CN113019490A - Micro-current control chip fixing clamp capable of being micro-adjusted - Google Patents
Micro-current control chip fixing clamp capable of being micro-adjusted Download PDFInfo
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- CN113019490A CN113019490A CN202110243150.5A CN202110243150A CN113019490A CN 113019490 A CN113019490 A CN 113019490A CN 202110243150 A CN202110243150 A CN 202110243150A CN 113019490 A CN113019490 A CN 113019490A
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- 239000007788 liquid Substances 0.000 claims abstract description 33
- 238000007789 sealing Methods 0.000 claims description 12
- 238000009434 installation Methods 0.000 claims 1
- 238000002474 experimental method Methods 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 239000012530 fluid Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 2
- 238000002032 lab-on-a-chip Methods 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
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Abstract
本发明公开了一种可微调节的微控流芯片固定夹具，涉及微控流芯片领域，包括上夹板和下夹板，其特征在于，所述上夹板包括基板，所述基板上表面开设滑槽，所述滑槽内滑动连接滑动螺栓，所述基板通过滑动螺栓连接有第一滑动板，所述第一滑动板前段开设T形滑槽，所述T形滑槽内滑动连接有第二滑动板，所述下夹板包括底座，所述底座上开设凹槽，所述凹槽底部开设滑道，所述凹糟中滑动连接有滑动块，本发明的优点在于，通过结构设计使得上夹板和下夹板的液道位置可移动，使得夹具可以适用与多种尺寸的微控流芯片，使用该夹具可以降低的夹具制造成本，提高了实验过程中的便利性。
The invention discloses a micro-adjustable micro-control flow chip fixing fixture, which relates to the field of micro-control flow chips, and includes an upper clamp plate and a lower clamp plate. , sliding bolts are slidably connected in the chute, the base plate is connected with a first sliding plate through the sliding bolts, a T-shaped sliding groove is provided in the front section of the first sliding plate, and a second sliding groove is slidably connected in the T-shaped sliding groove The lower splint includes a base, a groove is set on the base, a slideway is set at the bottom of the groove, and a sliding block is slidably connected in the groove. The advantage of the present invention is that the upper splint and the The position of the liquid channel of the lower splint can be moved, so that the fixture can be applied to micro-control flow chips of various sizes. Using the fixture can reduce the manufacturing cost of the fixture and improve the convenience in the experiment process.
Description
Technical Field
The invention relates to the field of micro-current control chips, in particular to a micro-adjustable micro-current control chip fixing clamp.
Background
Microfluidics (Microfluidics), which refers to the science and technology involved in systems using microchannels (tens to hundreds of microns in size) to process or manipulate tiny fluids (nanoliters to attoliters in volume), is an emerging interdiscipline of chemistry, fluid physics, microelectronics, new materials, biology and biomedical engineering. Because of their miniaturization, integration, etc., microfluidic devices are commonly referred to as microfluidic chips, also known as Lab-on-a-chips (Lab-on-a-chips) and micro-Total Analytical systems (micro-Total Analytical systems). The early concept of microfluidics can be traced back to gas chromatographs fabricated on silicon wafers by photolithography in the 70 s of the 19 th century, and then developed into microfluidic capillary electrophoresis instruments, microreactors and the like. One of the important features of microfluidics is the unique fluid properties in microscale environments, such as laminar flow and droplets. With these unique fluidic phenomena, microfluidics can achieve a range of microfabrication and micromanipulation that are difficult to accomplish with conventional methods. Microfluidics is currently considered to have great development potential and broad application prospects in biomedical research.
At present, the manufacturing cost of the micro-fluidic chip is directly related to the area of the micro-fluidic chip, according to the micro-fluidic chip fixing clamp disclosed in cn201910801183.x, the area of the micro-fluidic chip can be greatly reduced according to the micro-fluidic chip designed by the clamp, but the clamp has a small application range and extremely high requirements on the size of the micro-fluidic chip, when the positions of a liquid inlet and a liquid outlet of the micro-fluidic chip are slightly changed, the clamp cannot be used, and the clamp needs to be manufactured again when the size of the micro-fluidic chip is slightly changed, so that the experiment cost is increased.
Disclosure of Invention
In order to solve the technical problems, the technical scheme provides a micro-regulated micro-control flow chip fixing clamp, and solves the problems that the clamp provided in the background technology is small in application range, extremely high in requirements on the size of the micro-control flow chip, the clamp cannot be used when the position of a liquid inlet and outlet of the micro-control flow chip is slightly changed, the clamp needs to be manufactured again when the size of the micro-control flow chip is slightly changed, and the experiment cost is increased.
In order to achieve the above purposes, the technical scheme adopted by the invention is as follows:
a micro-adjustable micro-current control chip fixing clamp comprises an upper clamp plate and a lower clamp plate, wherein the upper clamp plate comprises a base plate, the upper surface of the base plate is provided with a sliding chute, a sliding bolt is connected in the sliding chute in a sliding manner, the base plate is connected with a first sliding plate through the sliding bolt, the front section of the first sliding plate is provided with a T-shaped sliding chute, the T-shaped sliding chute is connected in the sliding manner with a second sliding plate, the second sliding plate is provided with a threaded through hole, the lower surface of one side of the base plate, away from the first sliding plate, is symmetrically provided with a supporting groove, one side of the base plate, away from the first sliding plate, is provided with a through hole, the through hole;
the lower clamping plate comprises a base, a groove is formed in the base, a slide way is formed in the bottom of the groove, a threaded hole is formed in one end, away from the groove, of the base plate, a sliding block is connected to the groove in a sliding mode, the upper surface of the sliding block is provided with the groove, a liquid flow channel is formed in the groove, a liquid channel threaded hole is formed in one side face of the sliding block, a fixing bolt is connected to the threaded hole in a threaded mode, supporting holes are symmetrically formed in two sides of the threaded hole of the base plate, supporting springs are connected to the supporting holes in a sliding mode, a fixing threaded hole is formed in one end face of the base, and.
Preferably, the upper surface of the first sliding plate is fixedly connected with a threaded column, a shaft hole is formed in the threaded column, a rotating groove is formed in the bottom of the threaded column, a fixing through hole is formed in the position, far away from the T-shaped sliding groove, of the first sliding plate, a sliding bolt is arranged in the fixing through hole, and a nut is connected to the upper end of the sliding bolt in a threaded manner.
Preferably, one end of the second sliding plate is fixedly connected with a T-shaped sliding block, the front end of the T-shaped sliding block is fixedly connected with an upper gear, the upper gear is meshed with an upper gear, and an upper wheel shaft is arranged in the upper gear.
Preferably, the upper wheel shaft is arranged in a shaft hole formed in the threaded column, the middle of the upper wheel shaft is fixedly connected with a positioning block, the positioning block is arranged in the rotating groove, and the surface of the threaded column is in threaded connection with a positioning nut.
Preferably, the bottom parts of the two sides of the sliding block are fixedly connected with track sliding blocks, the bottom part of the sliding block is provided with a sliding groove, the sliding groove is fixedly connected with lower gear teeth, the lower gear teeth are meshed with a lower gear, a lower wheel shaft is arranged in the lower gear, and the lower wheel shaft is rotatably connected with the base.
Preferably, a first luer connector female connector is connected with the through hole and the threaded through hole in a threaded manner, the top of the first luer connector female connector is connected with a first luer connector male connector in a threaded manner, a sealing ring is arranged at the lower end of the first luer connector female connector, a second luer connector female connector is connected with the liquid channel threaded hole in a threaded manner, and the top of the second luer connector female connector is connected with a second luer connector in a threaded manner.
Compared with the prior art, the invention has the beneficial effects that:
the first sliding plate is fixed and slides with the base plate through a sliding bolt, when the micro-current control chip has larger size change, a nut can be unscrewed to enable the first sliding plate to slide in a sliding groove to finely adjust the liquid inlet position, the second sliding plate is meshed with an upper gear, when the micro-current control chip has smaller size change, the liquid inlet position is accurately and finely adjusted through rotating the gear, a positioning block is fixedly connected to an upper wheel shaft, when the liquid inlet position is determined, the nut on a threaded column is screwed to clamp the positioning block to fix the gear, the second sliding plate is further fixed to determine the liquid inlet position, the sliding block is meshed with a lower gear, the rotating gear can achieve the position of a lower liquid inlet in a fine adjustment mode, when the lower liquid inlet position is determined, the sliding block is fixed through screwing the fixing bolt, and the purpose that the clamp can be used by micro-current control chips with similar sizes can be, the special manufacture of clamps for chips with different specifications and sizes is not needed, the experiment cost is reduced, and the convenience of the experiment is greatly improved.
Drawings
FIG. 1 is a schematic perspective view of a micro-fluidic chip fixture according to the present invention;
FIG. 2 is a schematic perspective view of another view of the micro-fluidic chip fixture according to the present invention;
FIG. 3 is a schematic view of a side exploded structure of a micro-fluidic chip mounting fixture according to the present invention;
FIG. 4 is an exploded view of the first slide plate and the second slide plate of the micro flow control chip mounting fixture of the present invention;
FIG. 5 is a front view of an upper clamp plate of the micro-adjustable microfluidic chip mounting fixture in accordance with the present invention;
FIG. 6 is a cross-sectional view of an upper clamp plate of the micro-adjustable microfluidic chip mounting fixture in accordance with the present invention;
FIG. 7 is an elevation view of the upper hub of the micro-adjustable microfluidic chip mounting fixture of the present invention;
FIG. 8 is a schematic bottom perspective view of an upper clamp plate of a micro-fluidic chip mounting fixture according to the present invention;
FIG. 9 is an exploded view of a lower clamp plate of the micro-fluidic chip mounting fixture according to the present invention;
FIG. 10 is a front view of a lower plate of the micro-adjustable microfluidic chip mounting fixture in accordance with the present invention;
FIG. 11 is a front cross-sectional view of a lower clamp plate of the micro-adjustable microfluidic chip mounting fixture in accordance with the present invention;
FIG. 12 is a schematic bottom view of a slider for a micro-fluidic chip fixture according to the present invention.
FIG. 13 is a cross-sectional view of an upper luer fitting of a micro-adjustable microfluidic chip mounting fixture in accordance with the present invention;
fig. 14 is a cross-sectional view of a lower luer fitting of a micro-adjustable chip mounting fixture as provided herein.
The reference numbers in the figures are: 1. a substrate; 101. a through hole; 102. a support groove; 103. a liquid passage through hole; 2. a chute; 3. a sliding bolt; 4. a nut; 5. a first sliding plate; 501. a fixing through hole; 502. a threaded post; 503. A rotating groove; 504. a T-shaped chute; 6. an upper wheel axle; 7. positioning a nut; 8. a second sliding plate; 801. A threaded through hole; 802. a T-shaped slider; 803. upper gear teeth; 9. a luer connector female connector I; 10. a luer connector male connector I; 11. a base; 1101. a support hole; 1102. a threaded hole; 1103. a groove; 1104. a slideway; 1105. fixing the threaded hole; 1106. a gear mounting hole; 12. a slider; 1201. sealing the groove; 1202. A liquid passage threaded hole; 1203. a liquid flow channel; 1204. a sliding groove; 1205. a track slider; 1206. a lower gear tooth; 13. a luer joint female joint II; 14. a luer connector male connector II; 15. a connecting bolt; 16. a lower gear; 17. fixing the bolt; 18. a lower wheel axle; 19. supporting the short spring column; 20. a seal ring; 21. an upper gear.
Detailed Description
The following description is provided to disclose the invention so as to enable one skilled in the art to practice the invention, and the preferred embodiments are provided by way of example only, and other obvious variations will be apparent to those skilled in the art.
Referring to fig. 1-3, an adjustable micro-current control chip clamp comprises an upper clamp plate and a lower clamp plate, wherein the upper clamp plate comprises a base plate 1, a chute 2 is formed in the upper surface of the base plate 1, a sliding bolt 3 is slidably connected in the chute 2, the base plate 1 is connected with a first sliding plate 5 through the sliding bolt 3, a T-shaped chute 504 is formed in the front section of the first sliding plate 5, a second sliding plate 8 is slidably connected in the T-shaped chute 504, a threaded through hole 801 is formed in the second sliding plate 8, a liquid channel through hole 103 is formed in the front section of the base plate 1, the two sliding plates are respectively used under different size adjusting conditions, the first sliding plate 5 can be used for adjusting a larger size, the second sliding plate 8 can be used for fine and accurate position adjustment, and a higher size adjusting accuracy can be achieved;
the lower clamping plate comprises a base 11, a groove 1103 is formed in the base 11, a slide 1104 is formed at the bottom of the groove 1103, a threaded hole 1102 is formed in one end, away from the groove 1103, of the base 11, a sliding block 12 is connected to the groove 1103 in a sliding mode, a sealing groove 1201 is formed in the upper surface of the sliding block 12, a sealing ring 21 is arranged in the sealing groove 1201, a liquid flow channel 1203 is formed in the sealing groove 1201, a liquid flow channel threaded hole 1202 is formed in one side surface of the sliding block, a connecting bolt 15 is connected to the threaded hole 1102 in a threaded mode, supporting holes 1101 are symmetrically formed in two sides of the threaded hole 1102 of the base 11, supporting spring columns 19 are fixedly connected to the supporting holes 1101, a fixing threaded hole 1105 is formed in one end surface of the base 11, a fixing bolt 17 is connected to the fixing threaded hole 1105 in a threaded mode, a gear mounting hole 1106 is formed in the same end surface of the fixing threaded hole of the base 11.
Referring to fig. 4-8, a threaded post 502 is fixedly connected to the upper surface of the first sliding plate 5, a shaft hole is formed in the threaded post 502, a rotating groove 503 is formed at the bottom of the threaded post 502, a fixing through hole 501 is formed in the position of the first sliding plate away from the T-shaped sliding groove 504, a sliding bolt 3 is arranged in the fixing through hole 501, a nut 4 is connected to the upper end of the sliding bolt 3 in a threaded manner, the first sliding plate 5 can move along the sliding groove 2 by loosening the nut 4, the position of the first sliding plate 5 can be fixed by tightening the nut 4, supporting grooves 102 are symmetrically formed in the lower surface of the side of the base plate 1 away from the first sliding plate 5, a through hole 101 is formed in the side of the base plate 1 away from the first sliding plate 5, a connecting bolt 15 is connected to the through hole 101 in a threaded manner, a supporting spring post 19 is slidably connected to the, the clamping of the clamp is more stable;
one end of the second sliding plate 8 is fixedly connected with a T-shaped sliding block 802, the front end of the T-shaped sliding block 802 is fixedly connected with an upper gear tooth 803, the upper gear tooth 803 is meshed with the upper gear 21, an upper wheel shaft 6 is arranged in the upper gear 21, the upper gear tooth 803 is meshed with the upper gear 21, so that the rotation of the upper gear 21 can drive the second sliding plate 8 to move horizontally, the moving speed of the second sliding plate 8 can be adjusted by adjusting the size of the upper gear 21, and further, the second sliding plate 8 can be accurately adjusted, and therefore, the liquid channel position of the upper clamping plate can be adjusted more accurately, and the clamp can better meet the clamping requirements required by an actual experimental chip;
the upper portion shaft 6 is arranged in a shaft hole formed in the threaded column 502, the middle portion of the upper portion shaft 6 is fixedly connected with the positioning block 601, the positioning block 601 is arranged in the rotating groove 503, the surface of the threaded column 502 is in threaded connection with the positioning nut 7, the positioning block 601 plays a role in fixing the upper portion gear 21, when the position of a liquid channel of the upper clamping plate is adjusted to a proper position, the positioning nut 7 is screwed down to press the positioning block 601 tightly to limit the rotation of the upper portion shaft 6, the upper portion gear 21 can be fixed under the fixing of the upper portion shaft 6, and therefore the movement of the second sliding plate 8 is limited to enable the position of the liquid channel to be fixed.
Referring to fig. 9-12, rail sliders 1205 are fixedly connected to the bottoms of the two sides of sliding block 12, a sliding groove 1204 is formed in the bottom of sliding block 12, a lower gear tooth 1206 is fixedly connected to sliding groove 1204, lower gear tooth 1206 is engaged with lower gear 16, lower gear wheel 18 is arranged in lower gear 16, lower gear wheel 18 is rotatably connected to base 11, since the liquid inlet and outlet channel at the lower part of the chip is generally close to the central position, the adjustment of the lower liquid channel is not too large, the position adjustment of the lower liquid channel is completely completed by the cooperation of lower gear 16 and lower gear tooth 1206, when the position of the lower liquid channel is determined, fixing bolt 17 is screwed to press sliding block 12 to fix the position of the lower liquid channel, and the front section of fixing bolt 17 is provided with a rubber washer to achieve better fixing effect.
Referring to fig. 13-14, a first luer connector 9 is screwed into the through hole 103 and the threaded through hole 801, a first luer connector 10 is screwed into the top of the first luer connector 9, a sealing ring 20 is arranged at the lower end of the first luer connector 9, a second luer connector 13 is screwed into the liquid channel threaded hole 1202, and a second luer connector 14 is screwed into the top of the second luer connector 13, wherein the luer connector connected with the through hole 103 is a reference position and is not movable, and the central liquid inlet and outlet of the micro flow control chip is generally aligned with the reference position.
In summary, the present invention has the following advantages that the positions of the fluid passages of the upper clamp plate and the lower clamp plate are movable through the structural design, so that the clamp can be suitable for micro-fluidic chips with various sizes, the position adjustment is performed through the gear engagement, so that the position of the fluid passages is more accurate, and in the actual experiment process, the manufacturing number of the clamp can be reduced, the manufacturing cost of the clamp is reduced, and the convenience of the experiment process is improved.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
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| CN202110243150.5A CN113019490B (en) | 2021-03-05 | 2021-03-05 | Micro-control flow chip fixing clamp capable of being adjusted in micro mode |
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| CN202110243150.5A CN113019490B (en) | 2021-03-05 | 2021-03-05 | Micro-control flow chip fixing clamp capable of being adjusted in micro mode |
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| CN113019490B CN113019490B (en) | 2024-06-07 |
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| CN205731319U (en) * | 2016-06-22 | 2016-11-30 | 辽宁工业大学 | A kind of micro-fluidic chip fixing device |
| CN205761267U (en) * | 2016-07-07 | 2016-12-07 | 辽宁工业大学 | A kind of fixture of micro-fluidic chip |
| CN106582911A (en) * | 2017-01-06 | 2017-04-26 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Detection system and micro-fluidic chip clamp therefor |
| CN107552119A (en) * | 2017-07-14 | 2018-01-09 | 西北工业大学 | Towards the CD formula chip clamping mechanisms of centrifugal microfluidic control |
| CN208177479U (en) * | 2018-03-22 | 2018-12-04 | 广州安方生物科技有限公司 | A kind of microflow control chip clamping device |
| US20200046317A1 (en) * | 2018-08-13 | 2020-02-13 | Howard Hughes Medical Institute | Positioning apparatus and gripping apparatus |
| CN109985679A (en) * | 2019-04-24 | 2019-07-09 | 浙江警察学院 | A multi-channel microfluidic chip clamping system for SPR detector |
| CN210146035U (en) * | 2019-04-24 | 2020-03-17 | 浙江警察学院 | Multichannel micro-fluidic chip clamping system for SPR detector |
| CN210994383U (en) * | 2019-08-06 | 2020-07-14 | 山东远大朗威教育科技股份有限公司 | Clamp and device and system thereof |
| CN110404603A (en) * | 2019-08-28 | 2019-11-05 | 清华大学 | Fixture for a microfluidic chip |
| CN110716036A (en) * | 2019-10-23 | 2020-01-21 | 上海芯像生物科技有限公司 | Biochemical reaction chip and clamp thereof |
| CN110694703A (en) * | 2019-11-13 | 2020-01-17 | 新羿制造科技（北京）有限公司 | Micro-droplet detection chip fixing device |
| CN110841741A (en) * | 2019-12-20 | 2020-02-28 | 凡知医疗科技(江苏)有限公司 | Reversible micro-fluidic chip anchor clamps |
| CN215312481U (en) * | 2021-03-05 | 2021-12-28 | 苏州工业职业技术学院 | Micro-current control chip fixing clamp capable of being micro-adjusted |
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