CN113769267B - Implantable electrode capable of monitoring conductivity signal and device for inhibiting cell division - Google Patents
Implantable electrode capable of monitoring conductivity signal and device for inhibiting cell division Download PDFInfo
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- 230000032823 cell division Effects 0.000 title claims abstract description 38
- 238000012544 monitoring process Methods 0.000 title claims abstract description 23
- 230000002401 inhibitory effect Effects 0.000 title claims abstract description 14
- 239000000523 sample Substances 0.000 claims abstract description 61
- 230000005684 electric field Effects 0.000 claims abstract description 33
- 238000006243 chemical reaction Methods 0.000 claims description 19
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- 230000001629 suppression Effects 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 13
- 238000012545 processing Methods 0.000 claims description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 210000002615 epidermis Anatomy 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
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- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 229910010252 TiO3 Inorganic materials 0.000 description 2
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- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0504—Subcutaneous electrodes
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- Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Electrotherapy Devices (AREA)
Abstract
The embodiment of the application provides an implantable electrode capable of monitoring a conductivity signal and a device for inhibiting cell division. The implantable electrode comprises a bearing main body, at least one electrode slice, a flexible lead and a conductivity probe; the electrode plate is arranged on the bearing main body and is used for generating an alternating electric field; one end of the flexible lead is connected with the electrode plate and is used for transmitting an electric signal to the electrode plate; the conductivity probe is arranged on the bearing main body and is electrically connected with the conductivity converter, and is used for transmitting the detected conductivity signal to the conductivity converter. According to the embodiment, the conductivity probe is arranged on the implantable electrode, and the conductivity probe is used for detecting the conductivity signal so as to obtain the conductivity of the tissue around the implantable electrode, so that the electric signal transmitted to the electrode sheet can be conveniently adjusted, and a better treatment effect can be obtained; and the conductivity probe is arranged on the bearing main body, so that the conductivity probe and the bearing main body can be implanted into a patient together, and the operation difficulty is reduced.
Description
Technical Field
The application relates to the field of tumor treatment fields, in particular to an implantable electrode capable of monitoring conductivity signals and a device for inhibiting cell division.
Background
Tumor electric field therapy (Tumor-TREATING FIELDS, TTFIELDS) is a novel Tumor therapeutic method, and the principle is that a low-intensity and medium-frequency alternating electric field acts on tubulin of proliferating lesion cells to interfere with mitosis of the lesion cells, so that the affected lesion cells apoptosis and inhibit growth of the lesion cells.
One embodiment of TTFields is to use implantable electrodes, i.e., to implant the electrodes into the patient so that an electric field is directly applied to the lesion, TTFields has less side effects than conventional treatments such as surgery, radiation therapy, and medication, and has the advantages of lighter weight, no irritation to the patient's skin, low power, etc.
However, the environment in the patient is complex, and many factors affect the effect of applying the electric field, and even the therapeutic effect.
Disclosure of Invention
Aiming at the defects of the prior art, the application provides an implanted electrode capable of monitoring a conductivity signal and a cell division inhibition device, which can monitor the conductivity of an electrode implantation part of a patient so as to adjust an applied electric field according to the conductivity, thereby obtaining a better treatment effect.
In a first aspect, embodiments of the present application provide an implantable electrode capable of monitoring a conductivity signal, the implantable electrode comprising a carrier body, at least one electrode pad, a flexible lead, and a conductivity probe;
The electrode plate is arranged on the bearing main body and is used for generating an alternating electric field;
one end of the flexible lead is connected with the electrode plate and is used for transmitting an electric signal to the electrode plate;
The conductivity probe is disposed on the carrier body for electrically connecting with a conductivity transducer for transmitting a detected conductivity signal to the conductivity transducer.
Optionally, the electrode sheet is a flexible electrode sheet.
Optionally, the implantable electrode includes a plurality of flexible electrode pads, and the flexible electrode pads are arranged on the bearing body in an array.
Optionally, the implantable electrode further comprises a thermistor disposed on the carrier body, the thermistor being configured to be electrically connected to a temperature transducer, and to transmit a detected temperature signal to the temperature transducer.
Optionally, the bearing body comprises a substrate layer and a cover layer, the flexible electrode sheet is arranged between the substrate layer and the cover layer, a first through hole is formed in the cover layer, and the orthographic projection of the first through hole on the substrate layer is located in the orthographic projection of the flexible electrode sheet on the substrate layer.
Optionally, the electrode plates are provided with third through holes, one side, close to the substrate layer, of each electrode plate is provided with one conductivity probe or one thermistor, and the orthographic projection of the third through holes on the substrate layer is located in the orthographic projection of the conductivity probes on the substrate layer, or the orthographic projection of the third through holes on the substrate layer is located in the orthographic projection of the conductivity probes on the substrate layer.
Optionally, the thermistor and the conductivity probe are arranged between the substrate layer and the cover layer and between two adjacent flexible electrode sheets, and one thermistor or one conductivity probe is arranged between two adjacent flexible electrode sheets; the cover layer is provided with a second through hole, the orthographic projection of the second through hole on the basal layer is positioned in the orthographic projection of the conductivity probe on the basal layer, or the orthographic projection of the second through hole on the basal layer is positioned in the orthographic projection of the heat sensitive probe on the basal layer.
Optionally, the carrier body is a flexible carrier body.
Optionally, the electrode plate comprises a conductive sheet and a dielectric layer coated on the conductive sheet, the conductive sheet is electrically connected with the flexible wire, and the materials of the dielectric layer are all biocompatible.
Optionally, the implantable electrode further comprises a connector connected with the other end of the flexible lead, and the connector is used for implanting the implantable electrode to suture with the bioepidermal.
In a second aspect, embodiments of the present application provide a device for inhibiting cell division, comprising:
The implantable electrode is implanted into a target part of a patient according to a preset mode, and each pair of implantable electrodes are oppositely arranged;
the main controller comprises a voltage generation module and a signal conversion module, wherein the voltage generation module is electrically connected with the other end of the flexible wire and is used for generating an electric signal, the signal conversion module comprises a conductivity converter, and the conductivity converter is used for generating real-time conductivity of a target part of a patient according to a conductivity signal.
Optionally, when the implantable electrode comprises a thermistor, the signal conversion module further comprises a temperature converter for producing a real-time temperature of the target site of the patient from the temperature signal.
Optionally, the master controller further comprises a housing, the voltage generation module and the signal conversion module are located in the housing, and materials of the housing are biocompatible.
Optionally, the master controller further comprises a signal processing module, and the signal processing module is electrically connected with the voltage generating module and the signal conversion module respectively; the signal processing module is used for adjusting the electric signal generated by the voltage generation module according to the real-time conductivity generated by the conductivity converter, and controlling the voltage generation module to stop generating the electric signal when the real-time temperature is higher than a set temperature.
Optionally, the voltage generating module is a pulse voltage generating module or an AC voltage generating module.
Optionally, the implantable electrode is implanted in a patient, and the master controller is located outside the patient.
Optionally, the implantable electrode and the master are both implanted in the patient.
The technical scheme provided by the embodiment of the application has the beneficial technical effects that:
1. according to the implantable electrode capable of monitoring the conductivity signal, provided by the embodiment of the application, the conductivity probe is arranged on the implantable electrode, the conductivity probe is used for detecting the conductivity signal and transmitting the conductivity signal to the conductivity converter, so that the conductivity of tissues around the implantable electrode is obtained, and the electric signal transmitted to the electrode sheet is conveniently adjusted, so that a better treatment effect is obtained; the conductivity probe is arranged on the bearing main body, so that the conductivity probe and the bearing main body can be implanted into a patient together, and the operation difficulty is reduced;
2. the implantable electrode capable of monitoring the conductivity signal provided by the embodiment of the application further comprises a thermistor arranged on the bearing main body, wherein the thermistor can measure the temperature of a focus of a patient and timely acquire the temperature information of the focus of the patient so as to avoid the risk caused by overhigh temperature of the focus of the patient;
3. According to the implantable electrode capable of monitoring the conductivity signal, provided by the embodiment of the application, the connector is arranged, and the connector is sutured with the biological epidermis after the flexible electrode sheet is implanted, so that the flexible lead can be prevented from passing through the skin of a patient for a plurality of times, the operation difficulty can be reduced, and the risk of infection of the patient can be reduced;
4. The cell division suppression device provided by the embodiment comprises a main controller and implanted electrodes, wherein the main controller comprises a voltage generation module and a signal conversion module, the voltage generation module is used for generating an electric signal and transmitting the electric signal to electrode plates of the corresponding implanted electrodes through flexible wires, so that each implanted electrode has the corresponding voltage, and a voltage difference exists between the voltages on a pair of implanted electrodes which are oppositely arranged, and an electric field acting on a target part of a patient can be formed.
Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.
Drawings
The foregoing and/or additional aspects and advantages of the application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings, in which:
fig. 1 is a schematic structural diagram of an implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 2 is a schematic diagram of another implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 3 is a schematic diagram of another implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 4 is a schematic cross-sectional view of the implantable electrode of FIG. 3 along line A-A capable of monitoring a conductivity signal;
FIG. 5 is a schematic diagram of another implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 6 is a schematic cross-sectional view of the implantable electrode of FIG. 5 along line B-B capable of monitoring a conductivity signal;
FIG. 7 is a schematic diagram illustrating an application of a device for inhibiting cell division according to an embodiment of the present application;
FIG. 8 is a schematic diagram of a device for inhibiting cell division according to an embodiment of the present application;
fig. 9 is a schematic diagram of a frame structure of a signal conversion module in a device for inhibiting cell division according to an embodiment of the present application.
Reference numerals:
1-a carrying body; 11-a substrate layer; 12-a cover layer; 121-a first through hole; 122-a second via;
2-electrode sheet; 21-a conductive layer; 22-a dielectric layer;
3-flexible wires;
4-conductivity probe;
a 5-thermistor;
a 6-linker;
7-a first signal line;
8-a second signal line;
100-implantable electrode;
200-a master; 2001-housing; 2002-a voltage generation module; 2003-a signal processing module; 2004-signal conversion module.
Detailed Description
The present application is described in detail below, examples of embodiments of the application are illustrated in the accompanying drawings, wherein the same or similar reference numerals refer to the same or similar components or components having the same or similar functions throughout. Further, if detailed description of the known technology is not necessary for the illustrated features of the present application, it will be omitted. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the application.
It will be understood by those skilled in the art that all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs unless defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
TTFields is that by using low-intensity and medium-frequency alternating electric field, microtubulin of the proliferated pathological cells is acted to interfere the mitosis of the pathological cells, so that the affected pathological cells are apoptotic and the growth of the pathological cells is inhibited. The implantable electrode is implanted into the patient, namely, the electrode is implanted into the patient so as to directly apply an electric field to the focus, compared with the traditional treatment means such as operation, radiotherapy, drug treatment and the like, the TTFields has the advantages of smaller side effect, lighter weight, no stimulation to the skin of the patient, low power and the like.
However, the environment in the patient is complex, and many factors affect the effect of applying the electric field, and even the therapeutic effect. For example, the electrical signal on the implanted electrode is unchanged, but the electrical conductivity at the patient's lesion changes, which causes a change in the electric field applied to the patient's lesion, affecting the therapeutic effect.
The application provides an implantable electrode capable of monitoring conductivity signals and a cell division suppression device, and aims to solve the technical problems in the prior art.
The following describes the technical scheme of the present application and how the technical scheme of the present application solves the above technical problems in detail with specific embodiments.
The embodiment of the application provides an implantable electrode capable of monitoring a conductivity signal, as shown in fig. 1, and the implantable electrode provided by the embodiment comprises a bearing main body 1, at least one electrode slice 2, a flexible lead 3 and a conductivity probe 4.
The electrode plate 2 is arranged on the bearing main body 1 and is used for generating an alternating electric field; one end of the flexible lead 3 is connected with the electrode plate 2 and is used for transmitting electric signals to the electrode plate 2; a conductivity probe 4 is provided on the carrier body for electrical connection with the conductivity transducer for transmitting the detected conductivity signal to the conductivity transducer.
According to the embodiment, the conductivity probe 4 is arranged on the implanted electrode, the conductivity probe 4 is used for detecting a conductivity signal and transmitting the conductivity signal to the conductivity converter, so that the conductivity of tissue around the implanted electrode is obtained, and the electric signal transmitted to the electrode sheet 2 is conveniently adjusted, so that a better treatment effect is obtained; and the conductivity probe 4 is arranged on the bearing main body, so that the conductivity probe 4 can be implanted into a patient together with the bearing main body 1, and the operation difficulty is reduced.
It should be noted that the conductivity converter is used to convert the conductivity signal detected by the conductivity probe into real-time conductivity, so as to adjust the electrical signal according to the real-time conductivity, and the conductivity converter will be described in detail in the following embodiments of the device for inhibiting cell division.
Specifically, as shown in fig. 1, in the implantable electrode provided by the application, the electrode sheet 2 is a flexible electrode sheet.
Specifically, in the implantable electrode provided in the present embodiment, the material of the carrier body 1 includes silica gel. The silicone gum is soft and has good biocompatibility. The flexible electrode sheet and the flexible bearing main body 1 can better adapt to the requirements of different positions of patients, so that the adaptability of the implantable electrode is improved.
Specifically, as shown in fig. 1, in the implantable electrode provided by the application, the electrode plate 2 is circular, and the diameter of the electrode plate 2 is 0.5 cm-1.5 cm. The size of the electrode slice 2 can be designed according to factors such as the type of the tumor to be treated, the volume of the tumor, the position of the tumor and the like, so that implanted electrodes of different types can be manufactured to meet the demands of markets and patients.
In addition, because of process limitation, the manufactured circular electrode sheet 2 may be a non-standard circular shape, and thus, the term "the electrode sheet 2 is circular" in the present application means that the electrode sheet 2 is a standard circular shape or an approximate circular shape.
For example, the nearly circular flexible electrode sheet 21 may be elliptical, but the ratio of the short axis to the long axis is greater than 0.8, wherein the length of the short axis is 0.5cm to 1.5cm. Or the nearly circular flexible electrode sheet 21 may be a regular polygon (the number of sides n is 10 or more), for example, a regular icosahedron, in which the length of two times the radius of the regular icosahedron is 0.5cm to 1.5cm.
Optionally, as shown in fig. 2, the implantable electrode provided in this embodiment includes a plurality of electrode plates 2, where the electrode plates 2 are disposed on the carrier body 1 in an array. Specifically, the electrode plates 2 are arranged in an array of m rows and n columns, m and n are integers greater than or equal to 2, and in the implantable electrode shown in fig. 2, the electrode plates 21 are arranged in 5 rows and3 columns.
Alternatively, as shown in fig. 2, in the implantable electrode provided in this embodiment, the plurality of electrode sheets 21 are connected in series.
Specifically, as shown in fig. 2, in the implantable electrode provided in this embodiment, the thickness of the carrying body 1 is 0.01cm to 0.5cm, the length of the carrying body 1 is 3cm to 9cm, and the width of the carrying body 1 is 1cm to 5 cm.
Specifically, as shown in fig. 2, in the implantable electrode provided in this embodiment, the material of the carrying body 1 is silica gel, and the silica gel material is soft and has biocompatibility.
In this embodiment, the electrode plates 2 are arranged in an array manner, and the electrodes can be designed according to the condition of a patient, so that the requirements of the patient are more met, and the treatment effect is improved.
Optionally, as shown in fig. 2, the implantable electrode provided in this embodiment further includes a thermistor 5 disposed on the carrier body 1, and the thermistor 5 is configured to be electrically connected to a temperature transducer (not shown in fig. 2) to transmit a detected temperature signal to the temperature transducer.
The thermistor 5 can measure the temperature of the focus of the patient and acquire the temperature information of the focus of the patient in time so as to avoid dangers caused by overhigh temperature of the focus of the patient.
Optionally, as shown in fig. 2, the implantable electrode provided in this embodiment further includes a connector 6, where the connector 6 is connected to the other end of the flexible wire 3 and is used for suturing with the bioepidermal.
Specifically, the connector 6 may be a plug-in type connector or a push-type connector, as long as the connector 6 and the electric field generating device can be easily connected.
It should be noted that the surface of the connector 6 is made of a biocompatible material, so as to avoid injury to the patient.
In this embodiment, through setting up the joint 6 to stitch up joint 6 and biological epidermis after implanting flexible electrode piece 2, so can avoid flexible wire 3 to pass patient's skin many times, can reduce the operation degree of difficulty and reduce patient's risk of infection.
Optionally, as shown in fig. 3 and fig. 4, the implantable electrode carrying body 1 provided in this embodiment includes a base layer 11 and a cover layer 12, the electrode sheet 2 is disposed between the base layer 11 and the cover layer 12, and a first through hole 121 is disposed on the cover layer 12, and an orthographic projection of the first through hole 121 on the base layer 11 is located in an orthographic projection of the electrode sheet 2 on the base layer 11.
The implanted electrode provided in this embodiment, the carrying body 1 can well arrange and fix the electrode plates 2, so as to design the formed electric field to obtain a required electric field.
Alternatively, as shown in fig. 3 and 4, in the implantable electrode provided in this embodiment, the thermistor 5 and the conductivity probe 4 are disposed between the base layer 11 and the cover layer 12 and between the adjacent electrode sheets 2, and one thermistor 5 or one conductivity probe 4 is disposed between two adjacent electrode sheets 2. The cover layer 12 is provided with a second through hole 122, the orthographic projection of the second through hole 122 on the base layer 11 being located within the orthographic projection of the conductivity probe 4 on the base layer 11, or the orthographic projection of the second through hole 122 on the base layer 11 being located within the orthographic projection of the thermistor 5 on the base layer 11.
It should be noted that, although fig. 3 and 4 show that the conductivity probe 4 and the thermistor 5 and the flexible wire 3 overlap, in practical designs, the flexible wire 3 may also avoid the conductivity probe 4 and the thermistor 5, specifically, "the flexible wire 3 avoids the conductivity probe 4 and the thermistor 5" means that the front projection of the flexible wire 3 on the base layer 11 and the front projection of the conductivity probe 4 and the thermistor 5 on the substrate do not intersect.
Further, in order to improve the effect of measuring the conductivity and the temperature, in the case of designing the positions of the conductivity probe 4 and the thermistor 5, for example, in the implantable electrode shown in fig. 3, the conductivity probe 4 is disposed between the electrode sheet 2 of the first row and the first column and the electrode sheet 2 of the first row and the second column, the thermistor 5 is disposed between the electrode sheet 2 of the first row and the second column and the electrode sheet 2 of the first row and the third column, and the thermistor 5 is also disposed between the electrode sheet 2 of the second row and the second column. The conductivity probes 4 and the thermistors 5 are staggered, so that more accurate conductivity information and temperature information can be obtained.
In the implantable electrode provided in this embodiment, the thermistor 5 and the conductivity probe 4 are disposed between the electrode plates 2, so that the conductivity and the temperature near the electric field formed by the electrode plates 2 can be measured in real time, and a relatively accurate measurement result can be obtained, thereby improving the therapeutic effect of the implantable electrode.
Optionally, as shown in fig. 5 and 6, in the implantable electrode provided in this embodiment, the electrode plates 2 are provided with third through holes 23, one side of each electrode plate 2 near the base layer 12 is provided with one conductivity probe 4 or one thermistor 5, and the orthographic projection of the third through holes 23 on the base layer 11 is located in the orthographic projection of the conductivity probe 4 on the base layer 11, or the orthographic projection of the third through holes 23 on the base layer 11 is located in the orthographic projection of the conductivity probe 4 on the base layer 11.
Further, in order to improve the effect of measuring the conductivity and the temperature, the conductivity probe 4 and the thermistor 5 should be staggered in order to design the positions of the conductivity probe 4 and the thermistor 5, for example, in the implantable electrode shown in fig. 5, the conductivity probe 4 is disposed under the electrode sheet 2 of the first row and the first column, and the thermistor 5 is disposed under both the electrode sheet 2 of the first row and the second column adjacent to the electrode sheet 2 of the first row and the first column. The conductivity probes 4 and the thermistors 5 are staggered, so that more accurate conductivity information and temperature information can be obtained.
In the implantable electrode provided in this embodiment, the thermistor 5 and the conductivity probe 4 are disposed below the electrode plate 2, so that the conductivity and the temperature near the electric field formed by the electrode plate 2 can be measured in real time, and a relatively accurate measurement result can be obtained, thereby improving the therapeutic effect of the implantable electrode; the arrangement mode is beneficial to the arrangement design of the electrode plates 2 and the reduction of the volume of the implanted electrode.
Specifically, as shown in fig. 4 and 6, the electrode sheet 2 includes a conductive layer 21 and a dielectric layer 22 surrounding the conductive layer 21, and the material of the dielectric layer 22 has biocompatibility. Wherein the conductive layer 21 coated with the dielectric layer 21 may be coupled to form a capacitor.
As shown in fig. 4 and 6, the materials of the dielectric layer 22 include: filler Ba1-xR xTiO3 and biocompatible polymer, filler Ba1-xR xTiO3 is dispersed in biocompatible polymer, wherein R is one of nickel, zinc, manganese and iron. The material of the dielectric layer 22 provided in this embodiment not only has good dielectric properties, so that the electrode plates 2 can be equivalently used as capacitors to form corresponding electric fields, but also has biocompatibility.
Based on the same inventive concept, the embodiment of the present application further provides a device for inhibiting cell division, as shown in fig. 7, where the device for inhibiting cell division includes at least two pairs of implantable electrodes 100 in the above embodiment, and the beneficial effects of the implantable electrodes 100 in the above embodiment are not described herein.
Specifically, as shown in fig. 7, the implantable electrodes 100 are implanted in a target site of a patient in a preset manner, and each pair of implantable electrodes 100 is disposed opposite to each other. The target part of the patient is the focus of the patient, namely the part of the patient with tumor. "implantable electrode 100 is disposed opposite" means that sub-electrodes in implantable electrode 100 are disposed opposite, for example, when carrier body 1 includes base layer 11 and cover layer 12, "implantable electrode 100 is disposed opposite" means that cover layer 12 in implantable electrode 100 is disposed opposite.
Alternatively, as shown in fig. 7 and 8, in the cell division suppressing device provided in the present embodiment, the voltage generating module 2002 is a pulse voltage generating module 2002 or an AC voltage generating module 2002. Specifically, the pulse voltage generation module 2002 generates a pulse voltage and transmits the pulse voltage to the electrode sheet 2 through the flexible wire 3 so that the oppositely disposed implantable electrode 100 generates a pulse electric field; and AC voltage generation module 2002 generates an AC voltage and transmits the AC voltage to electrode pad 2 via flexible lead 3 such that oppositely disposed implantable electrode 100 generates an alternating electric field. The pulsed electric field or the alternating electric field acts on the tumor cells to inhibit the division of the tumor cells, thereby achieving the purpose of tumor treatment.
For dividing cells, when the cell is in the middle stage of cell division, an electric field acts on the cells, electric field lines induced in the cells are gathered at the equatorial plate, and organelles are subjected to electric field force directed to the equatorial plate, and the electric field force can limit the organelles to move towards two poles, so that the cell division can be inhibited to a certain extent.
In addition, as the cell division degree is deepened (i.e. the equatorial plate is narrowed), the electric field lines at the equatorial plate become denser toward the end of the cell division, and the increased electric field can pull the organelles toward the equatorial plate, thereby preventing the formation of the cell plate, inhibiting the cell division, and even inducing the cell rupture or apoptosis.
Further, the accumulation of organelles at the equatorial plate can lead to an increase in pressure near the equatorial plate, which can rupture the cell membrane, especially in the constricted state of the equatorial plate. And the electric field force applied to the organelle also affects the structure of the organelle, so that the organelle can be induced to be broken or ruptured, and then the cell is induced to be ruptured or apoptotic.
Specifically, as shown in fig. 8, the cell division suppression device provided in this embodiment further includes a main controller 200, where the main controller 200 includes a voltage generation module 2002 and a signal conversion module 2004, the voltage generation module 2002 is electrically connected to the other end of the flexible wire 3 and is used for generating an electrical signal, and the signal conversion module 2004 includes a conductivity converter, and the conductivity converter is used for obtaining real-time conductivity of a target site of a patient according to the conductivity signal.
The cell division suppression device provided in this embodiment includes a main controller 200 and implanted electrodes 100, where the main controller 200 includes a voltage generation module 2002 and a signal conversion module 2004, the voltage generation module 2002 is used to generate an electrical signal and transmit the electrical signal to the sub-electrodes of the corresponding implanted electrodes 100 through the flexible wires 3, so that each implanted electrode 100 has a corresponding voltage, and a voltage difference exists between the voltages on a pair of implanted electrodes 100 that are oppositely disposed, so as to form an electric field acting on a target site of a patient.
Specifically, as shown in fig. 8, in the cell division suppression device provided in this embodiment, the master controller 200 further includes a housing 2001, the voltage generation module 2002 and the signal conversion module 2004 are located in the housing 2001, and the material of the housing 2001 has biocompatibility. The biocompatible material can reduce damage caused by patients and improve the safety of the device for inhibiting cell division.
As shown in fig. 8, in the device for suppressing cell division provided in this embodiment, the implantable electrode 100 is implanted in a patient, and the master controller 200 is located outside the patient. Thus, the implantable electrode 100 is implanted in the patient, and the housing 2001 of the main controller 200 is biocompatible.
As shown in fig. 8, in the cell division suppressing device provided in this embodiment, both the implantable electrode 100 and the master controller 200 are implanted in the patient. At this time, the housing 2001 of the master 200 must be biocompatible.
Optionally, as shown in fig. 8 and 9, in the cell division suppression device provided in the present embodiment, the master controller 200 further includes a signal processing module 2003, and the signal processing module 2003 is electrically connected to the voltage generating module 2002 and the signal converting module 2004, respectively; the signal processing module 2003 is configured to adjust the electrical signal generated by the voltage generation module 2002 based on the real-time conductivity obtained by the conductivity converter. Specifically, the conductivity transducer and the conductivity probe 4 are electrically connected by a first signal line 7.
Optionally, as shown in fig. 8 and 9, in the cell division suppression device provided in the present embodiment, when the implantable electrode 100 includes the thermistor 5, the signal conversion module 2004 further includes a temperature converter, and the temperature converter generates a real-time temperature according to a temperature signal detected by the thermistor 5. Based on this, the signal processing module 2003 in the cell division suppression device provided in the present embodiment is further configured to control the voltage generating module to stop generating the electrical signal when the real-time temperature generated by the temperature converter is greater than the set temperature. Specifically, the temperature converter and the thermistor 5 are electrically connected through the second signal line 8.
The device for suppressing cell division provided in this embodiment includes a temperature converter that generates a real-time temperature according to a temperature signal detected by the thermistor 5, and once the real-time temperature exceeds a set temperature, the voltage generation module 2002 stops generating an electrical signal, so as to avoid damage to the patient due to excessive temperature.
It should be noted that, the flexible wire 3, the first signal wire 7 and the second signal wire 8 each include a metal wire and an insulating layer coated on the surface of the metal wire, and the insulating layer has biocompatibility.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
1. according to the implantable electrode capable of monitoring the conductivity signal, provided by the embodiment of the application, the conductivity probe is arranged on the implantable electrode, the conductivity probe is used for detecting the conductivity signal and transmitting the conductivity signal to the conductivity converter, so that the conductivity of tissues around the implantable electrode is obtained, and the electric signal transmitted to the electrode sheet is conveniently adjusted, so that a better treatment effect is obtained; the conductivity probe is arranged on the bearing main body, so that the conductivity probe and the bearing main body can be implanted into a patient together, and the operation difficulty is reduced;
2. the implantable electrode capable of monitoring the conductivity signal provided by the embodiment of the application further comprises a thermistor arranged on the bearing main body, wherein the thermistor can measure the temperature of a focus of a patient and timely acquire the temperature information of the focus of the patient so as to avoid the risk caused by overhigh temperature of the focus of the patient;
3. According to the implantable electrode capable of monitoring the conductivity signal, provided by the embodiment of the application, the connector is arranged, and the connector is sutured with the biological epidermis after the flexible electrode sheet is implanted, so that the flexible lead can be prevented from passing through the skin of a patient for a plurality of times, the operation difficulty can be reduced, and the risk of infection of the patient can be reduced;
4. The cell division suppression device provided by the embodiment comprises a main controller and implanted electrodes, wherein the main controller comprises a voltage generation module and a signal conversion module, the voltage generation module is used for generating an electric signal and transmitting the electric signal to the sub-electrodes of the corresponding implanted electrodes through flexible wires, so that each implanted electrode has the corresponding voltage, and a voltage difference exists between the voltages on the pair of implanted electrodes which are oppositely arranged, so that an electric field acting on a target part of a patient can be formed.
In the description of the present application, it should be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the present application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.
The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.
In the description of the present specification, a particular feature, structure, material, or characteristic may be combined in any suitable manner in one or more embodiments or examples.
The foregoing is only a partial embodiment of the present application, and it should be noted that it will be apparent to those skilled in the art that modifications and adaptations can be made without departing from the principles of the present application, and such modifications and adaptations should and are intended to be comprehended within the scope of the present application.
Claims (13)
1. An implantable electrode capable of monitoring conductivity signals is characterized by comprising a bearing main body, a plurality of electrode plates, a flexible wire and a conductivity probe;
The electrode plate is arranged on the bearing main body and is used for generating an alternating electric field;
one end of the flexible lead is connected with the electrode plate and is used for transmitting an electric signal to the electrode plate;
the conductivity probe is arranged on the bearing main body and is used for being electrically connected with a conductivity converter so as to transmit a detected conductivity signal to the conductivity converter; wherein:
The bearing main body is a flexible bearing main body, the material comprises silica gel, the thickness of the bearing main body is 0.01 cm-0.5 cm, the length of the bearing main body is 3 cm-9 cm, and the width of the bearing main body is 1 cm-5 cm;
the electrode plate is a flexible electrode plate and comprises a conductive plate and a dielectric layer coated on the conductive plate, the conductive plate is electrically connected with the flexible lead, the material of the dielectric layer has biocompatibility, and the size of the electrode plate is smaller than that of the bearing main body;
the flexible electrode plates are arranged on the bearing main body in an array mode, and the conductivity probes are arranged between two adjacent flexible electrode plates.
2. The implantable electrode according to claim 1, further comprising a thermistor disposed on the carrier body, the thermistor being configured to be electrically connected to a temperature transducer for transmitting a detected temperature signal to the temperature transducer.
3. The implantable electrode of claim 2, wherein the carrier body comprises a base layer and a cover layer, the flexible electrode sheet is disposed between the base layer and the cover layer, and a first through hole is disposed in the cover layer, and an orthographic projection of the first through hole on the base layer is located in an orthographic projection of the flexible electrode sheet on the base layer.
4. An implantable electrode capable of monitoring a conductivity signal according to claim 3, wherein the electrode pads are provided with third through holes, one side of each electrode pad adjacent to the substrate layer is provided with one of the conductivity probes or one of the thermistors, and the orthographic projection of the third through holes on the substrate layer is located in the orthographic projection of the conductivity probes on the substrate layer, or the orthographic projection of the third through holes on the substrate layer is located in the orthographic projection of the conductivity probes on the substrate layer.
5. An implantable electrode capable of monitoring a conductivity signal according to claim 3, wherein said thermistor and said conductivity probe are disposed between said base layer and said cover layer and between adjacent ones of said flexible electrode sheets, one of said thermistor or one of said conductivity probe being disposed between two adjacent ones of said flexible electrode sheets;
the cover layer is provided with a second through hole, the orthographic projection of the second through hole on the basal layer is positioned in the orthographic projection of the conductivity probe on the basal layer, or the orthographic projection of the second through hole on the basal layer is positioned in the orthographic projection of the heat sensitive probe on the basal layer.
6. The implantable electrode according to any one of claims 1-5, further comprising a connector connected to the other end of the flexible wire for implanting the implantable electrode for suturing with a biological epidermis.
7. A device for inhibiting cell division comprising:
At least two pairs of implantable electrodes according to any one of claims 1-6, the implantable electrodes being implanted in a predetermined manner at a target site of a patient, each pair of implantable electrodes being disposed opposite each other;
The main controller comprises a voltage generation module, a signal conversion module and a signal processing module, wherein the voltage generation module is electrically connected with the other end of the flexible wire and is used for generating an electric signal, the signal conversion module comprises a conductivity converter, and the conductivity converter is used for generating real-time conductivity of a target part of the patient according to the conductivity signal;
the signal processing module is respectively and electrically connected with the voltage generation module and the signal conversion module, and is used for adjusting the electric signal generated by the voltage generation module according to the real-time conductivity generated by the conductivity converter.
8. The cell division suppression apparatus of claim 7, wherein when the implantable electrode comprises a thermistor, the signal conversion module further comprises a temperature converter for producing a real-time temperature of a target site of the patient from the temperature signal.
9. The cell division suppression apparatus of claim 7, wherein the master controller further comprises a housing, the voltage generation module and the signal conversion module being located within the housing, the housing being of a material that is biocompatible.
10. The cell division suppression apparatus of claim 8, wherein the signal processing module is further configured to control the voltage generation module to stop generating the electrical signal when the real-time temperature is greater than a set temperature.
11. The cell division suppression apparatus of claim 7, wherein the voltage generation module is a pulse voltage generation module or an AC voltage generation module.
12. The cell division suppression device of any one of claims 7-11, wherein the implantable electrode is implanted in a patient and the master controller is located outside the patient.
13. The cell division suppression device of any one of claims 7-11, wherein the implantable electrode and the master are both implanted in a patient.
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| CN114225215B (en) * | 2021-12-31 | 2023-05-05 | 湖南安泰康成生物科技有限公司 | Electrode system |
| CN114191718B (en) * | 2022-02-16 | 2022-11-08 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating electrode paste and tumor electric field treatment device |
| CN114983610A (en) * | 2022-03-14 | 2022-09-02 | 浙江大学 | A measuring device for animal experiments of tumor electric field therapy |
| JP2025511076A (en) * | 2022-03-31 | 2025-04-15 | ノボキュア ゲーエムベーハー | Delivery of Tumor Treating Fields (TT Fields) Using Implanted Graphite Sheets |
| CA3180284A1 (en) * | 2022-09-29 | 2024-03-29 | Novocure Gmbh | Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment |
| CN118477260A (en) * | 2022-12-30 | 2024-08-13 | 江苏海莱新创医疗科技有限公司 | Electrode sheet, tumor electric field treatment system and treatment equipment |
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