CN113616324A - Matrix type pulsed electric field ablation catheter - Google Patents
Matrix type pulsed electric field ablation catheter Download PDFInfo
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- 238000002679 ablation Methods 0.000 title claims abstract description 101
- 230000005684 electric field Effects 0.000 title claims abstract description 65
- 239000011159 matrix material Substances 0.000 title abstract description 11
- 230000010412 perfusion Effects 0.000 claims description 27
- 230000002262 irrigation Effects 0.000 claims description 7
- 238000003973 irrigation Methods 0.000 claims description 7
- 230000007704 transition Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 14
- 210000001519 tissue Anatomy 0.000 description 22
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
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Abstract
The invention discloses a matrix type pulse electric field ablation catheter, comprising: a first catheter having a lumen therein; the ablation assembly is arranged at the distal end of the first catheter and comprises a plurality of splines, at least one electrode is arranged on each spline, and the splines are located on the same plane. According to the ablation catheter, the plurality of splines are located on the same plane, a large-area sheet-shaped ablation electric field can be formed, tissues to be ablated are fully covered, and the ablation effect is better in ablation of tissues with larger areas.
Description
Technical Field
The invention relates to a matrix type pulsed electric field ablation catheter.
Background
Irreversible electroporation (IRE) is a rapidly developing and FDA-approved treatment for solid tumors. IRE may be a promising approach for cardiac Ablation, especially in comparison to RF, where it can produce lesions without the consequences of thermal damage, i.e. the ability to preserve surrounding tissue structure, such voltage pulses are more commonly referred to in the art as Pulsed Field Ablation (PFA). Most basket-shaped pulse ablation catheters deliver a pulse electric field which is approximately spherical, and for the ablation of tissues with larger areas (such as the ablation of large areas of epicardium or tumors), the coverage of the pulse electric field is insufficient, and the ablation effect is poor.
Disclosure of Invention
According to one aspect of the present invention, there is provided a matrix-type pulsed electric field ablation catheter comprising:
a first catheter having a lumen therein;
the ablation assembly is arranged at the distal end of the first catheter and comprises a plurality of splines, at least one electrode is arranged on each spline, and the splines are located on the same plane.
According to the ablation catheter, the plurality of splines are located on the same plane, a large-area sheet-shaped ablation electric field can be formed, tissues to be ablated are fully covered, and the ablation effect is better in ablation of tissues with larger areas.
In some embodiments, the spline comprises a first section of tubing, a second section of tubing, and a third section of tubing connected in series from a distal end to a proximal end; the second lengths of the plurality of splines are substantially parallel to each other.
Therefore, the second section of the tubes of the plurality of splines are arranged in a substantially parallel mode, the generated pulse electric field is in a matrix shape, the shape of the pulse electric field is more standard, and the coverage area is larger.
In some embodiments, the distal ends of the first length of tubing of the plurality of splines are all connected together; the proximal ends of the third sections of tubing are all connected to the distal end of the first catheter.
In some embodiments, the junction of the first and second lengths of pipe and the second and third lengths of pipe is in an arc transition.
Thus, providing an arcuate transition can prevent/reduce trauma to the tissue by the ablation catheter.
In some embodiments, the electrode covers 1/3-1/2 of the lateral surface of the spline, and the plurality of spline upper electrodes are all facing the same side.
This can avoid the discharge to the air (discharge to other direction than the tissue) and reduce the generation of bubbles. The current flowing through the area is smaller, and the stimulation of the pulse electric field to the nerve and skeletal muscle of the patient can be reduced.
In some embodiments, the electrode is a ring electrode that fits around the outside of the spline.
In some embodiments, the number of the electrodes disposed on each spline is three, and the three electrodes are respectively a first electrode, a second electrode and a third electrode which are disposed on the second section of the tube at intervals.
Therefore, the electrodes are arranged on the second section of tubes which are parallel to each other, so that the generated pulse electric field is in a matrix shape, the shape of the pulse electric field is more standard, and the coverage area is larger.
In some embodiments, when the first electrode on the same spline is configured to a first polarity, the second and third electrodes are configured to a second polarity opposite the first polarity; or
When the first and third electrodes on the same spline are configured in a first polarity, the second electrode is configured in a second polarity opposite the first polarity; or
When the third electrode on the same spline is configured to a first polarity, the first and second electrodes are configured to a second polarity opposite the first polarity.
Thus, by arranging the three electrodes with different polarities, a longitudinal pulsed electric field can be generated, and the position of the ablation assembly with the strongest electric field strength in the longitudinal direction can be changed to adapt to the ablation needs of different tissues or different diseases.
In some embodiments, the polarity of the first electrode on two adjacent splines is opposite, and/or the polarity of the second electrode on two adjacent splines is opposite, and/or the polarity of the third electrode on two adjacent splines is opposite.
Therefore, a transverse pulse electric field can be generated, a matrix type sheet ablation electric field can be formed together with a longitudinal pulse electric field, the coverage area is large, and the ablation effect is good.
In some embodiments, the first electrodes on the plurality of splines are laterally aligned, and/or the second electrodes on the plurality of splines are laterally aligned, and/or the third electrodes on the plurality of splines are laterally aligned.
Therefore, the electrodes are arranged in order, the shape of the generated pulse electric field is more regular, and the tissue to be ablated can be better covered.
In some embodiments, the electrode is provided with a perfusion hole, and the spline is internally provided with a perfusion cavity which is communicated with the perfusion hole.
Therefore, the conductive liquid (physiological saline) can be poured into the lumen of the human body from the pouring hole on the electrode, so that the conductivity is enhanced, the distribution of the pulse electric field is enhanced, and the ablation effect is ensured.
In some embodiments, a plurality of perfusion tubes are arranged in the first conduit, and each perfusion tube is communicated with a perfusion cavity inside one spline.
Thus, all electrodes on each spline share one infusion tube for conducting the conductive liquid.
In some embodiments, the perfusion pores have a pore size of 0.05mm to 0.15 mm.
In some embodiments, the number of splines is 2-6.
Drawings
FIG. 1 is a partial perspective view of a matrix-type pulsed electric field ablation catheter in accordance with a first embodiment of the present invention;
FIG. 2 is a partial front view of a matrix-type pulsed electric field ablation catheter in accordance with a first embodiment of the present invention;
FIG. 3 is a partial perspective view of a matrix-type pulsed electric field ablation catheter in accordance with a second embodiment of the present invention;
FIG. 4 is a schematic partial cross-sectional view of a spline of a matrix-type pulsed electric field ablation catheter according to a second embodiment of the present invention;
fig. 5 is a schematic partial cross-sectional view of a first catheter of a matrix-type pulsed electric field ablation catheter according to a second embodiment of the invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Fig. 1 schematically shows a matrix type pulsed electric field ablation catheter according to an embodiment of the present invention, which is connected to a tissue ablation device (not shown in the drawings), wherein the ablation device performs ablation by releasing the pulsed electric field to cause irreversible electric breakdown damage to tissue cells, thereby achieving a therapeutic effect.
First, as shown in fig. 1 and 2, an ablation catheter includes a first catheter 100 and an ablation assembly 200.
A first catheter 100 having a proximal end and a distal end and having a lumen therein, the first catheter 100 having a proximal end connected to a control handle (not shown) of the ablation device and a distal end opposite the first catheter 100 along its longitudinal axis; specifically, the first catheter 100 is an elongated flexible hollow tube that is capable of bending to navigate the tortuous path of the patient's vasculature, and the proximal end of the first catheter 100 is attached to a control handle that controls the direction of bending/curving. The transverse cross-sectional shape of the first catheter 100 is preferably circular, and may be various geometric shapes such as an elliptical ring, a semi-elliptical ring, a square ring, etc., as long as the first catheter 100 has a lumen therethrough.
As shown in fig. 1 and 2, an ablation assembly 200 is disposed at the distal end of the first catheter 100, the ablation assembly 200 including a plurality of splines 210, each spline 210 having at least one electrode 220 disposed thereon, the electrode 220 being configured to deliver a pulsed electric field to tissue to effect ablation. The plurality of splines 210 of the ablation assembly 200 are all bar-shaped objects, and the splines 210 are made of shape memory materials, that is, the splines 210 have certain flexibility, and the shape thereof can be changed under the action of external force, but after the external force is removed, the splines 210 can return to the original shape, and under the condition of no external force, the plurality of splines 210 of the ablation assembly 200 are on the same plane.
Each spline 210 comprises a first section of tube 211, a second section of tube 212 and a third section of tube 213 which are sequentially connected from the far end to the near end, the second sections of tubes 212 of the plurality of splines 210 are approximately parallel and are approximately parallel to the longitudinal axis of the first catheter 100, and the second sections of tubes 212 of the plurality of splines 210 are approximately parallel, so that the generated pulse electric field is in a matrix shape, the shape of the pulse electric field is more standard, and the coverage area is larger.
The distal ends of the first length of tubing 211 of the plurality of splines 210 are all connected to one side, and in particular, the connection may be achieved by a distal cap 230, that is, the distal ends of the first length of tubing 211 are all connected to the distal cap 230; alternatively, the distal end cap 230 may not be provided, and the distal ends of the plurality of first tubes 211 may be directly affixed. The third length of tubing 213 of the plurality of splines 210 is connected to the distal end of the first catheter 100, thereby securing the entire ablation assembly 200 to the first catheter 100, specifically by snapping, gluing, etc.
The joints of the first tube section 211 and the second tube section 212, and the second tube section 212 and the third tube section 213 of each spline 210 are in arc transition, and arc transition is arranged to prevent/reduce the trauma of the ablation catheter to the tissue.
The first, second and third lengths of tubing 211, 212, 213 may be integrally formed, i.e., the entire spline 210 is directly integrally formed in the shape of a proximal and distal curved, mid-section straight line. In a split configuration, first tube section 211, second tube section 212, and third tube section 213 are joined by a connector, which is preferably configured in an arc that reduces trauma to the tissue.
The transverse cross-section of each spline 210 may be circular, or may be in the form of a semi-elliptical, square, or other geometric shape.
The number of splines 210 in the ablation assembly 200 may be 2-6, preferably 4 splines 210.
As shown in fig. 1 and 2, a plurality of electrodes 220 of the ablation assembly 200 are respectively disposed on each spline 210, specifically on the second section of tube 212 of each spline 210, one or more electrodes 220 may be disposed on the second section of tube 212, and the electrodes 220 are disposed on the splines 210 in an embedded manner, that is, the electrodes 220 are embedded in the splines 210, only the outer surfaces thereof are exposed to the surfaces of the splines 210, and the outer surfaces of the electrodes 220 are substantially flush with the surfaces of the splines 210. Each electrode 220 is connected to the ablation device by an electrical lead, at least a portion of the electrical lead is disposed inside the spline 210, the portion of the electrical lead inside the spline 210 is electrically connected to the portion of the electrode 220 embedded in the spline 210 to enable delivery of a voltage pulse from the ablation device to the electrode 220, and each electrode 220 is connected to the ablation device by a separate electrical lead such that each electrode 220 can be independently addressed, the ablation device can independently set the polarity of each electrode 220 or control the discharge of each electrode 220.
Preferably, as shown in fig. 1 and 2, the electrodes 220 cover 1/3 to 1/2 on the lateral surface of the spline 210, and the electrodes 220 on the plurality of splines 210 all face the same side, during the ablation, only one side of the ablation assembly 200 will contact the tissue, only one side will be ablated by discharging, blood will be contacted on the other side of the ablation assembly 200, and the electricity will be discharged in the direction of the rest non-facing tissue, the energy will be converted into joule heat or generate redox reaction (generate bubbles in the blood), and excessive bubbles in the blood will cause a certain harm to human body, therefore, the electrodes 220 of this embodiment only cover 1/3 to 1/2 on the lateral surface of the spline 210, and the electrodes 220 on the plurality of splines 210 all face the same side, such as the spline 210 with a circular lateral cross section, the electrodes 220 can cover the circumferential surface on the upward side of the spline 210, and are similarly designed (occupying approximately half ring 1/2 on the lateral surface), all of the electrodes 220 may be overlaid on the circumferential surface of the upward facing side, or all of the electrodes 220 may be overlaid on the circumferential surface of the downward facing side of the spline 210. The arrangement mode of the electrode 220 can avoid empty discharge (discharge to other directions not facing to tissues), reduce the current of pulse ablation, reduce the stimulation of a pulse electric field to the nerve and skeletal muscle of a patient, reduce the generation of bubbles and reduce the generation of bubbles while maintaining the same ablation effect.
In some other embodiments, the electrode 220 may also be a ring electrode 220, and the electrode 220 is in a full ring shape and is disposed on the outside of the second section of tube 212 of the spline 210.
The length direction of each electrode 220 is arranged along the longitudinal direction of the spline 210, and the length of each electrode 220 in the longitudinal direction is 0.5mm to 5mm, preferably 3 mm; the spacing between two adjacent electrodes 220 on the same spline 210 is 2mm to 5mm, preferably 3 mm.
The number of electrodes 220 disposed on each spline 210 is three, and the three electrodes are a first electrode 221, a second electrode 222 and a third electrode 223 disposed on the second length of tube 212 at intervals from the distal end to the proximal end. The first electrodes 221 on the plurality of splines 210 are approximately flush in the transverse direction, the second electrodes 222 on the plurality of splines 210 are approximately flush in the transverse direction, and the third electrodes 223 on the plurality of splines 210 are approximately flush in the transverse direction, that is, all the electrodes 220 are arranged in a matrix type, and the electrodes 220 are arranged in order, so that the generated pulse electric field is more regular in shape, and can better cover the tissue to be ablated.
The electrodes 220 on each spline 210 can discharge to form a pulsed electric field longitudinally along the spline 210, and the polarity arrangement of the three electrodes 220 on each spline 210 includes, but is not limited to, the following:
when the first electrode 221 on the same spline 210 is configured to be of a first polarity (e.g., anode), the second electrode 222 and the third electrode 223 are configured to be of a second polarity (e.g., cathode) opposite the first polarity; alternatively, the first polarity may be a cathode and the second polarity may be an anode;
optionally, when the first electrode 221 and the third electrode 223 on the same spline 210 are configured as a first polarity (e.g., an anode), the second electrode 222 is configured as a second polarity (e.g., a cathode) opposite the first polarity; alternatively, the first polarity may be a cathode and the second polarity may be an anode;
optionally, when the third electrode 223 on the same spline 210 is configured as a first polarity (e.g., anode), the first electrode 221 and the second electrode 222 are configured as a second polarity (e.g., cathode) opposite the first polarity; the first polarity may be a cathode and the second polarity may be an anode.
The polarities of the first electrode 221, the second electrode 222 and the third electrode 223 can be set by the ablation device, and the above-mentioned different polarities can change the position of the strongest electric field strength in the longitudinal direction, for example, the tissue to be ablated has a larger thickness at the position of the second electrode 222, and in order to make the depth of the lesion deep enough to achieve the desired ablation effect, an electric field with enough strength needs to be generated at the position of the second electrode 222, the first electrode 221 and the third electrode 223 can be configured as a first polarity (anode), the second electrode 222 can be configured as a second polarity (cathode) opposite to the first polarity, and the first electrode 221 and the third electrode 223 can discharge electricity to the second electrode 222 to achieve the electric field strength required for sufficient ablation. The position of the strongest electric field strength in the longitudinal direction of the ablation assembly 200 is changed to adapt to the ablation needs of different tissues or different diseases, so that the application scene of the ablation catheter is wider.
Further, the electrode 220 between two adjacent splines 210 can discharge laterally, forming a pulsed electric field along the spline 210 laterally. Specifically, when the polarity of the first electrode 221 on two adjacent splines 210 is opposite, that is, the first electrode 221 on one spline 210 is configured to be the first polarity (anode or cathode), the first electrode 221 on the spline 210 adjacent to the spline 210 is configured to be the first polarity (cathode or anode) opposite to the first polarity.
The polarity of the second electrode 222 on two adjacent splines 210 is opposite, that is, when the second electrode 222 on one spline 210 is configured to have a first polarity (anode or cathode), the second electrode 222 on the spline 210 adjacent to the spline 210 is configured to have a second polarity (cathode or anode) opposite to the first polarity.
When the polarity of the third electrode 223 on two adjacent splines 210 is opposite, that is, the third electrode 223 on one spline 210 is configured to be a first polarity (anode or cathode), the third electrode 223 on the spline 210 adjacent to the spline 210 is configured to be a second polarity (cathode or anode) opposite to the first polarity.
The electrode 220 is arranged in a polar mode, so that transverse discharge can be realized, a transverse pulse electric field is generated, a matrix type sheet ablation electric field can be formed together with a longitudinal pulse electric field, the coverage range is large, and the injury is more uniform and thorough.
In some other embodiments, taking the second electrodes 222 on 4 splines 210 as an example, the polarities of the second electrodes 222 on two adjacent splines 210 may also be the same, one second electrode 222 in the 4 splines 210 is a first polarity (anode or cathode), and the second electrodes 222 in the remaining 3 splines 210 are all a second polarity (cathode or anode) opposite to the first polarity, that is, the arrangement that one second electrode 222 in the 4 splines 210 discharges to the second electrodes 222 of the other 3 splines 210 to form a transverse pulsed electric field may also change the position of the strongest electric field strength of the pulsed electric field in the transverse direction, so as to adapt to ablation needs of different site tissues or different conditions, and make the application scenario of the ablation catheter wider. Similarly, the first electrode 221 and the third electrode 223 on the spline can also be set in their polarity in the same manner.
In the ablation catheter in the embodiment, the plurality of splines 210 are located on the same plane, the electrodes 220 are arranged on the second section of the tube 212 which is parallel to each other, and the electrodes 220 are arranged in a polar manner, so that transverse and longitudinal discharging between the electrodes 220 is realized, a large-area and regularly-shaped sheet-shaped ablation electric field can be formed, the tissue to be ablated is fully covered, and the ablation effect is better in the ablation of tissues with larger areas (such as epicardium or tumor).
Example two
As an explanation of the second embodiment provided in the present invention, only the differences from the above-described first embodiment will be explained below. When pulse ablation is carried out on some parts without blood flow (such as esophagus, nasopharynx, lung bronchus, stomach, duodenum, colon and cervix), the parts without blood flow are not filled with conductive liquid like blood vessels, so the ablation effect of the parts is not easy to guarantee. Based on this, as shown in fig. 3-5, the ablation catheter in the present embodiment is provided with an infusion hole 224 on each electrode 220, the infusion hole 224 is preferably a circular hole, and the aperture of the infusion hole 224 is 0.05mm-0.15mm, and the aperture is preferably 0.1 mm. The inside of each spline 210 is provided with a perfusion cavity 214, the perfusion cavity 214 is communicated with a perfusion hole 224, a plurality of perfusion tubes 110 are arranged in the first conduit 100, and each perfusion tube 110 is respectively communicated with the perfusion cavity 214 inside one spline 210.
The perfusion lumen 214 may be a lumen extending through the entire spline 210 in the longitudinal direction of the spline 210, or may extend through the second and third lengths of tubing 212, 213 only in the longitudinal direction of the spline 210.
As shown in fig. 5, the perfusion tube 110 is disposed in the lumen of the first catheter 100, the proximal end of the perfusion tube communicates with an external perfusion source (not shown in the drawings), and the distal end of the perfusion tube 110 communicates with the perfusion lumen 214 inside the spline 210, and in particular, the distal end of the perfusion tube 110 can be fixed inside the third segment of tube 213. All of the electrodes 220 on each spline 210 share a common irrigation tube 110 for conducting the conductive fluid.
The conductive liquid (physiological saline) of the external perfusion source can be conveyed to the perfusion cavity 214 in the spline 210 through the perfusion tube 110, and flows out of the perfusion hole 224 formed in each electrode 220 into the lumen of the human body, the conductivity can be enhanced by perfusing the physiological saline into the lumen of the human body, the distribution of the pulse electric field can be enhanced in the ablation process, the directional distribution and the stability of the pulse electric field are enhanced, and the ablation effect is ensured.
The ablation catheter of the embodiment can be used for ablating tumors in some bloodless cavities, such as nasopharynx, esophagus, stomach, lung bronchus, duodenum, colon, cervix and the like, and even if a conductive medium is lacked, saline can be infused between the electrode 220 and an ablation target point through the infusion hole 224 on the electrode of the ablation catheter to improve the distribution of a pulse electric field towards the target point, so that the ablation effect and stability are improved.
The ablation catheter of the embodiment can also be used for ablation of the epicardial surface of the heart, no blood flows on the epicardial surface of the heart, only a small amount of lubricating liquid is available, and saline is infused through the infusion holes 224 on the ablation catheter electrode 220, so that the effect and stability of the epicardial ablation are improved.
The ablation catheter in the embodiment is suitable for being applied to pulse electric field ablation in a human body cavity with insufficient electric conduction, and normal saline is poured into the human body cavity with insufficient electric conduction, so that the original cavity with insufficient electric conduction also has good conductivity, the distribution and the duration of a pulse electric field can be maintained, and the ablation effect is ensured.
It should be noted that the ablation catheter in this embodiment can only perform transverse discharge and not perform longitudinal discharge, and since the irrigation cavities 214 of each spline 210 are filled with saline and the electrodes 220 of the same spline 210 are set to different polarities, a short circuit is caused, so that all the electrodes 220 on the same spline 210 can only be of the same polarity and cannot perform longitudinal discharge.
In the description of the present invention, unless explicitly stated or limited otherwise, the terms "first", "second", "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance; the term "plurality" means two or more unless specified or indicated otherwise; the terms "connected," "fixed," and the like are to be construed broadly and may, for example, be fixedly connected, detachably connected, integrally connected, or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the description of the present invention, it should be understood that the terms of orientation such as "front", "back", "upper", "lower", "inner" and "outer" used in the embodiments of the present invention are described with respect to the angles shown in the drawings, and should not be construed as limiting the embodiments of the present invention. In addition, in this context, it will also be understood that when an element is referred to as being "directly connected to" or "directly behind" another element, it can also be indirectly connected to "directly" or "directly behind" the other element through intervening elements.
What has been described above are merely some embodiments of the present invention. It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the inventive concept thereof, and these changes and modifications can be made without departing from the spirit and scope of the invention.
Claims (14)
1. A matrix-type pulsed electric field ablation catheter, comprising:
a first catheter having a lumen therein;
the ablation assembly is arranged at the distal end of the first catheter and comprises a plurality of splines, at least one electrode is arranged on each spline, and the splines are located on the same plane.
2. The matrix-type pulsed electric field ablation catheter of claim 1, wherein the spline comprises a first section of tubing, a second section of tubing, and a third section of tubing connected in series from a distal end to a proximal end; the second lengths of the plurality of splines are substantially parallel to each other.
3. The matrix-type pulsed electric field ablation catheter of claim 2, wherein distal ends of the first plurality of splined tubes are all connected together; the proximal ends of the third sections of tubing are all connected to the distal end of the first catheter.
4. The matrix-type pulsed electric field ablation catheter of claim 2 wherein the junction of the first and second, second and third lengths of tubing is in an arcuate transition.
5. The matrix-type pulsed electric field ablation catheter of claim 1 wherein said electrodes cover 1/3-1/2 of the lateral surface of said splines, and a plurality of spline upper electrodes are all facing the same side.
6. The matrix-type pulsed electric field ablation catheter of claim 1, wherein said electrode is a ring electrode disposed outside of said splines.
7. The matrix-type pulsed electric field ablation catheter according to any of claims 1-6, wherein the number of said electrodes disposed on each of said splines is three, and the number of said electrodes is respectively a first electrode, a second electrode and a third electrode disposed at intervals on the second tube.
8. The matrix-type pulsed electric field ablation catheter of claim 7 wherein when the first electrode on the same spline is configured in a first polarity, the second and third electrodes are configured in a second polarity opposite the first polarity; or
When the first and third electrodes on the same spline are configured in a first polarity, the second electrode is configured in a second polarity opposite the first polarity; or
When the third electrode on the same spline is configured to a first polarity, the first and second electrodes are configured to a second polarity opposite the first polarity.
9. The matrix-type pulsed electric field ablation catheter of claim 8, wherein the polarity of the first electrodes on two adjacent splines is reversed, and/or the polarity of the second electrodes on two adjacent splines is reversed, and/or the polarity of the third electrodes on two adjacent splines is reversed.
10. The matrix-type pulsed electric field ablation catheter of claim 7 wherein the first electrodes on the plurality of splines are laterally aligned, and/or the second electrodes on the plurality of splines are laterally aligned, and/or the third electrodes on the plurality of splines are laterally aligned.
11. The matrix-type pulsed electric field ablation catheter according to any one of claims 1-6 and 8-10, wherein the electrode has an irrigation hole, the spline has an irrigation cavity inside, and the irrigation cavity is communicated with the irrigation hole.
12. The matrix-type pulsed electric field ablation catheter according to claim 11, wherein a plurality of perfusion tubes are disposed in the first catheter, each perfusion tube communicating with a perfusion chamber inside one of the splines.
13. The matrix-type pulsed electric field ablation catheter according to claim 11, wherein the aperture of the irrigation hole is 0.05mm-0.15 mm.
14. The matrix-type pulsed electric field ablation catheter of claim 11 wherein the number of splines is 2-6.
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