CN111157686B

CN111157686B - Biochemical chip entering and ejecting device

Info

Publication number: CN111157686B
Application number: CN202010061627.3A
Authority: CN
Inventors: 陈宣杨; 陈子天
Original assignee: Peking University
Current assignee: Peking University
Priority date: 2020-01-20
Filing date: 2020-01-20
Publication date: 2024-08-27
Anticipated expiration: 2040-01-20
Also published as: CN111157686A

Abstract

The invention discloses a biochemical chip entering and ejecting device, which utilizes the combination of mechanical structures, and can transport the chip to a designated position and compress the chip when external force is applied, and can also eject the chip when the external force is applied. The biochemical chip entering and ejecting device mainly comprises a chip fixing table, a pressing device, a linkage device and a chip; the chip fixing table further comprises a pressing device guide groove and a linkage device guide groove, wherein the pressing device guide groove is used for limiting the movement range of the pressing device, and the linkage device guide groove is used for limiting the movement range of the linkage device; the compressing device is used for compressing the chip through movement; the linkage device is provided with a movement direction conversion structure and is used for matching with the protruding or recessed part of the pressing device, so that the linkage device drives the pressing device to move.

Description

Biochemical chip entering and ejecting device

Technical Field

The invention relates to a biochemical chip entering and ejecting device, in particular to a sequencing chip ejecting device of a gene sequencing instrument, and belongs to the field of biochemistry.

Background

The biochemical field often uses a chip as a detection device. The sealed chip, typically containing a region for detection, such as a gene sequencing chip, has an array of micro-pits or array spots on one or both of its inner surfaces, typically 1-10 microns in diameter, which can be detected under a camera. In the biochemical chip detection process, especially in industrial instruments and equipment, detection instruments are needed. The convenient access detection instrument of the biochemical chip is an important embodiment aspect of customer experience. Commonly, a biochemical chip is transported to a designated position by a motor and then detected; similarly, the biochemical chip can be transported out of the detection instrument by using a motor. During this movement, relatively precise chips, such as gene sequencing chips and the like, are also involved in the problem of precise positioning, requiring the use of a motor to transport the chip to a designated location, and then the use of another motor to compress the chip against a platform or positioning device. The motor is high in cost, and needs to occupy a large space, so that the volume of the detecting instrument is increased, and the cost is increased. The invention discloses a mechanical ejecting device of a biochemical chip, which utilizes the combination of mechanical structures, and can transport the chip to a designated position and compress the chip when external force is applied, and can also eject the chip when the external force is applied; low cost and compact structure.

Disclosure of Invention

The aim of the invention is achieved by the following technical scheme.

A mechanical biochemical chip entering and ejecting device is characterized by comprising,

A chip fixing table (1), a pressing device (2), a linkage device (3) and a chip (4);

Wherein the chip fixing table (1) comprises a flat plate structure which is suitable for the chip (4), and a concave or convex structure is arranged at the edge of a specific position of the chip in a use state, so that the position of the chip is limited;

the chip fixing table (1) further comprises a pressing device guide groove and a linkage device guide groove, wherein the pressing device guide groove is used for limiting the movement range of the pressing device (2), and the linkage device guide groove is used for limiting the movement range of the linkage device (3);

the compressing device (2) compresses the chip by movement and is provided with a guiding component A; the guide component A is arranged in the guide groove of the pressing device and used for limiting the movement range of the pressing device 2;

The linkage device (3) is provided with a guide component B; the guide component B is arranged in the guide groove of the linkage device and is used for limiting the movement range of the linkage device (3);

The linkage device 3 is provided with a movement direction conversion structure and is used for matching with a protruding or recessed part of the pressing device (2), so that the linkage device (3) drives the pressing device (2) to move;

the linkage device (3) is also provided with a push handle for human interaction with the device.

According to a preferred embodiment, the chip-holding table (1) further comprises escapement swing arm means (11); the escapement swing arm device (11) is provided with a swing arm (111) and an elastic element; an escapement arm (113); the linkage (3) is provided with a motion limiting arm (304); the escapement arm (113) limits movement of the movement limiting arm (304) in the direction of the chip into and out of the instrument.

A biochemical chip entering and ejecting device is characterized by comprising the following components,

the chip fixing table (1) includes: a movement limiting device (10), an escapement swing arm device (11);

The movement limiting device (10) is provided with a pressing device guide groove (101) and a linkage device guide groove (102);

the escapement swing arm device (11) is provided with a swing arm (111), and an elastic element (112); an escapement arm (113), the linkage (3) comprising a slider (305),

The function of the pressing device (2) is to press the chip by movement, and the pressing device is provided with sliding positioning devices (2021, 2022);

The linkage device (3) is provided with a push handle (301), a movement direction conversion groove (302) and a sliding block (305); and an elastic device for connecting the linkage device (3) and the chip fixing table;

Wherein, the chip fixing table (1) is provided with a flat plate structure which is suitable for the chip, and is provided with a concave or convex structure at the edge of a specific position in the use state of the chip, so as to limit the position of the chip;

The movable limiting device (10) is arranged on the chip fixing table (1); the device is provided with a pressing device guide groove (101) for limiting the movement range of the pressing device (2), and a linkage device guide groove (102) for limiting the movement range of the linkage device 3;

the guide part of the pressing device (2) is arranged in the guide groove (101) of the pressing device; a sliding block (305) of the linkage device (3) is arranged in the linkage device guide groove (102);

The swing arm (111) and the escapement arm (113) of the escapement swing arm device (11) are rigidly connected components; the elastic element provides a rotational trend for the escapement swing arm (11);

The pressing device (2) presses the chip through the contact position when moving close to the chip;

a push handle (301) for human contact with the device;

The movement direction conversion groove (302) is linked with the sliding positioning device of the pressing device (2) and is used for converting the movement of the linkage device (3) into the movement of the pressing device (2) for pressing the chip.

According to a preferred embodiment, the sliding positioning device of the pressing device (2) is a sliding column (202); wherein the pressing device (2) is provided with a limiting cone (201) for directly pressing the chip.

According to an optimised embodiment, the linkage (3) is provided with a movement limiting arm (304); the escapement arm (113) limits movement of the movement limiting arm (304) in the direction of the chip into and out of the instrument.

According to a preferred embodiment, the holding-down device (2) is provided with a limiting cone (201). The limit cone (201) is symmetrical left and right relative to the center of the chip.

According to a preferred embodiment, the linkage guide groove (102) is an elongated through groove and is arranged horizontally, and four linkage devices (3) are provided with sliding blocks (305) protruding downwards; the slide (305) is horizontally movable in the linkage guide slot (102).

According to a preferred embodiment, the pressing device guide groove (101) is an elongated through groove and is arranged in a vertical direction; the compressing device (2) is provided with a sliding column (202); the sliding columns (202) are divided into a front group and a rear group, and are respectively a sliding column (2021) and a sliding guide column (2022); the sliding guide post (2022) passes through the movement direction conversion groove (302) on the linkage (3) and enters the pressing device guide groove (101) on the movement limiting device (10).

According to a preferred embodiment, the escapement swing arm device (11) comprises a vertical column (114), an elastic element torsion spring (112), a swing arm (111), and an escapement arm (113); wherein the swing arm (111), the vertical column (114), the escapement arm (113) are rigidly integrated; the torsion spring (112) is arranged on the vertical column (114); the torsion spring (112) always provides anticlockwise rotation force for the escapement swing arm device (11); when the chip enters, the chip is contacted with the swing arm (111), and the swing arm drives the escapement swing arm device (11) to do clockwise rotation along with the chip, so that the escapement arm (113) can not limit the movement of the movement limiting arm (304) any more.

According to a preferred embodiment, the chip is provided with chip bayonets (401) on both sides; when the limiting cone (201) of the pressing device (2) moves downwards, the conical surface of the limiting cone (201) pushes the chip downwards and inwards through the chip bayonet (401), so that the chip moves inwards and is simultaneously abutted against the chip table (132) and the limiting column (135); the XYZ three directions of the chip are fixed.

The invention provides a chip ejecting device with a mechanical three-layer structure. The chip is completely mechanically designed, and can be manually inserted without adopting complicated or expensive electronic components, and the chip can be ejected from the machine by pushing the handle. This involves a way that fully takes into account the interaction of human-machine use.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. In the drawings:

FIG. 1 illustrates the overall structure of an access ejection device;

FIG. 2 shows the structure of the chip fixing table 1, without the escapement swing arm device;

FIG. 3 shows a structure of the chip fixing table 1, which does not comprise a chip table;

FIG. 4 shows a structure of the pressing device;

FIG. 5. Linkage structure;

FIG. 6 chip not in the entered state

FIG. 7 chip entering into the middle state

Fig. 8. Chip in, and releasing the linkage state.

Detailed Description

Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure have been described, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

Except where specifically indicated, the terminology used in the present invention is the same as the term or terms used in the art.

In the present invention, terms related to positions, such as "upper", "lower", "left", "right", "vertical", "X-direction", "Y-direction", "Z-direction", "front", "rear", "high", "low", "inner" and "outer", refer to relative positional relationships, and do not represent specific positions. Those skilled in the art will appreciate that all positional relationships will change when the orientation of the entire device is adjusted.

In the present invention, terms such as "post", "cone", "slide", "arm", "slot" and the like are to be understood as a general collection of structures that may serve a similar function. For example, the "posts" are not necessarily limited to necessarily being circular, and suitable modifications, such as square protruding structures, may be made to achieve the same function, as are common alternatives in the art; for example, the arm is not necessarily a straight-line appearance structure, and the curved extending structure can also achieve the same function, for example, a slot or a penetrating slot, according to the function, if the arm is used for matching with a certain column to form a limit function of two structures, the slot or the penetrating slot can be replaced by a concave structure and the like, and does not need to penetrate; the combination of the concave structure and the corresponding convex structure can also achieve the function of limiting. It will be appreciated that simple modifications such as the exchange of slot and post positions, such as the simple modification of the exterior structure, such as the simple modification of the cone structure, on the basis of the structure described herein are within the scope of the invention. In addition, for example, "torsion spring" or "spring" is understood to mean an elastic component or elastic means.

The chip described in the present invention includes biochemical chips, or other chips having a plate structure, including microfluidic chips, protein chips, gene sequencing chips, and the like.

The biochemical chip refers to a detection chip in the biochemical field, the general chip is flat, and a sealed reaction chamber is arranged in the middle. The chip is provided with an outlet and an inlet for fluid. The gene chip belongs to one of the biochemical chips. The gene chip is mainly used for nucleic acid sequencing. At least one inner surface of the gene chip contains a plurality of micro-pits or lattice arrays arranged in an array for detection. The gene chip is placed under an objective lens, which is connected to a CCD through an optical device, and the reaction of the array in the chip can be detected. The specific structure and preparation of the gene sequencing chip are disclosed in patent CN2017208542125, CN2017208542017, CN2017105741742, CN2017105741441, which can be referred to. The contents of the cited patent referred to in the present invention are incorporated by reference into this patent as if necessary. Biochemical chips are typically provided with one or more rigid faces or substrates; the preparation is generally performed by using glass, silicon wafers and the like, so that the precision and the flatness of the glass and the silicon wafers are ensured.

In the process of using the biochemical chip, the biochemical chip can be directly placed under a microscope and other devices in a laboratory, and the biochemical chip needs to be placed in a special instrument in industrial or civil use. When the biochemical chip is placed in the instrument for use, the operation is simple, and the chip detection is beneficial to people unfamiliar with the instrument. The biochemical chip is placed in the instrument at a specific position, and in short, the positions in three directions of XYZ are all fixed. The means of fixation is particularly important. It is known that in general metal fixation surface machining, the accuracy of multi-point or planar positioning is difficult to achieve up to 10 microns, especially in the range of a few centimeters or more. When the microscope apparatus performs photographing, for example, using a 20-fold objective lens, a deviation of typically tens of micrometers or more may cause focusing to be difficult. Therefore, when the alignment is performed in combination with the biochemical chip, fixing it in a proper position can reduce the deviation of focusing. Has great significance for photographing the biochemical chip.

The invention discloses an entering and ejecting device of a biochemical chip, which can manually press the biochemical chip into a specific position and fix the biochemical chip, and can eject the chip when the ejecting device is pressed. No complex motor mechanism is required. Simple and is not easy to make mistakes. The following description is made with reference to the accompanying drawings.

In the drawings, the names of the components involved are as follows:

Chip fixing table 1, closing device 2, linkage 3, chip 4.

The components on the chip mount 1 are as follows:

A movement limiting device 10, an escapement swing arm device 11, a chip fixing table base 12 and a base 13; screw holes 103; screw hole 131, chip stage 132, screw hole 133, limiting wall 134, limiting post 135, limiting hole 136, screw hole 137, screw hole 138, and limiting hole 139;

the structural member of the escapement swing arm device 11 includes a swing arm 111, a torsion spring 112, an escapement arm 113, a vertical column 114, and a stopper column 115;

the movement limiting device 10 includes a pressing device guide groove 101 and a linkage guide groove 102.

The components of the compression device 2 are as follows:

Limiting cone 201, elastic device 2011, sliding column 202, sliding column 2012, sliding column 2021 and sliding guide column 2022.

The components of the linkage 3 are as follows:

Push handle 301, movement direction conversion groove 302, screw hole 303, movement limiting arm 304, slider 305, spring 306.

The components of the biochemical chip 4 are as follows:

Chip bayonet 401.

In particular, the structure of the invention is relatively complex, so that the figures take the form of a combination of explosive display and partial display, and do not show all the possibilities. It will be understood by those skilled in the art that the scope of the invention is not limited thereto, and any changes or substitutions that would be easily recognized by those skilled in the art within the scope of the present invention are intended to be covered by the scope of the invention

See fig. 1 for the device as a whole.

The structure of the chip mount 1 is shown in fig. 2 and 3:

The chip mount 1 includes a movement limiting device 10 (fig. 2), an escapement arm device 11 (fig. 3), and a chip mount base 12 (or a base 13).

Depending on the particular application, the chip station may consist of a separate movement limiting device 10, escapement swing arm device 11, chip mount base 12 (or base 13); the escapement swing arm device 11, the chip fixing table base 12 (or the base 13) and the chip table 1 can be directly formed into an integral structure. The movement limiting device 10 is required to be independently present and fixed on the chip stage 1.

The chip fixing table 1 is relatively motionless, which limits the up-and-down movement of the pressing device 2 (structure see fig. 4) and limits the forward-and-backward movement of the linkage device 3 (structure see fig. 5).

Here, in order to better explain the principle of the mechanical movement, it is defined that the pressing device 2 moves only up and down, and that the linkage 3 moves only back and forth. According to the preferred embodiment, the pressing device 2 can also move left and right to a certain extent, even move in an arc shape, and only the function of pressing the chip is required to be ensured. The linkage device 3 can move up and down to a certain extent, even move in an arc shape, and only needs to ensure that the pressing device is driven to move in a corresponding way.

The die attach table 1 includes a die table 132 (132 is a part of the susceptor 13). 132 have a flat surface for holding the chip and a lower surface (Z direction) for limiting the working position of the chip. The chip mount 1 includes a stopper post 135 for restricting the X direction of the chip. The chip mount 1 further includes a stopper wall 134 for restricting the Y-direction position of the chip.

The die pad 132 has five screw holes 138. Correspondingly, the chip fixing table 1 is provided with five screw holes 137. The die pad 132 is fixed to five screw holes 137 of the die pad 1 through five screw holes 138.

The die pad 132 and the base 12 form the base 13 of the die pad base 1 by screws 137 and 138.

May be substituted. The die table 132 is integral with the base 12. This eliminates the need for screw holes 137 and the fixing of screw holes 138.

In this embodiment, the die pad 132 and the base 12 are fixed together by screws through corresponding screw holes 137 and 138. For ease of distinction, a new component of die pad 132 and base 12 is referred to as base 13.

The chip fixing table 1 is provided with a movement limiting device 10. The movement limiting device 10 is provided with a pressing device guide groove 101; a linkage guide groove 102 is provided.

The linkage guide slot 102 is an elongated through slot. Is arranged in the horizontal direction. The slide block 305 on the linkage 3 can horizontally move in the linkage guide groove 102, thereby realizing the horizontal movement of the linkage 3 and limiting the linkage 3

Up and down and left and right swinging. The linkage guide grooves 102 are four in total and are arranged substantially centered on the center of the die table. The slider 305 is provided on the side surface of the linkage 3 and extends in the side surface direction.

The pressing device guide groove 101 is an elongated penetrating groove and is arranged in a vertical direction. The pressing device 2 is provided with a sliding column 202. The slide posts 202 may be divided into front and rear groups, respectively, slide posts 2021 and slide guide posts 2022. The slide guide post 2022 passes through the movement direction switching groove 302 on the link 3 and enters the pressing device guide groove 101 on the movement limiting device 10. The pressing device guide groove 101 allows the pressing device 2 to move up and down only.

The movement limiting device 10 further includes screw holes 103. The four screw holes 103 are fixed with 133 screw holes on the chip fixing table 1 by screws.

The chip mount 1 includes a stopper hole 136. The limiting aperture 136 is used to mount and limit the escapement swing arm 11. The escapement swing arm device 11 includes a vertical column 114 and a torsion spring 112; the arm is provided with a swing arm 111 and an escapement arm 113. Wherein the swing arm 111, the vertical post 114, and the escapement arm 113 are rigidly integrated. Torsion spring 112 is mounted above vertical post 114. Torsion spring 112 always provides counterclockwise rotational force to escapement swing arm 11. One end of the torsion spring is restrained by the swing arm 111, and the other end is restrained by the limit post 115. The limit posts 115 are fixed through limit holes 139 on the die pad 1.

The escapement swing arm 11 is mounted in the limit hole 136 of the chip holder 1 by its vertical post 114. In this way, the escapement swing arm 11 can perform a rotational movement about its vertical post 114 without being able to move up and down, left and right.

The swing arm 111 includes an escapement arm 113, and includes a vertical column 114 as an integral component. Therefore, when the escapement swing arm device 11 moves by the torsion spring 112, the swing arm 111 includes the escapement arm 113, and the vertical column 114 is linked. The torsion spring 112 keeps the escapement swing arm 11 always in a counter-clockwise direction.

The limit posts 115 are fixed through limit holes 139 on the die pad 1. The stopper 115 is a cylindrical member which is relatively immovable with the chip fixing table 1 after being fixed to the stopper hole 139. That is, the stopper posts 115 may be set on the die pad 1 in a fixed manner.

The swing arm 111 is an elongated member that functions like a trigger. When the chip enters, the chip contacts with the swing arm 111, and as the chip enters, the swing arm drives the (part of the vertical column 114, the swing arm 111 and the escapement arm 113) of the escapement arm device 11 to rotate clockwise, and when the chip moves to a certain degree, the escapement arm 113 has a new function trigger.

The escapement arm 113 is a meniscus-shaped protruding structure. The swing arm 111 and escapement arm 113 are stationary and form a reverse-like numeral "7" structure and move about the vertical post 114 with the corner of the "7" as the center of rotation.

The escapement arm 113 restricts the movement of the movement restricting arm 304 (fig. 5) in the front-rear direction. While the corresponding motion limiting arm 304 limits the rotational direction motion of the escapement arm 113.

When the chip is not in, the escapement arm 113 is at the far end of the counterclockwise movement, since the torsion spring 112 of the escapement swing arm 11 is in the opposite relaxed state; thus, it catches the movement restricting arm 304, resulting in the linkage 3 not being able to move back and forth. When the chip enters, the torsion spring 112 of the escapement swing arm device 11 is in an opposite tightening state, and the escapement arm 113 moves clockwise and leaves the farthest end in the anticlockwise direction; thus, movement of the movement limiting arm 304 cannot be limited, resulting in the linkage 3 being able to move outwardly (outwardly relative to the instrument) under the tension of the spring 306.

The chip entry chip can be divided into three states: (1) When the chip does not enter, the swing arm 111 is in an original state, and the torsion spring 112 is in a relatively relaxed state; referring to fig. 6, the chip 4 and other non-relevant components are hidden for a clearer illustration of the relationship of the swing arm arrangement 11 and the motion limiting arm 304. (2) When the chip enters, the swing arm 111 is pushed by the chip to move inwards, and the escapement arm 113 moves clockwise; see fig. 7. (3) As the chip continues to move, the escapement arm 113 continues to move clockwise until the escapement arm 113 no longer limits the movement of the movement limiting arm 304, and the linkage 3 can move outwardly (outwardly relative to the instrument) under the tension of the spring 306, see fig. 8.

Accordingly, when the push handle 301 is manually pushed, the escapement swing arm 11 moves in opposite directions, causing the chip to pop up. The specific manner of movement of the linkage 3 will be described later.

The structure of the compacting device 2 is shown in fig. 4:

the pressing device 2 can only move up and down. The pressing device 2 is provided with a limiting cone 201. The limiting cone 201 is symmetrical left and right relative to the center of the chip.

The limiting cone 201 has a flat smooth surface inclined at 45 degrees, and two opposite inclined surfaces form a cone. The limiting cone 201 takes on a shape with a large upper face and a relatively sharp lower face. The limiting cone 201 can slide up and down through the sliding column 2012. One end of the sliding column 2012 is fixed on the limiting cone 201, and the other end can move up and down in a hole at the corresponding position of the pressing device 2.

An elastic means 2011 is present between the limiting cone 201 and one surface of the compression means 2. The resilient means 2011 is adapted to provide a downward force such that the stop cone 201 tends to move downwardly.

The limiting cone is used for providing a contact point with the chip and compacting the chip when the compacting device moves downwards. Alternatively, the limiting cone does not necessarily need elastic means, for example, a protruding columnar structure may also perform the same function, for example, a protruding structure having elasticity, for example, a rigid downward extending structure, for example, a half triangular pyramid structure, may all have the function of extending downward and pressing the chip.

The pressing device 2 has a slide column 2021 and a slide guide column 2022. The slide guide post 2022 passes through the movement direction switching groove 302 on the link 3 and enters the pressing device guide groove 101 on the movement limiting device 10.

The linkage 3 has a push handle 301, a movement direction switching groove 302, a screw hole 303, a movement restricting arm 304, a slider 305, and a spring 306.

The push handle 301 is a trigger point for pushing the force. When ejection of the chip is required, finger pushing 301 causes the linkage 3 to move inwardly.

The movement direction conversion groove 302 is a through groove at an angle to the horizontal direction. The total of 4 movement direction conversion grooves 302 are used for driving the sliding column 2021 and the sliding guide column 2022 to move respectively, so as to drive the pressing device 2 to move up and down.

The slide block 305 on the linkage 3 can horizontally move in the linkage guide groove 102, so that the horizontal movement of the linkage 3 is realized, and the up-and-down movement and the left-and-right swinging of the linkage 3 are limited. The linkage guide grooves 102 are four in total and are arranged substantially centered on the center of the die table. The slider 305 is provided on the side surface of the linkage 3 and extends in the side surface direction.

Only one motion limiting arm 304; the function of which is to cooperate with the escapement arm means 11 to cause ejection or compaction of the chip.

The part escapement arm 113 of the escapement arm set 11 is jammed by 304 when the chip is already inside the instrument. Therefore, it cannot rotate counterclockwise, ejecting the chip out of the instrument.

Reference numeral 303 denotes a screw hole for fixing the tension spring 306. The other end of the tension spring 306 is fixed on the screw hole 131 of the chip fixing table 1.

The number of screw holes of 303 is two. The device is symmetrically arranged on the left side and the right side of the chip, so that the stress is uniform, and the chip is prevented from deviating.

The elastic means are intended to keep the linkage 3 in a tendency to move outwards. Typically, the resilient means may be a spring 306.

Tension spring 306 is always in a tensioned state. So that the linkage 3 maintains a tendency to move outwards. When the chip is inside the instrument, the tension spring 306 is in the looest state of tension; when the chip is not inside the instrument, the tension spring 306 is in the tightest state of tension.

When the push handle 301 is manually pushed, the whole of the linkage 3 moves inward of the instrument, causing the movement direction conversion groove 302 to push the slide column 2021 and the slide guide column 2022 upward; so that the pressing device 2 moves upwards, the limiting cone 201 does not press the chip any more and is separated from the chip; simultaneously, the movement limiting arm 304 moves inwards along with the linkage device 3 and is separated from contact with the escapement arm 113, so that the escapement arm 113 is released, and the swing arm 111 moves anticlockwise under the action of the torsion spring 112; thereby pushing the chip and ejecting the chip out of the instrument.

When the push handle 301 is manually pushed, the escapement swing arm 11 moves in opposite directions, causing the chip to pop up. The specific movement of the linkage 3 will be described later

Chip 4:

Preferably, the chip 4 can be provided with an adapted housing. The housing is preferably of plastics material. The shell made of plastic materials can better protect the edge of the chip and avoid the damage of the chip. Alternatively, the chip may be sized to fit, and no housing is required.

Preferably, the chip is provided with chip bayonets 401 on both sides. The chip bayonet 401 is notched. When the limiting cone 201 of the pressing device 2 moves downwards, the conical surface of the limiting cone 201 pushes the chip downwards and inwards through the chip bayonet 401, so that the chip moves inwards and is attached to the chip table 132 and the limiting column 135; the XYZ three directions of the chip are fixed.

It should be noted that all components related to the core function in the drawings of the present invention have been described. Other structures, such as a relatively large protrusion structure at one end of the pressing device 2, are chip sample introduction auxiliary devices, which are not involved in the core function part of the present invention, and thus will not be described in detail. The non-core functional parts of other similar parts are correspondingly processed.

Mutual position relation and cooperation of four main components:

A chip fixing table 1, a pressing device 2, a linkage device 3 and a chip 4;

The chip mount 1 is the bottommost component. The other parts are relatively moved with the chip fixing table 1 by means of equipment or pressing, or remain relatively positioned.

The chip 4 is located on the chip stage 132 of the chip holding stage 1 when entering the instrument.

The pressing device 2 is installed through the pressing device guide groove 101 of the component movement limiting device 10 of the chip fixing table 1. The hold-down device 2 is thus above the chip holding-down table 1 and the width dimension is slightly smaller than the distance between the two movement limiting devices 10.

The linkage 3 is mounted through the linkage guide groove 102 of the component movement limiting device 10 of the chip fixing table 1.

Alternatively, the linkage guide slots 102 may be two or of a design similar to the four of the compression guide slots 101.

The relative up-down positioning of the compression device 2 and the linkage 3 is not critical to the present invention. In the invention, the position relationship from bottom to top is a chip fixing table 1, a pressing device 2 and a linkage device 3 respectively. Alternatively, the compression device 2 and the linkage 3 do not have absolute context requirements. That is, the linkage 3 may be located below the hold-down device 2, only if the corresponding component parts do not collide.

Chip entering instrument:

The hand-held chip 4 is pushed into the instrument. The chip 4 enters the instrument along the chip table 132 and is limited by the left and right positions of the limiting walls 134. When the chip 4 contacts the swing arm 111, the swing arm 111 rotates in a clockwise direction, and the escapement arm 113 of the linkage part also rotates in the clockwise direction; when the escapement arm 113 rotates to a certain position, the forward-backward movement restriction of the movement restricting arm 304 is released; the linkage 3 is moved outwardly by the spring 306. During the outward movement of the linkage 3, the movement direction switching groove 302 causes the contact member slide column 2021 and the slide guide column 2022 thereof to move downward; causing the hold-down device 2 to move downwards and to seize and hold down the chip by the stop cone 201 (spring means 2011). When the chip reaches the innermost position, it is restrained by the restraining post 135 to the final position. The chip enters the instrument in a motion, the state of which can be seen in fig. 6, fig. 7 and fig. 8.

Chip ejection instrument:

Pushing the push handle 301 causes the linkage 3 as a whole to move inwardly. During inward movement of the linkage 3, the movement direction switching groove 302 causes upward movement of the contact member slide column 2021 and slide guide column 2022; causing the hold-down device 2 to move upwards and the stop cone 201 (spring means 2011) to disengage from the chip 4. As the link 3 moves inward as a whole, the movement restricting arm 304 reaches a position such that the rotation restricting state of the escapement arm 113 is released, the escapement arm 113 rotates counterclockwise, and the link swing arm 111 thereof also rotates clockwise. The swing arm 111 pushes the chip outwards as it rotates, ejecting the chip out of the instrument.

The overall dimensions of the device are set by the size of the chip. In simple terms, the dimensions of the die attach station 1 are about 100mm by 110mm when the external dimensions of the die are 40mm by 90 mm. The thickness of the chip is omitted here. When the thickness of the chip is changed, the chip can be adapted by adjusting the vertical size of other components. With respect to the compression device 2, the linkage 3 or other component design dimensions may be adjusted according to the change in function without strict limitations.

Example 1

A mechanical chip ejection device includes,

the chip fixing table (1) comprises a flat plate structure which is adaptive to the chip, and is provided with a concave or convex structure at the edge of a specific position in the use state of the chip, so that the position of the chip is limited;

The linkage device (3) is also provided with a push handle for the contact of a person with the device.

Wherein, the chip fixing table (1) is provided with an integrated and adaptive flat plate structure.

The guide part A is a part matched with the guide groove of the pressing device and is used for limiting the movement range of the pressing device 2. The embodiment corresponds to the slide column 2021 and the slide guide column 2022 in fig. 4. The guide member a may be of other forms, and the slide column 2021 and the slide guide column 2022 may be of the same structure. The design is not limited according to the specific dimensions.

The guide member B is embodied as a slider (305) in fig. 5. The specific design can be columnar, blocky or other shapes, and the functions of the device are not affected.

Example 2

A biochemical chip ejecting device is characterized by comprising the following components,

The compressing device (2) compresses the chip by movement and is provided with a guiding component A;

a push handle (301) for human contact with the device;

The specific embodiments of the guide member a may be a sliding column 2021 and a sliding guide column 2022, see fig. 4. The slide positioning device may be of other forms, and the slide column 2021 and the slide guide column 2022 may be of the same structure. The design is not limited according to the specific dimensions.

The elastic member 112 may be a torsion spring 112. See fig. 3.

The present invention is not limited to the above-mentioned embodiments, and any changes or substitutions that can be easily understood by those skilled in the art within the technical scope of the present invention are intended to be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1.A mechanical biochemical chip entering and ejecting device is characterized by comprising,

the compressing device (2) compresses the chip by movement and is provided with a guiding component A; the guide component A is arranged in the guide groove of the pressing device and used for limiting the movement range of the pressing device (2);

The linkage device (3) is provided with a movement direction conversion structure and is used for matching with a protruding or recessed part of the pressing device (2), so that the linkage device (3) drives the pressing device (2) to move;

The linkage device (3) is also provided with a push handle for human interaction with the device;

Wherein the chip fixing table (1) further comprises an escapement swing arm device (11); the escapement swing arm device (11) is provided with a swing arm (111), a torsion spring; an escapement arm (113); the linkage (3) is provided with a motion limiting arm (304); the escapement arm (113) limits the movement of the movement limiting arm (304) along the chip in and out instrument direction;

wherein the linkage (3) is provided with a motion limiting arm (304); the escapement arm (113) limits the movement of the movement limiting arm (304) along the chip in and out instrument direction;

Wherein the escapement swing arm device (11) is provided with a vertical column (114), an elastic element torsion spring (112), a swing arm (111) and an escapement arm (113); wherein the swing arm (111), the vertical column (114), the escapement arm (113) are rigidly integrated; the torsion spring (112) is arranged on the vertical column (114); the torsion spring (112) always provides anticlockwise rotation force for the escapement swing arm device (11); when the chip enters, the chip is in contact with the swing arm (111), and the swing arm drives the escapement swing arm device (11) to do clockwise rotation along with the chip entering, and the escapement arm (113) can not limit the movement of the movement limiting arm (304) any more;

Wherein, the two sides of the chip are provided with chip bayonets (401); when the limiting cone (201) of the pressing device (2) moves downwards, the conical surface of the limiting cone (201) pushes the chip downwards and inwards through the chip bayonet (401), so that the chip moves inwards and is simultaneously abutted against the chip table (132) and the limiting column (135); the XYZ three directions of the chip are fixed.

2. The device according to claim 1, characterized in that the hold-down device (2) is provided with a limiting cone (201); the limit cone (201) is symmetrical left and right relative to the center of the chip.

3. The device according to claim 1, wherein the linkage guide groove (102) is an elongated through groove arranged horizontally, and the linkage (3) is provided with a slider (305) protruding downwards; the slide (305) is horizontally movable in the linkage guide slot (102).

4. A biochemical chip entering and ejecting device is characterized by comprising the following components,

The escapement swing arm device (11) is provided with a swing arm (111), a torsion spring (112); an escapement arm (113), the linkage (3) comprising a slider (305),

The movable limiting device (10) is arranged on the chip fixing table (1); the device is provided with a pressing device guide groove (101) for limiting the movement range of the pressing device (2), and a linkage device guide groove (102) for limiting the movement range of the linkage device (3);

a push handle (301) for human contact with the device;

The movement direction conversion groove (302) is linked with the sliding positioning device of the pressing device (2) and is used for converting the movement of the linkage device (3) into the movement of the pressing device (2) for pressing the chip;

Wherein the sliding positioning device of the pressing device (2) is a sliding column (202); wherein the compressing device (2) is provided with a limiting cone (201) for directly compressing the chip;

5. The device according to claim 4, characterized in that the hold-down device (2) is provided with a limiting cone (201); the limit cone (201) is symmetrical left and right relative to the center of the chip.

6. The device according to claim 4, wherein the linkage guide groove (102) is an elongated through groove arranged horizontally, and the linkage (3) is provided with a slider (305) protruding downwards; the slide (305) is horizontally movable in the linkage guide slot (102).