CN120766861A - Remote respiratory disease inhalation drug management method and related device - Google Patents

Abstract

The invention discloses a remote respiratory disease inhalation medicine management method and a related device, wherein the method comprises the steps of dynamically constructing a personalized inhalation preparation management path according to clinical data, genome data and past medicine history of a patient, calling a patient visit or treatment portrait through a medical care end, automatically sending multi-mode guidance information to the patient end by combining with a time node of the personalized inhalation preparation management path, completing on-line card punching recording through the patient end to record inhalation medicine condition and physiological data during medicine taking, and evaluating inhalation operation videos and card punching recording transmitted by the patient end through the medical care end to obtain the proficiency of inhalation operation of the patient. By continuously monitoring, evaluating and guiding the inhalation technology capability of the patient, the inhalation technology grasping capability of the patient is improved, and the inhalation medication compliance of the patient is improved, so that the administration level of the inhalation medication of the patient with the respiratory chronic airway diseases is improved.

Description

Method and related device for managing inhalation medicine for remote respiratory diseases

Technical Field

The invention relates to the technical field of artificial intelligence auxiliary medical treatment, in particular to a remote respiratory disease inhalation medicine management method and device and computing equipment.

Background

Inhalation therapy is a main treatment method of chronic airway diseases, and factors such as misuse of an inhalation device, poor compliance and the like affect the curative effect of medicines and the prognosis of the diseases of patients, so that medical resources are wasted. Thus, the assessment of inhalation technology is an important element of the stationary phase management of chronic airway diseases. Traditional management mode limitations are typically demonstrated and guided by a doctor or nurse to the actual patient's operation when the patient first selects inhalation therapy, evaluating inhalation techniques, and part of the patient re-evaluates during review, checks usage, compliance and efficacy. Due to the influence of manpower, material resources, time, distance and other factors, it is difficult for medical staff to continuously evaluate and check the use methods, compliance and the like during the treatment of patients.

In order to solve the problems, the invention provides a remote respiratory disease inhalation drug management method, which is used for improving the grasping ability of a patient inhalation technology and improving the inhalation drug compliance of the patient by continuously monitoring, evaluating and guiding the inhalation technology ability of the patient, thereby improving the administration level of the inhalation drug of the patient with the respiratory chronic airway disease.

Disclosure of Invention

In view of the above, the present invention provides a method and apparatus for remote respiratory disease inhalation drug management, and a computing device.

According to one aspect of the present invention, there is provided a remote respiratory disease inhalation drug management method comprising:

Dynamically constructing a personalized inhalation preparation management path according to clinical data, genome data and prior medication history of a patient;

The medical care terminal is used for calling a patient to visit a doctor or a treatment portrait, and automatically sending multi-mode guiding information to the patient terminal by combining with a time node of the personalized inhalation preparation management path, wherein the multi-mode guiding information comprises an inhalation operation video, use notes and personalized medication reminding;

The patient end is used for finishing on-line punching records to record inhalation medication conditions and physiological data during medication, and the medical care end is used for evaluating inhalation operation videos and punching records transmitted by the patient end to obtain the proficiency of inhalation operation of the patient.

In an alternative, the dynamically constructing a personalized inhalation formulation management path further comprises:

Constructing a three-dimensional characteristic tensor through a patient clinical data matrix and a medical history sequence;

Performing dimension reduction on the three-dimensional feature tensor to reserve a preset number of principal components;

optimizing a dosing time node sequence by an objective function, wherein the objective function is:

The method comprises the steps of taking a medicine requirement amount as an ith administration time node, taking the medicine requirement amount as a main component amount, taking the contribution degree of the jth main component to the medicine effect as a contribution degree of the jth main component, taking the contribution degree of the jth main component as a constraint coefficient of an administration time interval, taking the administration time node interval as the administration time node interval and taking the total administration time node amount in an inhaled medicine management period as the administration time node amount.

In an alternative, assessing the proficiency of the inhalation maneuver of the patient further comprises:

Detecting human body key points in the video by adopting YOLOv model, and cutting out an operation area with 640 multiplied by 480 pixels;

Decomposing the inhalation operation into 5 stages of a taking device, an opening device, deep inhalation, breath-hold and closing devices, wherein 20 key frame templates are arranged in each stage;

And obtaining proficiency according to the structural similarity index and the optical flow motion trail deviation of each stage.

In an alternative way, the proficiency calculation formula is:

The method comprises the steps of obtaining a structural similarity index of each stage, obtaining an average angle of optical flow motion track deviation and obtaining a proficiency grading coefficient.

In an alternative manner, the operation step of on-line card punching recording further includes:

the activation time, duration and airflow rate for each medication was recorded by the bluetooth inhaler;

Constructing a multidimensional time sequence through HRV data and body temperature data of the intelligent bracelet;

And monitoring the deviation degree of the data in real time, generating Zhou Weidu reports, and starting a secondary auditing process when the abnormality index of the deviation degree is larger than a preset threshold value, wherein the circumferential dimension reports comprise medication compliance curves, symptom fluctuation thermodynamic diagrams and physiological index change trends.

In an alternative way, the patient end includes:

The interactive medication calendar module is used for converting a medication administration time node into an interactive 3D pill model through a time axis visualization method;

the gambling incentive system module is used for exchanging virtual medals according to the points;

And the real-time feedback loop module monitors the holding angle and the air suction flow in real time through a nine-axis sensor arranged in the Bluetooth inhaler, and triggers vibration reminding and a voice command when the operation deviation exceeds a preset threshold value.

In an alternative, the medical tip includes:

the multidimensional evaluation module is used for constructing a weighted evaluation model comprising operation standardization, medication compliance, physiological index improvement rate and subjective symptom scores;

And the risk prediction module is used for constructing an early warning model according to LightGBM algorithm and outputting the probability of acute exacerbation risk of 48 hours in the future, wherein the input characteristics of the early warning model comprise the median of the medication time deviation of the past 7 days, the rate of decline of the last FEV1/FVC ratio and the duration variation coefficient of the breath hold stage in the operation video.

In an alternative, the medical tip further comprises:

the patient initiative consultation module can make a question or a problem about inhalation treatment at any time, and the consultation form comprises characters, voice, pictures and video;

and the tertiary response module comprises a doctor intelligent assistant, a nurse and a doctor tertiary response mechanism to solve the problem of the patient in a layering way.

According to another aspect of the present invention, there is provided a remote respiratory disease inhalation drug management device comprising:

the personalized path construction module is used for dynamically constructing a personalized inhalation preparation management path according to clinical data, genome data and prior medication history of a patient;

The multi-mode guide information pushing module is used for calling a patient visit or treatment portrait through the medical care end, and automatically sending multi-mode guide information to the patient end by combining with the time node of the personalized inhalation preparation management path, wherein the multi-mode guide information comprises an inhalation operation video, a use notice and a personalized medication reminder;

The proficiency evaluation module is used for finishing on-line punching records through the patient end to record inhalation medication conditions and physiological data during medication, and evaluating inhalation operation videos and punching records transmitted by the patient end through the medical care end to obtain the proficiency of inhalation operation of the patient.

According to yet another aspect of the present invention, there is provided a computing device comprising a processor, a memory, a communication interface and a communication bus, the processor, the memory and the communication interface completing communication with each other through the communication bus;

the memory is used for storing at least one executable instruction, and the executable instruction enables the processor to execute the operation corresponding to the remote respiratory disease inhalation medicine management method.

According to the scheme provided by the invention, a personalized inhalation preparation management path is dynamically constructed according to clinical data, genome data and past medication history of a patient, a patient visit or treatment portrait is called through a medical care end, multi-mode guide information is automatically sent to the patient end by combining a time node of the personalized inhalation preparation management path, wherein the multi-mode guide information comprises inhalation operation videos, use notes and personalized medication reminders, on-line card punching records are completed through the patient end to record inhalation medication conditions and physiological data during medication, and the inhalation operation videos and card punching records transmitted by the patient end are evaluated through the medical care end to obtain the proficiency of patient inhalation operation. By continuously monitoring, evaluating and guiding the inhalation technology capability of the patient, the inhalation technology grasping capability of the patient is improved, and the inhalation medication compliance of the patient is improved, so that the administration level of the inhalation medication of the patient with the respiratory chronic airway diseases is improved.

The foregoing description is only an overview of the present invention, and is intended to be implemented in accordance with the teachings of the present invention in order that the same may be more clearly understood and to make the same and other objects, features and advantages of the present invention more readily apparent.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to designate like parts throughout the figures. In the drawings:

FIG. 1 is a flow chart of a method for remote respiratory disease inhalation drug management according to an embodiment of the present invention;

FIG. 2 shows a schematic frame diagram of a remote respiratory disease inhalation drug management device according to an embodiment of the present invention;

FIG. 3 illustrates a schematic diagram of a computing device in accordance with an embodiment of the invention.

Detailed Description

Exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

Fig. 1 shows a flow chart of a remote respiratory disease inhalation drug management method according to an embodiment of the present invention. Specifically, as shown in fig. 1, the method comprises the following steps:

step S101, dynamically constructing a personalized inhalation preparation management path according to clinical data, genome data and prior medical history of a patient.

In this example, the most appropriate drug type, dosage and time of administration can be selected by clinical data, genomic information and past history of administration, thereby maximizing drug efficacy. The management path is not constant, but is adjusted as the patient's condition changes, new clinical data or genomic information is obtained, ensuring that the treatment regimen is always in an optimal state.

For example, a patient with asthma has clinical data of 35 years of age and 5 years of disease progression, FEV1 was 70% of normal, frequent nocturnal cough, and symptoms were controlled using glucocorticoid/LABA complex inhalants. Genomic data gene detection shows that patients carry CYP2C9 x 3/x3 genotypes, and the metabolism speed of certain drugs is low. The prior medicine history has better effect on budesonide/formoterol compound inhalant, but palpitation appears when salmeterol/fluticasone compound inhalant is used. The extraction of age, course of disease, FEV1, nocturnal cough frequency, CYP2C9 genotype, response to budesonide/formoterol, response to salmeterol/fluticasone is characterized. Regression models were used to predict the patient response to different doses of budesonide/formoterol and the optimal dosing time. The optimal regimen for predicting patients is budesonide/formoterol 160/4.5 μg twice daily. The patient frequently coughs at night and is used once before sleeping. After one month the patients had significantly improved nocturnal cough, with FEV1 raised to 80% of normal. The medical care terminal App gives the reason for adjustment according to the recommended scheme, for example, the cough at night is obviously improved, the FEV1 is improved, and the frequency of pre-sleep medication is reduced.

In an alternative, the dynamically constructing a personalized inhalation formulation management path further comprises:

Constructing a three-dimensional characteristic tensor through a patient clinical data matrix and a medical history sequence;

Performing dimension reduction on the three-dimensional feature tensor to reserve a preset number of principal components;

optimizing a dosing time node sequence by an objective function, wherein the objective function is:

The method comprises the steps of taking a medicine requirement amount as an ith administration time node, taking the medicine requirement amount as a main component amount, taking the contribution degree of the jth main component to the medicine effect as a contribution degree of the jth main component, taking the contribution degree of the jth main component as a constraint coefficient of an administration time interval, taking the administration time node interval as the administration time node interval and taking the total administration time node amount in an inhaled medicine management period as the administration time node amount.

In this embodiment, the objective function minimizes the difference between the drug demand and the actual drug delivery outcome and takes into account constraints on the time interval of drug delivery, thereby optimizing the time node sequence of drug delivery.

Step S102, a patient visit or treatment portrait is called through a medical care end, and multi-mode guiding information is automatically sent to the patient end by combining with a time node of the personalized inhalation preparation management path, wherein the multi-mode guiding information comprises inhalation operation videos, use notes and personalized medication reminders.

In this embodiment, the medical care end invokes the patient's visit or treatment portrait, and combines with the personalized inhalation preparation management path to provide a customized treatment scheme for each patient, thereby improving the pertinence of treatment. The multimodal guidance information includes inhalation operation videos, usage notes and personalized medication reminders, improving patient compliance and operation accuracy. The multi-mode guiding information is automatically sent to the patient end, so that the workload of medical staff is reduced, and the patient is ensured to acquire the required treatment information in time.

Step S103, on-line punching recording is completed through the patient end to record inhalation medication conditions and physiological data during medication, and the inhalation operation video and punching recording transmitted by the patient end are evaluated through the medical care end to obtain the proficiency of inhalation operation of the patient.

In this embodiment, on-line card punching recording is completed through the patient end, and the inhalation medication condition and the physiological data during medication are recorded in real time. The medical care end evaluates the inhalation operation video and the punching record transmitted by the patient end, performs personalized evaluation according to the specific condition of the patient, provides targeted guidance, and can better solve the medication condition and the physiological data change of the patient, thereby improving medication compliance. Through the evaluation of the inhalation operation video and the punching record, the inhalation operation proficiency of the patient can be accurately evaluated, the patient is helped to improve the operation skill, and the treatment effect is improved.

In an alternative, assessing the proficiency of the inhalation maneuver of the patient further comprises:

Detecting human body key points in the video by adopting YOLOv model, and cutting out an operation area with 640 multiplied by 480 pixels;

Decomposing the inhalation operation into 5 stages of a taking device, an opening device, deep inhalation, breath-hold and closing devices, wherein 20 key frame templates are arranged in each stage;

And obtaining proficiency according to the structural similarity index and the optical flow motion trail deviation of each stage.

In this embodiment, the inhalation operation is decomposed into five stages (a picking device, an opening device, a deep inhalation, a breath-hold and a closing device), and 20 key frame templates are set in each stage, so that the whole inhalation process can be covered in a full scale, and each detail can be evaluated. The operation proficiency of the patient is evaluated through the Structural Similarity Index (SSIM) and the optical flow motion trail deviation, the operation condition of the patient can be more comprehensively reflected, and the evaluation result is dynamically adjusted.

In an alternative way, the proficiency calculation formula is:

The method comprises the steps of obtaining a structural similarity index of each stage, obtaining an average angle of optical flow motion track deviation and obtaining a proficiency grading coefficient.

In this embodiment, the weight of the SSIM and the optical flow motion trajectory deviation in the proficiency assessment is flexibly adjusted by the proficiency grading coefficient, so that the importance of different indexes can be adjusted according to the actual situation and experience, for example, in some cases, the normalization of the actions is more important than the similarity of the operation steps, such as the operation of a patient in a deep inspiration phase is more proficient, and the operation in a breath-hold phase needs to be improved.

In an alternative manner, the operation step of on-line card punching recording further includes:

the activation time, duration and airflow rate for each medication was recorded by the bluetooth inhaler;

Constructing a multidimensional time sequence through HRV data and body temperature data of the intelligent bracelet;

And monitoring the deviation degree of the data in real time, generating Zhou Weidu reports, and starting a secondary auditing process when the abnormality index of the deviation degree is larger than a preset threshold value, wherein the circumferential dimension reports comprise medication compliance curves, symptom fluctuation thermodynamic diagrams and physiological index change trends.

In the embodiment, the inhaler with the Bluetooth connection function is selected, the data such as the activation time, the duration time and the air flow rate of each medication are automatically recorded, the intelligent bracelet with the Heart Rate Variability (HRV) and the body temperature monitoring function is provided, the manual recording burden of a patient is reduced, and the data collection efficiency and accuracy are improved.

In an alternative way, the patient end includes:

The interactive medication calendar module is used for converting a medication administration time node into an interactive 3D pill model through a time axis visualization method;

the gambling incentive system module is used for exchanging virtual medals according to the points;

And the real-time feedback loop module monitors the holding angle and the air suction flow in real time through a nine-axis sensor arranged in the Bluetooth inhaler, and triggers vibration reminding and a voice command when the operation deviation exceeds a preset threshold value.

In this embodiment, the interactive medication calendar module converts the medication administration time node into an interactive 3D pill model through a time axis visualization method, so that the patient can intuitively understand his medication plan and progress. The holding angle and the air suction flow are monitored in real time through a nine-axis sensor arranged in the Bluetooth inhaler, and when the operation deviation exceeds a preset threshold value, vibration reminding and voice instructions are triggered, so that a patient is helped to correct operation errors in time. Through the interactive medication calendar and real-time feedback loop, the patient is able to better manage his own medication process.

In an alternative, the medical tip includes:

the multidimensional evaluation module is used for constructing a weighted evaluation model comprising operation standardization, medication compliance, physiological index improvement rate and subjective symptom scores;

And the risk prediction module is used for constructing an early warning model according to LightGBM algorithm and outputting the probability of acute exacerbation risk of 48 hours in the future, wherein the input characteristics of the early warning model comprise the median of the medication time deviation of the past 7 days, the rate of decline of the last FEV1/FVC ratio and the duration variation coefficient of the breath hold stage in the operation video.

In this example, the input features include median medication time bias over the past 7 days, rate of last FEV1/FVC ratio decrease, and breath hold period duration coefficient of variation in the operating video, more accurately reflecting patient health and treatment compliance.

In an alternative, the medical tip further comprises:

the patient initiative consultation module can make a question or a problem about inhalation treatment at any time, and the consultation form comprises characters, voice, pictures and video;

and the tertiary response module comprises a doctor intelligent assistant, a nurse and a doctor tertiary response mechanism to solve the problem of the patient in a layering way.

In this embodiment, for example, the patient encounters a problem when using the inhaler, and cannot operate correctly, and consultation can be initiated by the mobile application, and the video of operating the inhaler by himself is selected to be recorded in the form of video and sent to the medical care terminal. The intelligent assistant receives the video consultation, identifies the problems in the operation of the patient through video analysis and generates replies to provide operation guidance videos and text descriptions. If the intelligent assistant is unable to solve the problem, the system hands over the consultation to the nurse. The nurse receives the consultation and communicates with the patient through the video call to provide detailed operation guidance and notice. If the nurse is unable to resolve the problem, the consultation is handed over to the doctor. The doctor receives the consultation and communicates with the patient through video call, provides diagnosis and treatment advice and adjusts the treatment scheme of the patient.

According to the scheme provided by the invention, a personalized inhalation preparation management path is dynamically constructed according to clinical data, genome data and past medication history of a patient, a patient visit or treatment portrait is called through a medical care end, multi-mode guide information is automatically sent to the patient end by combining a time node of the personalized inhalation preparation management path, wherein the multi-mode guide information comprises inhalation operation videos, use notes and personalized medication reminders, on-line card punching records are completed through the patient end to record inhalation medication conditions and physiological data during medication, and the inhalation operation videos and card punching records transmitted by the patient end are evaluated through the medical care end to obtain the proficiency of patient inhalation operation. By continuously monitoring, evaluating and guiding the inhalation technology capability of the patient, the inhalation technology grasping capability of the patient is improved, and the inhalation medication compliance of the patient is improved, so that the administration level of the inhalation medication of the patient with the respiratory chronic airway diseases is improved.

Fig. 2 shows a schematic frame diagram of a remote respiratory disease inhalation drug management device according to an embodiment of the present invention. The remote respiratory disease inhalation drug management device comprises:

A personalized route construction module 210 for dynamically constructing a personalized inhalation formulation management route based on clinical data, genomic data, and past medical history of the patient;

The multi-mode guiding information pushing module 220 is configured to automatically send multi-mode guiding information to the patient end by using the medical care end to take a patient visit or treatment portrait and combining the time node of the personalized inhalation preparation management path, where the multi-mode guiding information includes inhalation operation video, use notes and personalized medication reminding;

The proficiency evaluation module 230 is used for finishing on-line punching records through the patient end to record inhalation medication conditions and physiological data during medication, and evaluating inhalation operation videos and punching records transmitted by the patient end through the medical care end to obtain the proficiency of inhalation operation of the patient.

FIG. 3 illustrates a schematic diagram of an embodiment of a computing device of the present invention, and the embodiments of the present invention are not limited to a particular implementation of the computing device.

As shown in FIG. 3, the computing device may include a processor 302, a communication interface (Communications Interface) 304, a memory 306, and a communication bus 308.

Wherein the processor 302, the communication interface 304, and the memory 306 communicate with each other via a communication bus 308. A communication interface 304 for communicating with network elements of other devices, such as clients or other servers. The processor 302 is configured to execute the program 310, and may specifically perform the relevant steps in the embodiments of the remote respiratory disease inhalation drug management method described above.

In particular, program 310 may include program code including computer-operating instructions.

The processor 302 may be a central processing unit CPU, or an Application-specific integrated Circuit ASIC (Application SPECIFIC INTEGRATED Circuit), or one or more integrated circuits configured to implement embodiments of the present invention. The computing device may include one or more processors of the same type, such as one or more CPUs, or of different types, such as one or more CPUs and one or more ASICs.

Memory 306 for storing programs 310. Memory 306 may comprise high-speed RAM memory or may also include non-volatile memory (non-volatile memory), such as at least one disk memory.

According to the scheme provided by the invention, a personalized inhalation preparation management path is dynamically constructed according to clinical data, genome data and past medication history of a patient, a patient visit or treatment portrait is called through a medical care end, multi-mode guide information is automatically sent to the patient end by combining a time node of the personalized inhalation preparation management path, wherein the multi-mode guide information comprises inhalation operation videos, use notes and personalized medication reminders, on-line card punching records are completed through the patient end to record inhalation medication conditions and physiological data during medication, and the inhalation operation videos and card punching records transmitted by the patient end are evaluated through the medical care end to obtain the proficiency of patient inhalation operation. By continuously monitoring, evaluating and guiding the inhalation technology capability of the patient, the inhalation technology grasping capability of the patient is improved, and the inhalation medication compliance of the patient is improved, so that the administration level of the inhalation medication of the patient with the respiratory chronic airway diseases is improved.

Those skilled in the art will appreciate that the modules in the apparatus of the embodiments may be adaptively changed and disposed in one or more apparatuses different from the embodiments. The modules or units or components of the embodiments may be combined into one module or unit or component and, furthermore, they may be divided into a plurality of sub-modules or sub-units or sub-components. Any combination of all features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or units of any method or apparatus so disclosed, may be used in combination, except insofar as at least some of such features and/or processes or units are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings), may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. Furthermore, those skilled in the art will appreciate that while some embodiments herein include some features but not others included in other embodiments, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the following claims, any of the claimed embodiments can be used in any combination. The invention may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware. The steps in the above embodiments should not be construed as limiting the order of execution unless specifically stated.

Claims (10)

1.A method of remote respiratory disease inhalation drug management, comprising:

Dynamically constructing a personalized inhalation preparation management path according to clinical data, genome data and prior medication history of a patient;

The medical care terminal is used for calling a patient to visit a doctor or a treatment portrait, and automatically sending multi-mode guiding information to the patient terminal by combining with a time node of the personalized inhalation preparation management path, wherein the multi-mode guiding information comprises an inhalation operation video, use notes and personalized medication reminding;

The patient end is used for finishing on-line punching records to record inhalation medication conditions and physiological data during medication, and the medical care end is used for evaluating inhalation operation videos and punching records transmitted by the patient end to obtain the proficiency of inhalation operation of the patient.

2. The method of claim 1, wherein the dynamically constructing a personalized inhalation formulation management path further comprises:

Constructing a three-dimensional characteristic tensor through a patient clinical data matrix and a medical history sequence;

Performing dimension reduction on the three-dimensional feature tensor to reserve a preset number of principal components;

optimizing a dosing time node sequence by an objective function, wherein the objective function is:

;

Wherein, the Is the ith administration time node; To be at a time node Is a pharmaceutical demand of (a); is the amount of the main component; the contribution degree of the jth principal component to the drug effect; To be at the time of When the contribution size of the j-th principal component is the same; is a constraint coefficient for the administration time interval; for dosing time node intervals; The total number of administration time nodes in the administration cycle for inhalation.

3. The method of claim 1, wherein assessing the proficiency of a patient's inhalation maneuver further comprises:

Detecting human body key points in the video by adopting YOLOv model, and cutting out an operation area with 640 multiplied by 480 pixels;

Decomposing the inhalation operation into 5 stages of a taking device, an opening device, deep inhalation, breath-hold and closing devices, wherein 20 key frame templates are arranged in each stage;

And obtaining proficiency according to the structural similarity index and the optical flow motion trail deviation of each stage.

4. A method of managing respiratory disease inhalation medication according to claim 3, wherein the proficiency calculation formula is:

;

Wherein, the A structural similarity index for each stage; the average angle of the deviation of the optical flow motion track; the coefficients are graded for proficiency.

5. The method of claim 1, wherein the step of on-line punch-recording further comprises:

the activation time, duration and airflow rate for each medication was recorded by the bluetooth inhaler;

Constructing a multidimensional time sequence through HRV data and body temperature data of the intelligent bracelet;

And monitoring the deviation degree of the data in real time, generating Zhou Weidu reports, and starting a secondary auditing process when the abnormality index of the deviation degree is larger than a preset threshold value, wherein the circumferential dimension reports comprise medication compliance curves, symptom fluctuation thermodynamic diagrams and physiological index change trends.

6. The method for remote respiratory disease inhaled medication management of claim 1, characterized in that the patient end comprises:

The interactive medication calendar module is used for converting a medication administration time node into an interactive 3D pill model through a time axis visualization method;

the gambling incentive system module is used for exchanging virtual medals according to the points;

And the real-time feedback loop module monitors the holding angle and the air suction flow in real time through a nine-axis sensor arranged in the Bluetooth inhaler, and triggers vibration reminding and a voice command when the operation deviation exceeds a preset threshold value.

7. The method for remote respiratory disease inhaled medication management of claim 1, the medical care end is characterized by comprising:

the multidimensional evaluation module is used for constructing a weighted evaluation model comprising operation standardization, medication compliance, physiological index improvement rate and subjective symptom scores;

And the risk prediction module is used for constructing an early warning model according to LightGBM algorithm and outputting the probability of acute exacerbation risk of 48 hours in the future, wherein the input characteristics of the early warning model comprise the median of the medication time deviation of the past 7 days, the rate of decline of the last FEV1/FVC ratio and the duration variation coefficient of the breath hold stage in the operation video.

8. The method for remote respiratory disease inhaled medication management of claim 1, the medical care terminal is characterized by further comprising:

the patient initiative consultation module can make a question or a problem about inhalation treatment at any time, and the consultation form comprises characters, voice, pictures and video;

and the tertiary response module comprises a doctor intelligent assistant, a nurse and a doctor tertiary response mechanism to solve the problem of the patient in a layering way.

9. A remote respiratory disease inhalation drug management device, comprising:

the personalized path construction module is used for dynamically constructing a personalized inhalation preparation management path according to clinical data, genome data and prior medication history of a patient;

The multi-mode guide information pushing module is used for calling a patient visit or treatment portrait through the medical care end, and automatically sending multi-mode guide information to the patient end by combining with the time node of the personalized inhalation preparation management path, wherein the multi-mode guide information comprises an inhalation operation video, a use notice and a personalized medication reminder;

The proficiency evaluation module is used for finishing on-line punching records through the patient end to record inhalation medication conditions and physiological data during medication, and evaluating inhalation operation videos and punching records transmitted by the patient end through the medical care end to obtain the proficiency of inhalation operation of the patient.

10. A computing device comprising a processor, a memory, a communication interface, and a communication bus, the processor, the memory, and the communication interface completing communication with each other over the communication bus;

the memory is used for storing at least one executable instruction, and the executable instruction enables the processor to execute the operation corresponding to the remote respiratory disease inhalation medicine management method.