CN112023019A - Medicine containing active polysaccharide with effect of reducing uric acid and preparation method thereof - Google Patents

Abstract

The invention discloses an active polysaccharide-containing medicament with the effect of reducing uric acid and a preparation method thereof, wherein the active polysaccharide-containing medicament comprises the following components in parts by weight: 8-15 parts of marine fish oligopeptide powder, 5-12 parts of taxus chinensis polysaccharide, 7-15 parts of pawpaw, 6-11 parts of pit viper, 7-13 parts of coix seed, 11-20 parts of celery powder, 11-19 parts of burdock root powder, 1-15 parts of corn stigma powder, 3-16 parts of egg white chlorella powder, 6-19 parts of vitamin, 11-30 parts of edible auxiliary material and 5-15 parts of phellinus igniarius. The active polysaccharide-containing medicament has synergistic effect of the raw materials and obvious effect of reducing uric acid.

Description

A kind of active polysaccharide-containing medicine with hyperuric acid lowering effect and preparation method thereof

technical field

The invention relates to the technical field of medicine, in particular to an active polysaccharide-containing medicine with the effect of reducing hyperuric acid and a preparation method thereof.

Background technique

Uric acid is the end product of purine metabolism in the human body. The daily production and excretion of uric acid in the body are approximately equal, but when the purine metabolism in the body is disordered, the uric acid content will increase. Stones or gout. Hyperuricemia refers to a state of the body in which the concentration of uric acid in the blood exceeds the normal range. It is generally believed that when the concentration of uric acid in the blood of men is greater than 400 μmol/L, and the concentration of uric acid in the blood of women is greater than 360 μmol/L, it should be considered as hyperuric acid. blood. Recent studies have shown that hyperuricemia is not only the most important biochemical basis for gout, but also an important cause of hypertension, hyperlipidemia, atherosclerosis, obesity, insulin resistance, metabolic syndrome, cardiovascular disease and death. It has become one of the main metabolic diseases that threaten human health.

At present, commonly used clinical drugs include non-steroidal anti-inflammatory drugs, colchicine, glucocorticoids, probenecid, benaumarone, and allopurinol, which have significant therapeutic effects, but they all have different degrees of toxic side effects and adverse reactions. Damage the liver, nervous system, cause skin allergies, life-threatening hypersensitivity reactions, etc.

SUMMARY OF THE INVENTION

The purpose of the present invention is to aim at the deficiencies in the prior art, to provide an active polysaccharide-containing medicine with the effect of lowering uric acid and a preparation method thereof.

For realizing the above-mentioned purpose, the technical scheme that the present invention takes is:

The first aspect of the present invention provides an active polysaccharide-containing medicine with the effect of lowering uric acid. The active polysaccharide-containing medicine comprises the following components by weight: 8-15 parts of marine fish oligopeptide powder, 5-12 parts of taxus polysaccharide parts, papaya 7-15 parts, pit viper 6-11 parts, coix seed 7-13 parts, celery powder 11-20 parts, burdock root powder 11-19 parts, corn silk powder 1-15 parts, chlorella pyrenoidosa 3-16 servings of powder, 6-19 servings of vitamins, 11-30 servings of edible accessories, and 5-15 servings of Phellinus linteus.

Preferably, the active polysaccharide-containing medicine comprises the following components by weight: 10-13 parts of marine fish oligopeptide powder, 7-10 parts of Taxus polysaccharide, 9-14 parts of papaya, 8-10 parts of Viper, Coix 8-11 servings of kernels, 17-20 servings of celery powder, 16-18 servings of burdock root powder, 13-15 servings of corn silk powder, 14-16 servings of Chlorella pyrenoidosa powder, 10-15 servings of vitamins, 12- 29 copies, Phellinus 8-12 copies.

Preferably, the vitamin is one or more of vitamin A, vitamin D, vitamin E, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, choline and niacinamide .

Preferably, the edible adjuvant is one or more of an excipient, a stabilizer, a flavor enhancer and a color protectant.

The second aspect of the present invention provides the preparation method of the active polysaccharide-containing medicine, comprising the following steps:

S1, weigh described papaya and pit viper by weight, add 12-15 times the amount of water, heat and extract several times, filter, merge the filtrate, and the filtrate is concentrated to 65-75 ℃ to measure the clear paste that the relative density is 1.2-1.4 ; Weigh the coix seed by weight, pulverize it into fine powder, and pass through a 60-90 mesh sieve;

S2, weigh described marine fish oligopeptide powder, Taxus chinensis polysaccharide, celery powder, burdock root powder, corn silk powder, Chlorella pyrenoidosa powder, vitamin, edible adjuvant and Phellinus linteus by weight, and add through the steps The clear paste and Coix seed powder prepared in S1 were mixed to obtain the active polysaccharide-containing pharmaceutical preparation.

Preferably, in S1, the heating and extraction are performed 2-3 times, each time for 2-3 hours.

Preferably, in S2, the dosage form of the active polysaccharide-containing pharmaceutical preparation is tablet, capsule, powder, pill or granule.

The third aspect of the present invention provides the application of the active polysaccharide-containing medicine in the preparation of health care products, foods or medicines with the effect of reducing hyperuric acid.

The present invention adopts the above technical scheme, compared with the prior art, has the following technical effects:

1. Taxus polysaccharide in the present invention has excellent uric acid-lowering and creatinine-lowering effects, and has a protective effect on the kidneys, and the taxus polysaccharide is used as an active ingredient to make medicine in clinical experiments. uric acid effect. The functions of marine fish oligopeptide powder are to reduce uric acid and relieve gout; prolong muscle exercise time and increase muscle exercise intensity; reduce inflammation; reduce gastric ulcer symptoms and accelerate healing; Myocardial ischemia and cerebral ischemia injury.

2. Papaya in the present invention is the dry near-ripe fruit of Rosaceae plant Begonia sticking to the stem, and has the effects of relaxing tendons and activating collaterals and eliminating dampness in the stomach; it is used for wet arthralgia, soreness and pain in waist and knee joints, muscle cramps, and beriberi. The treatment of conditions such as edema has significant effects. Pitviper is the dry body of Viperidae animals with internal organs removed, and has the functions of expelling wind, analgesia, detoxification, strengthening, and breast reduction; it is used for rheumatism, leprosy, lymph nodes, tuberculosis, sores and boils, physical weakness, sweating, and milk. The treatment of conditions such as insufficiency has dramatic effects. Coix seed is the dry and mature seed kernel of Coix coix, which has the functions of invigorating water and dampness, strengthening the spleen and stopping diarrhea, removing paralysis, pus, detoxifying and dispersing knots; it is used for edema, beriberi, dysuria, diarrhea due to spleen deficiency, and dampness , lung carbuncle, intestinal carbuncle, wart, cancer and other diseases have significant effects.

3. The present invention adopts the combination of celery powder, burdock root powder, corn silk powder and Chlorella pyrenoidosa powder as raw materials; wherein celery powder is cool in nature, sweet and pungent in taste, non-toxic; enters liver, gallbladder, and pericardium meridian; Calming the liver and removing vexation, expelling wind and dampness and reducing swelling. Combined with bitter cold burdock root powder, it can dispel wind and heat, reduce swelling and toxin; Corn silk powder Ganping can reduce swelling, relieve heat and calm the liver, and has an excellent diuretic effect. With the functions of clearing away heat and detoxification, expelling acid and reducing turbidity of Chlorella pyrenoidosa, it can replenish Qi, strengthen the spleen and dampness, dispel wind and dissipate heat, and expel acid and reduce turbidity from the meridians to the viscera. The four components are synergistically synergistic, and the effect of reducing uric acid is obviously better than that of a single or a combination of two or three raw materials, achieving the effect of effectively reducing uric acid without toxic and side effects.

4. The present invention adds a variety of vitamins, and the addition of vitamins interacts with other components to accelerate the dissolution rate of the active ingredients of the medicine, so that the pharmaceutical composition has a good effect.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments, but not as a limitation of the present invention.

It should be noted that the embodiments of the present invention and the features of the embodiments may be combined with each other under the condition of no conflict.

Example 1

An active polysaccharide-containing medicine with the effect of lowering hyperuric acid, the active polysaccharide-containing medicine comprises the following components by weight: 8 parts of marine fish oligopeptide powder, 5 parts of taxus polysaccharide, 7 parts of papaya, and 6 parts of pit viper , 7 parts of Coix seed, 11 parts of celery powder, 11 parts of burdock root powder, 1 part of corn silk powder, 3 parts of Chlorella pyrenoidosa powder, 6 parts of vitamin A, 11 parts of flavor enhancer, 5 parts of Phellinus linteus.

The preparation method of the above-mentioned active polysaccharide-containing medicine comprises the following steps:

S1, weigh described papaya and pit viper by weight, add 12 times the amount of water, heat and extract 2 times, each 2 hours, filter, merge the filtrate, the filtrate is concentrated to 65 ° C and the relative density is 1.2 clear paste; Weigh the Coix Seeds by weight, pulverize them into fine powder, and pass through a 60-mesh sieve;

S2, weigh described marine fish oligopeptide powder, Taxus chinensis polysaccharide, celery powder, burdock root powder, corn silk powder, Chlorella pyrenoidosa powder, vitamin, edible adjuvant and Phellinus linteus by weight, and add through the steps The clear paste and Coix seed powder prepared in S1 were mixed to obtain the active polysaccharide-containing pharmaceutical tablet.

Example 2

An active polysaccharide-containing medicine with the effect of reducing hyperuric acid, the active polysaccharide-containing medicine comprises the following components by weight: 11 parts of marine fish oligopeptide powder, 8 parts of taxus polysaccharide, 12 parts of papaya, and 9 parts of pit viper , 12 parts of Coix seed, 18 parts of celery powder, 16 parts of burdock root powder, 7 parts of corn silk powder, 10 parts of Chlorella pyrenoidosa powder, 111 parts of vitamin B, 25 parts of excipients, 9 parts of Phellinus linteus.

The preparation method of the above-mentioned active polysaccharide-containing medicine comprises the following steps:

S1, weigh described papaya and pit viper by weight, add 13 times the amount of water, heat and extract 3 times, 2.5 hours each time, filter, merge the filtrate, the filtrate is concentrated to 70 ° C and the relative density is 1.3 clear paste; Weigh the coix seed by weight, pulverize it into fine powder, and pass through an 80-mesh sieve;

S2, weigh described marine fish oligopeptide powder, Taxus chinensis polysaccharide, celery powder, burdock root powder, corn silk powder, Chlorella pyrenoidosa powder, vitamin, edible adjuvant and Phellinus linteus by weight, and add through the steps The clear paste and coix seed powder prepared in S1 were mixed to obtain the active polysaccharide-containing medicinal capsule.

Example 3

An active polysaccharide-containing medicine with the effect of reducing hyperuric acid, the active polysaccharide-containing medicine comprises the following components by weight: 15 parts of marine fish oligopeptide powder, 12 parts of taxus polysaccharide, 15 parts of papaya, 11 parts of pit viper , 13 parts of Coix seed, 20 parts of celery powder, 19 parts of burdock root powder, 15 parts of corn silk powder, 16 parts of Chlorella pyrenoidosa powder, 19 parts of niacin, 30 parts of stabilizer, 15 parts of Phellinus linteus.

The preparation method of the above-mentioned active polysaccharide-containing medicine comprises the following steps:

S1, weigh described papaya and pit viper by weight, add 15 times the amount of water, heat and extract 3 times, each 3 hours, filter, merge the filtrate, the filtrate is concentrated to 75 ° C and the relative density is 1.4 clear paste; Weigh the Coix Seeds by weight, pulverize them into fine powder, and pass through a 90-mesh sieve;

S2, weigh described marine fish oligopeptide powder, Taxus chinensis polysaccharide, celery powder, burdock root powder, corn silk powder, Chlorella pyrenoidosa powder, vitamin, edible adjuvant and Phellinus linteus by weight, and add through the steps The clear paste and Coix seed powder prepared in S1 were mixed to obtain the active polysaccharide-containing pharmaceutical granules.

Application example

Patient data: 150 patients, including 100 males, aged 35-75 years old; 50 females, aged 35-75 years old.

Diagnostic criteria: patients with joint pain, nocturnal attacks, difficulty sleeping; elevated blood uric acid, higher than 6.0 mg/dL in males and higher than 5.0 mg/dL in females; with tophi.

Dosing method: 3 times a day, 2 tablets or 2 tablets each time the active polysaccharide-containing pharmaceutical preparations prepared in Example 1, Example 2 or Example 3, once in the morning, noon and evening, for 7 weeks.

Efficacy evaluation criteria: Cure: normal blood uric acid value in laboratory examination, disappearance of joint pain symptoms, and removal of tophi; improvement: reduction in blood uric acid value in laboratory examination, subsidence of joint swelling, pain relief, and significant reduction in tophi; invalid: laboratory examination There was no change in blood uric acid value and symptoms, and no change in tophi. The test results are shown in Table 1:

Table 1

As can be seen from the data in Table 1, the raw materials of the active polysaccharide-containing medicine in the present invention are reasonably proportioned and scientifically compatible, and each component has played a synergistic role. Tablets, capsules, powders, pills or granules and other health care products, foods or drugs with side effects, the active polysaccharide-containing drug with significant uric acid-lowering effect can make patients take this uric acid-lowering drug for 7 weeks. The efficiency can reach more than 97.3%.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the embodiments and protection scope of the present invention. For those skilled in the art, they should be aware of the equivalent replacements and obvious changes made by using the contents of the description of the present invention. The solutions obtained by the changes of the above should be included in the protection scope of the present invention.

Claims (8)

1. an active polysaccharide-containing medicine with hyperuric acid-lowering effect is characterized in that, the active polysaccharide-containing medicine comprises the following components by weight: 8-15 parts of marine fish oligopeptide powder, 5-12 parts of taxus polysaccharide parts, papaya 7-15 parts, pit viper 6-11 parts, coix seed 7-13 parts, celery powder 11-20 parts, burdock root powder 11-19 parts, corn silk powder 1-15 parts, chlorella pyrenoidosa 3-16 servings of powder, 6-19 servings of vitamins, 11-30 servings of edible accessories, and 5-15 servings of Phellinus linteus. 2. The active polysaccharide-containing medicine with hyperuric acid-lowering effect according to claim 1, wherein the active polysaccharide-containing medicine comprises the following components by weight: 10-13 parts of marine fish oligopeptide powder, red bean 7-10 parts of cedar polysaccharide, 9-14 parts of papaya, 8-10 parts of viper, 8-11 parts of coix seed, 17-20 parts of celery powder, 16-18 parts of burdock root powder, 13-15 parts of corn silk powder, Chlorella pyrenoidosa powder 14-16 parts, vitamins 10-15 parts, edible accessories 12-29 parts, Phellinus 8-12 parts. 3. The active polysaccharide-containing medicine with hyperuric acid-lowering effect according to claim 1, wherein the vitamins are vitamin A, vitamin D, vitamin E, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B One or more of B12, niacin, folic acid, pantothenic acid, choline and niacinamide. 4. The active polysaccharide-containing medicine with hyperuric acid-lowering effect according to claim 1, wherein the edible adjuvant is one or more of an excipient, a stabilizer, a flavor enhancer and a color protectant. 5. the preparation method of the active polysaccharide-containing medicine according to any one of claims 1-4, is characterized in that, comprises the steps: S1, weigh described papaya and pit viper by weight, add 12-15 times the amount of water, heat and extract several times, filter, merge the filtrate, and the filtrate is concentrated to 65-75 ℃ to measure the clear paste that the relative density is 1.2-1.4 ; Weigh the coix seed by weight, pulverize it into fine powder, and pass through a 60-90 mesh sieve; S2, weigh described marine fish oligopeptide powder, Taxus chinensis polysaccharide, celery powder, burdock root powder, corn silk powder, Chlorella pyrenoidosa powder, vitamin, edible adjuvant and Phellinus linteus by weight, and add through the steps The clear paste and Coix seed powder prepared in S1 were mixed to obtain the active polysaccharide-containing pharmaceutical preparation. 6 . The preparation method of the active polysaccharide-containing medicine according to claim 5 , wherein, in S1 , the heating and extraction are performed 2-3 times, and each time is 2-3 hours. 7 . 7. The preparation method of active polysaccharide-containing medicine according to claim 1, wherein in S2, the dosage form of the active polysaccharide-containing medicine preparation is tablet, capsule, powder, pill or granule. 8. The application of the active polysaccharide-containing medicine according to any one of claims 1 to 4 in the preparation of a health product, food or medicine with the effect of reducing hyperuric acid.