Negative pressure transmission pathology examination whole-flow system for infectious specimen
Technical Field
The invention relates to the technical field of specimen inspection, in particular to a negative pressure transmission pathology inspection whole-flow system for infectious specimens.
Background
The progress of clinical medicine is not separated from pathological anatomy, and the pathology reveals the nature of the disease, including etiology, pathogenesis and changes and rules of organism organs, tissues, cells and even molecules in the disease process, and is the root of the origin and development of modern medicine.
Infectious diseases, such as new coronavirus infection, are complex diseases with lung lesions as the main part, involving multiple organs throughout the body and a wide range of injuries. Without a deep understanding of the etiology and pathological changes, clinical treatment works face significant challenges. Through pathological anatomy and subsequent microscopic observation and molecular inspection, the distribution of viruses in human bodies and the damage state of organs can be intuitively known, so that the occurrence mechanism, transmission path and target organs of diseases are recognized, and key clues are provided for clinical diagnosis and treatment.
At present, a pathology dissecting room is simply divided into a pollution area and a cleaning area, dissectors do not have a safe and effective pathology examination operation platform and related special facility equipment, viruses are easy to diffuse pollution to the personnel and the dissecting room through mediums such as personnel, dissected products and air, pathology staff are exposed at high risk, meanwhile, the current dissection and sampling of viscera specimens are all performed manually, a great deal of time and labor cost are required for pathology examination, sampling and the like of a great deal of viscera and tissue specimens, meanwhile, the current pathology examination lacks a corresponding pipelining design, the specimen or the processing flow of the specimen cannot realize that the whole period of time is in an isolated and sealed environment, and the current automated and intelligent pipelining pathology adherence processing device and system are also lacking.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a negative pressure transmission pathology examination whole flow system for infectious specimens, and the whole system is an automatic pipeline model pathology dissection sampling system and is in a negative pressure step-by-step closed structure, thereby being suitable for viscera and tissue pathology examination application.
In order to achieve the technical purpose and the technical effect, the invention is realized by the following technical scheme:
The negative pressure transmission pathology examination full-flow system for the infectious specimens comprises an autopsy room, an organ specimen sampling room, a specimen storage room after sampling, a pathology technology room and a monitoring control room, wherein the autopsy room, the organ specimen sampling room and the pathology technology room are communicated in one direction through a pipeline system and a transmission channel, the negative pressure in each room is gradually reduced to enable the flow direction of internal gas to flow in one direction, the organ specimen sampling room is communicated with the specimen storage room after sampling in two directions through the pipeline system and the transmission channel, the monitoring control room is communicated with each room through a video dialogue system and a remote operation system and uploads graphic information of pathology examination to a pathology data analysis center through a wireless information system, and the autopsy room and the pathology technology room end are provided with an air intake and exhaust and purification system.
Furthermore, the whole viscera specimen sampling chamber is of a closed cabinet structure, the inside of the viscera specimen sampling chamber is divided into a tissue specimen pretreatment component, a tissue specimen sampling component, a sample treatment component and a sample conveying component which are communicated with each other, and the operation table surfaces of the components are positioned on the same plane and are provided with mutually independent conveying belts;
The specimen pretreatment component is used for automatic or manual filling of viscera specimen fixing liquid, specimen code scanning numbering, timing of specimens or manual/automatic conveying;
The specimen sampling assembly is used for general examination and sampling of specimens, assisting in processing continuous tissue slices with different thicknesses and batch tissue blocks with different sizes, configuring a required flushing device, a disinfection device and an audio-visual device, and simultaneously setting arm operation holes;
The sample treatment assembly is used for fixing and inactivating microorganisms of the taken pathological samples, and the sample conveying assembly conveys the inactivated samples without biological safety hazard to a pathological technical room at the next stage;
The pathology technology chamber comprises a tissue dehydrator, a slicing machine and a dyeing machine device which are arranged in the biological safety cabinet body structure, and the image information is wirelessly uploaded to a monitoring control chamber through a slicing scanning device, and the monitoring control chamber is arranged and summarized to a pathology information analysis center.
Further, the sample pretreatment component, the sample sampling component, the sample treatment component, the sample retention chamber after sampling and the sample conveying component of the viscera sample chamber are sequentially a functional part, an operation part and a control part from top to bottom.
Further, the functional part of the specimen pretreatment component is provided with a negative pressure device, a fixing liquid filling component and a disinfection component, the operation part is a conveyor belt for placing a specimen fixing container, and the control part comprises control buttons for fixing liquid filling and the specimen fixing container;
The control buttons comprise an automatic or manual filling button of the fixed liquid, an automatic or manual control button for disinfection and a timing or manual/automatic conveying button for pretreatment of the specimen, and corresponding indications are arranged above each button.
Further, the functional part of the specimen sampling assembly comprises a sterilizing device, a flushing sensing device, an audio-video device and an anatomic instrument cleaning and accommodating device, and the operating part comprises a plurality of groups of automatic/semi-automatic auxiliary material drawing devices and two arm operating channels;
The flushing sensing device and the instrument cleaning and accommodating device comprise a sensing element and an executing element, the audio and video device is positioned between the sensing element and the executing element, and the automatic/semi-automatic material taking device comprises a parallel section cutting device, a standard size section cutting device and an irregular section cutting device.
Further, the functional part of the sample processing component comprises an inactivation device, a slice sampling sample is placed on a conveyor belt of the operation part, and the control part comprises an inactivation function selection button, a time setting button and a flushing button and is provided with a corresponding indicator lamp;
the inactivating device comprises a liquid filling device and an ultraviolet irradiation device.
Furthermore, the sample conveying component conveys samples through a conveyor belt, the functional part of the sampled sample storage chamber is a fixed liquid filling device and a low-temperature maintaining device, and the sampled sample storage chamber and the viscera sample sampling chamber are conveyed by adopting an annular conveyor belt.
Further, the sample pretreatment assembly, the sample sampling assembly, the sample treatment assembly, the sample storage chamber after sampling and the sample conveying assembly are mutually provided with induction opening and closing windows to realize conduction and sealing, passages are arranged between the opening and closing windows of all stages, and logic between the induction opening and closing windows is that when the next stage of transmission is carried out, the induction transmission door of the next stage is preferentially opened, and after the transmission is completed, the induction opening and closing window of the previous stage is closed, and no reaction is carried out.
It is another object of the present invention to provide the use of a semiautomatic pathology examination negative pressure system for infectious specimens in human infectious disease cadaver pathology dissection.
It is another object of the present invention to provide the use of a semiautomatic pathology examination negative pressure system for infectious specimens in the pathology dissection of experimental animals.
The invention has the beneficial effects that:
The invention relates to an infectious disease pathological anatomy automatic treatment system, which comprises an autopsy room, an organ specimen sampling room, a specimen retention room after sampling, a pathological technology room and a monitoring control room, wherein the autopsy room, the organ specimen sampling room, the pathological technology room and the monitoring control room are sequentially communicated through a pipeline system, the specimen retention room after sampling is connected with the rear side of the organ specimen sampling room, and the pathological anatomy automatic treatment is carried out through a treatment system with an integrated structure;
The invention discloses an viscera specimen sampling chamber which is integrally a closed cabinet body, wherein a specimen pretreatment component, a specimen sampling component, a specimen processing component and a specimen conveying component are communicated through an induction opening and closing window, the operation table surfaces of the components are positioned on the same plane, a conveyor belt is arranged for conveying the processing components, the conveyor belt runs independently, the specimen pretreatment component is used for automatic or manual filling of a fixing liquid and timing or manual/automatic conveying of a pretreated specimen, the specimen sampling component is used for sampling, flushing, disinfecting and shooting the specimen, and is simultaneously provided with an operation channel for manual sampling operation, the specimen processing component is used for carrying out selective inactivation treatment on the sampled specimen, the sample conveying component conveys the inactivated specimen to the next, pathological anatomy is carried out from autopsy, specimen sampling, specimen retention and specimen processing through an integrated automatic pathological anatomy system, and the pathological anatomy sampling is carried out through a closed automatic assembly line mode, and the sample sampling chamber is suitable for pathological anatomy sampling application;
the invention relates to a cadaver dissecting room, an viscera specimen sampling room, a specimen retention room after sampling, a pathology technical room and a monitoring control room, wherein related image data information of a pathology specimen is obtained through related operation of the monitoring control room, meanwhile, the whole system is a pathology dissecting sampling system in an automatic assembly line mode and is in a negative pressure step-by-step closed structure, and is suitable for viscera and tissue pathology examination application;
The invention realizes unidirectional communication of the pathology technical room through the assembly line system and the transmission channel, the negative pressure in each room is gradually reduced to ensure that the internal gas flows in a unidirectional flow mode, the autopsy room and the pathology technical room end are provided with the air inlet and outlet and purifying system to realize unidirectional transportation of specimens and negative pressure, and meanwhile, the design of the air inlet and outlet system and the purifying system can ensure that the gas which enters the system and is discharged from the system is harmless, and also ensure the safety of pathological anatomy of infectious diseases.
Of course, it is not necessary for any one product to practice the invention to achieve all of the advantages set forth above at the same time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of an automated infectious disease pathology processing system according to an embodiment of the present invention;
FIG. 2 is a schematic view of a sample chamber for an organ specimen according to an embodiment of the present invention;
FIG. 3 is a schematic plan view of an organ specimen sampling chamber according to an embodiment of the present invention;
FIG. 4 is a schematic plan view of a sample pretreatment assembly, a sample sampling assembly, a sample processing assembly, and a sample delivery assembly according to an embodiment of the present invention;
FIG. 5 is a schematic view showing the internal structure of the pretreatment module, the specimen sampling module, the sample processing module, and the sample delivery module according to the embodiment of the present invention;
FIG. 6 is a schematic view of a sample sampling assembly according to an embodiment of the present invention;
FIG. 7 is a schematic plan view of a sample-retaining chamber according to an embodiment of the present invention;
FIG. 8 is a flowchart of the operation of an automated infectious disease pathology processing system according to an embodiment of the present invention;
In the drawings, the list of components represented by the various numbers is as follows:
1-autopsy room, 2-organ specimen sampling room, 201-closed cabinet, 202-specimen pretreatment unit, 2021-negative pressure unit, 2022-fixed fluid filling unit, 2023-specimen fixing container, 2024-automatic or manual filling button, 2025-timing or manual/automatic transfer button, 203-specimen sampling unit, 2031-flushing sensing unit, 2032-instrument cleaning and storage unit, 2033-audio and video unit, 2034-operation channel, 2035-automatic/semiautomatic sampling unit, 204-sample processing unit, 2041-liquid filling unit, 2042-ultraviolet irradiation unit, 2043-function selection button, 2044-time setting button, 2045-flushing button, 205-sample delivery unit, 206-conveyor belt, 207-opening and closing window, 208-aisle, 3-post-sampling specimen retention unit, 301-fixed fluid filling unit, 302-low temperature holding unit, 4-pathology control room, 5-monitoring and control room.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
As shown in fig. 1-6
The negative pressure transmission pathology examination full-flow system for the infectious specimens comprises an autopsy room, an organ specimen sampling room, a specimen storage room after sampling, a pathology technology room and a monitoring control room, wherein the autopsy room, the organ specimen sampling room and the pathology technology room are communicated in one direction through a pipeline system and a transmission channel, the negative pressure in each room is gradually reduced to enable the flow direction of internal gas to flow in one direction, the organ specimen sampling room is communicated with the specimen storage room after sampling in two directions through the pipeline system and the transmission channel, the monitoring control room is communicated with each room through a video dialogue system and a remote operation system and uploads graphic information of pathology examination to a pathology data analysis center through a wireless information system, and the autopsy room and the pathology technology room end are provided with an air intake and exhaust and purification system.
A semiautomatic pathology examination negative pressure system for infectious specimens comprises a autopsy room 1, an organ specimen sampling room 2, a specimen storage room 3 after sampling, a pathology technology room 4 and a monitoring control room 5, wherein the autopsy room 1, the organ specimen sampling room 2 and the pathology technology room 4 are communicated unidirectionally through a pipeline system and a transmission channel, the indoor negative pressure is gradually reduced to enable the flow direction of internal gas to flow unidirectionally, the organ specimen sampling room 2 is communicated bidirectionally with the specimen storage room 3 after sampling through the pipeline system and the transmission channel, the monitoring control room 5 is communicated with the rooms through a video dialogue system and a remote operation system and uploads graphic information of pathology examination to a pathology data analysis center through a wireless information system, and the autopsy room and the pathology technology room end are provided with an air inlet and exhaust and purification system.
The exhaust and purification system accords with the national P3 laboratory air inlet and outlet standard, and the air inlet and outlet systems are provided with the purification system
The whole viscera specimen sampling chamber 2 is a closed cabinet body 201, the inside of the closed cabinet body is divided into a specimen pretreatment component 202, a specimen sampling component 203, a specimen treatment component 204 and a specimen conveying component 205 which are communicated with each other, the operation table surfaces of the components are positioned on the same plane and are provided with a conveyor belt 206,
The specimen pretreatment component 202 is used for automatic or manual filling of viscera specimen fixing liquid, specimen code scanning numbering, timing of specimens or manual/automatic conveying;
the specimen sampling component 203 is used for general examination and sampling of specimens, assisting in processing continuous tissue slices with different thicknesses and batch tissue blocks with different sizes, configuring a required flushing device, a disinfection device and an audio-visual device, and simultaneously setting arm operation holes;
The sample processing component 204 is used for fixing and inactivating microorganisms of the taken pathological samples, and the sample conveying component 205 conveys the inactivated biological safety hazard-free samples to the pathological technology room 4 at the next stage;
The pathology technology room 4 comprises a tissue dehydrator, a slicing machine and a dyeing machine device in the biological safety cabinet body structure, and the image information is wirelessly uploaded to the monitoring control room 5 through the slicing scanning device, and the monitoring control room 5 is arranged and summarized to the pathology information analysis center.
The specimen pretreatment unit 202, the specimen sampling unit 203, the specimen processing unit 204, the specimen storage chamber 3 after sampling, and the specimen transport unit 205 of the organ specimen sampling chamber 2 are sequentially a functional unit, an operation unit, and a control unit from top to bottom.
The functional part of the specimen pretreatment component 202 is provided with a negative pressure device 2021 and a fixing solution filling component 2022, the operation part is a conveyor belt 206 for placing a specimen fixing container 2023, and the control part comprises a fixing solution filling and control buttons of the specimen fixing container;
the control buttons include an automatic or manual priming button 2024 for fixative, a timing or manual/automatic transfer button 2025 for pre-treatment of the specimen, and a corresponding indicator light above each button.
The functional parts of the specimen sampling assembly 203 comprise a flushing sensing device 2031, an audio-video device 2033 and an instrument cleaning and accommodating device 2032, and the operation part comprises a plurality of groups of automatic/semi-automatic sampling devices 2035 and two operation channels 2034;
the flushing sensing device 2031 and the instrument cleaning and storing device 2032 comprise sensing elements and executing elements, the audio/video device 2033 is located between the sensing elements and the audio/video device 2035 comprises a parallel cutting device, a standard size slicing device and an irregular slicing device.
The functional part of the sample processing assembly 204 comprises an inactivation device, a slice sample is placed on a conveyor belt 206 of the operation part, and the control part comprises an inactivation function selection button 2043, a time setting button 2044 and a flushing button 2045, and corresponding indicator lamps are arranged;
the inactivating means comprises liquid filling means 2041 and ultraviolet irradiation means 2042.
The sample conveying component 205 conveys samples through a conveyor belt, the functional parts of the sampled sample retaining chamber 3 are a fixed liquid filling device 301 and a low-temperature maintaining device 302, and the sampled sample retaining chamber 3 and the viscera sample sampling chamber 2 are conveyed through an annular conveyor belt.
The sample preprocessing component 202, the sample sampling component 203, the sample processing component 204, the sampled sample reserving chamber 3 and the sample conveying component 205 are mutually provided with induction opening and closing windows to realize conduction and sealing.
The transmission systems among the autopsy room 1, the viscera specimen sampling room 2, the specimen retention room 3 after sampling, the pathology technique room 4 and the monitoring control room 5 are mutually independent;
In the technical scheme of the application, the integrated structure comprises an autopsy room, an organ specimen sampling room, a specimen retention room after sampling, a pathology technology room and a monitoring control room, wherein the autopsy room, the organ specimen sampling room, the pathology technology room and the monitoring control room are sequentially communicated through a pipeline system, the specimen retention room after sampling is connected with the rear side of the organ specimen sampling room, the pathology dissection automatic treatment is carried out through a treatment system of an integrated structure, the parameters of a negative pressure system are required according to relevant national regulations, safety facility equipment, waste liquid and the like are executed according to relevant national standards, the whole system is completely sealed, and the indoor parts of the system are in a negative pressure state and are changed step by step, so that the gas in the indoor parts of the systems can not leak to the outside to cause pollution, and the relevant standards of a secondary or tertiary biological safety protection laboratory can be achieved.
The technical scheme of the application also comprises a ventilation system which accords with the national standard, the inside is in a negative pressure state relatively, the discharge and ventilation are provided with a standard purification system, and a high-efficiency filtration system is arranged, so that high-efficiency filtration is adopted for both air intake and air exhaust, meanwhile, the pressure is ensured to be relatively proper, the relative pressure in the space is between-30 pa and-40 pa, the air cleanliness is between seven and eight levels in GB 50073-2001 clean factory building design specification, the illumination is uniform and not dazzling, and the illumination is not lower than 500lx;
Example 2
The application of a semiautomatic pathological examination negative pressure system for infectious diseases pathological anatomy is provided.
Infectious disease pathology dissection, due to its specificity, is not suitable for corresponding operation compared with common pathology dissection or common pathology dissection room;
The invention relates to an infectious disease pathological anatomy automatic treatment system, which comprises an autopsy room, an organ specimen sampling room, a specimen retention room after sampling, a pathological technology room and a monitoring control room, wherein the autopsy room, the organ specimen sampling room, the pathological technology room and the monitoring control room are sequentially communicated through a pipeline system, the specimen retention room after sampling is connected with the rear side of the organ specimen sampling room, and the pathological anatomy automatic treatment is carried out through a treatment system with an integrated structure;
When pathological anatomy of infectious diseases is performed, autopsy of cadavers is performed from an autopsy room and is transmitted to an organ specimen sampling room for corresponding operation;
the viscera sample chamber adopts a closed cabinet body as a whole, and comprises a sample pretreatment component, a sample sampling component, a sample treatment component and a sample conveying component which are communicated through an induction opening and closing window, wherein the operation table surfaces of the components are positioned on the same plane, and a conveyor belt is arranged for conveying the treatment components, and the conveyor belt runs independently;
the sample pretreatment assembly carries out automatic or manual filling of the fixing liquid and timing or manual/automatic conveying of the pretreated sample through a designed negative pressure device and a fixing liquid filling device, and the filling of the fixing liquid carries out manual or automatic filling of the fixing liquid on the viscera sample placed in the sample fixing container through sensing;
The functional part of the specimen sampling assembly comprises a flushing sensing device, an audio-video device and an instrument cleaning and accommodating device, and the operating part comprises a plurality of groups of automatic/semi-automatic sampling devices and two operating channels;
the automatic/semi-automatic sampling device comprises a parallel section cutting device, a standard size section cutting device and an irregular section cutting device, the section cutting device can carry out section cutting operation with or without specification according to the size of a pathological specimen, the automatic/semi-automatic sampling device can save physical strength and is convenient to operate, then, one part of the pathological specimen after section cutting is transmitted to a specimen storage chamber after sampling for filling and low-temperature maintaining of fixing liquid, and the other part of the pathological specimen is transmitted to a sample processing assembly for carrying out selective inactivation treatment on the sampled specimen;
The inactivation device of the sample processing assembly comprises a liquid filling device and an ultraviolet irradiation device, a slice sample is placed on a conveyor belt of the operation part, the control part comprises an inactivation function selection button, a time setting button and a flushing button, corresponding indicator lamps are arranged, corresponding inactivation operation is carried out through the selection function, and the inactivation operation is further transmitted to the next stage;
pathological anatomy is carried out from autopsy, pathological specimen sampling, specimen retention and specimen treatment through an integrated automatic pathological anatomy system, and the pathological anatomy material is obtained through a closed automatic pipeline mode, so that the method is suitable for pathological anatomy material obtaining application.
Example 3
The application of a semiautomatic pathology examination negative pressure system for infectious specimens in pathology dissection;
Based on the above embodiments, the infectious disease pathology anatomical automatic treatment system of the present invention may be applied to general pathology dissection;
the system is designed for an automatic or semi-automatic system, can adaptively process pathological anatomy specimens, and is convenient to operate.
The invention relates to an infectious disease pathological anatomy automatic treatment system, which comprises an autopsy room, an organ specimen sampling room, a specimen retention room after sampling, a pathological technology room and a monitoring control room, wherein the autopsy room, the organ specimen sampling room, the pathological technology room and the monitoring control room are sequentially communicated through a pipeline system, the specimen retention room after sampling is connected with the rear side of the organ specimen sampling room, and the pathological anatomy automatic treatment is carried out through a treatment system with an integrated structure;
The invention discloses an viscera specimen sampling chamber which is integrally a closed cabinet body, wherein a specimen pretreatment component, a specimen sampling component, a specimen processing component and a specimen conveying component are communicated through an induction opening and closing window, the operation table surfaces of the components are positioned on the same plane, a conveyor belt is arranged for conveying the processing components, the conveyor belt runs independently, the specimen pretreatment component is used for automatic or manual filling of a fixing liquid and timing or manual/automatic conveying of a pretreated specimen, the specimen sampling component is used for sampling, flushing, disinfecting and shooting of the specimen, an operation channel is arranged for manual sampling operation, the specimen processing component is used for carrying out selective inactivation treatment on the sampled specimen, the sample conveying component conveys the inactivated specimen to the next, pathological anatomy is carried out from autopsy, specimen sampling, specimen preservation and specimen processing through an integrated automatic pathological anatomy system, and pathological anatomy sampling is carried out through a closed automatic assembly line mode, and the viscera specimen sampling chamber is suitable for pathological anatomy sampling application.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.