CN207253396U - A kind of rodent nebulization equipment - Google Patents

Abstract

The utility model relates to an atomization and inhalation device for rodents, which is mainly composed of a medicine delivery tube, an atomization chamber, a medicine feeding chamber and a rubber plug. The device can be used for inhalation administration to animals during pharmaceutical research. With this device, the drug can enter the atomization chamber through the drug delivery tube, and under the action of the mechanical stirrer, the atomized state can be maintained, and then the experimental mice or rats can be put into the drug feeding room, and their noses can be fixed At the drug hole, the animal entrance and exit of the feeding room were closed with a rubber stopper, so that the experimental animals could inhale the drug in an awake state. The device can be connected to a vacuum pump to generate negative pressure, which is helpful for the separation of drugs and excipients, and enters the atomization chamber, and the space of the atomization chamber is relatively narrow, which is conducive to the enrichment of drug concentration; the lower part of the atomization chamber is equipped with a mechanical stirrer, which can It is beneficial to keep the drug in an atomized state; the experimental animals inhale the drug in an awake state without anesthetizing the animal, and at the same time, it can reduce the exposure of the eyes, skin and other organs to the drug and affect the animal's absorption of the drug, so that more realistic experimental data can be obtained.

Description

Rodent atomization inhalation device

technical field

The utility model relates to an atomization inhalation drug delivery device, in particular to a rodent atomization inhalation device for drug research.

Background technique

Inhalation preparations refer to liquid or solid preparations in which the raw drug is dissolved or dispersed in a suitable medium and delivered to the lungs in the form of vapor or aerosol to exert local or systemic effects. These include inhalation aerosols, inhalation powders, liquid preparations for nebulizers, or preparations that can be converted to vapor.

Inhalation administration refers to a kind of drug administration method in which one or more drugs enter the lungs through a special drug delivery device to exert local or systemic effects, so as to achieve the purpose of prevention, treatment or diagnosis. Compared with ordinary oral preparations, inhalation preparations have advantages in tissue physiology: lung tissue has a rich and permeable capillary network, and drugs can quickly reach lung tissue; pulmonary administration does not go through enterohepatic circulation, thereby avoiding the first pass of oral drugs Effect, which can avoid the destruction of the drug and help to improve the bioavailability of the drug. Therefore, inhalation administration has the characteristics of higher therapeutic index and less side effects than oral administration. (Qian Bochu, Shi Hong, Lv Yanping. Research progress of inhalation drug experiment methodology in pharmacology and toxicology research [J]. Chinese Pharmacology Bulletin, 2006,11:1285-1290.).

Due to the particularity of the route of administration of inhalation preparations, there are currently no good animal inhalation administration atomization devices for drug research, including the US FDA, the European Union, and my country. The current commonly used method uses anesthetized rats for pulmonary administration. most. The respiratory function of animals under anesthesia is obviously different from the normal state, which cannot truly reflect the characteristics of inhalation administration. Therefore, it is necessary to provide a device capable of administering drugs in the normal state of experimental animals to conduct drug research by inhalation.

Contents of the invention

The purpose of this utility model is to provide an atomized inhalation device for rodents, on which drug research such as pharmacokinetic experiments of inhalation preparations can be carried out, which can keep the experimental animals in a awake state all the time, and can reduce other diseases caused by animals. Organs, such as eyes and skin, are exposed to drugs to affect the absorption of drugs by animals, so that they can truly reflect the characteristics of inhalation administration.

The utility model is realized by adopting the following technical solutions: a rodent atomization inhalation device, which is mainly composed of a drug delivery tube, an atomization chamber, a feeding drug room and a rubber plug; the drug delivery tube is located above the atomization room, and the delivery One end of the drug tube is a drug inlet, and the other end is a sleeve; the sleeve is composed of an inner tube, an outer tube and an exhaust tube, and the outer tube is fixedly connected to the atomization chamber; there are 6 feeding chambers connected to the outside of the atomization chamber; One end of the feeding chamber is fixedly connected with the atomization chamber, and the connection is provided with a feeding hole, and the other end is an animal entrance; the animal entrance is detachably inserted and connected with a rubber plug.

The drug infusion tube is an elbow with a bending angle of 80°-120°, which facilitates the combination of the drug inlet and the commonly used clinical inhalation preparation drug delivery device during the experiment; the diameter of the inner tube is 10mm-30mm, and the outer diameter is 10mm-30mm. The diameter of the pipe is 30mm-50mm, and the distance between the inner pipe and the outer pipe is 5mm-10mm; the inner pipe and the outer pipe form a structure with a closed top and an open bottom. When the medicine is administered, the vacuum pump can be adjusted so that the medicine can be pumped from the whole device at a flow rate of 28.3L/min, so that the whole device can generate negative pressure, which helps the medicine enter the atomization chamber and separate from the excipients.

The atomization chamber is cylindrical, with a diameter of 150 mm and a height of 125 mm. A mechanical stirrer is installed at the bottom with a rotation speed of 100-180 rpm. The mechanical stirrer can keep the atomization state of the drug; the material of the atomization chamber is plexiglass, which is beneficial to observe the atomization of the drug; there are 6 feeding chambers connected to the upper and middle parts of the atomization chamber, and the feeding chambers are evenly distributed in the Outside the spray chamber.

The feeding chamber is a tubular structure with a diameter of 30mm-80mm and a length of 80mm-150mm; one end is connected to the atomization chamber, and there is a feeding hole at the connection, and the diameter of the feeding hole is 10mm-30mm, which can fix rodent experimental animals. The nose; the other end is the entrance and exit of the animal, which is connected with the detachable rubber stopper.

When doing the experiment, the rubber stopper is removed, so that the experimental mice or rats can enter the feeding room, and then the animal entrance and exit of the feeding room can be closed with the rubber stopper, so that the experimental mice or rats can be closed in the feeding room middle.

The atomized inhalation device for rodents can be used for inhalation powder spray and inhalation aerosol.

The rodent atomization inhalation device can complete the experimental process of the entire animal atomization inhalation administration according to the following steps:

(1) Use rubber plugs to seal the animal entrances and exits of the feeding room, and check the airtightness of the entire nebulization inhalation device;

(2) Connect the suction tube on the outer tube of the cannula located at the connection between the drug delivery tube of the atomization inhalation device and the atomization chamber to the vacuum pump, start the vacuum pump, and put the device under negative pressure; place the inhalation preparation to be studied in the preparation self- In the drug delivery device with the belt, it is connected with the drug delivery port of the drug delivery tube, so that the drug enters the atomization chamber through the drug delivery tube;

(3) Start the mechanical agitator, turn off the vacuum pump, and carefully and slowly remove the rubber plug at the animal entrance and exit of the feeding room, so that the pressure of the device is consistent with the external environment;

(4) Put the experimental mice or rats into the drug feeding room, fix the nose on the drug feeding hole at the junction of the drug feeding room and the atomization room, and seal the animal entrance and exit of the drug feeding room with rubber plugs, forcing the experimental animals to inhale the drug ;

(5) After the experiment, turn off the mechanical stirrer, take out the experimental animals, seal the animal entrance and exit of the feeding room with rubber plugs again, and connect the device to a vacuum pump to pump out the drugs that are not inhaled by the experimental animals, and clean the experimental device if necessary .

Beneficial effect:

1. The device can be connected to a vacuum pump to make the whole device generate negative pressure, which helps to separate the drug from the excipients and enter the atomization chamber, which can increase the concentration of the drug inhaled by animals;

2. The space of the atomization chamber of the device is small, which is conducive to the enrichment of drug concentration; the lower part of the atomization chamber is equipped with a mechanical stirrer, which is conducive to maintaining the atomized state of the drug and making the concentration of the drug inhaled by animals more uniform;

3. The device allows experimental animals to inhale drugs in an awake state without anesthetizing the animals. At the same time, it can reduce the exposure of eyes, skin and other organs to drugs and affect the absorption of drugs by animals, so that more realistic experimental data can be obtained.

Description of drawings

Fig. 1 is a top view of a rodent atomization inhalation device of the present invention.

Fig. 2 is a vertical sectional view of a rodent atomization inhalation device of the present invention.

In the picture:

1-feeding medicine room; 2-medicine delivery tube; 3-exhaust pipe; 4-spray chamber; 5-feeding medicine hole; 6-stirring device; 7-rubber plug; 8-outer tube; 9-inner tube; 10 -exhaust pipe; 11-animal entrance and exit, 12-medicine inlet.

Detailed ways

The utility model will be further described in conjunction with the accompanying drawings and embodiments.

Example 1:

An atomized inhalation device for rodents, composed of a drug delivery tube 2, an atomization chamber 3, a drug feeding room 1 and a rubber stopper 7; the drug delivery tube 2 is located above the atomization room 4, and one end of the drug delivery tube 2 is for feeding mouth 12, the other end is a casing 3, which is fixedly connected with the atomization chamber 4; there are 6 feeding chambers 1 connected to the outside of the atomization chamber 4; one end of the feeding chamber 1 is fixedly connected with the atomization chamber 4, and a feeding The drug hole 5 has an animal entrance and exit 11 at the other end; the animal entrance and exit 11 is detachably inserted and connected with the rubber plug 7 .

The drug delivery tube 2 is a curved tube with a bending angle of 90°; the sleeve tube 3 is composed of an inner tube 9, an outer tube 8 and an air extraction tube 10, the inner tube 9 has a diameter of 30 mm, the outer tube 8 has a diameter of 50 mm, and the inner tube 9 has a diameter of 50 mm. The distance between 9 and the outer tube 8 is 10 mm; the inner tube 9 and the outer tube 8 form a structure with a closed top and an open bottom; the exhaust pipe 10 is fixedly arranged on the outer tube 8 .

The atomization chamber 4 is cylindrical, with a diameter of 150 mm and a height of 125 mm. A mechanical stirrer 6 is installed in the lower part, and the rotating speed is 100-180 revolutions/min; there are 6 feeding chambers 1 connected to the middle and upper part of the outer side of the atomization chamber 4. The medicine chambers 1 are evenly distributed outside the spray chamber 4 .

The feeding drug chamber 1 is a tubular structure with a diameter of 30 mm and a length of 80 mm; one end of the feeding drug room 1 is connected to the atomization chamber 4, and there is a feeding drug hole 5 at the connection, and the diameter of the feeding drug hole 5 is 10 mm; the other end of the feeding drug room 1 is an animal The inlet and outlet 11 are detachably inserted and connected with the rubber plug 7 .

Example 2:

An atomized inhalation device for rodents, composed of a drug delivery tube 2, an atomization chamber 3, a drug feeding room 1 and a rubber stopper 7; the drug delivery tube 2 is located above the atomization room 4, and one end of the drug delivery tube 2 is for feeding mouth 12, the other end is a casing 3, which is fixedly connected with the atomization chamber 4; there are 6 feeding chambers 1 connected to the outside of the atomization chamber 4; one end of the feeding chamber 1 is fixedly connected with the atomization chamber 4, and a feeding The drug hole 5 has an animal entrance and exit 11 at the other end; the animal entrance and exit 11 is detachably inserted and connected with the rubber plug 7 .

The drug delivery tube 2 is a curved tube with a bending angle of 120°; the sleeve tube 3 is composed of an inner tube 9, an outer tube 8 and an air extraction tube 10, the diameter of the inner tube 9 is 30mm, the diameter of the outer tube 8 is 50mm, and the inner tube The distance between 9 and the outer tube 8 is 10 mm; the inner tube 9 and the outer tube 8 form a structure with a closed top and an open bottom; the exhaust pipe 10 is fixedly arranged on the outer tube 8 .

The atomization chamber 4 is cylindrical, with a diameter of 150 mm and a height of 125 mm. A mechanical stirrer 6 is installed in the lower part, and the rotating speed is 100-180 revolutions/min; there are 6 feeding chambers 1 connected to the middle and upper part of the outer side of the atomization chamber 4. The medicine chambers 1 are evenly distributed outside the spray chamber 4 .

Feeding drug chamber 1 is a tubular structure with a diameter of 50 mm and a length of 120 mm; one end of feeding drug chamber 1 is connected to atomization chamber 4, and there is a feeding drug hole 5 at the connection, and the diameter of feeding drug hole 5 is 20 mm; the other end of feeding drug room 1 is for animals The inlet and outlet 11 are detachably inserted and connected with the rubber plug 7 .

Example 3:

An atomized inhalation device for rodents, composed of a drug delivery tube 2, an atomization chamber 3, a drug feeding room 1 and a rubber stopper 7; the drug delivery tube 2 is located above the atomization room 4, and one end of the drug delivery tube 2 is for feeding mouth 12, the other end is a casing 3, which is fixedly connected with the atomization chamber 4; there are 6 feeding chambers 1 connected to the outside of the atomization chamber 4; one end of the feeding chamber 1 is fixedly connected with the atomization chamber 4, and a feeding The drug hole 5 has an animal entrance and exit 11 at the other end; the animal entrance and exit 11 is detachably inserted and connected with the rubber plug 7 .

The drug delivery tube 2 is a curved tube with a bending angle of 80°; the sleeve tube 3 is composed of an inner tube 9, an outer tube 8 and an air extraction tube 10, the inner tube 9 has a diameter of 30 mm, the outer tube 8 has a diameter of 50 mm, and the inner tube 9 has a diameter of 50 mm. The distance between 9 and the outer tube 8 is 10 mm; the inner tube 9 and the outer tube 8 form a structure with a closed top and an open bottom; the exhaust pipe 10 is fixedly arranged on the outer tube 8 .

The atomization chamber 4 is cylindrical, with a diameter of 150 mm and a height of 125 mm. A mechanical stirrer 6 is installed in the lower part, and the rotating speed is 100-180 revolutions/min; there are 6 feeding chambers 1 connected to the middle and upper part of the outer side of the atomization chamber 4. The medicine chambers 1 are evenly distributed outside the spray chamber 4 .

The feeding drug chamber 1 is a tubular structure with a diameter of 80 mm and a length of 150 mm; one end of the feeding drug room 1 is connected to the atomization chamber 4, and there is a feeding drug hole 5 at the connection, and the diameter of the feeding drug hole 5 is 30 mm; the other end of the feeding drug room 1 is an animal The inlet and outlet 11 are detachably inserted and connected with the rubber plug 7 .

Embodiment 4:

On the basis of Example 1, the entrance and exit of the feeding chamber 1 of the rodent nebulization inhalation device is closed with a rubber plug 7 to check the airtightness of the entire inhalation device. Connect the exhaust pipe 10 on the atomization inhalation device to the vacuum pump, start the vacuum pump, and make the inside of the entire atomization inhalation device be in a negative pressure state. Then the self-made clarithromycin inhalation type powder and aerosol capsules are placed in the powder and aerosol drug delivery device, and connected to the drug inlet 12 at one end of the auxiliary medicine tube 2 of the rodent atomization inhalation device, and the drug is administered by the powder aerosol The device breaks the capsule, the clarithromycin powder aerosol enters the atomization chamber 4, and the mechanical agitator 6 at the lower part of the atomization chamber 4 is turned on to make the atomization uniform. Close the vacuum pump, then take out the rubber plug 7 at the animal entrance and exit 11 of the feeding chamber 1, so that the air pressure inside the device is consistent with the atmosphere. The mice were placed in the feeding chamber 1, and their noses were fixed in the feeding hole 5 connected to the feeding chamber 1 and the atomization chamber 4, and the animal entrance 11 of the feeding chamber 1 was closed with a rubber plug 7, so that the mice Rats inhaled the drug powder in an awake state, and after the specified time, the mice were taken out, dislocated and killed, and the lungs were dissected to detect the blood drug concentration in the mice.

The above is only a preferred embodiment of the utility model, and is not intended to limit the utility model in any form. Any person familiar with the art can make many possible changes and modifications using the methods disclosed above. It belongs to the scope of protection of the claims.

Claims (9)

1. a kind of rodent nebulization equipment, is mainly made of grug transportation tube, spray chamber, feeding coyote hole and rubber plug；Grug transportation tube Above spray chamber, grug transportation tube one end is feeding opening, and the other end is casing；Described sleeve pipe is by inner tube, outer tube and exhaust tube structure Into inner tube forms top seal, the structure of bottom-open with outer tube, and outer tube is fixedly connected with spray chamber；Connection on the outside of spray chamber There are 6 feeding coyote holes；Raise coyote hole one end to be fixedly connected with spray chamber, junction, which is equipped with, raises medicine hole, and the other end is animal entrance, is moved Thing entrance is connected with the detachable insertion of rubber plug, it is characterised in that：The spray chamber is cylindrical, lower part installation mechanical agitation Device.

2. rodent nebulization equipment as claimed in claim 1, it is characterised in that one bend pipe of loading piping； The exhaust tube is fixed on the outer tube of casing；The diameter of inner pipe of described sleeve pipe is 10mm-30mm, and outer tube diameter is The spacing of 30mm-50mm, inner tube and outer tube is 5mm-10mm.

3. rodent nebulization equipment as claimed in claim 2, it is characterised in that the angle of bend of the grug transportation tube For 80 ° -120 °.

4. rodent nebulization equipment as claimed in claim 1, it is characterised in that the spray chamber it is a diameter of 150mm, is highly 125mm.

5. rodent nebulization equipment as claimed in claim 1, it is characterised in that described to raise a diameter of of coyote hole 30-80mm, length 80mm-150mm.

6. rodent nebulization equipment as claimed in claim 1, it is characterised in that the material of the spray chamber is to have Machine glass.

7. rodent nebulization equipment as claimed in claim 1, it is characterised in that the feeding coyote hole is tubulose knot Structure, the middle and upper part on the outside of spray chamber.

8. rodent nebulization equipment as claimed in claim 1, it is characterised in that the feeding coyote hole is uniformly distributed in On the outside of spray chamber.

9. the rodent nebulization equipment as described in claim 1 to 8 is any, it is characterised in that the feeding medicine hole A diameter of 10mm-30mm.