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CN113166974A - 一种生物芯片及其制备方法与应用 - Google Patents

一种生物芯片及其制备方法与应用 Download PDF

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Publication number
CN113166974A
CN113166974A CN201980082590.8A CN201980082590A CN113166974A CN 113166974 A CN113166974 A CN 113166974A CN 201980082590 A CN201980082590 A CN 201980082590A CN 113166974 A CN113166974 A CN 113166974A
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chip
biochip
reaction
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reagent
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CN113166974B (zh
Inventor
汪建
徐讯
汪军
沈玥
倪鸣
章文蔚
王勇
江湘儿
黄小罗
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Shenzhen Huada Technology Holding Group Co ltd
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BGI Shenzhen Co Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B01J2219/00549—2-dimensional
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

一种化学修饰的可识别的生物芯片，其制备方法和应用。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201980082590.8A 2018-12-12 2019-12-11 一种生物芯片及其制备方法与应用 Active CN113166974B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811514682 2018-12-12
CN2018115146822 2018-12-12
PCT/CN2019/124473 WO2020119706A1 (zh) 2018-12-12 2019-12-11 一种生物芯片及其制备方法与应用

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CN113166974A true CN113166974A (zh) 2021-07-23
CN113166974B CN113166974B (zh) 2024-04-05

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US (1) US20220395799A1 (zh)
EP (1) EP3907293B8 (zh)
JP (1) JP7375998B2 (zh)
CN (1) CN113166974B (zh)
AU (1) AU2019395588B2 (zh)
CA (1) CA3123119A1 (zh)
DK (1) DK3907293T3 (zh)
SG (1) SG11202106282RA (zh)
WO (1) WO2020119706A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114682309A (zh) * 2020-12-29 2022-07-01 深圳华大生命科学研究院 芯片、制备芯片的方法及芯片的用途
CN115386965A (zh) * 2022-08-30 2022-11-25 上海交通大学 基于空间交错编码多组学芯片及其制备方法与应用
WO2024065585A1 (zh) * 2022-09-30 2024-04-04 深圳华大生命科学研究院 生物芯片及其使用和制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113096507A (zh) * 2021-03-19 2021-07-09 北京龙迈达斯科技开发有限公司 一种教学芯片及其制备方法
CN113092218A (zh) * 2021-03-19 2021-07-09 北京龙迈达斯科技开发有限公司 一种教学芯片及其制备方法
CN112986556B (zh) * 2021-05-12 2022-02-18 佛山微奥云生物技术有限公司 一种用于快速检测的芯片及其加工方法
WO2025073263A1 (zh) * 2023-10-07 2025-04-10 深圳华大生命科学研究院 生物芯片及其制备方法与应用

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WO2002096552A2 (en) * 2001-06-01 2002-12-05 Scientific Generics Limited Biochip and apparatus and methods for its manufacture and use
US20030162185A1 (en) * 1999-12-07 2003-08-28 Oleg Melnyk Products comprising a support to which nucleic acids are fixed and their use as dna chips
US20030203369A1 (en) * 2002-04-30 2003-10-30 Leproust Eric M. Micro arrays with structured and unstructured probes
US20040039532A1 (en) * 2000-01-26 2004-02-26 Bass Jay K. Feature quality in array fabrication
US20040132005A1 (en) * 2002-09-10 2004-07-08 Jing-Hsiang Hsu Method of forming biochip and application thereof
US20040152081A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Viscosity control during polynucleotide synthesis
WO2004068104A2 (en) * 2003-01-24 2004-08-12 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target activated microtransfer
US20050100905A1 (en) * 2002-02-13 2005-05-12 Centre National De La Recherche Scientifique (Cnrs Novel method for production of dna biochips and applications thereof
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US20040039532A1 (en) * 2000-01-26 2004-02-26 Bass Jay K. Feature quality in array fabrication
WO2002096552A2 (en) * 2001-06-01 2002-12-05 Scientific Generics Limited Biochip and apparatus and methods for its manufacture and use
US20050100905A1 (en) * 2002-02-13 2005-05-12 Centre National De La Recherche Scientifique (Cnrs Novel method for production of dna biochips and applications thereof
US20030203369A1 (en) * 2002-04-30 2003-10-30 Leproust Eric M. Micro arrays with structured and unstructured probes
US20040132005A1 (en) * 2002-09-10 2004-07-08 Jing-Hsiang Hsu Method of forming biochip and application thereof
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CN102230003A (zh) * 2011-06-03 2011-11-02 中国人民解放军南京军区福州总医院 一种临床检测用适配子信标-液态芯片
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114682309A (zh) * 2020-12-29 2022-07-01 深圳华大生命科学研究院 芯片、制备芯片的方法及芯片的用途
CN114682309B (zh) * 2020-12-29 2024-04-09 深圳华大生命科学研究院 芯片、制备芯片的方法及芯片的用途
CN115386965A (zh) * 2022-08-30 2022-11-25 上海交通大学 基于空间交错编码多组学芯片及其制备方法与应用
CN115386965B (zh) * 2022-08-30 2025-08-29 上海交通大学 基于空间交错编码多组学芯片及其制备方法与应用
WO2024065585A1 (zh) * 2022-09-30 2024-04-04 深圳华大生命科学研究院 生物芯片及其使用和制备方法

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Publication number Publication date
AU2019395588B2 (en) 2023-11-09
EP3907293B1 (en) 2025-08-13
JP2022514227A (ja) 2022-02-10
EP3907293B8 (en) 2025-09-24
CN113166974B (zh) 2024-04-05
US20220395799A1 (en) 2022-12-15
EP3907293A1 (en) 2021-11-10
SG11202106282RA (en) 2021-07-29
WO2020119706A1 (zh) 2020-06-18
AU2019395588A1 (en) 2021-07-22
JP7375998B2 (ja) 2023-11-08
EP3907293A4 (en) 2022-04-06
DK3907293T3 (da) 2025-10-06
CA3123119A1 (en) 2020-06-18

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