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CN209996294U - device for accurately measuring optical path difference between front and back surfaces of human cornea - Google Patents

device for accurately measuring optical path difference between front and back surfaces of human cornea Download PDF

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CN209996294U
CN209996294U CN201822259464.0U CN201822259464U CN209996294U CN 209996294 U CN209996294 U CN 209996294U CN 201822259464 U CN201822259464 U CN 201822259464U CN 209996294 U CN209996294 U CN 209996294U
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cornea
light
mirror
optical path
path difference
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黄银瑞
秦嘉
谭海曙
安林
蓝公仆
黄燕平
陈国杰
吴小翠
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Guangdong Weiren Medical Technology Co ltd
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Foshan University
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Abstract

device of surface optical path difference around accurate measurement people's eye cornea, reference arm includes collimating mirror, neutral density light filter and speculum, the sample arm includes the second collimating mirror, second mirror and liquid lens, the light that the light source of surveying sent is divided into two tunnel with the light after passing through fiber coupler, way light reachs the second mirror after the second collimating mirror, the light that reflects through the second mirror reachs people's eye cornea measuring area after passing through liquid lens focus, way light is at first through the collimation of collimating mirror, directly arrive speculum through neutral density light filter, speculum is installed at fine setting translation bench, the light that reflects back through takes place to interfere in fiber coupler, then get into the spectrum appearance, the application zooms lens fast and can accurately focus on the front surface and the back surface of cornea, can calculate the optical path difference of cornea front surface and back surface through the distance that reference arm removed.

Description

一种精确测量人眼角膜前后表面光程差的装置A device for accurately measuring the optical path difference between the front and rear surfaces of the human cornea

技术领域technical field

本实用新型属于光学检测技术领域,具体地说,涉及一种精确测量角膜前后表面光程差的装置。The utility model belongs to the technical field of optical detection, in particular to a device for accurately measuring the optical path difference between the front and rear surfaces of the cornea.

背景技术Background technique

角膜是眼睛最前面的透明部分,覆盖虹膜、瞳孔及前房,并为眼睛提供70%的屈光力,角膜的微小改变即可引起屈光状态的较大改变,因此,人们一直致力于研究角膜的形状和光学特性。准确测量角膜曲率和角膜中央厚度(CCT)为角膜疾病的早期诊断、角膜屈光手术术前筛查和术后随访、人工晶体度数计算等提供重要的依据,对矫正眼压、排查青光眼等方面也具有重要意义。The cornea is the most transparent part of the front of the eye, covering the iris, pupil and anterior chamber, and provides 70% of the refractive power of the eye. A small change in the cornea can cause a large change in the refractive state. shape and optical properties. Accurate measurement of corneal curvature and central corneal thickness (CCT) provides an important basis for early diagnosis of corneal diseases, preoperative screening and postoperative follow-up of corneal refractive surgery, calculation of intraocular lens power, etc. also important.

与本实用新型创造中所设计的技术方案最接近的现有技术方案是专利《一种角膜测量方法及系统》(CN108634928A)中采用的角膜厚度和折射率测量的方法。它利用光学相干层析成像系统测量获得角膜前表面到后表面的光程L0;其次,移动聚焦透镜,当探测光的焦点位于角膜前后表面时,信号强度为极大值,然后获得当探测光的焦点位于角膜前后表面时,透镜对应的两个位置的间距L1;最后,利用光线追迹技术获得角膜的折射率和角膜厚度。The prior art solution closest to the technical solution designed in the creation of the present invention is the method for measuring corneal thickness and refractive index adopted in the patent "A Cornea Measurement Method and System" (CN108634928A). It uses the optical coherence tomography system to measure and obtain the optical path L0 from the anterior surface of the cornea to the posterior surface; secondly, move the focusing lens, when the focus of the probe light is located on the anterior and posterior surfaces of the cornea, the signal intensity is the maximum value, and then obtain when the probe light When the focal point is located on the anterior and posterior surfaces of the cornea, the distance between the two positions corresponding to the lens is L1; finally, the refractive index and corneal thickness of the cornea are obtained by using ray tracing technology.

上述专利中运用到的利用光学相干层析成像获得角膜前表面到后表面的光程差,采用的方法是聚焦透镜焦点在角膜前表面和后表面之间时的图像,得到前表面和后表面对应的频率,然后计算得到的光程差为比例系数k乘以频率差,这种计算方法比例系数k难以准确测量,存在一定误差;其次是计算聚焦透镜焦点改变的距离也存在一定误差,在移动透镜时有可能会改变测量位置,导致测量的角膜前后表面不在同一竖直线上。The optical coherence tomography used in the above-mentioned patent is used to obtain the optical path difference from the front surface of the cornea to the back surface. The corresponding frequency, and then the calculated optical path difference is the proportional coefficient k multiplied by the frequency difference. This calculation method is difficult to accurately measure the proportional coefficient k, and there is a certain error; secondly, there is also a certain error in calculating the distance of the focus change of the focusing lens. When moving the lens, it is possible to change the measurement position so that the measurement of the anterior and posterior surfaces of the cornea is not in the same vertical line.

实用新型内容Utility model content

为了实现人眼角膜厚度和折射率的准确测量,本实用新型提供了一种测量角膜中心厚度和眼轴长的装置,解决了两大问题:第一个问题是如何实现角膜前后表面光程差的在体测量;第二个问题是如何改变透镜焦距而不改变测量位置。In order to realize the accurate measurement of the thickness and refractive index of the human cornea, the utility model provides a device for measuring the thickness of the center of the cornea and the axial length of the eye, which solves two major problems: the first problem is how to realize the optical path difference between the front and rear surfaces of the cornea. In-body measurement; the second problem is how to change the lens focal length without changing the measurement position.

为了解决上述技术问题,本实用新型是通过以下技术方案实现的:In order to solve the above-mentioned technical problems, the utility model is realized through the following technical solutions:

一种精确测量人眼角膜前后表面光程差的装置,包括探测光源、光纤耦合器、参考臂、样品臂和光谱仪,所述参考臂包括第一准直镜、中性密度滤光片和第一反射镜,所述样品臂包括第二准直镜、第二反射镜和液体透镜,所述探测光源发出的光经过光纤耦合器后将光分成两路,一路光经过第二准直镜后到达第二反射镜,经第二反射镜反射的光经过液体透镜聚焦后到达人眼角膜测量区域;另一路光首先经过第一准直镜准直,然后经过中性密度滤光片直射到第一反射镜,第一反射镜安装在微调平移台上,经第一反射镜反射回来的光在光纤耦合器中发生干涉,然后进入光谱仪。A device for accurately measuring the optical path difference between the front and rear surfaces of human cornea, comprising a detection light source, an optical fiber coupler, a reference arm, a sample arm and a spectrometer, the reference arm comprising a first collimating lens, a neutral density filter and a first Reflecting mirror, the sample arm includes a second collimating mirror, a second reflecting mirror and a liquid lens, the light emitted by the detection light source is divided into two paths after passing through the optical fiber coupler, and one light reaches after passing through the second collimating mirror The second reflecting mirror, the light reflected by the second reflecting mirror is focused by the liquid lens and then reaches the cornea measurement area of the human eye; the other light is first collimated by the first collimating mirror, and then directly directed to the first through the neutral density filter. Reflecting mirror, the first reflecting mirror is installed on the fine-tuning translation stage, the light reflected by the first reflecting mirror interferes in the optical fiber coupler, and then enters the spectrometer.

进一步,所述光谱仪包括光依次进入的第三准直镜、光栅、聚焦透镜和e2v 线阵相机。Further, the spectrometer includes a third collimating mirror, a grating, a focusing lens and an e2v line scan camera into which light enters in sequence.

进一步,所述探测光源为中心波长为840nm,带宽为49nm的超辐射发光二极管。Further, the detection light source is a superluminescent light emitting diode with a center wavelength of 840 nm and a bandwidth of 49 nm.

进一步,所述液体透镜的孔径是2.5mm,屈光度为-5到13,聚焦范围从5cm 到无穷远。Further, the aperture of the liquid lens is 2.5mm, the diopter is -5 to 13, and the focusing range is from 5cm to infinity.

进一步,所述光纤耦合器为50/50的光纤耦合器,其将光分成强度相等的两路。Further, the fiber coupler is a 50/50 fiber coupler, which divides the light into two paths of equal intensity.

进一步,所述微调平移台为一维手动微调平移台。Further, the fine-tuning translation stage is a one-dimensional manual fine-tuning translation stage.

与现有技术相比,本实用新型的有益效果是:Compared with the prior art, the beneficial effects of the present utility model are:

本实用新型采用时域光学相干层析成像技术(TD-OCT)对人眼的角膜进行高分辨率成像,运用快速变焦透镜能够准确聚焦在角膜的前表面和后表面,通过参考臂移动的距离能够计算出角膜前表面和后表面的光程差,是一种非接触精确测量角膜前后表面光程差的装置。The utility model adopts the time-domain optical coherence tomography technology (TD-OCT) to perform high-resolution imaging on the cornea of the human eye, and can accurately focus on the anterior surface and the posterior surface of the cornea by using a fast zoom lens. It can calculate the optical path difference between the anterior surface and the posterior surface of the cornea.

本实用新型主要有两大优势:第一个优势是不用移动聚焦透镜,用快速变焦透镜改变焦距,保证了改变焦距时不改变人眼角膜的测量位置;第二个优势是角膜前表面到后表面的光程差可以直接测量得到,不用转到频域,避免了由于转换频域时必须经过插值和色散补偿带来的误差。The utility model mainly has two major advantages: the first advantage is that the focusing lens is not moved, and the focal length is changed with a fast zoom lens, which ensures that the measurement position of the human cornea does not change when the focal length is changed; the second advantage is that the front surface of the cornea is The optical path difference of the surface can be directly measured without going to the frequency domain, which avoids the error caused by interpolation and dispersion compensation when converting the frequency domain.

附图说明Description of drawings

附图用来提供对本实用新型的进一步理解,与本实用新型的实施例一起用于解释本实用新型,并不构成对本实用新型的限制,在附图中:The accompanying drawings are used to provide a further understanding of the present utility model, and are used to explain the present utility model together with the embodiments of the present utility model, and do not constitute a limitation to the present utility model. In the accompanying drawings:

图1是本实用新型的结构原理图;Fig. 1 is the structural principle diagram of the present utility model;

图2是液体透镜焦距改变示意图。FIG. 2 is a schematic diagram of the change of the focal length of the liquid lens.

图中:In the picture:

1——探测光源; 2——光纤耦合器;1—detection light source; 2—fiber coupler;

3——第一准直镜; 4——中性密度滤光片;3——First collimating lens; 4——Neutral density filter;

5——第一反射镜; 6——第二准直镜;5——The first reflector; 6——The second collimator;

7——第二反射镜; 8——液体透镜;7——Second mirror; 8——Liquid lens;

9——眼睛; 10——第三准直镜;9—eyes; 10—third collimating mirror;

11——光栅; 12——聚焦透镜;11 - grating; 12 - focusing lens;

13——e2v线阵相机; 14——电脑;13—e2v line scan camera; 14—computer;

15——经第二反射镜反射的光; 16——聚焦角膜前表面的光线;15 - the light reflected by the second mirror; 16 - the light focused on the front surface of the cornea;

17——聚焦角膜后表面的光线; 18——人眼角膜。17—focusing light on the posterior surface of the cornea; 18—human cornea.

具体实施方式Detailed ways

以下结合附图对本实用新型的优选实施例进行说明,应当理解,此处所描述的优选实施例仅用于说明和解释本实用新型,并不用于限定本实用新型。The preferred embodiments of the present utility model will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present utility model, but not to limit the present utility model.

如图1和2所示,本实用新型所述一种精确测量角膜前后表面光程差的装置,包括中心波长为840nm,带宽为49nm的超辐射发光二极管作为探测光源1、 50/50的光纤耦合器2、参考臂、样品臂和光谱仪,参考臂包括第一准直镜3、中性密度滤光片4和第一反射镜5,样品臂包括第二准直镜6、第二反射镜7和液体透镜8,探测光源1发出的光经过光纤耦合器2后将光分成强度相等的两路,一路光经过第二准直镜6后到达第二反射镜7,经第二反射镜反射的光15经过液体透镜8聚焦后到达人眼睛9角膜测量区域;另一路光首先经过第一准直镜3 准直,然后经过中性密度滤光片4直射到第一反射镜5,第一反射镜5安装在一维手动微调平移台上,经第一反射镜5反射回来的光在光纤耦合器2中发生干涉,然后进入光谱仪,光谱仪包括光依次进入的第三准直镜10、光栅11、聚焦透镜12和e2v线阵相机13,采用Cobra-S800光谱仪(这款光谱仪具有非常好的信号衰减性能和更高的相机灵敏度)接收反射回来的干涉信号。As shown in Figures 1 and 2, a device for accurately measuring the optical path difference between the front and rear surfaces of the cornea described in the present utility model, comprising a central wavelength of 840nm, a superluminescent diode with a bandwidth of 49nm as a detection light source 1, a 50/50 optical fiber coupling 2, a reference arm, a sample arm and a spectrometer, the reference arm includes a first collimating mirror 3, a neutral density filter 4 and a first reflecting mirror 5, and the sample arm includes a second collimating mirror 6, a second reflecting mirror 7 And the liquid lens 8, the light emitted by the detection light source 1 passes through the optical fiber coupler 2 and divides the light into two paths of equal intensity. The light 15 reaches the cornea measurement area of the human eye 9 after being focused by the liquid lens 8; the other light is firstly collimated by the first collimating mirror 3, and then directly directed to the first reflecting mirror 5 through the neutral density filter 4, and the first reflection The mirror 5 is installed on a one-dimensional manual fine-tuning translation stage, and the light reflected by the first mirror 5 interferes in the fiber coupler 2, and then enters the spectrometer. The spectrometer includes a third collimating mirror 10 and a grating 11 that light enters in sequence , focusing lens 12 and e2v line scan camera 13, use Cobra-S800 spectrometer (this spectrometer has very good signal attenuation performance and higher camera sensitivity) to receive the reflected interference signal.

液体透镜8是brilliantoptics公司生产的D-A-25H液体透镜8,它的孔径是2.5mm,屈光度为-5到13,聚焦范围从5cm到无穷远。The liquid lens 8 is a D-A-25H liquid lens 8 produced by Brilliantoptics, which has an aperture of 2.5 mm, a diopter of -5 to 13, and a focusing range from 5 cm to infinity.

最后应说明的是:以上仅为本实用新型的优选实施例而已,并不用于限制本实用新型,尽管参照实施例对本实用新型进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换,但是凡在本实用新型的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本实用新型的保护范围之内。Finally, it should be noted that the above are only the preferred embodiments of the present utility model, and are not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the embodiments, for those skilled in the art, it is still The technical solutions described in the foregoing embodiments can be modified, or some technical features thereof can be equivalently replaced, but any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model shall be Included within the scope of protection of the present invention.

Claims (6)

  1. The device for accurately measuring the optical path difference between the front surface and the rear surface of the human eye cornea is characterized by comprising a detection light source, an optical fiber coupler, a reference arm, a sample arm and a spectrometer, wherein the reference arm comprises a th collimating mirror, a neutral density optical filter and a th reflecting mirror, the sample arm comprises a second collimating mirror, a second reflecting mirror and a liquid lens, light emitted by the detection light source is divided into two paths after passing through the optical fiber coupler, paths of light reach the second reflecting mirror after passing through the second collimating mirror, light reflected by the second reflecting mirror reaches a measurement area of the human eye cornea after being focused by the liquid lens, another paths of light are collimated by the collimating mirror and then directly reach a th reflecting mirror after passing through the neutral density optical filter, an th reflecting mirror is installed on a fine-tuning translation stage, and light reflected by a undergoes interference in the optical fiber coupler and then enters the spectrometer.
  2. 2. The apparatus for precisely measuring the optical path difference between the front and back surfaces of the cornea of a human eye according to claim 1, wherein the spectrometer comprises a third collimating mirror, a grating, a focusing lens and an e2v line camera, wherein the third collimating mirror, the grating, the focusing lens and the e2v line camera are sequentially arranged in the spectrometer.
  3. 3. The apparatus for accurately measuring the optical path difference between the anterior and posterior surfaces of the cornea of a human eye as claimed in claim 1, wherein the detecting light source is a superluminescent light emitting diode (superluminescent diode) with a central wavelength of 840nm and a bandwidth of 49 nm.
  4. 4. The device for accurately measuring the optical path length difference between the anterior and posterior surfaces of the cornea of a human eye according to claim 1, wherein the liquid lens has an aperture of 2.5mm, a diopter of-5 to 13 and a focusing range of 5cm to infinity.
  5. 5. The apparatus for accurately measuring the optical path difference between the anterior and posterior surfaces of the cornea of human eye according to claim 1, wherein the optical fiber coupler is 50/50 optical fiber coupler, which splits the light into two paths with equal intensity.
  6. 6. The apparatus for accurately measuring the optical path difference between the anterior and posterior surfaces of the cornea of a human eye according to claim 1, wherein the fine adjustment translation stage is a dimension manual fine adjustment translation stage.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109691972A (en) * 2018-12-29 2019-04-30 佛山科学技术学院 Anterior corneal surface optical path difference measurement device and the method for measuring corneal thickness and refractive index
CN112244759A (en) * 2020-09-24 2021-01-22 温州医科大学 OCT imaging system suitable for dynamic determination of Schlemm's canal in angle outflow channel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109691972A (en) * 2018-12-29 2019-04-30 佛山科学技术学院 Anterior corneal surface optical path difference measurement device and the method for measuring corneal thickness and refractive index
CN112244759A (en) * 2020-09-24 2021-01-22 温州医科大学 OCT imaging system suitable for dynamic determination of Schlemm's canal in angle outflow channel
WO2022062050A1 (en) * 2020-09-24 2022-03-31 温州医科大学 Oct imaging system suitable for all-round dynamic determination of schlemm's canal of anterior chamber angle outflow channel

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