CN111904590B - Ablation electrode needle and needle tract ablation device for irreversible electroporation ablation - Google Patents
Ablation electrode needle and needle tract ablation device for irreversible electroporation ablation Download PDFInfo
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- CN111904590B CN111904590B CN202010900590.9A CN202010900590A CN111904590B CN 111904590 B CN111904590 B CN 111904590B CN 202010900590 A CN202010900590 A CN 202010900590A CN 111904590 B CN111904590 B CN 111904590B
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- 238000002679 ablation Methods 0.000 title claims abstract description 111
- 238000004520 electroporation Methods 0.000 title claims abstract description 32
- 230000002427 irreversible effect Effects 0.000 title claims abstract description 30
- 238000010438 heat treatment Methods 0.000 claims abstract description 18
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 8
- 230000000740 bleeding effect Effects 0.000 abstract description 4
- 238000002513 implantation Methods 0.000 abstract description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 238000001914 filtration Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1402—Probes for open surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
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Abstract
本公开提供了一种用于不可逆电穿孔消融的消融电极针及针道消融装置，消融电极针包括：针管本体，所述针管本体为中空管状；接线端子，所述接线端子设置于所述针管本体，包括第一接线端子与第二接线端子，所述第一接线端子和第二接线端子分别连接预定直流电源的正负极，使得所述第一接线端子和第二接线端子之间形成发热区域；温度传感器，设置于所述针管本体内第一接线端子和第二接线端子之间，用于检测发热区域的温度。本公开的消融电极针为单针自加热方式，无需额外电极构成输出回路，简化了手术方式；针道消融装置解决了不可逆电穿孔消融无法进行针道消融的问题，减少出血和种植。
The present disclosure provides an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation, the ablation electrode needle comprising: a needle tube body, the needle tube body being a hollow tube; a wiring terminal, the wiring terminal being arranged on the needle tube body, comprising a first wiring terminal and a second wiring terminal, the first wiring terminal and the second wiring terminal being respectively connected to the positive and negative poles of a predetermined DC power supply, so that a heating area is formed between the first wiring terminal and the second wiring terminal; a temperature sensor, being arranged between the first wiring terminal and the second wiring terminal in the needle tube body, for detecting the temperature of the heating area. The ablation electrode needle of the present disclosure is a single-needle self-heating method, which does not require an additional electrode to form an output circuit, thus simplifying the surgical method; the needle tract ablation device solves the problem that needle tract ablation cannot be performed in irreversible electroporation ablation, thereby reducing bleeding and implantation.
Description
Technical Field
The present disclosure relates to the field of electroporation ablation, and in particular, to an ablation electrode needle and needle tract ablation device for irreversible electroporation ablation.
Background
Irreversible electroporation ablation is a new way of ablation in the field of tumor ablation. Irreversible electroporation ablation uses high-voltage narrow pulses to act on focal sites, causing nanoscale permanent perforation of cell membranes, resulting in tumor cell apoptosis.
In minimally invasive ablation surgery, when ablation is finished, needle tract ablation is usually needed, needle tract hemorrhage during needle withdrawal is prevented, and the implantation risk caused by viruses on the needle left in a needle tract area when an ablation electrode needle is pulled out of a focus of a human body is reduced. The current electroporation ablation equipment does not have a special needle tract ablation function, and bleeding and implantation risks are caused during operation. Thus, there is a need for an ablation electrode needle and needle tract ablation device for irreversible electroporation ablation.
Disclosure of Invention
First, the technical problem to be solved
The present disclosure provides an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation to at least partially address the technical problems set forth above.
(II) technical scheme
According to one aspect of the present disclosure, there is provided an ablation electrode needle for irreversible electroporation ablation, comprising:
The needle tube body is hollow and tubular;
the connecting terminal is arranged on the needle tube body and comprises a first connecting terminal and a second connecting terminal, the first connecting terminal and the second connecting terminal are respectively connected with the positive electrode and the negative electrode of a preset direct current power supply, a heating area is formed between the first connecting terminal and the second connecting terminal, and
And the temperature sensor is arranged between the first wiring terminal and the second wiring terminal in the needle tube body and used for detecting the temperature of the heating area.
According to the embodiment of the disclosure, the first wiring terminal is located at the needle point of the needle tube body, and the distance between the first wiring terminal and the second wiring terminal is not smaller than the length of the maximum exposure area of the electrode needle.
According to an embodiment of the present disclosure, the temperature sensor is disposed at a midpoint between the first connection terminal and the second connection terminal in the needle tube body.
According to an embodiment of the disclosure, the temperature sensor is a thermocouple.
According to an embodiment of the present disclosure, the ablation electrode needle further comprises:
The electrode pin connector is electrically connected to the first wiring terminal, the second wiring terminal and the temperature sensor and is used for realizing the electrical connection between the first wiring terminal, the second wiring terminal and the temperature sensor and the outside.
According to another aspect of the present disclosure, there is provided a needle tract ablation device for irreversible electroporation ablation, comprising:
An ablation electrode needle as previously described;
the temperature acquisition module is used for acquiring temperature signals detected by the temperature sensor;
a constant current module for applying a constant current between the first and second terminals, and
And the controller module is connected to the temperature acquisition module and the constant current module and is used for controlling the output of the constant current module according to the temperature data acquired by the temperature acquisition module so as to keep the temperature of the heating area at a constant value.
According to the embodiment of the disclosure, the temperature acquisition module comprises a filtering circuit sub-module, an amplifying circuit sub-module and an analog-to-digital conversion sub-module.
According to the embodiment of the disclosure, the power supply voltage of the constant current module is 5-9V, and the output current is 3-5A.
According to the embodiment of the disclosure, the temperature acquisition module is connected with a temperature sensor of the ablation electrode needle through the electric connector, and the constant current module is connected with a first wiring terminal and a second wiring terminal of the ablation electrode needle through the electric connector.
According to another aspect of the present disclosure, there is provided a device for irreversible electroporation ablation comprising an ablation electrode needle as described above or a needle tract ablation device as described above.
(III) beneficial effects
According to the technical scheme, the ablation electrode needle for irreversible electroporation ablation and the needle tract ablation device have at least one of the following beneficial effects:
(1) The ablation electrode needle is in a single-needle self-heating mode, an output loop is not required to be formed by an additional electrode, and an operation mode is simplified;
(2) The needle tract ablation device solves the problem that irreversible electroporation ablation cannot perform needle tract ablation, and reduces bleeding and planting;
(3) The needle tract ablation device disclosed by the disclosure uses a low-voltage power supply to supply power, so that the safety is improved.
Drawings
Fig. 1 is a schematic structural view of an ablation electrode needle for irreversible electroporation ablation in accordance with an embodiment of the present disclosure.
Fig. 2 is a schematic structural view of a needle tract ablation device for irreversible electroporation ablation in accordance with an embodiment of the present disclosure.
Fig. 3 is a schematic structural diagram of a constant current module according to an embodiment of the present disclosure.
Detailed Description
The invention provides an ablation electrode needle and a needle tract ablation device for irreversible electroporation ablation, wherein the ablation electrode needle comprises a needle tube body, a wiring terminal and a temperature sensor, the needle tube body is hollow, the wiring terminal is arranged on the needle tube body and comprises a first wiring terminal and a second wiring terminal, the first wiring terminal and the second wiring terminal are respectively connected with a positive electrode and a negative electrode of a preset direct current power supply, a heating area is formed between the first wiring terminal and the second wiring terminal, and the temperature sensor is arranged between the first wiring terminal and the second wiring terminal in the needle tube body and is used for detecting the temperature of the heating area. The needle tract ablation device comprises a temperature acquisition module, a controller module, a constant current module and the ablation electrode needle.
For the purposes of promoting an understanding of the principles and advantages of the disclosure, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same.
Certain embodiments of the present disclosure will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments are shown. Indeed, various embodiments of the disclosure may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather as provided so that the disclosure meets applicable legal requirements.
In one exemplary embodiment of the present disclosure, an ablation electrode needle for irreversible electroporation ablation is provided.
Fig. 1 is a schematic structural view of an ablation electrode needle for irreversible electroporation ablation in accordance with an embodiment of the present disclosure. As shown in fig. 1, an ablation electrode needle 100 for irreversible electroporation ablation of the present disclosure includes a needle tube body 101, a connection terminal 102, and a temperature sensor 103.
The following describes in detail the respective portions of the ablation electrode needle for irreversible electroporation ablation of the present embodiment.
The needle tube body 101 has a hollow tubular shape. The needle tube body 101 of the ablation electrode needle for irreversible electroporation is generally made of metal and has conductive performance.
The connecting terminal 102 is disposed in the needle tube body 101 and includes a first connecting terminal 1021 and a second connecting terminal 1022, where the first connecting terminal 1021 and the second connecting terminal 1022 are respectively connected with the positive and negative poles of a predetermined dc power supply, so that a heating area is formed between the first connecting terminal 1021 and the second connecting terminal 1022.
Specifically, in the embodiment of the disclosure, a direct current voltage with constant current output is applied to two ends of a section of needle tube body 101, when the internal resistance of the needle tube passes through a large current, self-heating causes the surface temperature of the needle tube to rise rapidly, so that the purpose of needle tract ablation is achieved.
Referring to fig. 1 again, in order to implement the ablation electrode needle 100 of the disclosure, a first connection terminal 1021 and a second connection terminal 1022 may be respectively disposed near the needle tip of the needle tube body 101 and at a distance from the needle tip, and a lead may be welded to serve as a positive electrode and a negative electrode (without distinguishing the positive electrode from the negative electrode) of the dc voltage, where a region between the leads is a heating region.
The ablation temperature needs to be controlled during the ablation of the needle tract, so that the temperature sensor 103 is required to measure the temperature of the needle tube body 101. The temperature sensor 103 is disposed between the first connection terminal 1021 and the second connection terminal 1022 on the inner wall of the needle tube body 101, and is used for detecting the temperature of the heating area.
The ablation electrode needle further comprises an electrode needle connector (not shown), and the electrode needle connector is electrically connected to the first connection terminal 1021 and the second connection terminal 1024 and the temperature sensor 103, so as to realize the electrical connection between the first connection terminal 1021 and the second connection terminal 1022 and the temperature sensor 103 and the outside.
Specifically, a thermocouple is employed as the temperature sensor 103 in the present embodiment. As shown in fig. 1, a thermocouple may be welded to the middle portion of the heat generating region. The point a is the set position of the first connecting terminal 1021 and is located near the needle point, the point B is the set position of the second connecting terminal 1022 and is 4cm away from the point a, and the distance between the points AB is not smaller than the length of the maximum exposed area of the electrode needle. Point C is the location of the weld thermocouple, midpoint between AB. The V+ connecting wire, the V-connecting wire and the thermocouple connecting wire are connected to the electrode needle connector in the needle tube and are connected with the needle tract ablation device through the connector.
The ablation electrode needle of the embodiment of the disclosure adopts a single-needle self-heating mode, and an output loop is not required to be formed by an additional electrode, so that the operation mode is simplified.
In yet another exemplary embodiment of the present disclosure, a needle tract ablation device for irreversible electroporation ablation is provided.
Fig. 2 is a schematic structural view of a needle tract ablation device for irreversible electroporation ablation in accordance with an embodiment of the present disclosure. As shown in fig. 2, the needle tract ablation device for irreversible electroporation ablation of the present disclosure includes an ablation electrode needle 100, a temperature acquisition module 200, a constant current module 300, and a controller module 400.
Wherein the ablation electrode needle 100 is employed as described in the previous embodiment.
The temperature acquisition module 200 is used for acquiring temperature signals detected by the temperature sensor. Specifically, in this embodiment, the temperature sensor uses a thermocouple, so the temperature acquisition module may use a dedicated thermocouple acquisition chip.
In the embodiment of the disclosure, the temperature acquisition module 200 includes a filtering circuit sub-module, an amplifying circuit sub-module and an analog-to-digital conversion sub-module. The temperature acquisition module 200 may be connected to the temperature sensor of the ablation electrode needle through the electrical connector, and the temperature acquisition module 200 acquires thermocouple signals, performs filtering and amplification, and converts analog quantities into digital quantities for the controller module 400.
The constant current module 300 is used to apply a constant current between the first and second connection terminals. The constant current module 300 is connected 1022 through the electrical connector to the first connection terminal 1021 and the second connection terminal of the ablation electrode pin.
Fig. 3 is a schematic structural diagram of a constant current module according to an embodiment of the disclosure, and as shown in fig. 3, the constant current module 300 includes an operational amplifier connected as negative feedback. The constant current module 300 uses 5V power supply, a needle tube body 101 is connected between a v+ connecting wire and a V-connecting wire, the internal resistance of the needle tube body 101 is used as a load, and the on-resistance of the MOS tube Q is adjusted through the negative feedback characteristic of an operational amplifier, so that constant current is realized. In addition, the controller module 400 may also stop the constant current output by saturating Q1 on by the RST signal.
In this embodiment, the constant current value i=vref/R, where Vref is a reference voltage connected to the positive electrode of the operational amplifier, and R is a resistor connected between the negative electrode of the operational amplifier and ground. Since the internal resistance of the syringe body 101 in the heat generating region is small (typically less than 0.5 ohms), a large current is required to generate heat rapidly, and thus a 5A current is a viable set point. In one embodiment, R is optionally 0.5 ohms and the reference voltage Vref is 2.5V.
The controller module 400 is connected to the temperature acquisition module 200 and the constant current module 300, and is configured to control the output of the constant current module 300 according to the temperature data acquired by the temperature acquisition module 200, so that the temperature of the heating area is kept at a constant value.
The needle tract ablation device solves the problem that irreversible electroporation ablation cannot perform needle tract ablation, reduces bleeding and implantation, and simultaneously, the needle tract ablation device is powered by a low-voltage power supply, so that safety is improved.
In yet another embodiment of the present disclosure, a device for irreversible electroporation ablation is provided, comprising an ablation electrode needle as described in the previous embodiments or a needle tract ablation device as described in the previous embodiments.
Thus, embodiments of the present disclosure have been described in detail with reference to the accompanying drawings. It should be noted that, in the drawings or the text of the specification, implementations not shown or described are all forms known to those of ordinary skill in the art, and not described in detail. Furthermore, the above definitions of the elements and methods are not limited to the specific structures, shapes or modes mentioned in the embodiments, and may be simply modified or replaced by those of ordinary skill in the art.
Unless otherwise known, numerical parameters in this specification and the appended claims are approximations that may vary depending upon the desired properties sought to be obtained by the present disclosure. In particular, all numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term "about". In general, the meaning of expression is meant to include a variation of + -10% in some embodiments, a variation of + -5% in some embodiments, a variation of + -1% in some embodiments, and a variation of + -0.5% in some embodiments by a particular amount.
Furthermore, the word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.
The use of ordinal numbers such as "first," "second," "third," etc., in the description and the claims to modify a corresponding element does not by itself connote any ordinal number of elements or the order of manufacturing or use of the ordinal numbers in a particular claim, merely for enabling an element having a particular name to be clearly distinguished from another element having the same name.
Furthermore, unless specifically described or steps must occur in sequence, the order of the above steps is not limited to the list above and may be changed or rearranged according to the desired design. In addition, the above embodiments may be mixed with each other or other embodiments based on design and reliability, i.e. the technical features of the different embodiments may be freely combined to form more embodiments.
The algorithms and displays presented herein are not inherently related to any particular computer, virtual system, or other apparatus. Various general-purpose systems may also be used with the teachings herein. The required structure for a construction of such a system is apparent from the description above. In addition, the present disclosure is not directed to any particular programming language. It will be appreciated that the disclosure described herein may be implemented in a variety of programming languages, and the above description of specific languages is provided for disclosure of enablement and best mode of the present disclosure.
The disclosure may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. Various component embodiments of the present disclosure may be implemented in hardware, or in software modules running on one or more processors, or in a combination thereof. Those skilled in the art will appreciate that some or all of the functions of some or all of the components in a related device according to embodiments of the present disclosure may be implemented in practice using a microprocessor or Digital Signal Processor (DSP). The present disclosure may also be embodied as a device or apparatus program (e.g., computer program and computer program product) for performing a portion or all of the methods described herein. Such a program embodying the present disclosure may be stored on a computer readable medium, or may have the form of one or more signals. Such signals may be downloaded from an internet website, provided on a carrier signal, or provided in any other form.
Those skilled in the art will appreciate that the modules in the apparatus of the embodiments may be adaptively changed and disposed in one or more apparatuses different from the embodiments. The modules or units or components of the embodiments may be combined into one module or unit or component and, furthermore, they may be divided into a plurality of sub-modules or sub-units or sub-components. Any combination of all features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or units of any method or apparatus so disclosed, may be used in combination, except insofar as at least some of such features and/or processes or units are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings), may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. Also, in the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware.
Similarly, it should be appreciated that in the above description of exemplary embodiments of the disclosure, various features of the disclosure are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various disclosed aspects. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed disclosure requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this disclosure.
While the foregoing embodiments have been described in some detail for purposes of clarity of understanding, it will be understood that the foregoing embodiments are merely illustrative of the invention and are not intended to limit the invention, and that any modifications, equivalents, improvements, etc. that fall within the spirit and principles of the present disclosure are intended to be included within the scope of the present disclosure.
Claims (8)
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