CN1483393A - Starch hollow capsule and production process thereof - Google Patents
Starch hollow capsule and production process thereof Download PDFInfo
- Publication number
- CN1483393A CN1483393A CNA021347506A CN02134750A CN1483393A CN 1483393 A CN1483393 A CN 1483393A CN A021347506 A CNA021347506 A CN A021347506A CN 02134750 A CN02134750 A CN 02134750A CN 1483393 A CN1483393 A CN 1483393A
- Authority
- CN
- China
- Prior art keywords
- starch
- assisted
- plasticizer
- glue
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002472 Starch Polymers 0.000 title claims abstract description 28
- 239000008107 starch Substances 0.000 title claims abstract description 22
- 235000019698 starch Nutrition 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 14
- 239000002775 capsule Substances 0.000 title abstract 3
- 239000004014 plasticizer Substances 0.000 claims abstract description 19
- 229920000881 Modified starch Polymers 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 235000019426 modified starch Nutrition 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 239000003292 glue Substances 0.000 claims description 31
- 238000009413 insulation Methods 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 229920001875 Ebonite Polymers 0.000 claims description 11
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims description 11
- 235000019890 Amylum Nutrition 0.000 claims description 6
- 238000003825 pressing Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 210000003097 mucus Anatomy 0.000 claims description 2
- 238000002156 mixing Methods 0.000 abstract 2
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000643 oven drying Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 239000008273 gelatin Substances 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 235000011852 gelatine desserts Nutrition 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The hollow starch capsule is prepared with plant starch or starch derivative, plasticizer, water and other components in the weight ratio of 25-94.9 wt%, 0.1-30 wt% and 5-20 wt%. The preparation method comprises mixing starch or starch derivatives and water at a certain ratio, heating to above 60 deg.C, stirring, adding plasticizer at a certain ratio, mixing, standing at a certain temperature, removing bubbles, soaking in liquid, oven drying, and making into capsule. The product has the advantages of difficult denaturation and brittleness, stable disintegration time limit, greatly prolonged storage shelf life and reduced cost.
Description
Technical field
The present invention relates to a kind of medicinal hollow glue and assist and production technology, the hollow glue that does not especially contain animal proteinum is assisted, and comprises that ebonite is assisted with flexible glue to assist and production technology.
Background technology
At present, hollow glue is assisted and is comprised that it is gelatin that ebonite is assisted the main component of assisting with flexible glue, its production technology mainly is to utilize the skin from animal, the gelatin that bone extracts, and adds some plasticizers, edible pigment and opacifier and make gelatin solution, and the reuse mould is stained with glue, solidify, dry and form.This glue by manufacturing of gelatin assist behind the filling medicine owing to gelatin contain animal proteinum be subject to environmental change and in the composition influence of powder charge thing, defective such as existence easily becomes fragile, degeneration, disintegration exceed standard.In view of this, it is that primary raw material is made plant gum and assisted that people attempt again with water-soluble cellulose, overcome effectively because the hidden danger that animal proteinum exists, but its poor mobile performance, disintegration instability, and cost height is difficult to adapt to mechanization filling medicine.In sum, existing glue,medicinal is assisted owing to be subjected to raw-material the influence and the restriction of traditional handicraft, and its character remains the instability objectively, affects the shelf-life that it is deposited widely.
Summary of the invention
The objective of the invention is to disclose the hollow glue of a kind of starch and assist, this glue is assisted and is had stable in properties, thereby can prolong the shelf-life that stores, energy savings.
Another object of the present invention is to disclose the production technology that the hollow glue of above-mentioned starch is assisted, thereby reaches environment-friendly high-efficiency, and simple and direct easy control is convenient and practical.
Above-mentioned purpose of the present invention is to realize by such technical scheme, be that the hollow glue of starch of the present invention is assisted by components such as plant amylum or starch derivatives, plasticizer, water and formed, the percentage by weight of described plant amylum or starch derivatives, plasticizer, water is plant amylum or starch derivatives 25%-94.9%, plasticizer 0.1%-30%, water 5%-20%.
Moreover, as the production technology that the present invention taked, comprise the production technology that empty hard is assisted and flexible glue is assisted, wherein ebonite is assisted and is comprised that system liquid, mucus, oven dry, cutting, fit, flexible glue are assisted and comprise system liquid, be stained with liquid, cooling, suction mould, material filling, pressing, oven dry; The system liquid that described ebonite is assisted and flexible glue is assisted all is that starch or starch derivatives, water is mixed and be heated to more than 60 ℃ after by proportioning, evenly stirs, and then adds plasticizer by proportioning, and mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper into behind the bubble and wait to be stained with.
The system liquid that described ebonite is assisted and flexible glue is assisted all is to be by mixed after 10.2-61.8% and the 35.3-88.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then the proportioning of pressing 0.1-25.3% adds plasticizer, mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
The system liquid that described ebonite is assisted and flexible glue is assisted all is to be by mixed after 41.2% and 52.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then add plasticizer, mix homogeneously by 6.6% proportioning, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
Described plasticizer is a glycerol.
Adopt technique scheme, do not contain thereby amylan disclosed in this invention is assisted animal proteinum make its not changeableness, become fragile, disintegration is stable, prolongs greatly to store the shelf-life and reduce cost.Moreover the environmental pollution that can avoid the extraction because of animal proteinum to cause, be beneficial to the simple and direct easy control of environmental protection and technology.
The specific embodiment
Below in conjunction with embodiment the present invention is made further enumeration.
With 100g is example, takes by weighing starch or starch derivatives 10.2-61.8g,, be preferably 41.2g; Add entry 35.3-88.2g then, preferably 52.2g; And be heated to 65 ℃, evenly be stirred to and fully dissolve the back and add plasticizer glycerol 0.1-25.3g, be preferably 6.6g, mix homogeneously, insulation is left standstill, pour in the insulation hopper after removing bubble, again through be stained with liquid, dry, pull out shell, cutting, fit and make ebonite and assist.Or again through being stained with liquid, cooling, suction mould, material filling, pressing, oven dry and make flexible glue and assist.
Claims (6)
1, the hollow glue of a kind of starch is assisted, it is characterized in that the hollow glue of described starch is assisted by components such as plant amylum or starch derivatives, plasticizer, water is formed, and the percentage by weight of described plant amylum or starch derivatives, plasticizer, water is plant amylum or starch derivatives 25%-94.9%, plasticizer 0.1%-30%, water 5%-20%.
2, the hollow glue of a kind of starch according to claim 1 is assisted, and it is characterized in that described plasticizer is a glycerol.
3, the hollow glue of a kind of starch production technology of assisting comprises the production technology that empty hard is assisted and flexible glue is assisted, and wherein ebonite is assisted and comprised that system liquid, mucus, oven dry, cutting, fit, flexible glue are assisted and comprise system liquid, be stained with liquid, cooling, suction mould, material filling, pressing, oven dry; It is characterized in that described ebonite is assisted and flexible glue is assisted system liquid all is that starch or starch derivatives, water is mixed and be heated to more than 60 ℃ after by proportioning, evenly stir, and then add plasticizer, mix homogeneously by proportioning, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
4, the hollow glue of a kind of starch according to claim 2 production technology of assisting, it is characterized in that described ebonite is assisted and flexible glue is assisted system liquid all is is by mixed after 10.2-61.8% and the 35.3-88.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then the proportioning of pressing 0.1-25.3% adds plasticizer, mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
5, the hollow glue of a kind of starch according to claim 3 production technology of assisting, it is characterized in that described ebonite is assisted and flexible glue is assisted system liquid all is is by mixed after 41.2% and 52.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then add plasticizer by 6.6% proportioning, mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
6, the production technology of assisting according to the hollow glue of any starch described in the claim 3-5 is characterised in that described plasticizer is a glycerol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021347506A CN1483393A (en) | 2002-09-17 | 2002-09-17 | Starch hollow capsule and production process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021347506A CN1483393A (en) | 2002-09-17 | 2002-09-17 | Starch hollow capsule and production process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1483393A true CN1483393A (en) | 2004-03-24 |
Family
ID=34145937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA021347506A Pending CN1483393A (en) | 2002-09-17 | 2002-09-17 | Starch hollow capsule and production process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1483393A (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1333006C (en) * | 2005-04-07 | 2007-08-22 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| CN100393296C (en) * | 2004-12-09 | 2008-06-11 | 浙江工业大学 | A composition for making hollow capsules and a preparation method thereof |
| WO2010020098A1 (en) * | 2008-08-18 | 2010-02-25 | 北京天衡药物研究院 | Gastric retention drug delivery system, preparation method and use thereof |
| CN101817938A (en) * | 2010-03-18 | 2010-09-01 | 上海心尔新材料科技股份有限公司 | Transparent starch-packaging material and production method thereof |
| CN101708174B (en) * | 2009-12-11 | 2011-04-13 | 梁贤昌 | Plant hollow capsule, soft capsule composition and preparation methods thereof |
| CN101693020B (en) * | 2009-10-22 | 2011-04-20 | 华慧颖 | Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
| CN104324381A (en) * | 2014-09-29 | 2015-02-04 | 湖南尔康制药股份有限公司 | Starch capsule having moisturizing capability and preparation method thereof |
| EP2865374A1 (en) | 2013-10-26 | 2015-04-29 | Zhongshan Capsule Starch Material Technology Co., Ltd. | Mixing and extruding method for preparing starch softgel capsules |
| CN104688711A (en) * | 2015-03-09 | 2015-06-10 | 湖南尔康制药股份有限公司 | Hollow plant capsule and preparation method thereof |
| EP2937081A1 (en) | 2014-04-21 | 2015-10-28 | Hunan Er-Kang Pharmaceutical Co., Ltd. | Hydroxypropyl starch vacant capsules and a process for producing them |
| CN105475942A (en) * | 2015-12-18 | 2016-04-13 | 湖南尔康制药股份有限公司 | Freeze-dried bee product capsule |
| CN105709234A (en) * | 2016-01-29 | 2016-06-29 | 中国药科大学 | Oxidized hydroxypropyl starch empty capsules and preparation process thereof |
| CN104666275B (en) * | 2015-03-09 | 2017-04-26 | 湖南尔康制药股份有限公司 | Starch-based plant empty capsule |
| US12161605B2 (en) | 2016-12-08 | 2024-12-10 | R.P. Scherer Technologies, Llc | Method to relieve stress in capsule shells to reduce propensity to break |
-
2002
- 2002-09-17 CN CNA021347506A patent/CN1483393A/en active Pending
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393296C (en) * | 2004-12-09 | 2008-06-11 | 浙江工业大学 | A composition for making hollow capsules and a preparation method thereof |
| CN1333006C (en) * | 2005-04-07 | 2007-08-22 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| WO2010020098A1 (en) * | 2008-08-18 | 2010-02-25 | 北京天衡药物研究院 | Gastric retention drug delivery system, preparation method and use thereof |
| CN101693020B (en) * | 2009-10-22 | 2011-04-20 | 华慧颖 | Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process |
| CN101708174B (en) * | 2009-12-11 | 2011-04-13 | 梁贤昌 | Plant hollow capsule, soft capsule composition and preparation methods thereof |
| CN101817938A (en) * | 2010-03-18 | 2010-09-01 | 上海心尔新材料科技股份有限公司 | Transparent starch-packaging material and production method thereof |
| CN101817938B (en) * | 2010-03-18 | 2013-01-09 | 上海心尔新材料科技股份有限公司 | Transparent starch-packaging material and production method thereof |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
| CN102525995B (en) * | 2011-12-23 | 2013-10-30 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
| EP2865374A1 (en) | 2013-10-26 | 2015-04-29 | Zhongshan Capsule Starch Material Technology Co., Ltd. | Mixing and extruding method for preparing starch softgel capsules |
| EP2937081A1 (en) | 2014-04-21 | 2015-10-28 | Hunan Er-Kang Pharmaceutical Co., Ltd. | Hydroxypropyl starch vacant capsules and a process for producing them |
| US9693964B2 (en) | 2014-04-21 | 2017-07-04 | Hunan Er-Kang Pharmaceutical Co., Ltd. | Hydroxypropyl starch vacant capsules and a process for producing them |
| CN104324381A (en) * | 2014-09-29 | 2015-02-04 | 湖南尔康制药股份有限公司 | Starch capsule having moisturizing capability and preparation method thereof |
| CN104324381B (en) * | 2014-09-29 | 2017-01-18 | 湖南尔康制药股份有限公司 | Starch capsule having moisturizing capability and preparation method thereof |
| CN104688711A (en) * | 2015-03-09 | 2015-06-10 | 湖南尔康制药股份有限公司 | Hollow plant capsule and preparation method thereof |
| CN104666275B (en) * | 2015-03-09 | 2017-04-26 | 湖南尔康制药股份有限公司 | Starch-based plant empty capsule |
| CN104688711B (en) * | 2015-03-09 | 2017-08-29 | 湖南尔康制药股份有限公司 | A kind of phyteral Capsules and preparation method thereof |
| CN105475942A (en) * | 2015-12-18 | 2016-04-13 | 湖南尔康制药股份有限公司 | Freeze-dried bee product capsule |
| CN105709234A (en) * | 2016-01-29 | 2016-06-29 | 中国药科大学 | Oxidized hydroxypropyl starch empty capsules and preparation process thereof |
| US12161605B2 (en) | 2016-12-08 | 2024-12-10 | R.P. Scherer Technologies, Llc | Method to relieve stress in capsule shells to reduce propensity to break |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |