CN113908898B - Contamination-resistant sealed cap with barrier filter, multi-chamber sample preparation device - Google Patents
Contamination-resistant sealed cap with barrier filter, multi-chamber sample preparation device Download PDFInfo
- Publication number
- CN113908898B CN113908898B CN202111370729.4A CN202111370729A CN113908898B CN 113908898 B CN113908898 B CN 113908898B CN 202111370729 A CN202111370729 A CN 202111370729A CN 113908898 B CN113908898 B CN 113908898B
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- barrier filter
- base
- sealing
- hole
- cover body
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- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 230000004888 barrier function Effects 0.000 title claims abstract description 25
- 238000011109 contamination Methods 0.000 title 1
- 238000007789 sealing Methods 0.000 claims abstract description 69
- 239000000443 aerosol Substances 0.000 claims abstract description 22
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 14
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 14
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 14
- 238000005245 sintering Methods 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 description 28
- 239000007789 gas Substances 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 5
- 238000005086 pumping Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012229 microporous material Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/0027—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with additional separating or treating functions
- B01D46/0032—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with additional separating or treating functions using electrostatic forces to remove particles, e.g. electret filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
本发明提供一种设有阻隔滤芯的防污染密封盖、多腔室样本制备装置，其中的防污染密封盖，包括相向扣合的盖体及底座，所述盖体与所述底座之间形成密封腔体，且所述盖体与所述底座之间形成进气间隙，所述进气间隙内装设有阻隔滤芯，所述阻隔滤芯能够拦截所述进气间隙进入的气体中的核酸气溶胶而允许气体通过，所述底座上构造有与所述进气间隙连通的过气孔，所述底座远离所述盖体的一侧能够与多腔室样本制备盒体密封连接。本发明，能够对进出气流中可能存在的核酸气溶胶实现拦截，从而防止气溶胶进入系统内部产生气溶胶污染问题。
The present invention provides an anti-pollution sealing cover and a multi-chamber sample preparation device provided with a barrier filter, wherein the anti-pollution sealing cover comprises a cover body and a base that are buckled in opposite directions, a sealed cavity is formed between the cover body and the base, and an air intake gap is formed between the cover body and the base, a barrier filter is installed in the air intake gap, the barrier filter can intercept the nucleic acid aerosol in the gas entering the air intake gap and allow the gas to pass through, an air hole connected to the air intake gap is constructed on the base, and the side of the base away from the cover body can be sealed and connected to the multi-chamber sample preparation box. The present invention can intercept the nucleic acid aerosol that may exist in the inlet and outlet airflows, thereby preventing the aerosol from entering the system and causing aerosol pollution.
Description
Technical Field
The invention belongs to the technical field of nucleic acid molecular diagnosis, and particularly relates to an anti-pollution sealing cover with a separation filter element and a multi-chamber sample preparation device.
Background
With the continuous development of in-vitro diagnosis technology and the continuous exploration of accurate medical treatment, molecular diagnosis technology is gradually accepted by the medical examination staff due to the advantages of high sensitivity, high detection speed and the like. The PCR product occupies the main market of molecular diagnosis, has high sensitivity, strong specificity and short diagnosis window period, can be used for qualitative or quantitative detection, and is widely used for diagnosing infectious diseases, prepotency, genetic diseases genes, tumors and other diseases. The PCR detection requires steps of sample pretreatment, nucleic acid extraction and purification, PCR amplification, software analysis and interpretation and the like from sample acquisition to detection result acquisition, thereby bringing a series of problems such as the need of various professional equipment, complex operation steps, high requirement on the operation skills of practitioners, long time consumption, laboratory pollution and the like.
In order to solve the problems, a plurality of fully integrated microfluidic chip products are developed in recent years, one instrument is provided with a multifunctional integrated chip, reagents required by all reactions are integrated in the chip, and the full-flow operation of sample inlet-outlet can be realized. One type of microfluidic chip product controls the flow of liquid in the chip by pumping through a micropump valve, and in the pumping process of the pump valve, air in the environment can be brought into the chip along with the pumping, and if the test environment is polluted by nucleic acid aerosol, a detection chip behind the test environment can cause false positive problem due to aerosol pollution. Therefore, when designing such integrated chips, in addition to the storage of various reagents and the design of flow path functions, the design of pollution prevention of the gas exchange portion between the inside and the outside of the chip is also important to consider.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide the anti-pollution sealing cover with the blocking filter element and the multi-chamber sample preparation device, which can intercept nucleic acid aerosol possibly existing in inlet and outlet air flow, thereby preventing aerosol from entering the system to generate aerosol pollution.
In order to solve the problems, the invention provides an anti-pollution sealing cover with a blocking filter element, which comprises a cover body and a base which are buckled in opposite directions, wherein a sealing cavity is formed between the cover body and the base, an air inlet gap is formed between the cover body and the base, the blocking filter element is arranged in the air inlet gap, the blocking filter element can intercept nucleic acid aerosol in gas entering from the air inlet gap to allow the gas to pass through, an air passing hole communicated with the air inlet gap is formed in the base, and one side of the base far away from the cover body can be in sealing connection with a multi-cavity sample preparation box body.
In some embodiments, the barrier filter element is electrically, preferably positively, charged and/or is formed from a hydrophobic material.
In some embodiments, the barrier filter element is a porous structure made of powdery polymer material through high-temperature sintering or stamping, and the pore diameter of the porous structure is between 0.05 and 10 mu m
In some embodiments, a first through hole is penetrated in the central position of the base, a second through hole corresponding to the first through hole is formed in the central position of the cover body, the air inlet gap is formed between the orifice of the second through hole and the orifice of the first through hole, and the upper end face and the lower end face of the blocking filter element are clamped by the orifice of the second through hole and the orifice of the first through hole.
In some embodiments, the base has a sealing platform extending toward one side of the cover at a position of the aperture of the first through hole, and the plurality of air passing holes are configured on the sealing platform.
In some embodiments, the sealing platform is a circular boss, the inner diameter of the circular boss is larger than the apertures of the first through hole and the second through hole, and the blocking filter element is cylindrical.
In some embodiments, a sealing membrane is attached to the sealing platform.
In some embodiments, the cover body is screwed with the base, and/or a sealing ring is arranged between the cover body and the base, so that gas can only enter the sealing cavity through the blocking filter element.
In some embodiments, a sealing rib is arranged on one side of the base, which faces away from the cover body, and the sealing rib separates the plurality of air passing holes into mutually independent spaces one by one.
The invention also provides a multi-cavity sample preparation device which comprises a multi-cavity sample preparation box body, wherein the anti-pollution sealing cover provided with the blocking filter element is connected to the opening of the top of the multi-cavity sample preparation box body in a sealing way.
According to the anti-pollution sealing cover provided by the invention, when the corresponding multi-cavity sample preparation box body needs to have gas inlet and outlet, the blocking filter element can intercept nucleic acid aerosol possibly existing in inlet and outlet air flow, so that the problem of aerosol pollution caused by the fact that the aerosol enters the system is prevented.
Drawings
FIG. 1 is a schematic perspective view of an anti-pollution seal cover according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of FIG. 1 (curved arrows in the figure illustrate the general flow direction of the air flow);
FIG. 3 is a schematic perspective view of the cover in FIG. 1;
fig. 4 is a schematic perspective view of the base in fig. 1.
The reference numerals are expressed as:
1. The filter comprises a cover body, a cover body annular wall, 12 parts of first radial protrusions, 13 parts of second through holes, 2 parts of a base, 21 parts of gas passing holes, 22 parts of first through holes, 23 parts of base annular walls, 24 parts of second radial protrusions, 25 parts of sealing platforms and 3 parts of blocking filter elements.
Detailed Description
Referring to fig. 1 to 4, according to an embodiment of the present invention, an anti-pollution sealing cover provided with a blocking filter element is provided, and the anti-pollution sealing cover comprises a cover body 1 and a base 2 which are buckled in opposite directions, a sealing cavity is formed between the cover body 1 and the base 2, an air inlet gap is formed between the cover body 1 and the base 2, a blocking filter element 3 is installed in the air inlet gap, the blocking filter element 3 can intercept nucleic acid aerosol in gas entering in the air inlet gap to allow the gas to pass through, a gas passing hole 21 communicated with the air inlet gap is formed in the base 2, and one side, far away from the cover body 1, of the base 2 can be in sealing connection with a multi-chamber sample preparation box body, and it can be understood that the blocking filter element 3 is made of a microporous material which can be ventilated so as to ensure that both forward and reverse directions of air can pass through, specifically, the blocking filter element 3 is a porous structure made of a powder polymer material through high temperature sintering or punching, and the pore diameter of the porous structure is between 0.05 μm and 10 μm. According to the technical scheme, when the corresponding multi-cavity sample preparation box body needs to have gas inlet and outlet, the separation filter element 3 can realize physical interception on nucleic acid aerosol possibly existing in inlet and outlet gas flow, so that the problem of aerosol pollution caused by the fact that the aerosol enters the system is prevented.
Furthermore, the blocking filter element 3 is provided with electropositivity, so that the electrostatic adsorption function can be compounded on the basis of physically intercepting the nucleic acid aerosol by the blocking filter element 3, the intercepting effect of the aerosol is further improved, and/or the blocking filter element 3 is made of a hydrophobic material, so that the blocking filter element 3 can adsorb water vapor in the air flow to influence the air passing rate. It can be understood that the smaller the aperture of the blocking filter element 3, the higher the interception efficiency of the nucleic acid aerosol, but the smaller the aperture, the lower the air permeability, so that the screening is performed in consideration of the actual use of the sealing cover. Preferably, however, the barrier filter element 3 is only capable of passing gases, but not liquids and solids. In some embodiments, the blocking filter element 3 is one of nylon, teflon, polypropylene and polyethylene, preferably a filter element made by a polyethylene sintering process, and can effectively block nucleic acid aerosol.
In some embodiments, the central position of the base 2 is penetrated by a first through hole 22, the central position of the cover 1 is provided with a second through hole 13 corresponding to the first through hole 22, the air inlet gap is formed between the orifice of the second through hole 13 and the orifice of the first through hole 22, the upper end surface and the lower end surface of the blocking filter element 3 are clamped by the orifice of the second through hole 13 and the orifice of the first through hole 22, the first through hole 22 and the second through hole 13 are penetrated in the axial direction of the sealing cover, a through passage of a suction pump valve provided with the multi-chamber sample preparation box body is formed, and the assembly requirement of related instruments and equipment is met, and meanwhile, the orifices of the two also form the air inlet gap and clamp the blocking filter element 3, so that the sealing cover has a simple and compact structure.
In some embodiments, the base 2 has a sealing platform 25 extending towards one side of the cover 1 at the position of the opening of the first through hole 22, a plurality of air passing holes 21 are configured on the sealing platform 25, further, the sealing platform 25 is a circular boss, the inner diameter of the circular boss is larger than the apertures of the first through hole 22 and the second through hole 13, and the blocking filter element 3 is cylindrical, so that the inner hole of the circular boss forms a positioning structure of the blocking filter element 3, so that the position of the blocking filter element 3 is more stable, and the central through hole of the cylindrical blocking filter element 3 can avoid a suction rod of a corresponding instrument.
The sealing platform 25 is connected with a sealing film (not shown in the figure), when the preparation box body is sealed with the sealing cover and the sealing film can be fixed on the sealing platform 25 in a hot pressing, ultrasonic welding and other modes after the preparation box body is filled with the reagent, the liquid reagent is prevented from being poured or volatilized, the solid reagent is prevented from being affected with damp and spoiled, when the sealing film is uncovered by a user (namely an operator), the air passing hole 21 is restored to a smooth state, and the function of controlling the liquid through pumping of the pump valve is realized.
In some embodiments, the cover 1 and the base 2 are connected in a screwing manner, the screwing manner may be a rotary engagement or a threaded screwing manner, specifically, the base 2 has a base annular wall 23 extending towards one side of the cover 1, when the cover 1 is fastened to the base 2, the cover annular wall 11 of the cover 1 and the base annular wall 23 are sealed together, wherein the inner wall of the cover annular wall 11 is provided with a plurality of first radial protrusions 12 arranged at intervals circumferentially, the outer wall of the base annular wall 23 is provided with a plurality of second radial protrusions 24 arranged at intervals circumferentially, and the plurality of first radial protrusions 12 and the plurality of second radial protrusions 24 are staggered with each other and can form axial overlapping under the action of an operator, so that the axial connection of the cover 1 and the base 2 is realized, and at this time, the top end surface of the base annular wall 23 is provided with a sealing ring (not shown in the figure) so that the axial connection between the cover 1 and the base annular wall 2 can be sealed only by the axial connection of the filter element 3. When the screwing connection is screwed, the sealing ring is not arranged, and sealing is realized through interference fit among threads in the screwing process.
In some embodiments, a sealing rib (not shown in the figure) is disposed on a side of the base 2 facing away from the cover 1, the sealing rib separates the plurality of air passing holes 21 into mutually independent spaces, and the independent spaces are respectively in one-to-one correspondence with the plurality of chambers of the multi-chamber sample preparation cartridge body and are in sealing connection with each other through the sealing rib.
According to the embodiment of the invention, the multi-cavity sample preparation device comprises a multi-cavity sample preparation box body, and the anti-pollution sealing cover provided with the blocking filter element is connected to the opening of the top of the multi-cavity sample preparation box body in a sealing way. That is, the base 2 needs to be sealed with the multi-chamber sample preparation cartridge, and the periphery of the central through hole (concentrically arranged with the first through hole 22) of the sample preparation cartridge is provided with a plurality of accommodating chambers isolated from each other, the accommodating chambers are pre-filled with liquid or solid biological detection reagents, and the base 2 and the preparation cartridge can be sealed by ultrasonic welding, laser welding, heat sealing and the like. Besides the peripheral and peripheral sealing of the base 2 and the central through hole of the preparation box, a plurality of containing cavities isolated from each other in the preparation box are sealed independently, so that a sealing groove (namely the sealing rib) corresponding to the wall of the containing cavity is arranged on the back surface of the base, and the sealing is convenient. At least one air passing hole 21 is arranged in the sealing groove in a surrounding mode, the size of the air passing holes 21 can be equal or different, the size of the air passing holes 21 can be set according to the use requirement, and the air passing holes 21 can be used for ventilation, liquid injection and the like.
It will be readily appreciated by those skilled in the art that the above advantageous ways can be freely combined and superimposed without conflict.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention. The foregoing is merely a preferred embodiment of the present invention, and it should be noted that it will be apparent to those skilled in the art that modifications and variations can be made without departing from the technical principles of the present invention, and these modifications and variations should also be regarded as the scope of the invention.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111370729.4A CN113908898B (en) | 2021-11-18 | 2021-11-18 | Contamination-resistant sealed cap with barrier filter, multi-chamber sample preparation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111370729.4A CN113908898B (en) | 2021-11-18 | 2021-11-18 | Contamination-resistant sealed cap with barrier filter, multi-chamber sample preparation device |
Publications (2)
| Publication Number | Publication Date |
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| CN113908898A CN113908898A (en) | 2022-01-11 |
| CN113908898B true CN113908898B (en) | 2025-03-28 |
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| CN202111370729.4A Active CN113908898B (en) | 2021-11-18 | 2021-11-18 | Contamination-resistant sealed cap with barrier filter, multi-chamber sample preparation device |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113913282B (en) * | 2021-11-18 | 2024-08-20 | 鲲鹏基因(北京)科学仪器有限公司 | Anti-pollution sealing cover with barrier film and multi-chamber sample preparation device |
Citations (3)
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| CN214654798U (en) * | 2020-11-26 | 2021-11-09 | 深圳市理邦精密仪器股份有限公司 | Molecular diagnosis centrifugal test card |
| CN216368044U (en) * | 2021-11-18 | 2022-04-26 | 鲲鹏基因（北京）科技有限责任公司 | Anti-pollution sealed lid, multi-chamber sample preparation facilities with separation filter core |
| CN217103881U (en) * | 2021-11-18 | 2022-08-02 | 鲲鹏基因（北京）科技有限责任公司 | Anti-pollution sealed cover with barrier film and multi-cavity sample preparation device |
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| DE4220560C1 (en) * | 1992-06-24 | 1993-09-16 | Bergwerksverband Gmbh, 45307 Essen, De | Gravimetric dust measuring device - has filter holder fitted with lids to form transport container |
| US5404762A (en) * | 1993-01-15 | 1995-04-11 | The Regents Of The Univ. Of California Office Of Technology Transfer | Quick-change filter cartridge |
| GB2311857A (en) * | 1996-04-02 | 1997-10-08 | Molyneux Shlosberg Lindsay | Monitoring gas for particulates |
| JP4407909B2 (en) * | 2004-03-16 | 2010-02-03 | 理研計器株式会社 | Gas analyzer filter |
| CN101210910B (en) * | 2006-12-31 | 2011-03-09 | 同方威视技术股份有限公司 | Gas filter and buffer integrated device |
| DE102012017972B4 (en) * | 2012-09-12 | 2017-06-22 | Sartorius Stedim Biotech Gmbh | combifilter |
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| US11946843B2 (en) * | 2017-06-26 | 2024-04-02 | Splitrx Llc | Sample filtration device |
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| CN214654798U (en) * | 2020-11-26 | 2021-11-09 | 深圳市理邦精密仪器股份有限公司 | Molecular diagnosis centrifugal test card |
| CN216368044U (en) * | 2021-11-18 | 2022-04-26 | 鲲鹏基因（北京）科技有限责任公司 | Anti-pollution sealed lid, multi-chamber sample preparation facilities with separation filter core |
| CN217103881U (en) * | 2021-11-18 | 2022-08-02 | 鲲鹏基因（北京）科技有限责任公司 | Anti-pollution sealed cover with barrier film and multi-cavity sample preparation device |
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