CN113075176B - Tumor Marker Multiplex Analysis Device - Google Patents

Abstract

The invention belongs to the technical field of medical detection equipment, in particular to a device for multiple analysis of tumor markers. It includes an outer casing, the top of the outer casing is provided with a dust cover, the inside of the outer casing is divided into a test paper detection area and a reagent detection area by a longitudinal partition, and the test paper detection area is provided with a test paper method for detecting tumor markers. A test paper detection component, the reagent detection area is provided with a reagent detection component for detecting tumor markers by a reagent method; the test paper detection component includes a first sample inlet and a test paper placement slot; the reagent detection component includes a second sample injection A port, a shunt quantitative tube, a plurality of detection devices, a second detection stage, a telescopic device, a controller and a display screen. The device of the invention is suitable for test strip detection and reagent detection methods, has a wide range of application, the detection process is automated, can detect different tumor markers simultaneously, realizes multiple detection effects, saves time, and has high detection efficiency.

Description

Tumor marker multiple analysis device

technical field

The invention belongs to the technical field of medical detection equipment, and in particular relates to a multiple analysis device for tumor markers.

Background technique

Tumor markers, also known as tumor markers, refer to substances that are characteristically present in malignant tumor cells, or abnormally produced by malignant tumor cells, or produced by the host in response to tumor stimuli, and can reflect the occurrence and development of tumors. A class of substances that monitor tumor response to therapy. Tumor markers exist in the tissues, body fluids and excreta of tumor patients, and can be detected by immunological, biological and chemical methods.

The detection of tumor markers is mostly through serum or urine detection, and the detection methods include reagent detection method and dipstick detection method. The reagent detection method is to mix the reaction reagent with the sample to be tested to produce products with special properties, such as fluorescent products, which are detected by a detector and finally calculate the content of tumor markers. The test paper detection method refers to attaching a special substance that can bind to tumor markers on the test paper, setting a quality control line and a detection line on the test paper, and comparing the quality control line and the detection line after the sample is injected from the test paper sampling area. The degree of color was used to judge the content of tumor markers. However, due to the different chemical properties of different tumor markers, the target substances that bind to them are also different, so the above methods can only detect one tumor marker at a time, and cannot detect samples containing many tumor markers at the same time, resulting in a high detection efficiency. Low.

There are some devices related to tumor marker analysis in the prior art, such as the blood tumor marker analysis device disclosed in Chinese patent CN211669207U, which includes a seat, and there are grooves on the side walls on both sides of the seat, and the grooves of the two grooves There are rotating shafts between the walls; the device of this patent rotates the dustproof case through the rotating shaft and places the body of the blood testing device in the storage slot, through the first connecting block, the first T-shaped connecting rod, the first spring, the second The combination of the T-shaped connecting rod, the second connecting block and other components fixes the two dust-proof shells to each other and protects the body of the blood testing device from dust, which effectively solves the problem of long-time storage of the blood testing device for general manual testing and analysis. The outside may cause dust to enter the blood testing device or be subject to unexpected shocks, resulting in damage; however, this patent cannot detect multiple tumor markers at the same time, and does not improve the detection efficiency. For another example, a blood tumor marker analysis device disclosed in Chinese patent CN209167322U includes a box body, a control switch group is arranged on one side of the upper surface of the box body, and the input end of the control switch group is electrically connected with the output end of the external power supply. The inner bottom of the body is provided with detection boxes, the number of detection boxes is five and arranged at equal intervals, the inner top of the box is provided with conduits, the number of conduits is not less than five, and the five conduits are connected with the five detection boxes respectively. Correspondingly, the bottom end of the catheter is located directly above the detection box, the upper part of the catheter is provided with a one-way valve, and the upper parts of the five catheters are connected to a cylinder; the patented device can stir the blood and make the tumor markers in the blood uniform Distribution, blood flows into multiple detection boxes, and by putting different types of tumor marker detection cards into multiple detection boxes, multiple tumor markers can be detected, and a variety of tumor diseases can be initially diagnosed at one time. To a certain extent, the detection efficiency is improved; however, the device needs to rely on the one-way valve to control the flow of the test sample. The test samples such as blood and urine are biological pollutants, which are easy to adhere to the one-way valve, which makes the one-way valve difficult. Cleaning and disinfection will cause the subsequent test samples to be easily contaminated by the previous test samples, which will eventually lead to a decrease in the accuracy of the device, and the device lacks detection components suitable for kit detection methods, so it can only be used for test strip detection, resulting in a reduction in its application range.

In summary, it is necessary to develop a tumor marker analysis device with high detection efficiency, low contamination rate and wide application range.

Contents of the invention

In order to solve the above technical problems, the present invention provides a tumor marker multiple analysis device, which has high detection efficiency, low pollution rate and wide application range.

The purpose of the present invention is to provide a multiple analysis device for tumor markers, which includes an outer shell, the top of which is provided with a dustproof cover, and the inside of the outer shell is divided into a test paper detection area and a reagent detection area by a longitudinal partition. The test paper detection area is provided with a test paper detection assembly for the test paper method to detect tumor markers, and the reagent detection area is provided with a reagent detection assembly for the reagent method to detect tumor markers;

The test paper detection assembly includes a first sample inlet and a test paper placement groove, the first sample inlet is fixed on the inner wall of the test paper detection area, the test paper placement groove is located below the first sample inlet and communicates with it, The side wall of the test paper detection area and the test paper placement groove are made of transparent materials;

The reagent detection assembly includes a second sample inlet, a split quantitative tube, a plurality of detection devices, a second detection platform, a telescopic device, a controller, and a display screen; the split quantitative tube includes a A step-shaped shunt pipe inclined downwards, the bottom of each "step" of the shunt pipe is connected with a sample column with a constant volume, and the second detection platform is set at the bottom of the reagent detection area, located at all Below the shunt quantitative tube, the top table of the second detection platform is a ladder shape matching the shape of the split quantitative tube, and each step of the second detection platform is provided with a detection device, so The number of the sample passing column is greater than the number of the detection device, the bottom of the sample passing column at the lowest point is a blind end, and is not connected to the detection device, and the rest of the sample passing columns and the detection device are detachable Connected, the telescopic device is provided on the inner bottom wall of the housing and located in the reagent detection area, and the telescopic device is used to adjust the position of the detection device; the inner bottom of the sample column at the lowest position is provided with a humidity sensor, the controller is located on the outer wall of the housing, the controller is respectively connected to the humidity sensor, the detection device, the telescopic device, and the display screen, and the controller is also connected to a power supply and switch.

Preferably, in the above-mentioned tumor marker multiple analysis device, the detection device includes a light-tight shell, and a sample pool with an arc-shaped cross section is arranged inside the light-tight shell, and the vertical edge of the sample pool is connected to the The inner walls of the light-tight shell are connected by a light-shielding plate. A light emitter is arranged in the area where the convex surface of the sample pool is located, and the light of the light emitter is irradiated to the convex surface of the sample pool. There are detection sensors; the controller is respectively connected with the light emitter and the detection sensor.

Preferably, in the multiple analysis device for tumor markers described above, a light-shielding panel is provided in the area where the concave surface of the sample pool is located, and a detection port is provided on the light-shielding panel, and the probe of the detection sensor is located at the detection port.

Preferably, in the above-mentioned tumor marker multiple analysis device, the light-shielding panel is attached to the concave surface of the sample pool.

Preferably, the above-mentioned tumor marker multiple analysis device, the telescopic device is an electric telescopic rod, which is connected between the bottom of the second detection platform and the bottom of the reagent detection area; the top of the sample pool is equipped with a Pierce the bottom of the sample column with a piercing needle.

Preferably, in the above-mentioned multiplex analysis device for tumor markers, the sample pool is a vacuum pool with detection reagents placed inside.

Preferably, in the above multiple analysis device for tumor markers, the telescopic device is a plurality of horizontal telescopic rods installed on the longitudinal partition, and the multiple horizontal telescopic rods are respectively connected to the controller; except for the lowest Outside the sample passing column, the bottom of the rest of the sample passing columns is a movable sealing plate, and the sides of the sealing plate are fixed on the horizontal telescopic rods one by one. The top of the sample pool is an opening, and the The openings are located directly below their corresponding sample posts.

Preferably, in the above tumor marker multiple analysis device, the test paper detection assembly includes a first sample inlet, a sample dividing tube, a branch tube, a first detection platform and a test paper placement groove; one end of the sample dividing tube is connected to the first The bottom of a sample inlet is connected, and the other end extends downwards obliquely. The tube body and the other end of the sample-dividing tube are connected with the branch pipe, and the first detection platform is arranged at the bottom of the test paper detection area. 1. Located below all the branch pipes, the first test platform is provided with the test paper placement slots, and the branch pipes extend into the corresponding test paper placement slots one by one.

Preferably, in the above tumor marker multiple analysis device, the test paper storage tank includes a tank body with a blind bottom, and a liquid-permeable permeable layer is provided at the opening of the upper end of the tank body.

Preferably, in the above-mentioned tumor marker multiple analysis device, a test paper inlay groove is provided at the bottom of the permeable layer, and a sample introduction area for inlaying test paper is provided in the test paper inlay groove.

Compared with the prior art, the present invention has the following beneficial effects:

1. The test paper detection area of the present invention is provided with a test paper detection assembly for the detection of tumor markers by the test paper method, and a reagent detection assembly for the detection of tumor markers by the reagent method is provided in the reagent detection area. The test strip detection component includes a plurality of branch tubes and test strip placement slots, and if the test strips with different tumor marker detection functions are selected, different tumor markers can be detected through one sample injection. The reagent detection component includes a controller and multiple detection devices, and can also detect different tumor markers. The device of the present invention is suitable for test paper detection and reagent detection methods, has a wide range of applications, and the detection process is automated, and can simultaneously detect different tumor markers, thereby achieving multiple detection effects, saving time, and high detection efficiency.

2. The present invention makes the liquid sample to be tested flow automatically by setting the sample dividing tube and the step-shaped shunt quantitative tube. Only one sample injection operation is required to complete the detection of various tumor markers. The present invention is also realized by setting the controller The automatic detection function reduces the workload of personnel.

3. The present invention provides a permeable layer so that the liquid sample to be tested enters the sample feeding area of the test paper gently, reducing the probability of contamination of the test paper caused by sample splashing.

4. For the arc-shaped sample cell provided by the present invention, the light emitter is irradiated on its convex surface, and the light can enter the sample cell from multiple directions, which can prevent the emitted light from focusing on the detection sensor, and the detection sensor can detect the sample cell in a targeted manner. Internal changes to improve detection accuracy.

Description of drawings

Fig. 1 is a schematic diagram of the structure of the multiple analysis device for tumor markers in Example 1 of the present invention after the dust cover is covered;

Fig. 2 is a schematic diagram of the structure of the multiple analysis device for tumor markers in Example 1 of the present invention after the dust cover is removed;

Fig. 3 is the structural representation of the test paper detection assembly of embodiment 1 of the present invention;

Fig. 4 is the structural representation of the test paper placing groove of embodiment 1 of the present invention;

5 is a schematic structural diagram of the reagent detection component of Example 1 of the present invention;

6 is a schematic structural diagram of a detection device according to Embodiment 1 of the present invention;

7 is a schematic diagram of the concave structure of the light-shielding panel in Embodiment 1 of the present invention;

Fig. 8 is a module connection diagram of Embodiment 1 of the present invention;

Fig. 9 is a schematic structural diagram of a reagent detection component according to Example 2 of the present invention.

Detailed ways

In order to enable those skilled in the art to better understand that the technical solutions of the present invention can be implemented, the present invention will be further described below in conjunction with specific embodiments and accompanying drawings.

In describing the present invention, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", The orientations or positional relationships indicated by "top", "bottom", "inner", "outer", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying References to devices or elements must have a particular orientation, be constructed, and operate in a particular orientation and therefore should not be construed as limiting the invention.

The terms "first" and "second" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of these features; in the description of the present invention, unless otherwise specified, the meaning of "plurality" is two or more.

Example 1

This embodiment provides a tumor marker multiple analysis device, see Figure 1-2, comprising an outer shell 1, the top of the outer shell 1 is covered or hinged with a dust cover 2, and the inside of the outer shell 1 is divided into two parts by a longitudinal partition 3. The test paper detection area 11 and the reagent detection area 12, the test paper detection area 11 is provided with a test paper detection assembly for the detection of tumor markers by the test paper method, and the reagent detection area 12 is provided with a reagent detection assembly for the detection of tumor markers by the reagent method.

Referring to Fig. 3, the test paper detection assembly includes a first sample inlet 4, a sample dividing tube 41, a branch pipe 42, a first detection platform 43 and a test paper placement groove 44; the first sample inlet 4 is fixed on the outer casing by a first fixing plate 1 on the inner wall, or the first sample inlet 4 is fixed on the longitudinal partition 3 through the first fixing plate, the first sample inlet 4 is used to enter the liquid sample to be tested, and one end of the sample dividing tube 41 is connected to the first sample inlet 4. The bottom is connected, and the other end extends obliquely downward. The tube body of the sample dividing tube 41 and the other end thereof are connected with a branch pipe 42. The number of branch pipes 42 is at least one. Since the sample dividing tube 41 starts from the first The mouth 4 is set downwards, so the liquid sample to be tested can be quickly shunted into each branch pipe 42 under the action of gravity; the first detection platform 43 is set at the bottom of the test paper detection area 11 of the outer shell 1, and is located in all the branch pipes 42 Below, the first testing platform 43 is provided with a test paper placement groove 44, and the quantity of the test paper placement groove 44 is equal to the quantity of the branch pipes 42, and the branch pipes 42 extend into the test paper placement grooves 44 of corresponding positions one by one, and the test paper placement grooves 44 is used for placing the detection test paper that can detect tumor markers. The liquid sample to be tested flowing through the branch pipe 42 enters the test paper placement groove 44 and is detected by the detection test paper in the corresponding area. The process of detecting tumor markers with test strips has been completed. The side wall of the outer casing 1 located in the test paper detection area 11 and the test paper placement groove 44 are made of transparent materials, so that the test results can be observed from the outside. Since multiple branch tubes 42 and test paper slots 44 are provided in this embodiment, different tumor markers can be detected through one sample injection by selecting detection test papers with different tumor marker detection functions.

Preferably, referring to Fig. 4, the structure of the test paper placing groove 44 includes a groove body 441 with a blind end at the bottom, the groove body 441 is a longitudinal groove or an inclined groove, the inside of the groove body 441 is used to place detection test paper, and the upper opening of the groove body 441 is covered Or be inlaid with the permeable layer 442 that can permeate liquid, and the permeable layer 442 can adopt sponge layer or sterile cotton layer; The mosaic groove 443, the test paper mosaic groove 443 is provided with a sample introduction area for inlaying and contacting the test paper, the sample to be tested gradually penetrates or is chromatographically penetrated into the sample introduction area of the test paper through the permeable layer 442, and further on the upper layer of the test paper Analyze penetration to the end of the test strip.

Referring to Figures 5-8, the reagent detection assembly of this embodiment includes a second sample inlet 5, a split quantitative tube 51, a plurality of detection devices, a second detection platform 52, a telescopic device, a controller and a display screen 53; the second sample injection The port 5 is fixed on the inner wall of the outer casing 1 through the second fixing plate, or the second sample inlet 5 is fixed on the longitudinal partition 3 through the second fixing plate, and the split quantitative tube 51 includes a downward direction from the second sample inlet 5. An inclined step-shaped shunt tube, the shunt tube includes multiple "steps", the bottom of each "step" of the shunt tube is connected to a sample column with a constant volume, and the top surface of the sample column and each "step" The bottom is flush, so that the sample column is filled with the liquid sample to be tested, and then it will automatically flow into the next sample column, and the bottom of the sample column can be pierced by a puncture needle. The second detection platform 52 is arranged on the outer shell The bottom of the reagent detection area 12 of 1 is located below all the split quantitative tubes 51. The top platform of the second detection platform 52 is a ladder shape matching the shape of the split quantitative tubes 51. Each step of the second detection platform 52 is equipped with One detection device, the number of detection devices is less than the number of sample passing columns, and the bottom end of the lowest sample passing column is a blind end, and the detection device is not connected, and the remaining sample passing columns are detachably connected to the detection devices. On the inner bottom wall of the outer casing 1, a telescopic device is arranged in the reagent detection area 12. In this embodiment, the telescopic device is used to adjust the height of the detection device. The telescopic device is an electric telescopic rod 55, and its fixed end is installed on the outer shell On the inner bottom wall of the body 1, it is located in the reagent detection area 12, and the movable end is installed on the bottom of the second detection platform 52. By adjusting the height of the detection device, the sample column of the split flow quantitative tube 51 can be communicated with the detection device, and the The test liquid sample is delivered to the detection device, and the tumor markers therein are detected by the detection device, and the detection result is displayed on the display screen 53 .

The principle of reagent detection of tumor markers is that the combination of tumor markers and detection reagents produces special biochemical properties that can be detected, such as special colors or fluorescent properties, and then the detector is used to detect changes in this biochemical property, and finally the tumor markers are calculated. substance content. The most common is that the reaction product generates fluorescence after being irradiated with ultraviolet light, and the fluorescence intensity change is detected by a fluorescence detection sensor, and finally the content of the tumor marker is calculated to realize the quantification of the tumor marker. Therefore, referring to Fig. 6-7 for the structure of the detection device in this embodiment, it includes a light-tight casing 54, which is cylindrical or elliptical, and is provided with an arc-shaped cross section inside the light-tight casing 54. The sample pool 541, the sample pool 541 is used to receive the liquid sample to be tested in the shunt tube, the inside of the sample pool 541 is a vacuum and is found to have added a detection reagent, the top of the sample pool 541 is provided with a puncture needle, and the outer wall of the sample pool 541 and the light-proof A distance of 1-10 cm is left between the inner walls of the shells 54, and the vertical edge of the sample cell 541 is connected with the inner walls of the light-tight shell 54 through a light-shielding plate 542, and the light-shielding plate 542 divides the light-tight shell 54 into a light emission area and a light-tight shell 54. The result receiving area, the area where the convex surface of the sample cell 541 is located is a light emitting area, and a light emitter 543 is arranged in the light emitting area, and the light emitter 543 can be an ultraviolet light emitter, a laser emitter, an X-ray emitter, a white light emitter, etc. , the light from the light emitter 543 irradiates the convex surface of the sample pool 541, so that the substance in the sample pool 541 presents fluorescence or other reactions, the concave surface of the sample pool 541 is located in the result receiving area, and a detection sensor is also arranged in the result receiving area. Detect the detection sensor model of the result; For example, if the light emitter 543 adopts an ultraviolet light emitter to excite the substance in the sample pool 541 to generate fluorescence, then the detection sensor adopts a fluorescence detection sensor; if the light emitter 543 adopts a white light emitter to illuminate When the color of the substance in the sample cell 541 changes, the detection sensor adopts a color detection sensor.

A humidity sensor is arranged at the inner bottom of the sample passing column at the lowest point, and the sample passing column at the lowest point is used as a buffer, and it is not connected to a detection device. , the detection sensor, the telescopic device, and the display screen 53 are connected, the controller is also connected with a power supply for supplying power to the equipment, and the controller is also connected with a switch for controlling whether the detection operation is carried out. Refer to Figure 8 for the module connection diagram. The specific working principle is as follows: when the switch is turned on, the components such as the controller and the expansion device are in the waiting state, and the liquid sample to be tested is added to the second sample inlet 5, and the liquid sample to be tested flows through the split quantitative tube under the action of gravity Each sample passing column of 51, since what we set is the step-shaped split quantitative tube 51, the volume of the liquid sample to be tested added in each sample passing column is constant, and the volume of different sample passing columns can be set as required. 10 microliters, 50 microliters, 100 microliters, 200 microliters, etc., the split quantitative tube 51 can be set to be detachable and clamped on the second fixed plate, and the split quantitative tube 51 of different specifications can be replaced to realize detection without reagents Injection requirements. When the humidity sensor in the lowest sample passing column detects a signal, it means that all the sample passing columns above it are filled with the liquid sample to be tested, and the humidity sensor transmits the signal to the controller, and the controller controls the display screen 53 to display "plus". If the signal is “full”, the sample addition will be manually stopped, and the excess liquid sample to be tested in the shunt tube will enter the lowest sample passing column. After that, the controller will control the telescopic device to work, so that the second detection platform 52 and the detection device will move up, and the The puncture needle pierces the bottom of the corresponding sample column, and the liquid sample to be tested enters the sample pool 541 under the action of vacuum, and after a period of reaction t, the controller controls the light emitter 543 to emit corresponding light, and then the detection sensor will detect The signal is transmitted to the controller for processing, and the final processing result is displayed on the display screen 53, and the operator watches the detection result through the display screen 53. Note that the time t is designed according to the chemical reaction requirements, such as 5-60 minutes.

The detection methods of the above-mentioned test paper detection component and reagent detection component are suitable for test paper detection and reagent detection methods, and have a wide range of applications. The detection process is automated, and different tumor markers can be detected at the same time, achieving multiple detection effects and saving time. efficient.

The arc-shaped sample cell 541 provided by the present invention, when the light emitter 543 is irradiated on its convex surface, under the results of light scattering, refraction, reflection, etc., the light can enter the sample cell 541 from multiple directions, even if the light penetrates The strong force can also prevent the emitted light from focusing on the detection sensor, so the detection sensor can detect the internal changes of the sample cell 541 in a targeted manner, and improve the detection accuracy. In order to further improve the detection accuracy, a light-blocking panel 544 is provided in the receiving area. Preferably, the light-blocking panel 544 is attached to the concave surface of the sample pool 541, and the light-blocking panel 544 is provided with a detection port 5441, and the probe of the detection sensor is located at the detection port. 5441, then it can avoid interferences such as light refraction in other positions in the light emitter 543 and the sample cell 541.

Example 2

A multiple analysis device for tumor markers in this embodiment has basically the same structure as that in Embodiment 1, the difference is that the telescopic device is a plurality of horizontal telescopic rods 56, and the fixed ends of the horizontal telescopic rods 56 are installed on the longitudinal partition 3. Two horizontal telescopic rods 56 are respectively connected with the controller, except the sample passing column at the lowest place, the bottom of the remaining sample passing columns is a movable sealing plate, and the sides of the sealing plate are fixed on the movable ends of the horizontal telescopic rods 56 one by one. The top of the pool 541 is an opening, and the opening is located directly below its corresponding sampling column. Before sample injection, the sealing plate is located directly under the sample column, and seals the bottom of the sample column so that it does not leak. As the sample injection process progresses, when the humidity sensor in the lowest sample column detects a signal , it means that all the sample columns above it are filled with the liquid samples to be tested, the humidity sensor transmits the signal to the controller, and the controller controls the display screen 53 to display the "filling up" signal, then manually stop adding samples, and the excess liquid in the shunt tube The liquid sample to be tested enters the lowest part of the sample column, and then the controller controls the telescopic device to work, so that the sealing plate moves in the direction of the longitudinal partition 3, the bottom of the sample column is opened, and the liquid sample to be tested inside falls into the sample. Pool 541 inside.

Since some tumor marker detection reagents are added to the sample pool 541 in batches, the structure of this embodiment does not require a vacuum sample pool 541, and the reagents can be added to the sample pool 541 multiple times. After mixing, the detection device is placed The above-mentioned detection work is carried out again on the second detection platform 52 steps.

It should be noted that the connection relationship of components not specifically mentioned in the present invention adopts the prior art by default. Since it does not involve the invention point and is commonly used in the prior art, the structural connection relationship will not be described in detail.

It should be noted that when the present invention involves a numerical range, it should be understood that the two endpoints of each numerical range and any value between the two endpoints can be selected. Since the steps and methods adopted are the same as those in the embodiments, in order to avoid repeating , the invention describes preferred embodiments. While preferred embodiments of the present invention have been described, additional changes and modifications can be made to these embodiments by those skilled in the art once the basic inventive concept is appreciated. Therefore, it is intended that the appended claims be construed to cover the preferred embodiment as well as all changes and modifications which fall within the scope of the invention.

Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention also intends to include these modifications and variations.

Claims (9)

1. Tumor marker multiple analysis device, comprising an outer shell (1), the top of the outer shell (1) is provided with a dust cover (2), it is characterized in that, the inside of the outer shell (1) passes through a longitudinal partition ( 3) Divided into a test paper detection area (11) and a reagent detection area (12), the test paper detection assembly for detecting tumor markers by the test paper method is arranged in the test paper detection area (11), and the reagent detection area (12) is A reagent detection component for detecting tumor markers by the reagent method is provided; The test paper detection assembly includes a first sample inlet (4) and a test paper placement groove (44), the first sample inlet (4) is fixed on the inner wall of the test paper detection area (11), and the test paper placement groove ( 44) located below the first sample inlet (4) and communicated with it, the side wall of the test paper detection area (11) and the test paper placement groove (44) are made of transparent materials; The reagent detection assembly includes a second sample inlet (5), a split quantitative tube (51), a plurality of detection devices, a second detection platform (52), a telescopic device, a controller and a display screen (53); the split flow The quantitative tube (51) includes a step-shaped shunt pipe inclined downward from the second sample inlet (5), and each "step" bottom of the shunt pipe is communicated with a constant-volume sample column, The second detection station (52) is arranged at the inner bottom of the reagent detection area (12) and below all the split quantitative tubes (51), and the top table of the second detection station (52) is connected to the split flow The stepped shape of the quantitative tube (51) is matched in shape, and each step of the second detection platform (52) is provided with a detection device, and the number of the sample passing columns is greater than the number of the detection devices, The bottom end of the sample passing column at the lowest position is a blind end, and is not connected to the detection device, and the rest of the sample passing columns are detachably connected to the detection device. On the inner bottom wall of the outer casing (1), The telescopic device is located in the reagent detection area (12), and the telescopic device is used to adjust the position of the detection device; a humidity sensor is provided at the bottom of the sample column at the lowest point, and the controller is located at On the outer wall of the outer casing (1), the controller is respectively connected to the humidity sensor, the detection device, the telescopic device, and the display screen (53), and the controller is also connected to a power supply and a switch . 2. The tumor marker multiple analysis device according to claim 1, characterized in that, the detection device comprises a light-tight shell (54), and the light-tight shell (54) is provided with a cross-section that is arc-shaped The sample pool (541), the vertical edge of the sample pool (541) is connected with the inner wall of the light-tight shell (54) through a light shield (542), and the convex surface of the sample pool (541) is located in the region A light emitter (543) is provided, and the light of the light emitter (543) is irradiated to the convex surface of the sample pool (541), and a detection sensor is arranged in the area where the concave surface of the sample pool (541) is located; the controller respectively connected with the light emitter (543) and the detection sensor. 3. The multiple analysis device for tumor markers according to claim 2, characterized in that, a light-shielding panel (544) is arranged in the region where the concave surface of the sample pool (541) is located, and a light-shielding panel (544) is provided on the light-shielding panel (544). There is a detection port (5441), and the probe of the detection sensor is located at the detection port (5441). 4. The tumor marker multiple analysis device according to claim 3, characterized in that, the light-shielding panel (544) is attached to the concave surface of the sample pool (541). 5. The multiple analysis device for tumor markers according to claim 2, characterized in that, the telescopic device is an electric telescopic rod (55), which is connected to the bottom of the second detection platform (52) and detects the reagents. Between the inner bottom of the zone (12); the top of the sample pool (541) is provided with a puncture needle capable of piercing the bottom of the sample passing column. 6. The tumor marker multiple analysis device according to claim 5, characterized in that, the sample pool (541) is a vacuum pool with detection reagents placed inside. 7. The tumor marker multiple analysis device according to any one of claims 1-6, characterized in that, the test paper detection assembly comprises a first sample inlet (4), a sample dividing tube (41), a branch tube ( 42), the first detection platform (43) and the test paper placement groove (44); one end of the sample dividing tube (41) communicates with the bottom of the first sample inlet (4), and the other end extends obliquely downwards, so that The tube body and the other end of the sample-dividing tube (41) are connected with the branch tube (42), and the first detection platform (43) is arranged at the inner bottom of the test paper detection area (11) and is located at all Below the branch pipes (42), the first detection platform (43) is provided with the test paper placement slots (44), and the branch pipes (42) extend into the corresponding positions one by one to place the test papers. In the groove (44). 8. The multiple analysis device for tumor markers according to claim 7, characterized in that, the test paper placement groove (44) comprises a groove body (441) with a blind end at the bottom, and an opening at the upper end of the groove body (441) is set There is a permeable layer (442) permeable to liquid. 9. The tumor marker multiple analysis device according to claim 8, characterized in that, the bottom of the permeable layer (442) is provided with a test paper mosaic groove (443), and the test paper mosaic groove (443) is provided with a Injection area for test strips.

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