acquisition accuracy and can avoid the overlapping of average peak staggering.
The purpose of the invention is realized by the following technical scheme:
a method of visual evoked potential acquisition, comprising the steps of:
and S1, connecting the potential acquisition device and the recording electrode, assembling the synchronization device on the test display screen, and connecting the synchronization device with the acquisition device through a cable.
And S2, the subject wears the recording electrode according to the test requirement, debugs the test display screen to be in a test state, and sets the test display screen at a proper position.
And S3, sending a test instruction to the acquisition device through the communication cable in the signal processing terminal, and controlling the test display screen to circularly display the stimulation pattern according to the set frequency by the acquisition device.
And S4, the acquisition device starts to record the evoked potential waveform signal of the head of the subject when receiving the test instruction, simultaneously receives the square wave signal from the synchronization device, and uploads the received evoked potential waveform signal and the received square wave signal to the signal processing terminal.
And S5, keeping the test process for a certain time, synchronizing the evoked potential waveform signal and the square wave signal received by the signal processing terminal, simultaneously dividing the synchronized waveform data, calculating the divided waveform data by adopting a superposition average method to obtain the final evoked potential, and displaying the final evoked potential on the signal processing terminal.
Specifically, the synchronizing device in step S1 is installed in a corner of the test display screen to avoid visual interference to the test process, and the synchronizing device is configured to output a level signal with varying levels according to the black and white brightness variation of the test display screen.
Specifically, the appropriate position in step S2 is; the head of the subject is in a head-up distance of 1 meter with the test display screen.
Specifically, the synchronization waveform in step S5 is divided according to the rising or falling time of the synchronization device.
Specifically, in the step S5, when performing the superposition average calculation, the superposition average calculation needs to be performed on the divided synchronization waveforms in a left-alignment manner, and redundant waveform samples are ignored.
A kind of visual evoked potential acquisition device, including signal processing terminal 12, is used for issuing the test command and processing and displaying the visual evoked potential signal; the test display screen 1 is used for circularly displaying the stimulation patterns according to the control instruction and is arranged at a test position which is proper to the testee; the acquisition device is used for receiving the visual evoked potential signals and the synchronous signals and uploading the received signals to the signal processing terminal 12; the synchronizer is used for outputting a level signal with high and low changes according to the black and white brightness changes of the test display screen 1; the recording electrode is used for acquiring and recording visual evoked potential signals of different positions of the head of the subject; the synchronous device is assembled on a test display screen 1 and connected with the acquisition device, the test display screen 1 is connected with the signal processing terminal 12, and the acquisition device is respectively connected with the recording electrode and the signal processing terminal 12.
Specifically, the collecting device comprises a collector 8, the collector 8 is provided with a collecting and recording interface 10 and a synchronous interface 9, and the collecting and recording interface 10 is connected with the recording electrode through a recording electrode bundle 5; the synchronization interface 9 is connected to the synchronization device via a synchronization cable.
Specifically, the recording electrodes comprise a forehead recording electrode 2, an occipital recording electrode 3 and an ear clip recording electrode 4, and the forehead recording electrode 2 is arranged at the forehead position of the head of the subject; the occipital bone recording electrode 3 is arranged at the occipital bone position of the head of the subject; the ear clip recording electrodes 4 are provided at the ear positions on both sides of the head of the subject.
Specifically, the synchronizing device is a synchronizing sensor 7, and the synchronizing sensor 7 includes a photosensitive sensing receiving circuit 20, a light shielding housing 21, an adhesive area 22, and a photosensitive sensing receiving tube 23.
Specifically, the adhesive area 22 is disposed on the back surface of the light shielding shell 21, the photosensitive sensing receiving tube 23 is disposed on the back surface of the light shielding shell 21, and the photosensitive sensing receiving circuit 20 is disposed on the front surface of the light shielding shell 21; the photosensitive induction receiving circuit 20 and the photosensitive induction receiving tube 23 are electrically connected.
The invention has the beneficial effects that:
1. ensuring the relative accuracy of the time between the moment of image switching and the moment of occurrence of evoked potential, and avoiding the occurrence of peak error
2. The accuracy of the latency period and the amplitude of the evoked potential are improved, and the collection quality of the evoked potential is improved.
Drawings
FIG. 1 is a flow chart of the method of the present invention.
Fig. 2 is a synchronized split waveform diagram of the present invention.
Fig. 3 is a schematic structural diagram of the device of the present invention.
Fig. 4 is a structural diagram of a synchronization device of the present invention.
Fig. 5 is an exemplary diagram of a stimulation pattern of the present invention.
In fig. 3: the method comprises the following steps of 1-testing a display screen, 2-forehead core recording electrodes, 3-occipital bone recording electrodes, 4-ear clip recording electrodes, 5 recording electrode bundles, 6-stimulation patterns, 7-synchronous sensors, 8-collectors, 9-synchronous interfaces, 10-collection recording interfaces, 11-communication cables and 12-signal processing terminals.
In fig. 4: 20-photosensitive induction receiving circuit, 21-shading shell, 22-adhesive area and 23-photosensitive induction receiving tube.
Detailed Description
In order to more clearly understand the technical features, objects, and effects of the present invention, embodiments of the present invention will now be described with reference to the accompanying drawings.
In this embodiment, as shown in fig. 1, a method for acquiring a visual evoked potential mainly includes the following steps:
firstly, the acquisition device of the visual evoked potential is connected with each recording electrode, the synchronizing device is assembled in the corner of the test display screen, and the synchronizing device can be used for outputting level signals with variable height according to the black and white brightness change of the test display screen, thereby avoiding the visual interference to the test process. Meanwhile, the synchronizing device is connected with the collecting device through a cable.
According to the test requirement, a test subject wears the recording electrode, debugs the test display screen to be in a test state, and sets the test display screen at a position which is about 1 meter away from the head of the test subject.
And sending a test instruction to an acquisition device through a communication cable in the signal processing terminal, wherein the acquisition device controls the test display screen to circularly display the stimulation patterns according to the set frequency.
And S4, the acquisition device starts to record the evoked potential waveform signal of the test display screen when receiving the test instruction, simultaneously receives the square wave signal from the synchronization device, and uploads the received evoked potential waveform signal and the received square wave signal to the signal processing terminal.
And S5, keeping the test process for a certain time, synchronizing the waveform of the evoked potential waveform signal and the square wave signal received by the signal processing terminal, dividing the synchronized waveform data into graphs as shown in figure 2, calculating the divided waveform data by a superposition average method to obtain the final evoked potential, and displaying the final evoked potential on the signal processing terminal.
Specifically, the appropriate position in step S2 is; the head of the subject is in a head-up distance of 1 meter with the test display screen.
Specifically, the synchronization waveform in step S5 is divided according to the rising or falling time of the synchronization device.
Specifically, in the step S5, when performing the superposition average calculation, the superposition average calculation needs to be performed on the divided synchronization waveforms in a left-alignment manner, and redundant waveform samples are ignored.
As shown in fig. 3, a visual evoked potential collecting device includes a signal processing terminal 12 for issuing a test command and processing and displaying a visual evoked potential signal; the test display screen 1 is used for circularly displaying the stimulation patterns according to the control instruction and is arranged at a test position which is proper to the testee; the acquisition device is used for receiving the visual evoked potential signals and the synchronous signals and uploading the received signals to the signal processing terminal; the synchronizer is used for outputting a level signal with high and low changes according to the black and white brightness changes of the test display screen 1; the recording electrode is used for acquiring and recording visual evoked potential signals of different positions of the head of the subject; the synchronous device is assembled on a test display screen 1 and connected with the acquisition device, the test display screen 1 is connected with the signal processing terminal 12, and the acquisition device is respectively connected with the recording electrode and the signal processing terminal 12.
Specifically, the collecting device comprises a collector 8, the collector is provided with a collecting and recording interface 10 and a synchronous interface 9, and the collecting and recording interface 10 is connected with the recording electrode through a recording electrode bundle 5; the synchronization interface 9 is connected to the synchronization device via a synchronization cable.
Specifically, the recording electrodes comprise a forehead recording electrode 2, an occipital recording electrode 3 and an ear clip recording electrode 4, and the forehead recording electrode 2 is arranged at the forehead position of the head of the subject; the occipital bone recording electrode 3 is arranged at the occipital bone position of the head of the subject; the ear clip recording electrodes 4 are provided at the ear positions on both sides of the head of the subject.
As shown in fig. 4, the synchronization device is a synchronization sensor 7, and the synchronization sensor 7 includes a photosensitive sensing receiving circuit 20, a light shielding housing 21, an adhesive area 22, and a photosensitive sensing receiving tube 23.
Specifically, the adhesive area 22 is disposed on the back surface of the light shielding shell 21, the photosensitive sensing receiving tube 23 is disposed on the back surface of the light shielding shell 21, and the photosensitive sensing receiving circuit 20 is disposed on the front surface of the light shielding shell 21; the photosensitive induction receiving circuit 20 and the photosensitive induction receiving tube 23 are electrically connected.
As shown in fig. 5, the stimulation patterns include a stimulation pattern a and a stimulation pattern B, both of which are black and white square stimulation patterns, and the two stimulation patterns are cyclically turned and displayed according to a set frequency through a test display screen when a test is started, so as to stimulate the subject to generate potential variation.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A visual evoked potential acquisition method is characterized by comprising the following steps:
s1, connecting the potential acquisition device with the recording electrode, assembling the synchronization device on the test display screen, and connecting the synchronization device with the acquisition device through a cable;
s2, the subject wears the recording electrode according to the test requirement, debugs the test display screen to the test state, and sets the test display screen at a proper position;
s3, sending a test instruction to an acquisition device through a communication cable in the signal processing terminal, and controlling the test display screen to circularly display the stimulation pattern according to a set frequency by the acquisition device;
s4, the acquisition device starts to record evoked potential waveform signals of the head of the subject when receiving the test instruction, simultaneously receives square wave signals from the synchronization device, and uploads the received evoked potential waveform signals and the received square wave signals to the signal processing terminal;
and S5, keeping the test process for a certain time, synchronizing the evoked potential waveform signal and the square wave signal received by the signal processing terminal, simultaneously dividing the synchronized waveform data, calculating the divided waveform data by adopting a superposition average method to obtain the final evoked potential, and displaying the final evoked potential on the signal processing terminal.
2. The method according to claim 1, wherein the synchronizing device in step S1 is installed in the corner of the test display screen to avoid visual interference to the test process, and the synchronizing device is used to output a level signal with varying levels according to the black and white brightness variation of the test display screen.
3. The method according to claim 1, wherein the suitable positions in step S2 are; the head of the subject is in a head-up distance of 1 meter with the test display screen.
4. The method according to claim 1, wherein the synchronization waveform of step S5 is divided according to the rising or falling time of the synchronization device.
5. The method as claimed in claim 1, wherein in step S5, when performing the superposition average calculation, the segmented synchronous waveforms are required to be subjected to the superposition average calculation in a left-aligned manner, and redundant waveform samples are ignored.
6. A visual evoked potential acquisition device is characterized by comprising
The signal processing terminal is used for issuing a test instruction and processing and displaying the visual evoked potential signal;
the test display screen is used for circularly displaying the stimulation pattern according to the control instruction and is arranged at a test position which is proper to the testee;
the acquisition device is used for receiving the visual evoked potential signals and the synchronous signals and uploading the received signals to the signal processing terminal;
the synchronous device is used for outputting a level signal with high and low changes according to the black and white brightness changes of the test display screen;
the recording electrode is used for acquiring and recording visual evoked potential signals of different positions of the head of the subject;
the synchronous device is assembled on the test display screen and connected with the acquisition device, the test display screen is connected with the signal processing terminal, and the acquisition device is respectively connected with the recording electrode and the signal processing terminal.
7. The device according to claim 6, wherein the device comprises a collector, the collector is provided with a collection and recording interface and a synchronization interface, and the collection and recording interface is connected with the recording electrode through a recording electrode bundle; the synchronous interface is connected with the synchronous device through a synchronous cable.
8. The device according to claim 6, wherein the recording electrodes comprise forehead recording electrodes, occipital recording electrodes and ear clip recording electrodes, and the forehead recording electrodes are arranged on the forehead of the head of the subject; the occipital bone recording electrode is arranged at the occipital bone position of the head of the subject; the ear clip recording electrodes are arranged at the ear positions on the two sides of the head of the testee.
9. The device of claim 6, wherein the synchronizing device is a synchronization sensor, and the synchronization sensor comprises a photosensitive receiving circuit, a light-shielding housing, an adhesive area, and a photosensitive receiving tube.
10. The device according to claim 9, wherein said adhesive region is disposed on the back side of said light-shielding housing, said photosensitive receiver tube is disposed on the back side of said light-shielding housing, and said photosensitive receiver circuit is disposed on the front side of said light-shielding housing; the photosensitive induction receiving circuit and the photosensitive induction receiving tube are electrically connected.
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Application publication date: 20200512 |