CN113798011B - Heparin sodium production is with dry reducing mechanism - Google Patents

Abstract

The invention discloses a dry crushing device for producing heparin sodium, and relates to the technical field of heparin sodium production and processing. It includes a concentration box, a drying box, a crushing box and a base. There are steam outlets on both sides of the upper end of the drying box. The center of the lower end inside the drying box is rotated and connected to a hollow centrifugal column. A plurality of dispersing grooves are arranged on the upper surface of the plate, the upper end of the centrifugal bucket is slidably connected with the top of the drying box, the first communication port is connected with the center of the upper end of the centrifugal bucket, and an electric heating layer is set on the inner wall of the drying box. The invention overcomes the shortcomings of the prior art, has reasonable design, is convenient to use, can effectively dry and pulverize the heparin sodium solution, has high drying efficiency, good production and processing continuity, and the obtained heparin sodium powder product has high stability and is convenient for large-scale production use.

Description

A dry crushing device for producing heparin sodium

technical field

The invention relates to the technical field of heparin sodium production and processing, in particular to a dry crushing device for heparin sodium production.

Background technique

Heparin sodium is a sodium salt of aminodextran sulfate extracted from animal viscera, which belongs to mucopolysaccharides, and produces anticoagulant function by combining with antithrombin. Clinical studies have shown that in addition to its anticoagulant effect, heparin sodium also has a variety of other biological activities and clinical applications. In vitro arteriovenous thrombosis, without affecting platelet aggregation and fibrinogen binding to platelets, may also be used to reduce the recurrence of cancer-associated venous thrombosis. In addition, heparin sodium also has biological functions such as anti-inflammatory and anti-allergic.

Generally, the preparation of heparin sodium is mostly extracted from the pig small intestinal mucosa. During the extraction process, it is usually necessary to use a variety of solvents to obtain the extract. Finally, the extract is dried and the dried product is crushed to collect the finished product of heparin sodium. Powder, due to the good heat resistance of heparin sodium, most of the existing drying methods directly adopt high-temperature drying, but due to the high liquid content in the extract, the efficiency of direct high-temperature drying is low, and the later crushing treatment requires a transfer device for processing, the product Poor production continuity reduces the efficiency of actual production.

Contents of the invention

The purpose of the present invention is to solve the problems of low drying and crushing efficiency of heparin sodium and cumbersome operation in the prior art, and propose a dry crushing device for heparin sodium production.

In order to achieve the above object, the present invention adopts the following technical solutions:

A dry crushing device for the production of heparin sodium, comprising a concentration box, a drying box and a crushing box connected in sequence, and a base is provided at the bottom of the drying box, and a first communication port is provided in the center of the bottom of the concentration box to communicate with the drying box. There are steam outlets on both sides of the upper end of the drying box, and a second communication port is provided on the bottom side of the drying box to communicate with the upper side of the crushing box. A centrifugal motor is provided, and the output shaft of the centrifugal motor extends to the inside of the drying box, and the output shaft of the centrifugal motor is connected with the centrifugal column through a rotating belt. The upper end of the centrifugal column is provided with a centrifugal disc, and the center of the centrifugal disc is connected with a side wall A hollow centrifugal bucket, the upper surface of the centrifugal disc is provided with a plurality of dispersion grooves from the center to the surroundings, the upper end of the centrifugal bucket is slidably connected to the top of the drying box, the first communication port is connected to the center of the upper end of the centrifugal bucket, The inside of the centrifuge barrel is provided with a first air pipe, and the outer middle section of the centrifugal bucket is provided with a ring-shaped air pipe. The lower ends of both sides of the annular air pipe are symmetrically connected with second air pipes. The centrifugal disc is rotatably connected with the centrifugal disc. The bottom ends of the first ventilation pipe and the second ventilation pipe pass through the drying box and extend to the inside of the base to communicate with the hot air blower. A plurality of first blowing ports are arranged around the first ventilation pipe , a plurality of second blowing ports are provided on the side of the annular ventilation pipe close to the centrifuge barrel, and a layer of electric heating layer is provided on the inner wall of the drying box.

Preferably, a ring-shaped scraper is slidably connected to the inner wall of the drying box, and cylinders are arranged symmetrically on both sides of the top of the drying box, and the cylinder is connected to the upper end of the ring-shaped scraper through a telescopic rod.

Preferably, an exhaust fan is provided inside the steam outlet, and a filter layer is provided at the lower end of the exhaust fan.

Preferably, the first air blowing port is arranged obliquely downward, the second air blowing port is arranged obliquely downward to one side, and the top of the first ventilation pipe is provided with an inclined plate inclined downward from the center to the surrounding.

Preferably, the periphery of the centrifugal disc is bent upwards.

Preferably, a first feeding port is provided on one side of the top of the concentration box, and a stirring motor is provided in the center above the top of the concentration box, and the stirring motor is connected to a first rotating shaft provided inside the concentration box, and the first Electric heating plates are arranged around the rotating shaft, and a liquid separation mechanism is arranged at the first communication port to communicate with the drying box.

Preferably, the liquid distributing mechanism includes a second rotating shaft that is rotatably connected inside the first communication port and a distributing leaf arranged around the second rotating shaft, the distributing leaf is slidably connected with the inner wall of the first communicating port, and the second rotating shaft It is connected with the distribution motor outside the enrichment tank.

Preferably, the upper end of one side of the crushing box is provided with a second feeding port, and a circle of grinding layer is provided on the inner central side wall of the crushing box, and three grinding rollers arranged in an inverted triangle are arranged in the center of the grinding layer, A second outlet is provided on one side of the bottom of the crushing box.

Preferably, a layer of sieving mesh layer is arranged under the grinding roller, the sieving mesh layer is inclined, and the side wall of the inclined lower end of the sieving mesh layer is provided with a first discharge port, and the sieving mesh layer is inclined. A vibrator is arranged at the bottom of the mesh layer.

Preferably, a heating layer is arranged inside the grinding roller.

Compared with the prior art, the present invention provides a dry crushing device for the production of heparin sodium, which has the following beneficial effects:

1. Through the setting of the centrifugal barrel, centrifugal disc, centrifugal column, rotating belt, first air pipe, first air blowing port, second air pipe, annular air pipe, second air blowing port and electric heating layer in the drying box, it can be used to heparin The sodium solution is subjected to high-temperature centrifugation, and the solution is centrifugally thrown out, and the solvent component is quickly evaporated by blowing hot air, and the solid particles of heparin sodium enter the bottom of the drying box with the downward hot air, improving the drying efficiency of heparin sodium;

2. Through the setting of the stirring motor, the first rotating shaft, the electric heating plate, the first connecting port, the second rotating shaft and the distributing leaf in the concentration box, the heparin sodium extract can be effectively evaporated and concentrated, and the heparin sodium after concentration can be controlled. The falling speed is convenient to control the density of the droplets thrown out during centrifugation in the later stage, improving the drying efficiency, and at the same time ensuring that the obtained heparin sodium is in the form of dispersed powder, which is convenient for later grinding;

3. Through the setting of the grinding layer, grinding roller, heating layer, sieving mesh layer, first discharge port, second discharge port and vibrator in the crushing box, the dried heparin sodium can be effectively ground and pulverized to improve The fineness of the heparin sodium is checked and sieved through the sieve mesh layer, and the unqualified ones are continued to be ground to ensure the stability of the obtained heparin sodium product.

The parts not involved in the device are the same as the prior art or can be realized by using the prior art. The present invention is reasonable in design, easy to use, can effectively dry and pulverize the heparin sodium solution, has high drying efficiency, and has good production and processing continuity. The obtained heparin sodium powder product has high stability and is convenient for large-scale production and use.

Description of drawings

Fig. 1 is the schematic diagram of the front view sectional structure of the present invention;

Fig. 2 is a side view sectional structure schematic diagram of the present invention;

Fig. 3 is the schematic diagram of the front section structure of the drying oven of the present invention;

Fig. 4 is a schematic diagram of a top view sectional structure of a drying oven of the present invention;

Fig. 5 is a schematic diagram of the front view section structure of the concentration box of the present invention;

Fig. 6 is a front view sectional structure diagram of a crushing box of the present invention.

In the figure: 1. Drying box; 2. Concentration box; 3. Crushing box; 4. Base; 5. Hot air blower; 6. Centrifugal motor; 7. First feed port; ; 10, electric heating plate; 11, the first communication port; 12, the second rotating shaft; 13, the distribution leaf; 14, the centrifugal barrel; 15, the centrifugal disc; 16, the centrifugal column; 17, the rotating belt; Trachea; 19, the first blowing port; 20, the second venting pipe; 21, the annular venting pipe; 22, the second blowing port; 23, the electric heating layer; 24, the ring scraper; 25, the cylinder; 26, the expansion rod; 27 , steam outlet; 28, exhaust fan; 29, filter layer; 30, inclined plate; 31, second communication port; 32, second feed port; 33, grinding layer; 34, grinding roller; 35, heating layer ; 36, screen mesh layer; 37 first outlet; 38, second outlet; 39, distribution motor; 40, dispersion tank; 41, vibrator.

detailed description

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.

In describing the present invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", " The orientation or positional relationship indicated by "outside", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, so as to Specific orientation configurations and operations, therefore, are not to be construed as limitations on the invention.

Example 1:

Referring to Figures 1-6, a dry crushing device for heparin sodium production includes a concentration box 2, a drying box 1 and a crushing box 3 connected in sequence, and a base 4 is provided at the bottom of the drying box 1, and the center of the bottom of the concentration box 2 is set The first communication port 11 communicates with the drying box 1, and the upper side of the drying box 1 is provided with a steam outlet 27, and the bottom side of the drying box 1 is provided with a second communication port 31, which communicates with the upper side of the crushing box 3. The center of the lower end of the drying box 1 is rotated to connect the hollow centrifugal column 16, the base 4 is provided with a centrifugal motor 6, the output shaft of the centrifugal motor 6 extends to the inside of the drying box 1, and the output shaft of the centrifugal motor 6 is rotated The belt 17 is connected with the centrifugal column 16, the upper end of the centrifugal column 16 is provided with a centrifugal disc 15, and the center above the centrifugal disc 15 is connected with a centrifugal barrel 14 with a hollow side wall, and the upper surface of the centrifugal disc 15 is from the center to the surrounding A plurality of dispersion tanks 40 are provided, the upper end of the centrifugal bucket 14 is slidingly connected to the top of the drying box 1, the first communication port 11 communicates with the center of the upper end of the centrifugal bucket 14, and a first air pipe is arranged inside the centrifugal bucket 14 18. The outer middle section of the centrifugal barrel 14 is provided with a ring-shaped ventilation pipe 21, and the lower ends of both sides of the annular ventilation pipe 21 are symmetrically connected with the second ventilation pipe 20, and the lower end of the first ventilation pipe 18 passes through the centrifugal disc 15 and is connected with the The centrifugal disc 15 is connected in rotation. The bottom ends of the first ventilation pipe 18 and the second ventilation pipe 20 pass through the drying box 1 and extend to the inside of the base 4 to communicate with the hot air blower 5. The first ventilation pipe 18 is surrounded by a plurality of first ventilation pipes. An air blowing port 19, a plurality of second air blowing ports 22 are provided on the side of the annular ventilation pipe 21 close to the centrifuge barrel 14, and a layer of electric heating layer 23 is provided on the inner wall of the drying box 1.

The falling solution can be centrifugally thrown out at a high speed through the centrifugal disc 15 and the centrifugal barrel 14, so as to increase the contact area between the solution and the hot air and improve the drying efficiency.

Example 2:

Referring to Figures 1-6, this embodiment is basically the same as Embodiment 1. Preferably, an annular scraper 24 is slidably connected to the inner wall of the drying box 1, and cylinders 25 are symmetrically arranged on both sides of the top of the drying box 1, so that The cylinder 25 is connected with the upper end of the annular scraper 24 through a telescoping rod 26 . The heparin sodium powder bonded on the side wall of the drying box 1 can be effectively scraped off for convenient collection.

In order to facilitate the rapid overflow of steam, preferably, an exhaust fan 28 is arranged inside the steam outlet 27 , and a filter layer 29 is arranged at the lower end of the exhaust fan 28 .

In order to make the heparin sodium solids fall below, it is convenient to collect, preferably, the first gas blowing port 19 is arranged obliquely downward, and the second gas blowing port 22 is arranged obliquely downward to one side, and at the same time, for the convenience of the solution falling into the centrifuge bucket When it is in the middle of 14, it will be centrifugally thrown out after being in contact with the wall of the centrifuge barrel 14 quickly. The top of the first ventilation pipe 18 is provided with an inclined plate 30 that inclines from the center to the surrounding downwards.

In order to control the direction in which the centrifugal disk 15 centrifugally throws out the liquid, preferably, the periphery of the centrifugal disk 15 is in an upwardly inclined bent shape.

Example 3:

Referring to Fig. 5, this embodiment is basically the same as Embodiment 1. Preferably, a first feeding port 7 is provided on the top side of the concentration box 2, and a stirring motor 8 is provided in the center above the top of the concentration box 2. The stirring motor 8 is connected with the first rotating shaft 9 provided inside the concentration box 2 , the first rotating shaft 9 is surrounded by an electric heating plate 10 , and the first communication port 11 is provided with a liquid separator to communicate with the drying box 1 . Effective initial concentration of the solution, convenient for post-drying treatment.

In order to control the falling speed of the solution and further control the effect of easy and centrifugal drying, preferably, the liquid separation mechanism includes a second rotating shaft 12 that is rotatably connected inside the first communication port 11 and a distributing blade 13 that is arranged around the second rotating shaft 12 , the distributing vane 13 is slidably connected to the inner wall of the first communication port 11 , and the second rotating shaft 12 is connected to the distributing motor 39 outside the concentration box 2 .

Example 4:

Referring to Fig. 6, this embodiment is basically the same as Embodiment 1. Preferably, the upper end of one side of the crushing box 3 is provided with a second feeding port 32, and a circle of grinding layer 33 is provided on the inner central side wall of the crushing box 3. , the center of the grinding layer 33 is provided with three grinding rollers 34 arranged in an inverted triangle, and the bottom side of the crushing box 3 is provided with a second discharge port 38, which can effectively quickly remove the sodium heparin falling into the crushing box 3. Effective crushing improves the continuity of device use.

In order to sieve the heparin sodium powder conveniently and control the fineness of the heparin sodium powder, preferably, a sieving mesh layer 36 is arranged below the grinding roller 34, the sieving mesh layer 36 is inclined, and A first outlet 37 is provided on the side wall of the inclined lower end of the screen layer 36 , and a vibrator 41 is provided at the bottom of the screen layer 36 .

In order to further ensure the completeness of the drying of the heparin sodium and improve the grinding efficiency, preferably, a heating layer 35 is provided inside the grinding roller 34 .

Working principle: when in use, add the heparin sodium solution into the concentration box 2, start the stirring motor 8 and energize the electric heating plate 10, so that the heparin sodium solution is stirred, heated and concentrated, and after the concentration reaches a certain level, start the feeding motor 39 and the centrifugal motor 6, Simultaneously start the hot air blower 5, and energize and heat the electric heating layer 23, and the concentrated heparin sodium solution slowly falls into the centrifuge bucket 14 through the distributing leaf 13 and passes the inclined plate 30 close to the side wall of the centrifuge bucket 14, and then centrifuges at a high speed and passes through the hollow. The position is thrown out and dried, and part of the solution falls on the centrifugal disc 15, and is centrifugally thrown out through the dispersion tank 40. After the liquid droplets thrown out are dried by hot air and the electric heating layer 23, the exhaust fan 28 is started to discharge the steam, and the dried The solids gather downward with the direction of the hot air and fall into the crushing box 3, and the cylinder 25 is started in time during the drying process, and the residual heparin sodium on the inner wall of the drying box 1 is scraped off by the annular scraper 24, and the heparin sodium enters the crushing box 3 to start Grinding roller 34 and vibrator 41, after the sodium heparin is ground and sieved by the sieving net layer 36, the sieved powder is collected, and the powder that fails to pass the sieve is continued to be ground.

The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto, any person familiar with the technical field within the technical scope disclosed in the present invention, according to the technical solution of the present invention Any equivalent replacement or change of the inventive concepts thereof shall fall within the protection scope of the present invention.

Claims (10)

1. a dry crushing device for sodium heparin production, comprising successively connected concentrating box (2), drying box (1) and crushing box (3), and the bottom of drying box (1) is provided with base (4), its feature In that: the center of the bottom of the concentration box (2) communicates with the center of the top of the drying box (1) through a first communication port (11), and steam outlets (27) are provided on both sides of the upper end of the drying box (1). One side of the bottom of the drying box (1) is provided with a second communication port (31) to communicate with the upper side of the crushing box (3). The base (4) is provided with a centrifugal motor (6) inside, and the output shaft of the centrifugal motor (6) extends to the inside of the drying box (1), and the output shaft of the centrifugal motor (6) is connected to the centrifugal column ( 16) are connected, the upper end of the centrifugal column (16) is provided with a centrifugal disc (15), and the center of the centrifugal disc (15) is connected with a centrifugal bucket (14) with a hollow side wall, the centrifugal disc (15) The upper surface is provided with a plurality of dispersion grooves (40) from the center to the surroundings, the upper end of the centrifugal bucket (14) is slidably connected to the top of the drying box (1), and the first communication port (11) is connected to the upper end of the centrifugal bucket (14). The center is connected, the inside of the centrifugal barrel (14) is provided with a first air pipe (18), the outer middle section of the centrifugal barrel (14) is provided with a circle of annular air pipe (21), and the two ring air pipes (21) The lower end of the side is symmetrically communicated with a second air pipe (20), the lower end of the first air pipe (18) passes through the centrifugal disc (15) and is rotatably connected with the centrifugal disc (15), the first air pipe (18) and The bottom end of the second ventilation pipe (20) passes through the drying box (1) and extends to the inside of the base (4) to communicate with the hot air blower (5), and the first ventilation pipe (18) is surrounded by a plurality of first blowing ports ( 19), the annular ventilation pipe (21) is provided with a plurality of second blowing ports (22) near the side of the centrifuge barrel (14), and a layer of electric heating layer (23) is provided on the inner wall of the drying box (1). 2. a kind of heparin sodium production dry crushing device according to claim 1, is characterized in that, on the inner wall of described drying box (1), a ring-shaped scraper (24) is slidably connected, and described drying box (1) A cylinder (25) is arranged symmetrically on both sides of the top end, and the cylinder (25) is connected with the upper end of the annular scraper (24) through a telescoping rod (26). 3. a kind of heparin sodium production according to claim 1 is characterized in that, described steam outlet (27) inside is provided with exhaust fan (28), and described exhaust fan (28) lower end is provided with There is one deck filter net layer (29). 4. The dry crushing device for heparin sodium production according to claim 1, characterized in that, the first air blowing port (19) is arranged obliquely downward, and the second air blowing port (22) is downward to one side It is arranged obliquely, and the top end of the first ventilation pipe (18) is provided with an inclined plate (30) inclined from the center to the surrounding downwards. 5 . The dry crushing device for producing heparin sodium according to claim 1 , characterized in that, the periphery of the centrifugal disc ( 15 ) is in an upwardly inclined bent shape. 6 . 6. a kind of heparin sodium production according to claim 1 is characterized in that, described concentrating case (2) top side is provided with the first feed inlet (7), and described concentrating case (2) ) is provided with a stirring motor (8) in the center above the top, and the stirring motor (8) is connected with the first rotating shaft (9) provided inside the concentration box (2), and electric heating plates are arranged around the first rotating shaft (9) (10), the first communication port (11) is provided with a liquid separation mechanism to communicate with the drying box (1). 7. The dry crushing device for producing heparin sodium according to claim 6, characterized in that, the liquid separation mechanism includes a second rotating shaft (12) and a second rotating shaft that are rotatably connected inside the first communication port (11) (12) Distributing blades (13) arranged around, the distributing blades (13) are slidingly connected with the inner wall of the first communicating port (11), and the second rotating shaft (12) is connected with the distributing parts outside the concentration box (2). Material motor (39) is connected. 8. a kind of heparin sodium production according to claim 1 is characterized in that, described pulverizing case (3) one side upper end is provided with the second feeding inlet (32), described pulverizing case (3) ) is provided with a circle of grinding layer (33) on the inner central side wall, and the center of the grinding layer (33) is provided with three grinding rollers (34) arranged in an inverted triangle, and one side of the bottom of the crushing box (3) is provided with The second outlet (38). 9. a kind of heparin sodium production according to claim 8 is characterized in that, described grinding roller (34) below is provided with one deck sieving mesh layer (36), and described sieving mesh layer (36) ) is inclined, and the side wall of the inclined lower end of the screen layer (36) is provided with a first discharge port (37), and the bottom of the screen layer (36) is provided with a vibrator (41). 10. The dry crushing device for producing heparin sodium according to claim 9, characterized in that a heating layer (35) is arranged inside the grinding roller (34).

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