CN204246683U - Intellectual drug import system can be worn - Google Patents

Abstract

The utility model provides a wearable intelligent medicine introduction system, which comprises a power supply, a medicine bag structure, a storage storehouse, and an electrode structure. The utility model can accurately and precisely control the dosage and the conduction time of the ionized medicine, reduce and avoid the uncontrollable dosage of the transdermal medicine conduction. In the utility model, a plurality of medicines can be stored in one storage or multiple storages, and can be conducted into the body at the same time or at different times through one or more power sources; and multiple medicines can be stored in multiple storages. The reaction and mutual interference between the drugs can be avoided; the skin penetration accelerator can also be unnecessary and the irritation to the skin can be reduced.

Description

Wearable smart drug introduction system

technical field

The utility model relates to a wearable intelligent drug introduction system.

Background technique

Drugs provide therapeutic effects for different diseases, and usually must be administered at a certain time or in a certain time pattern or must be maintained at a certain concentration level to achieve the best therapeutic effect. Unfortunately patients often do not take their medications at the required intervals or times. Moreover, due to the high acidity environment of the stomach or the first-pass effect of the liver, oral drugs can cause partial or complete failure.

To overcome these problems, drugs can be administered through the skin. Common methods of parenteral administration are injecting different doses of the drug by syringe or continuous infusion. These methods may not be suitable for long-term treatment of patients because of the repeated injury of needle sticks and IV drip devices that restrict the patient's freedom of movement and cause pain to the patient.

A more comfortable device for drug delivery is through the skin. In the field of traditional Chinese medicine in China, the application of this plaster or ointment is extremely extensive. Administration by means of a patch usually provides a continuous dosage over a period of time (eg, one day to one week) without the patient actively requesting the administration. Drugs suitable for daily application through the skin include: nicotine, hormones, and some pain relievers (such as fentanyl). Applications include nicotine patches for smoking cessation; patches for contraception by continuously delivering low levels of estrogen and progestin into the skin. This epidermal drug delivery device is portable, comfortable and ideal for patients with a fear of needle sticks. The main advantages of transdermal drug delivery are: providing sustained dosage according to the designed release rate; avoiding the first-pass effect of gastrointestinal tract and liver on oral drugs; non-invasive; no need for patient intervention, but patients can also administer or Withdrawal. However, its advantages are also its disadvantages for some therapeutic drugs: due to the maintenance of a continuous constant dose in the body, drug resistance and drug resistance of the body or disease are caused; some physiological functions or pathological phenomena of the human body show obvious circadian rhythms, and the administration should be based on The circadian rhythm changes in the bioavailability, blood concentration, metabolism and excretion of drugs, and continuous constant dosage will affect the curative effect, and produce adverse reactions and side effects.

Ionophoresis is a physical process in which ionic currents diffuse through an external electric field medium, so that soluble ionic salt drugs enter the body under the action of electric current, thereby achieving the purpose of treatment. Devices for iontophoresis were first developed before 1900. In 1934, a British patent (410,009) described an iontophoresis device manufactured to include: a plurality of electrodes and a material containing a therapeutic ingredient or drug that can be penetrated through the skin, and a device that provides iontophoresis for drug delivery. A battery that requires energy. The device was accepted for reducing the impact of drug delivery on the patient's daily life and was an early implementation of iontophoresis drug delivery. Recently, U.S. patents have published related technologies of iontophoresis, indicating that this method has renewed interest in drug delivery, such as Anderson et al's patent U.S. Pat. No. 7,844,327; Durand's patent U.S. Pat. No. 7,945,320; Kananmura Patents U.S. Pat. No. 8,386,030 to et al.; U.S. Pat. No. 8,463,373 to Anderson; U.S. Pat. No. 8,666,486 to Dombdisclose, etc. list iontophoresis devices and some applications.

Usually in an iontophoresis device, at least two electrodes are used, which are in direct contact with the skin, and a skin penetration enhancer is used at the time of use. An electrode, called an active electrode, applies electricity to a chemical, compound, agent, or drug for its delivery or entry into the body. The other is the counter electrode. Together with the skin and the power supply, the two electrodes form a closed voltage or current loop. For example: a drug ion is a positive polarity (positively charged ion), then the positive electrode (anode) is the active electrode and the counter electrode (cathode) forms a closed loop. If the drug ion is negatively charged, then the negative electrode is the active electrode and the positive electrode is the counter electrode. The most prominent advantage of iontophoresis lies in the control of the amount and time of drug delivery, and the existing devices cannot be used after one use, resulting in a large waste of some materials.

Contents of the invention

The technical problem to be solved by the utility model is to provide a wearable intelligent drug introduction system, which is convenient for users to use and reduces irritation to the skin.

The first solution of the utility model is realized in the following way: a wearable intelligent medicine introduction system, including a first power supply, a first medicine bag structure and a second medicine bag structure, and a first storage warehouse is arranged in the first medicine bag structure , a first electrode is provided in the first storage, a first opening is provided on one side of the first storage, the first storage is filled with a gel-like liquid medicine, and the second drug bag structure is A second storage warehouse is provided, a second electrode is arranged in the second storage warehouse, a second opening is provided on one side of the second storage warehouse, and the second storage warehouse is filled with gel-like liquid medicine or electrolyte , the positive and negative poles of the first power supply are respectively connected to the first electrode and the second electrode.

Further, the first opening is opposite to the first electrode, and the second opening is opposite to the second electrode.

Further, a first release membrane is provided at the first opening, and a second release membrane is provided at the second opening.

Further, it also includes a second power supply, a first buffer storage room is provided in the first storage close to the first opening, a third electrode is provided on the upper side of the first buffer storage room, and the third electrode is Film or mesh, one side of the first buffer storage chamber is provided with a buffer opening, the buffer opening coincides with the first opening, the third electrode is opposite to the buffer opening, and the second power supply The positive and negative electrodes are respectively connected to the third electrode and the second electrode.

Further, the first buffer storage room is detachably arranged in the first storage.

Further, it also includes a first drug storage room and a third power supply, the first drug storage room is connected to the first storage bank or the second storage bank, and a fourth electrode is arranged on one side of the first drug storage room , a fifth electrode is provided on one side of the first storage or the second storage, the fourth electrode is opposite to the fifth electrode, and the positive and negative poles of the third power supply are respectively connected to the fourth electrode and the fifth electrode.

Further, it also includes at least one third capsule structure, each of the third capsule structures is provided with a third reservoir, each of the third reservoirs is provided with a fourth electrode, and each of the third reservoirs is provided with a fourth electrode. One side of the three reservoirs is provided with a third opening, each of the third reservoirs is filled with gel-like liquid medicine or electrolyte, and the positive or negative pole of the first power supply is connected to each of the fourth electrodes.

Further, the third opening is opposite to the fourth electrode.

Further, a third release membrane is provided at the third opening.

Further, a fourth power supply is also included, a second buffer storage room is provided in each of the third storage chambers near the third opening, a sixth electrode is provided on the top of the second buffer storage room, and the fourth power supply One electrode is connected to the sixth electrode, and the other electrode is connected to the first electrode or the second electrode.

Further, it also includes a second drug storage room and a fifth power supply, the second drug storage room is connected to the third storage library, a seventh electrode is arranged on one side of the second drug storage room, and the third drug storage room is connected to the third storage room. An eighth electrode is provided on one side of the storage chamber, the seventh electrode is opposite to the eighth electrode, and the positive and negative electrodes of the fifth power supply are respectively connected to the seventh electrode and the eighth electrode.

Further, the second drug storage chamber is detachably arranged in the third drug bag structure.

Further, the third storage library is detachably arranged in the third medicine bag structure.

Further, the first storage is detachably arranged in the first medicine bag structure, and the second storage is detachably arranged in the second medicine bag structure.

The second solution of the utility model is realized in the following way: a wearable intelligent drug introduction system includes a first power supply and a medicine bag structure, and a detachable first storage storehouse and a detachable first medicine bag structure are arranged in the medicine bag structure. Two storage warehouses, the first storage warehouse is provided with a first electrode, one side of the first storage warehouse is provided with a first opening, the first storage warehouse is filled with gel-like medicinal liquid, and the second storage warehouse A second electrode is provided in the storage, and a second opening is provided on one side of the second storage. The second storage is filled with a gel-like liquid medicine or electrolyte, and the positive and negative electrodes of the first power supply are respectively connected to The first electrode and the second electrode.

Further, the first opening is opposite to the first electrode, and the second opening is opposite to the second electrode.

Further, a first release membrane is provided at the first opening, and a second release membrane is provided at the second opening.

Further, it also includes a second power supply, a detachable first buffer storage room is provided in the first storage close to the first opening, a third electrode is provided on the upper side of the first buffer storage room, and the first buffer storage room is provided with a third electrode. The three electrodes are film-shaped or mesh-shaped, a buffer opening is provided on one side of the first buffer storage chamber, the buffer opening coincides with the first opening, the third electrode is opposite to the buffer opening, and the first buffer opening is opposite to the buffer opening. The positive and negative electrodes of the two power sources are respectively connected to the third electrode and the second electrode.

Further, it also includes a first drug storage room and a third power supply, the first drug storage room is detachably arranged in the medicine bag structure, the first drug storage room is connected to the first storage library or the second Two storage warehouses, one side of the first drug storage chamber is provided with a fourth electrode, one side of the first storage warehouse or the second storage warehouse is provided with a fifth electrode, and the fourth electrode is connected to the fifth electrode. In contrast, the positive and negative poles of the third power supply are respectively connected to the fourth electrode and the fifth electrode.

Further, it also includes at least one third storage chamber, each of the third storage chambers is detachably arranged in the drug capsule structure, each of the third storage chambers is provided with a fourth electrode, and each of the third storage chambers is provided with a fourth electrode. A third opening is provided on one side of the third storage, each of the third storages is filled with a gel-like medicinal solution or an electrolyte, and the positive or negative pole of the first power supply is connected to each of the fourth electrodes.

Further, the third opening is opposite to the fourth electrode.

Further, a third release membrane is provided at the third opening.

Further, it also includes a fourth power supply, a detachable second buffer storage chamber is provided in each of the third storage chambers near the third opening, and a sixth electrode is provided on the top of the second buffer storage chamber, and the One electrode of the fourth power supply is connected to the sixth electrode, and the other electrode is connected to the first electrode or the second electrode. the

Further, it also includes a second drug storage room and a fifth power supply, the second drug storage room is detachably arranged in the medicine bag structure, the second drug storage room is connected to the third storage library, the A seventh electrode is provided on one side of the second drug storage chamber, an eighth electrode is provided on one side of the third storage chamber, the seventh electrode is opposite to the eighth electrode, and the positive and negative poles of the fifth power supply are connected to the seventh electrode and the eighth electrode respectively.

The utility model has the following advantages: the utility model can wear an intelligent drug introduction system, which can accurately and precisely control the dose and conduction time of the ionized drug; It is lower than the dose of iontophoresis through the skin, so that the uncontrollable dose of drug transdermal conduction can be minimized or avoided; in the utility model, multiple drugs can be stored in one storage or multiple storages, through one or more A power supply can be conducted into the body at the same time or at different times; and the storage of multiple drugs in multiple storage banks can avoid the reaction and mutual interference between drugs; decrease.

Description of drawings

The utility model will be further described below in conjunction with the embodiments with reference to the accompanying drawings.

Fig. 1 is a schematic diagram of Embodiment 1 of the utility model.

Fig. 2 is a schematic diagram of the second embodiment of the utility model.

Fig. 3 is a schematic diagram of the third embodiment of the utility model.

Fig. 4 is a schematic structural diagram of Embodiment 3 of the present utility model.

Fig. 5 is a schematic structural diagram of Embodiment 4 of the present utility model.

Fig. 6 is a schematic diagram of the fifth embodiment of the utility model.

Fig. 7 is a schematic structural diagram of Embodiment 5 of the present utility model.

Fig. 8 is a schematic diagram of Embodiment 6 of the present utility model.

Fig. 9 is a schematic structural diagram of Embodiment 6 of the present utility model.

Detailed ways

One of the proposals of the present utility model: a wearable intelligent drug introduction system, including a first power supply, a first medicine bag structure and a second medicine bag structure, the first medicine bag structure is provided with a first storage warehouse, the first medicine bag structure A first electrode is provided in the storage, a first opening is provided on one side of the first storage, the first storage is filled with a gel-like liquid medicine, and a second storage is provided in the second medicine bag structure. library, a second electrode is provided in the second storage, a second opening is provided on one side of the second storage, and the second storage is filled with a gel-like liquid medicine or electrolyte, and the first The positive and negative poles of the power supply are respectively connected to the first electrode and the second electrode, the first opening is opposite to the first electrode, the second opening is opposite to the second electrode, and the first opening is provided with There is a first release membrane, the second opening is provided with a second release membrane, the first storage warehouse is detachably arranged in the first medicine bag structure, and the second storage warehouse is detachably arranged in the Inside the second drug capsule structure.

The utility model also includes a second power supply, a first buffer storage room is provided in the first storage close to the first opening, a third electrode is provided on one side of the first buffer storage room, and the third electrode is Film or mesh, one side of the first buffer storage chamber is provided with a buffer opening, the buffer opening coincides with the first opening, the third electrode is opposite to the buffer opening, and the second power supply The positive and negative electrodes are respectively connected to the third electrode and the second electrode, and the first buffer storage chamber is detachably arranged in the first storage storehouse.

The utility model also includes a first medicine storage room and a third power supply, the first medicine storage room is connected to the first storage warehouse or the second storage warehouse, and a fourth electrode is arranged on one side of the first medicine storage room , a fifth electrode is provided on one side of the first storage or the second storage, the fourth electrode is opposite to the fifth electrode, and the positive and negative poles of the third power supply are respectively connected to the fourth electrode and the fifth electrode, the utility model also includes at least one third capsule structure, each of the third capsule structures is provided with a third storage, and each of the third storage is provided with a fourth electrode, A side of each third storage is provided with a third opening, each of the third storages is filled with a gel-like liquid medicine or electrolyte, and the positive or negative pole of the first power supply is connected to each of the third storages. Four electrodes, the third opening is opposite to the fourth electrode, the third opening is provided with a third release membrane, wherein the utility model also includes a fourth power supply, each of the third storage warehouses is close to A second buffer storage chamber is provided at the third opening, a sixth electrode is provided on the top of the second buffer storage chamber, one electrode of the fourth power supply is connected to the sixth electrode, and the other electrode is connected to the first electrode Or the second electrode, the utility model also includes a second drug storage room and a fifth power supply, the second drug storage room is connected to the third storage library, and a seventh electrode is arranged on one side of the second drug storage room , an eighth electrode is provided on one side of the third storage, the seventh electrode is opposite to the eighth electrode, and the positive and negative electrodes of the fifth power supply are respectively connected to the seventh electrode and the eighth electrode, so The second medicine storage chamber is detachably arranged in the third medicine bag structure, and the third storage library is detachably arranged in the third medicine bag structure.

Wherein the first permeable membrane, the second permeable membrane and each of the third permeable membranes are protective layers, and drug ions are conducted to the skin through the above permeable membranes, or may also be referred to as permeable membranes, which have certain The uniform small pores of the pore size make up the thin film structure.

The second solution of the utility model: a wearable intelligent drug introduction device with interchangeable electrolyte positions, including a first power supply and a medicine bag structure, and a detachable first storage warehouse and a detachable medicine bag structure are arranged in the medicine bag structure. The second storage warehouse, the first storage warehouse is provided with a first electrode, a side of the first storage warehouse is provided with a first opening, the first storage warehouse is filled with a gel-like medicinal solution, and the first storage warehouse is filled with a gel-like liquid medicine. A second electrode is provided in the second storage, one side of the second storage is provided with a second opening, the second storage is filled with gel-like liquid medicine or electrolyte, the positive and negative poles of the first power supply The first electrode and the second electrode are respectively connected, the first opening is opposite to the first electrode, the second opening is opposite to the second electrode, and a first diathermy is provided at the first opening. membrane, the second opening is provided with a second release membrane, wherein the utility model also includes a second power supply, and a detachable first buffer storage room is provided in the first storage close to the first opening, so One side of the first buffer storage chamber is provided with a third electrode, the third electrode is film-shaped or mesh-shaped, and a buffer opening is provided on one side of the first buffer storage chamber, and the buffer opening is connected to the first opening. Coincidentally, the third electrode is opposite to the buffer opening, and the positive and negative electrodes of the second power supply are respectively connected to the third electrode and the second electrode.

The utility model also includes a first medicine storage room and a third power supply, the first medicine storage room is detachably arranged in the medicine bag structure, and the first medicine storage room is connected to the first storage warehouse or the second medicine bag structure. Two storage warehouses, one side of the first drug storage chamber is provided with a fourth electrode, one side of the first storage warehouse or the second storage warehouse is provided with a fifth electrode, and the fourth electrode is connected to the fifth electrode. In contrast, the positive and negative poles of the third power supply are respectively connected to the fourth electrode and the fifth electrode, and at least one third storage chamber is included, and each third storage chamber is detachably arranged in the medicine bag structure , each of the third storage houses is provided with a fourth electrode, one side of each of the third storage houses is provided with a third opening, and each of the third storage houses is filled with gel-like liquid medicine or electrolyte , the positive or negative pole of the first power supply is connected to each of the fourth electrodes, the third opening is opposite to the fourth electrode, the third opening is provided with a third release membrane, and a fourth Power supply, a detachable second cache storage chamber is provided near the third opening in each of the third storage chambers, the top of the second cache storage chamber is provided with a sixth electrode, and an electrode of the fourth power supply is connected to To the sixth electrode, the other electrode is connected to the first electrode or the second electrode. The utility model also includes a second medicine storage chamber and a fifth power supply. The second medicine storage chamber is detachably arranged on the medicine bag In the structure, the second medicine storage chamber is connected to the third storage warehouse, a seventh electrode is arranged on one side of the second medicine storage chamber, and an eighth electrode is arranged on one side of the third medicine storage chamber, so that The seventh electrode is opposite to the eighth electrode, and the positive and negative electrodes of the fifth power supply are respectively connected to the seventh electrode and the eighth electrode.

Wherein the first permeable membrane, the second permeable membrane and each of the third permeable membranes are protective layers, and drug ions are conducted to the skin through the above permeable membranes, or may also be referred to as permeable membranes, which have certain The uniform small pores of the pore size make up the thin film structure.

In order to describe the utility model more clearly, further illustrate the utility model in conjunction with the accompanying drawings, as follows:

Embodiment one:

Referring to Fig. 1 , which is a specific embodiment of the present utility model, the wearable intelligent medicine introduction system 10 is composed of a power supply 19, two separate first medicine capsule structures 11 and a second medicine capsule structure 15, the first medicine capsule structure 11 and the second medicine capsule structure 15. The capsule structure 11 is provided with a first storage warehouse 13, and the second drug capsule structure 15 is provided with a second storage warehouse 17. On the top of the first storage warehouse 13 and the second storage warehouse 17, a first electrode 12 and a second electrode are provided. 16 links to each other with power supply 19. A first release membrane 14 is provided at the bottom of the first storage 13 , and a second release membrane 18 is provided at the bottom of the second storage 17 . The sides of the first release membrane 14 and the second release membrane 18 that are in contact with the skin may be in the form of gel, which is used to fix the first drug capsule structure 11 and the second drug capsule structure 15 on the skin. The power supply 19 can be a constant voltage source, a constant current source, or an output programmable constant voltage source/constant current source. Two ends of the power supply 19 are respectively connected to the first electrode 12 and the second electrode 16 . For positive ionized agents, gel-like ionized agents may be stored in the first reservoir 13 . The positive power terminal of the power supply 19 is applied to the first electrode 12 in the first storage bank 13, and the negative power supply terminal of the power supply 19 is applied to the second electrode 16 in the second storage bank 17, wherein in the second storage bank 17 The gel can be a gel containing only electrolyzed ions. Therefore, when the power supply 19 is activated, the positively charged ionized medicine in the first storage warehouse 13 is transported from the first storage warehouse 13 to the skin below it through the first permeable release membrane 14 under the action of Coulomb force, and passes through the skin. into the body. By controlling the intensity of the output current or voltage of the power supply 19, the ionized medicine can be delivered to the body according to the dosage; for the negatively charged ionized medicine, the gel-like ionized medicine can be stored in the second storage warehouse 17. Whereas the gel in the first reservoir 13 may be a gel containing only electrolyzed ions. The positive power supply terminal of the power supply 19 is applied to the first electrode 12 in the first reservoir 13 and the negative power supply terminal of the power supply 19 is applied to the second electrode 16 in the second reservoir 17 . Therefore, when the power supply 19 is activated, the negatively charged ionized medicine in the second storage warehouse 17 is transported from the second storage warehouse 17 to the skin below it through the second permeable release membrane 18 under the action of Coulomb force, and passes through the skin. into the body. Similarly, by controlling the intensity of the output current or voltage of the power supply 19, the ionized medicine can be delivered to the body according to the dosage. Wherein the positively ionized medicine is stored in the first storage warehouse 13, and the negatively ionized medicine is stored in the second storage warehouse 17, and the positively ionized medicine and the negatively ionized medicine can be conducted into the body at the same time, Wherein the first medicine capsule structure 11 and the second medicine capsule structure 15 are detachable and replaceable.

The two separate first drug bag structure 11 and the second drug bag structure 15 of the wearable smart drug introduction system 10 can be made of plastic or silicon rubber. The reference size of the first capsule structure 11 and the second capsule structure 15 may be 30 mm in length, 25 mm in width and 5 mm in height, but other sizes are also applicable. The reference size of the first reservoir 13 and the second reservoir 17 may be 25 mm long, 20 mm wide, and 3 mm high, but other sizes are also applicable to these reservoirs. The bottom areas of the first reservoir 13 and the second reservoir 17 are equal or approximately equal, and the first capsule structure 11 and the second capsule structure 15 are fixed on the skin at a certain distance, so as to ensure uniform transmission of current into the skin.

Positively ionized medicaments and negatively ionized medicaments can be mixed with the gel matrix to form gel medicaments, which are stored in the first storage storehouse 13 or the second storehouse 17, wherein the positively or negatively ionized medicaments can be a A drug, or multiple drugs. The reference gel matrix can be organogel, hydrogel, in addition, hydroxyethyl cellulose can be mixed with the gel matrix, but other gel matrix can also be used.

The first electrode 12 and the second electrode 16 can be made of inert metal or inert conductive material, such as flake platinum, gold, silver, silver/silver chloride, or graphite.

Embodiment two:

As shown in Figure 2, it is the second specific embodiment of the present utility model. The wearable intelligent drug introduction system 20 is composed of a power supply 29, two separate first drug bag structures 21 and a second drug bag structure 25, the first drug bag structure 21 and the second drug bag structure 25 respectively have The first cavity structure 23 and the second cavity structure 27 of the first storage bank 24 and the second storage bank 28, and the first electrode 22 on the top of the first storage bank 24 and the first electrode 22 on the top of the second storage bank 28 The second electrode 26 , the first electrode 22 and the second electrode 26 are connected to a power source 29 . The first reservoir 24 and the second reservoir 28 may be a gel of ionized agents and a gel of electrolytic ions, respectively, and may have a permeable membrane at the bottom thereof. When in use, the first storage warehouse 24 and the second storage warehouse 28 are respectively put into the first cavity structure 23 and the second cavity structure 27 of the first medicine capsule structure 21 and the second medicine capsule structure 25 in the direction of the arrow in the figure. Among them, the upper parts of the first reservoir 24 and the second reservoir 28 are in contact with the first electrode 22 and the second electrode 26, and the lower parts of the first reservoir 24 and the second reservoir 28 are in contact with the skin. For positively ionized medicaments, the positive power terminal of the power supply 29 is applied to the first electrode 22 in the first capsule structure 21, and the negative power supply terminal of the power supply 29 is applied to the second electrode in the second capsule structure 25. 26 on. Therefore, when the power supply 29 is turned on, the positively charged ionized medicine in the first storage 24 is transported from the first storage 24 to the skin below it under the action of Coulomb force, and passes through the skin into the body. By controlling the intensity of the output current or voltage of the power supply 29, the ionized medicine can be delivered to the body according to the dose, wherein the first storage warehouse 24 and the second storage warehouse 28 are detachable and replaceable, and the positive or negative ionized medicine can be a A drug, or multiple drugs.

Embodiment three:

As shown in Fig. 3 and Fig. 4, it is the third specific embodiment of the present utility model. The wearable intelligent medicine introduction system 30 is composed of a medicine bag structure main body 31 and a power supply 50 . There is in the main body 31 of the medicine capsule structure. The first electrode 34, the second electrode 32, and the third electrode 36 are installed on top of the first reservoir 35, the second reservoir 33, and the third reservoir 37, respectively. At the bottom of the first storage 35 , the second storage 33 , and the third storage 37 , there is a release membrane 38 . The side of the release membrane 38 that is in contact with the skin can be in the form of jelly, which is used to fix the drug capsule structure 31 on the skin. The power supply 50 can be a constant voltage source, a constant current source, or an output programmable constant voltage source/constant current source. Both ends of the power source 50 are connected to the first electrode 34 , the second electrode 32 and the third electrode 36 . For positively ionized agents, gel-like ionized agents may be stored in the second reservoir 33 . The positive power terminal of the power supply 50 is applied to the second electrode 32 in the second storage bank 33, and the negative power supply terminal of the power supply 20 is applied to the first electrode 34 in the first storage bank 35, the third storage bank 37 and the second electrode 32 in the second storage bank 37. On the two electrodes 36, among them the first reservoir 35, the gel in the second reservoir 37 may be a gel containing only electrolyzed ions. Therefore, when the power is turned on, the positively charged ionized medicine in the second storage warehouse 33 is transported from the second storage warehouse 33 through the permeable membrane 38 to the skin below it under the action of Coulomb force, and passes through the skin into the body. . By controlling the intensity of the output current or voltage of the power supply 50, the ionized medicine can be delivered to the body according to the dosage.

For negatively ionized agents, gel-like ionized agents may be stored in the first reservoir 35 and the third reservoir 37 . Whereas the gel in the second reservoir 33 may be a gel containing only electrolyzed ions. The positive power terminal of the power supply 50 is applied to the second electrode 32 in the second storage bank 33, and the negative power supply terminal of the power supply 50 is applied to the first electrode 34 and the first electrode 34 in the third storage bank 37 in the first storage bank 35 and the third storage bank 37. on the three electrodes 36 . Therefore, when the power supply 50 is activated, the negatively charged ionized drug in the first storage warehouse 35 and the third storage warehouse 37 is transported from the first storage warehouse 35 and the third storage warehouse 37 through the permeable membrane 38 under the action of Coulomb force. onto the skin beneath it, and through the skin into the body. Similarly, by controlling the intensity of the output current or voltage of the power supply 50, the ionized medicine can be delivered to the body according to the dosage.

The positively ionized medicine is stored in the second storage warehouse 33, and the negatively charged medicine is stored in the first storage warehouse 35 and the second storage warehouse 37. In this embodiment, the positively charged medicine and the negatively charged medicine can be simultaneously stored. The ionized agent is transported into the body.

The main body 31 of the drug capsule structure of the wearable smart drug introduction system 30 can be made of plastic or silicon rubber. The reference size of the wearable smart drug delivery system 30 may be 100 mm in length, 25 mm in width, and 5 mm in height, but other sizes are also applicable. The reference size of the second reservoir 33 may be 20 mm in length, 20 mm in width, and 3 mm in height. The reference size of the first storage bank 35 and the third storage bank 37 may be 10 mm in length, 20 mm in width, and 3 mm in height, but other sizes are also applicable to these storage banks. The reference structure of these 3 reservoirs, the area of the administration area at the bottom of the second reservoir 33 is twice the area of the administration area at the bottom of the first reservoir 35 and the second reservoir 37 on both sides. The reservoirs on both sides are symmetrically placed in the middle reservoir, and the distance between the two reservoirs and the middle reservoir should be greater than 10-20mm, so as to ensure that the current is evenly transmitted into the skin.

Positively ionized agents and negatively ionized agents can be mixed with the gel matrix to form gel agents, which are stored in the first reservoir 33 or the second reservoir 35 and the third reservoir 37, respectively. The reference gel matrix can be organogel, hydrogel, moreover, hydroxyethyl cellulose can be mixed with the gel matrix, but other gel matrix can also be used, where the positively or negatively ionized agent can be a drug , can also be multiple drugs.

The first electrode 32 , the second electrode 34 and the third electrode 36 can be made of inert metal or inert conductive material, such as flake platinum, gold, silver, silver/silver chloride, or graphite.

Embodiment four:

As shown in FIG. 5 , which is the fourth specific embodiment of the present invention, a wearable smart drug introduction device 200 with interchangeable electrolyte positions includes a drug capsule structure 201 and a power supply (not shown in the figure). The drug capsule structure main body 201 includes a first storage warehouse 202 , a second storage warehouse 203 , a third storage warehouse 204 and a fourth storage warehouse 205 . The top of the first storage 202 is provided with a first electrode (not shown in the figure), the top of the second storage 203 is provided with a second electrode (not shown in the figure), and the top of the third storage 204 is provided with a third electrode ( not shown in the figure), the top of the fourth reservoir 205 is provided with a fourth electrode (not shown in the figure). In the fourth repository 205 . One electrode of a power supply or two power supplies can be applied to the third electrode and the fourth electrode together or respectively, and the other electrode of the power supply is connected to the first electrode and the second electrode respectively, so that the third storage warehouse 204 and the fourth storage warehouse 205 can penetrate the medicine into the body at the same time or at different times.

Embodiment five:

As shown in FIG. 6 and FIG. 7 , which is the fifth specific embodiment of the present invention, the wearable smart medicine introduction system 300 is composed of a medicine bag structure 301 , a first power source 320 , and a second power source 330 . The first storage warehouse 302, the second storage warehouse 303 and the third storage warehouse 304 are arranged in the said medicine capsule structure 301, a diarrhoea 308 is arranged at the bottom of the said medicine capsule structure 301, and the top of the first storage warehouse 302 A first electrode 306 is provided, a second electrode 309 is provided on the top of the second reservoir 303 , and a third electrode 305 is provided on the top of the third reservoir 304 . A buffer storage 308 is arranged inside the third storage 304, and a fourth electrode 307 is arranged on the top thereof, and the fourth electrode 307 may be a network or film made of graphite, inert metal or carbon nanotube. The first power source 320 and the second power source 330 can be constant voltage, constant current or can be set as constant voltage/constant current devices. The positive power terminal of the first power supply 320 is connected to the third electrode 305 , and the positive power terminal of the second power supply 330 is connected to the fourth electrode 307 . Negative power terminals of the first power source 320 and the second power source 330 are connected to the first electrode 306 and the second electrode 309 .

Taking a drug ionized by conducting a positive charge as an example, the gel-like drug exists in the third reservoir 304 , and the gel-like electrolyte exists in the first reservoir 302 and the second reservoir 303 . The positive power supply terminal of the first power supply 320 is connected to the third electrode 305 , and the negative power supply terminal is connected to the first electrode 306 and the second electrode 309 . After the first power supply 320 is energized, the positively charged ionized medicine in the third reservoir 304 is transported from the third reservoir 304 to the skin below it through the membrane or mesh fourth electrode 307 and the buffer reservoir 308 under the action of Coulomb force on and into the skin. After a certain period of time, the first power supply 320 is powered off, and the second power supply 330 is turned on. Positively ionized agents present in buffer reservoir 308 continue to penetrate the skin. Because the buffer storehouse 308 is very thin, most of the positively ionized medicaments present in the buffer storehouse 308 penetrate into the skin quickly, and after the second power supply 330 is turned off, there is little positively ionized medicament left therein, so It avoids that the part of the medicament close to the skin enters the skin through diffusion. This embodiment provides a precise and controllable transdermal drug delivery, and prevents drug ions from permeating and diffusing into the skin after iontophoresis drug delivery.

For this embodiment to conduct a positively charged ionized drug, the following precise and controllable transdermal drug delivery process can also be used: the gel-like drug is present in the third reservoir 304, and the gel-like electrolyte is present in the first repository 302 and the second repository 303 . The positive power supply terminal of the first power supply 320 is connected to the third electrode 305 , and the negative power supply terminal is connected to the first electrode 306 and the second electrode 309 . After the first power supply 320 is energized, the positively ionized drug in the third storage 304 enters the buffer storage 308 from the third storage 304 through the membrane or mesh fourth electrode 307 under the action of Coulomb force. After a certain amount of time, the first power supply 320 is powered down, whereby an amount of positively ionized agent is in the buffer reservoir 308 . This operation prepares the buffer reservoir 308 for a dose of drug delivery. Thereafter, the second power supply 330 is turned on. Positively ionized agents present in the buffer reservoir 308 penetrate the skin. In this way, this embodiment provides a kind of precise and controllable transdermal drug delivery, and avoids drug ion penetration and diffusion into the skin after iontophoresis drug delivery, wherein the positively or negatively ionized medicament can be a kind of drug, also can be multiple kind of drug.

Embodiment six:

As shown in FIG. 8 and FIG. 9 , the sixth specific embodiment of the present utility model is shown. The wearable intelligent drug introduction system 400 is composed of a drug bag structure device body 401 , a first power source 420 , and a second power source 430 . A first storage warehouse 402, a second storage warehouse 403, a third storage warehouse 404, and a medicine storage warehouse 405 are arranged in the medicine capsule structure device body 401, and a first electrode 406 is arranged on the top of the first storage warehouse 402. The top of the second storage 403 is provided with a second electrode 407, and the top of the third storage 404 is provided with a third electrode 408. When the first power supply 420 acts on the first electrode 406, the second electrode 407 and the third electrode 408 , the ionized drugs in the first storage 402 , the second storage 403 and the third storage 404 are conducted into the body, and the drug storage 405 is connected to the second storage 403 through a small fluid channel 411 . A fourth electrode 410 is placed on the side wall of the drug reservoir 405 ; a fifth electrode 409 is placed on the side wall of the second reservoir 403 . All electrodes in this embodiment can be made of graphite plates or inert metal plates. The first power source 420 and the second power source 430 can be a constant voltage circuit, a constant current circuit or a programmable voltage/current meter. The positive power supply terminal of the first power supply 420 is connected to the second electrode 407, the negative power supply terminal of the first power supply 420 is connected to the first electrode 406 and the second electrode 408, and the positive and negative power supply terminals of the second power supply 430 are respectively connected to the fourth electrode 410 , the fifth electrode 409 .

Taking conductive positively ionized medicine as an example, the ionized medicine is stored in the drug storage 405 in a gel form, and the gel electrolyte is in the first storage 402 , the second storage 403 and the third storage 404 . Firstly, the second power supply 430 is applied to the fourth electrode 410 and the fifth electrode 409 to form a current to carry the ionized drug in the drug storage through the fluid channel 411 into the second storage 403 . This operation prepares a dose of drug delivery in the second reservoir 403 . After a dose in the second storage 403 is ready, the second power supply 430 is turned off, and the first power supply 420 is turned on. The ionized medicament in the second storage 403 enters the skin, and this embodiment provides a precise dose control of medicament delivery, wherein the positively or negatively ionized medicament can be one kind of medicine or multiple medicines.

The utility model has the following advantages: the utility model can wear an intelligent drug introduction system, which can accurately and precisely control the dose and conduction time of the ionized drug; It is lower than the dose of iontophoresis through the skin, so that the uncontrollable dose of drug transdermal conduction can be minimized or avoided; in the utility model, multiple drugs can be stored in one storage or multiple storages, through one or more A power supply can be conducted into the body at the same time or at different times; and the storage of multiple drugs in multiple storage banks can avoid the reaction and mutual interference between drugs; decrease.

Although the specific embodiments of the present utility model have been described above, those skilled in the art should understand that the specific embodiments we describe are only illustrative, rather than used to limit the scope of the present utility model. Equivalent modifications and changes made by those skilled in the art in accordance with the spirit of the present utility model shall fall within the protection scope of the claims of the present utility model.

Claims (24)

1. can wear intellectual drug import system for one kind, it is characterized in that: comprise the first power supply, first medicine bag structure and the second medicine bag structure, the first storage vault is provided with in described first medicine bag structure, the first electrode is provided with in described first storage vault, described first storage vault one side is provided with the first opening, gel medicinal liquid is full of in described first storage vault, the second storage vault is provided with in described second medicine bag structure, the second electrode is provided with in described second storage vault, described second storage vault one side is provided with the second opening, gel medicinal liquid or electrolyte is full of in described second storage vault, the both positive and negative polarity of described first power supply connects described first electrode and the second electrode respectively.

2. according to claim 1ly wear intellectual drug import system, it is characterized in that: described first opening is relative with described first electrode, described second opening is relative with described second electrode.

3. according to claim 1ly wear intellectual drug import system, it is characterized in that: described first opening part is provided with first and thoroughly releases film, described second opening part is provided with second and thoroughly releases film.

4. according to claim 1ly wear intellectual drug import system, it is characterized in that: also comprise second source, the first cache storage room is provided with near the first opening part in described first storage vault, the indoor upper side of described first cache storage is provided with the 3rd electrode, described 3rd electrode is membranaceous or netted, described first side, cache storage room is provided with buffer memory opening, described buffer memory opening overlaps with described first opening, described 3rd electrode is relative with described buffer memory opening, and the both positive and negative polarity of described second source is connected to the 3rd electrode and the second electrode respectively.

5. according to claim 4ly wear intellectual drug import system, it is characterized in that: described first cache storage room is detachably located in described first storage vault.

6. according to claim 1ly wear intellectual drug import system, it is characterized in that: also comprise the first medicine storage chamber and the 3rd power supply, described first medicine storage chamber is connected to described first storage vault or the second storage vault, the indoor face, side of described first medicament storage is provided with one the 4th electrode, in described first storage vault or the second storage vault, a side is provided with the 5th electrode, described 4th electrode is relative with described 5th electrode, and the both positive and negative polarity of described 3rd power supply connects described 4th electrode and the 5th electrode respectively.

7. according to claim 1ly wear intellectual drug import system, it is characterized in that: also comprise at least one the 3rd medicine bag structure, the 3rd storage vault is provided with in each described 3rd medicine bag structure, the 4th electrode is provided with in each described 3rd storage vault, each described 3rd storage vault one side is provided with the 3rd opening, be full of gel medicinal liquid or electrolyte in each described 3rd storage vault, described first positive source or negative pole are connected to each described 4th electrode.

8. according to claim 7ly wear intellectual drug import system, it is characterized in that: described 3rd opening is relative with described 4th electrode.

9. according to claim 7ly wear intellectual drug import system, it is characterized in that: described 3rd opening part is provided with the 3rd and thoroughly releases film.

10. according to claim 7ly wear intellectual drug import system, it is characterized in that: also comprise the 4th power supply, the second cache storage room is provided with near the 3rd opening part in each described 3rd storage vault, described second top, cache storage room is provided with the 6th electrode, one Electrode connection of described 4th power supply is to the 6th electrode, and another Electrode connection is to described first electrode or the second electrode.

11. according to claim 7ly wear intellectual drug import system, it is characterized in that: also comprise the second medicine storage chamber and the 5th power supply, described second medicine storage chamber is connected to described 3rd storage vault, the indoor face, side of described second medicament storage is provided with one the 7th electrode, in described 3rd storage vault, a side is provided with the 8th electrode, described 7th electrode is relative with described 8th electrode, and described 5th power positive cathode connects described 7th electrode and the 8th electrode respectively.

12. according to claim 11ly wear intellectual drug import system, it is characterized in that: described second medicine storage chamber is detachably located in described 3rd medicine bag structure.

13. according to claim 11ly wear intellectual drug import system, it is characterized in that: described 3rd storage vault is detachably located in described 3rd medicine bag structure.

14. according to claim 1ly wear intellectual drug import system, it is characterized in that: described first storage vault is detachably located in described first medicine bag structure, and described second storage vault is detachably located in described second medicine bag structure.

Intellectual drug import system can be worn for 15. 1 kinds, it is characterized in that: comprise the first power supply and a medicine bag structure, dismountable first storage vault and dismountable second storage vault is provided with in described medicine bag structure, the first electrode is provided with in described first storage vault, described first storage vault one side is provided with the first opening, gel medicinal liquid is full of in described first storage vault, the second electrode is provided with in described second storage vault, described second storage vault one side is provided with the second opening, gel medicinal liquid or electrolyte is full of in described second storage vault, the both positive and negative polarity of described first power supply connects described first electrode and the second electrode respectively.

16. according to claim 15ly wear intellectual drug import system, and it is characterized in that: described first opening is relative with described first electrode, described second opening is relative with described second electrode.

17. according to claim 15ly wear intellectual drug import system, and it is characterized in that: described first opening part is provided with first and thoroughly releases film, described second opening part is provided with second and thoroughly releases film.

18. according to claim 15ly wear intellectual drug import system, it is characterized in that: also comprise second source, a dismountable first cache storage room is provided with near the first opening part in described first storage vault, the indoor upper side of described first cache storage is provided with the 3rd electrode, described 3rd electrode is membranaceous or netted, described first side, cache storage room is provided with buffer memory opening, described buffer memory opening overlaps with described first opening, described 3rd electrode is relative with described buffer memory opening, the both positive and negative polarity of described second source is connected to the 3rd electrode and the second electrode respectively.

19. according to claim 15ly wear intellectual drug import system, it is characterized in that: also comprise the first medicine storage chamber and the 3rd power supply, described first medicine storage chamber is detachably located in described medicine bag structure, described first medicine storage chamber is connected to described first storage vault or the second storage vault, the indoor face, side of described first medicament storage is provided with one the 4th electrode, in described first storage vault or the second storage vault, a side is provided with the 5th electrode, described 4th electrode is relative with described 5th electrode, the both positive and negative polarity of described 3rd power supply connects described 4th electrode and the 5th electrode respectively.

20. according to claim 15ly wear intellectual drug import system, it is characterized in that: also comprise at least one the 3rd storage vault, each described 3rd apotheca is detachably located in described medicine bag structure, the 4th electrode is provided with in each described 3rd storage vault, each described 3rd storage vault one side is provided with the 3rd opening, be full of gel medicinal liquid or electrolyte in each described 3rd storage vault, described first positive source or negative pole are connected to each described 4th electrode.

21. according to claim 20ly wear intellectual drug import system, it is characterized in that: described 3rd opening is relative with described 4th electrode.

22. according to claim 20ly wear intellectual drug import system, it is characterized in that: described 3rd opening part is provided with the 3rd and thoroughly releases film.

23. according to claim 20ly wear intellectual drug import system, it is characterized in that: also comprise the 4th power supply, dismountable second cache storage room is provided with near the 3rd opening part in each described 3rd storage vault, described second top, cache storage room is provided with the 6th electrode, one Electrode connection of described 4th power supply is to the 6th electrode, and another Electrode connection is to described first electrode or the second electrode.

24. according to claim 20ly wear intellectual drug import system, it is characterized in that: also comprise the second medicine storage chamber and the 5th power supply, described second medicine storage chamber is detachably located in described medicine bag structure, described second medicine storage chamber is connected to described 3rd storage vault, the indoor face, side of described second medicament storage is provided with one the 7th electrode, in described 3rd storage vault, a side is provided with the 8th electrode, described 7th electrode is relative with described 8th electrode, and described 5th power positive cathode connects described 7th electrode and the 8th electrode respectively.