CN222870542U - Liquid sample collector - Google Patents

Abstract

A liquid sample collector is disclosed comprising an absorbent element for absorbing a liquid sample, a holding pan for holding an absorbent member, the holding pan being connected to a rod comprising a channel for receiving an indicator strip for indicating a sufficient amount of liquid or a test element for testing an analyte in the liquid sample, the channel comprising an outlet in fluid communication with the holding pan.

Description

Liquid sample collector

Technical Field

The utility model belongs to the field of in-vitro diagnosis and is used for testing an analyte in a liquid sample, in particular to a collecting device for collecting the liquid sample.

Background

In the field of detection, a detection device is a commonly used medical detection instrument, and is used for detecting a sample to be detected for storing a liquid, where the sample to be detected is typically urine, blood, sewage, a semisolid substance (a semisolid substance refers to a liquid sample converted by any suitable method), or the like. The common detection tools for detecting liquid samples are reagent strips, and the two modes of obtaining the liquid samples by the reagent strips are usually adopted, namely, the reagent strips are directly placed into the liquid samples, the bottoms of the reagent strips are contacted with the liquid samples at the moment so as to obtain the liquid samples by the reagent strips, and the other modes are dripping modes, namely, the liquid samples are sucked by the tools such as a dropper and then are dripped into the reagent strips so as to obtain the liquid samples by the reagent strips. The reagent strips in two common modes are in local contact with the liquid sample, and often can only detect one item, and when the detection item is to be replaced, different reagent strips need to be replaced.

In the field of testing, collecting devices for collecting liquids are often used, such as swabs, flocked swabs, for absorbing liquids, and also sponge polyesters as absorbing liquids, which are then released by compression of the polyester, especially in saliva collection. The traditional saliva collector is generally adhered to an absorption disc through glue, but the glue is complex in adhesion process, harmful substances are contained in the glue, damage is caused to the environment or human body, in addition, the healthy and harmless glue is sometimes adopted, the adhesion process is complex, and other procedures are caused, so that the saliva collector is not easy to produce in batches.

This necessitates an improvement over the structure of conventional collectors to avoid the use of glue, which, when used, would not affect the auxiliary functional structure.

Disclosure of utility model

The present utility model overcomes the deficiencies of the prior art by providing a collection device for collecting a liquid sample, the device comprising an absorbent member for absorbing the liquid sample and allowing the liquid sample to be stored on the absorbent member, and a securing member for securing the absorbent member to the securing member.

In some embodiments, the absorbent member may be an absorbent component that includes a first end and a second end, the first end being coupled to the fixation element. In some embodiments, the fixation element is a non-water absorbent material. In some embodiments, the fastening element is a sheet-like or a segmented structure with depressions, and one end of the absorbent member is fastened to the sheet-like structure.

In some embodiments, an elastic piece is disposed in the recess of the fixing element, and the elastic piece has an opening or a through hole. In some embodiments, there is also a rod-like structure connected to the fixing element, wherein the rod-like structure contains a channel, the outlet of which is identical to the opening in the elastic sheet. In some embodiments, the channel is for receiving an indicator strip for indicating whether the absorbent member has absorbed a sufficient amount of liquid sample. Of course, a test strip may also be disposed in the channel, with the indicator strip or test strip being in contact with the absorbent member.

In some embodiments, a layer of glue is provided between the elastic sheet and the absorbent member, and the absorbent member is bonded to the elastic sheet by bonding the glue. In some embodiments, the fastening element is also glued to the absorbent element by means of glue. The elastic sheet is surrounded by the fixing element, and the absorbing element is fixed by glue coated on the elastic sheet and the fixing element.

In some embodiments, the opening in the resilient sheet extends outwardly to form a protrusion resembling a channel from which one end of the indicator or test strip extends, and a layer of glue is provided around the channel, through which the absorbent member is bonded to the mounting member. The channel with the protrusion can not be used for coating glue into the channel when the glue is coated, so that the problem of glue leakage is solved, and in addition, if the glue is coated into the channel, the indicator strip cannot be inserted when being inserted into the channel.

The absorption element comprises polyester, sponge, cotton and filter paper.

In some embodiments, the absorbent member is a polyester foam that is rigid and incompressible when dry and compressible when liquid is absorbed. In some versions, the absorbent member is a sponge, melamine foam, whether dry or wet, that is compressible, or a flexible compressible material.

In some embodiments, the fixing element includes a cavity having an opening, and a bottom connected to the rod-like structure, and a portion of the absorbing element is contained in the cavity, and further includes an elastic element disposed between the cavity wall and the absorbing element, the elastic element being compressed, and the absorbing element being fixed in the cavity by a rebound force of the elastic element.

The elastic fixing element is annular rubber or latex, and the absorption part is fixed in the cavity on the fixing disc through interaction force between the annular elastic rubber or latex and the absorption element as well as the inner surface of the side wall.

In some embodiments, the number of the elastic elements is two, and the two elastic elements are located at two sides of the absorbing element, so that the absorbing element is fixed in the cavity by the resilience of the two elastic elements. In some embodiments, the absorbent member is a cylinder and the resilient member is in the shape of a ring that surrounds the outer surface of the cylinder to secure the absorbent member to the cavity.

In some embodiments, the bottom of the cavity has an opening that is identical to the channel in the tubular structure so that the indicator strip or test element can be inserted through the opening while the indicator element or test element is in contact with the absorbent element. When collecting a liquid sample with the absorbent member, if there is sufficient liquid sample absorbed, the liquid will flow to the indicator strip, and the indicator strip will also have liquid, indicating that liquid collection is sufficient. In the case of a test strip, there is a flow of liquid onto the test strip, and an assay of the nature of the liquid or of the analyte can be performed.

Drawings

Fig. 1 is a schematic view of a conventional collector (prior art).

Fig. 2 is a schematic view of the structure of the collector in one embodiment of the present utility model.

Fig. 3 is a schematic longitudinal sectional view of a collector according to an embodiment of the present utility model.

Fig. 4 is an exploded perspective view of a collector in accordance with one embodiment of the present utility model.

Fig. 5 is an exploded perspective view of a collector in accordance with one embodiment of the present utility model.

Fig. 6 is a schematic view showing a longitudinal sectional structure of a collector according to an embodiment of the utility model.

Fig. 7 is a schematic perspective view of a collector in one embodiment of the utility model.

Fig. 8 is a schematic view of a longitudinal sectional structure of a collector in one embodiment of the utility model.

Fig. 9 is a schematic exploded view of a collector in one embodiment of the utility model.

Fig. 10 is a partial structural sectional view (schematic view) of a collector in one embodiment of the utility model.

Fig. 11 is a schematic illustration of a fixed absorbent element in a collector in accordance with one embodiment of the present utility model.

Fig. 12 is a schematic illustration of the fastening of an absorbent element in a collector in accordance with one embodiment of the present utility model.

Detailed Description

Detailed Description

Detection of

Detection indicates the assay or testing for the presence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolic product, a drug or drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein or a polymer. In addition, the detection indicates the amount of the test substance or material. Further, assays also refer to immunoassays, chemical assays, enzymatic assays, and the like.

Sample of

Samples that may be detected by the detection device of the present utility model include biological fluids (e.g., case fluids or clinical samples). The liquid sample or liquid specimen may be derived from solid or semi-solid samples, including fecal matter, biological tissue, and food samples. The solid or semi-solid sample may be converted to a liquid sample using any suitable method, such as mixing, mashing, macerating, incubating, dissolving, or digesting the solid sample with enzymatic digestion in a suitable solution (e.g., water, phosphate solution, or other buffer solution). "biological samples" include animal, plant and food samples, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures and media derived from humans or animals. Preferably the biological sample is urine, preferably the biological sample is saliva, sputum, nasal secretions and the like. Food samples include food processed materials, end products, meat, cheese, wine, milk and drinking water. Plant samples include plants, plant tissues, plant cell cultures and media derived from any plant. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample, an earth sample, groundwater, seawater, and a waste liquid sample). The environmental sample may also include sewage or other wastewater.

In some embodiments, the sample of the present utility model may be a urine sample of a human or mammal, or may be a saliva sample, sputum sample, or a liquid sample secreted from the nasal cavity.

Downstream and upstream

Downstream or upstream is divided with respect to the direction of liquid flow, typically liquid flowing from upstream to downstream regions. The downstream region receives liquid from the upstream region and liquid may also flow along the upstream region to the downstream region. Here, the flow direction of the liquid is generally divided, for example, on some materials that use capillary force to promote the flow of the liquid, the liquid may flow in a direction opposite to the gravity, and at this time, the upstream and downstream are also divided according to the flow direction of the liquid. For example, in some preferred embodiments of the collection device of the present utility model, an absorbent member is used to absorb a liquid sample, and an indicator strip attached to one end of the absorbent member is also used to absorb liquid from the absorbent member, the indicator strip having a sufficient amount of color to identify the liquid when sufficient liquid is absorbed by the absorbent member. The liquid flows by capillary action and can flow in the direction opposite to the gravity direction.

Gas or liquid communication

Gas or liquid communication refers to the ability of a liquid or gas to flow from one location to another, where the flow may be directed through some physical structure. By physical structures is generally meant that liquid flows passively or actively to another place through the surfaces of the physical structures, or through the spaces within the structures, the passive being generally flow caused by external forces, such as capillary action. The flow may be liquid or gas, or may be passive, due to its own action (gravity or pressure).

Detachable combination

By removable combination is meant that the connection between two components is in several different states or positional relationships, for example, when the components are in two physical senses, they may initially be separated, when connected or combined together in a suitable first instance, and when in a suitable second instance, the two components may be separated, which is physically spatially separated from contact. Or the two components may be initially brought together, where appropriate, to form a physical spatial separation. In general, the combination of the two or the separation between the two can be easily performed, and the combination or the separation can be repeated for a plurality of times, and of course, the combination and the separation can also be disposable. In addition, the two components can be combined in a detachable way, and the three or more components can be combined in a detachable way. For example, having first, second and third members, the first member and the second member may be removably combined, and the second member and the third member may also be removably combined. For example, the elastic piece 203 and the fixing plate are in a detachable combination, and certainly cannot be detached after being assembled, and the elastic fixing element 801,802,901,902 and the cavity of the fixing plate are in a detachable combination and can be detached from the cavity of the fixing plate after being assembled.

Test element

The test element may be a lateral flow test strip that detects multiple analytes. Of course, other suitable test elements may be used in the present utility model, and any element that can detect whether a sample or sample contains an analyte of interest may be referred to as a test element, and such detection may be based on any technical principles, immunological, chemical, electrical, optical, physical, etc. Various test elements may be combined together for use in the present utility model. One form is test paper.

The test strips used in the present utility model may be so-called Lateral flow strips (latex flow TEST STRIP) whose specific structure and detection principles are well known to those of ordinary skill in the art. A typical test strip comprises a sample collection area, a label area, a detection area and a bibulous area, wherein the sample collection area comprises a sample receiving pad, the label area comprises a label pad, and the bibulous area may comprise a bibulous pad, wherein the detection area comprises a necessary chemical, such as an immunological or enzymatic chemical, capable of detecting the presence of an analyte. The commonly used detection reagent strip is a nitrocellulose membrane reagent strip, namely, a detection area comprises a nitrocellulose membrane, a specific binding molecule is immobilized on the nitrocellulose membrane to display the detection result, and the detection reagent strip can also be a cellulose acetate membrane or a nylon membrane, and the like, and a detection result control area (C line) can also be arranged at the downstream of the detection area (T line), and usually, the control area and the detection area are in the form of transverse lines and are detection lines or control lines. Such test strips are conventional, although other types of strips that utilize capillary action for testing are possible. In addition, the test strip typically carries a dry reagent component, such as an immobilized antibody or other reagent, which, upon encountering the liquid, flows along the strip with capillary action, and with the flow, dissolves the dry reagent component in the liquid, thereby allowing the dry reagent in the zone to react to the next zone for the necessary test. The liquid flow is mainly by capillary action. Any analyte may be detected using the present utility model and a suitable detection element. Preferably, the utility model is used for detecting drug small molecules in saliva and urine. Of course, any of the above forms of sample may be collected using the collection device of the present utility model, whether initially in a solid or liquid state, and testing may be performed as long as the liquid or liquid sample flows from one end of the absorbent member to the test member after flowing into the absorbent member.

In some embodiments, as shown in fig. 2-9, a cavity 201 may be provided in the rod-shaped body 200 of the collector, where the test element according to the present utility model is provided, and the test element includes a test area, where one end of the test element contacts one end 102 of the absorbent element 100, and when sufficient liquid is absorbed by the absorbent element 100, excess liquid is absorbed by the test element 300, and if an analyte is present in the liquid sample, the test element may be tested in the test area to obtain a test result. In some embodiments, the absorbent member has a water absorption capacity that is less than the water absorption capacity of the test member. The water absorbing capacity here does not refer to how much liquid is absorbed, but rather the amount of capillary force. If the capillary force of the absorbent member is smaller than the capillary force of the test member, the test member in contact with the absorbent member has a greater traction on the liquid, which accelerates the flow of liquid over the absorbent member, at the same time as it can fill the absorbent member quickly, and if there is excess liquid, it can flow along the test strip from one end to the other, if there is a color change over the test area, on the one hand the analyte can be tested, and on the other hand it can be indicated that the liquid absorbed by the absorbent member reaches a maximum saturation capacity. In some embodiments, the test area includes a test line (T) and a test result control line (C), and liquid sample collection is sufficient, whether or not the analyte is present, as long as the line C is present, indicating that the absorbent member 100 has reached saturated absorbent capacity. In some embodiments, the test area of the test element and where the test result control area faces the rod-like structure 200 is transparent, and a color change between the test area and the test result control area can be observed. In some embodiments, the end of the sample application region of the test element is in contact with one end 102 of the absorbent element 100 and is not necessarily inserted into the absorbent element 100, which allows for filling of the absorbent element with the liquid sample everywhere.

Indicating element

The indicator element is also made of a water absorbent material, and one end of the element is in contact with the absorbent element 100, and when the absorbent element absorbs liquid, the liquid always flows from one end 101 to the other end 102, and when in contact with the other end 102, if there is an excess sample, the indicator element will flow onto the indicator element, and the indicator element indicates that the absorbent element has collected enough sample or that the absorbent element has reached a saturated absorption capacity. In some forms, the indicator strip has an indicator area, wherein the indicator strip is treated with a colored pigment that is covered and invisible to the naked eye, and when the liquid flows through the indicator area, the liquid causes the colored pigment to flow together, and the presence of the color on the indicator element is visually observed to indicate that the absorbent element is sufficiently absorbent. Of course, there are also chemical reagents that can be processed on the indicator strip that are colorless and that exhibit color when the liquid sample is encountered, such as by reacting with certain substances in the liquid sample or the nature (pH) of the liquid sample. The indicator area herein is not intended to be used to test the sample for analyte and merely serves to determine whether the absorbent member 100 has collected a sufficient liquid sample. When liquid is able to flow automatically from one end 101 of the absorbent member to the other end 102, this indicates that the absorbent member is full of liquid sample, and if there is an indicator member that excess liquid sample is able to flow to the cavity 201 of the rod, this may indicate that the absorbent member 100 has absorbed enough liquid or that the absorbent member has reached a maximum saturated absorption. The absorbent element herein may be 50 microliters-5 milliliters, such as 100 microliters, 200 microliters, 300 microliters, 400 microliters, 500 microliters, 600 microliters, 700 microliters, 800 microliters, 1000 microliters, 1500 microliters, 2000 microliters, 2500 microliters, 3000 microliters, etc., of sufficient liquid sample or maximum saturated absorption.

In the conventional art, it is generally necessary to insert one end of the indicator element into the absorbent element (fig. 1), and then to advance a hole in the resorbable element, and to extend one end of the indicator strip into the hole, which in effect has several drawbacks, such as the collector 44 shown in fig. 7 of U.S. patent No. US9,414,813B2 (fig. 1 of the present utility model), with a portion 56 of the indicator strip 48 directly in the absorbent element 51 and another portion in the channel 54 of the rod structure 52, and with the indicator areas 48 and 46 on the indicator strip. This approach has the disadvantage that firstly, typically the absorbent member 51 is intended for saliva collection and is intended to be chewed in the mouth, if a portion of the indicator member is located on the absorbent member, some of the chemicals on the indicator member will flow back to the absorbent head during collection, causing contamination or even damaging the mouth of the collector, and further, if the absorbent member 51 is softened by absorption, it will be forced against the end of the indicator strip located in the absorbent member if it is still chewed in the mouth, the effect of chewing is that it is desired that more saliva sample can be collected by the hypersecretion, and secondly, such an arrangement will often not be fully representative of the saturated absorption of the absorbent member because the portion of the indicator strip is located on the absorbent member, liquid will always be absorbed by the indicator member first, but the liquid sample will not necessarily be absorbed in the absorbent region around the portion 56 of the indicator member inserted into the absorbent member 51. Thirdly, the absorbent member 21 needs to be perforated in advance to allow the indicator member to be inserted into the hole of the absorbent member, and the process is complicated, and in addition, if the absorbent member is a soft material such as melamine foam, it is very difficult to perforated the absorbent member. Fourth, absorbFinally, it is necessary to fixedly connect the test strip to the rod 52, and glue is typically applied to the disc of the rod, and if one end of the indicator strip is inserted into the absorber and glue is also applied to the disc, the operation is inconvenient, and whether the test strip is inserted into the absorbent element 51 or glue is applied to the surface of the disc, the assembly is inconvenient and the assembly process is complicated. In addition, if glue is first applied to the tray, it may be that glue will contact the test strip as well, and if the indicator strip is first attached to the absorbent member, it is inconvenient to apply glue to the tray.

In one form of the utility model, as shown in figures 5-6, the absorbent element 100 of the utility model has one end 102 in direct contact with the holding pan 207, and a resilient pan 203 is provided in the holding pan, the resilient pan 203 having an opening or through hole 210 therein, the resilient pan being disposed in a recessed region 212 in the middle of the pan, the recessed region 212 being the outlet 215 of the cavity 201 of the rod-like structure 200, and when the resilient pan is disposed in the recessed region 212, the upper surface 205 of the resilient pan is on the same surface as the edge surface 202 of the holding pan. At the time of assembly, the test or indicator element 300 is inserted or inserted directly through the aperture 210 of the elastomeric disk with the end 301 of the test or indicator element positioned at the aperture 210 or slightly exposing the aperture 210. If so, the test strip 300 can be inserted through the hole 210 in the flexible disk alone, then one end of the test strip is inserted into the cavity 201 of the rod-like structure, then the flexible disk 203 is pressed into the recessed area 212, and is fixed in the recessed area by the elastic force of the flexible disk 203, and then the end 301 of the test strip or the indicator strip is pressed, so that the end 301 is slightly exposed out of the hole 210. Or the elastomeric disk is first secured in recessed area 212 and then a test or indicator element is inserted from aperture 210 such that end 301 is slightly exposed through the aperture. After installation, the surface 205 of the elastic disc 206 may be coated with a glue layer, and then the absorbent element 102 is brought into contact with the glue layer, typically by pressing the end 102 of the absorbent element 100 against the fixing disc with a force, and during pressing, the glue previously coated on the surface 205 of the elastic disc 203 spreads over the area of the edge surface 202 of the fixing disc, so that the absorbent element is fixed to the fixing disc 207. Here, the material of the absorbent member 100 is generally relatively rigid or hard, so that it can be pressed by applying pressure, so that the glue adheres the absorbent member 100 to the fixing plate 207. Such hard, absorbent materials are typically polypropylene sponge (PP), polyvinyl alcohol sponge PVA, polypropylene, etc., which are hard materials when dry and which become pliable when liquid is absorbed. Therefore, during assembly, the absorbent member is relatively rigid, so that the absorbent member 100 can be adhered to the mounting plate edge surface 202 of the mounting plate 207 by applying pressure. By means of the separate elastic disc 203, the assembly procedure and steps are simplified, the glue applying step is separated from the insertion step of the test strip, and the end of the test element can be inserted into the absorbent element 100 without the drawbacks of the conventional prior art.

In some ways, although in the embodiment of fig. 5-6, the improvement in structure over the prior art is provided, whether by the assembly step or by the application of glue, there is still a drawback in that, when glue is applied to the surface 205 of the flexible disk 203, glue easily flows into the hole 210 to seal the hole 210, some will flow into the cavity 201 along the hole 210, and once the glue becomes solid from the liquid state, it actually serves to block the flow of liquid from the end 102 of the absorbent element 100 to the end 301 of the test strip or indicator strip, even if one end of the indicator strip 300 is slightly exposed to a small extent, e.g., a few millimeters, and when glue is applied to the surface 205 of the flexible disk, it may be inadvertently applied to the hole 210, or when the end 102 of the absorbent element 100 is pressed against the surface 205 of the flexible disk, the glue is now in the liquid state, the pressing process also causes the end 301 of the test strip to shrink into the hole 210, at least under the hole 210, and forms a thin layer of glue at the hole, etc., which is not sufficient to achieve a natural flow of liquid from the end 301 of the indicator strip (if a thin layer of the absorbent element is not sufficiently fluid from the end 301 is not being able to absorb liquid from the sample). After all, the elastic disc 203, for example, with a size of 0.3 square cm-1 square cm, shows that the accuracy requirement for glue application is very high, and that manual glue application is used, which is less controllable to allow liquid glue to flow into the holes 210 to block the holes 210.

Thus, in the embodiment shown in fig. 2-4,10, a protruding channel 211 is provided in the hole 210 of the flexible disc, i.e. a channel-like structure is provided extending outwards in the hole 210, which channel is higher than the surface of the flexible disc 205, e.g. by 1-5 mm, or higher than the thickness of the glue applied to the surface 205, e.g. by 1,2,3,4,5 mm, so that the glue does not overflow onto the channel opening 204 when the surface 205 of the flexible disc 203 is coated with glue, so that the end 301 of the indicator element inserted from the opening 204 is not in contact with the glue, and the glue does not naturally seal the opening 204, and the glue layer applied to the surrounding surface 205 of the channel will allow the absorbent element to adhere to the flexible disc when the end 102 of the absorbent element 100 is pressed against the surface 205 of the flexible disc 203. Although the absorbent element 100 is rigid after all, with the slightly protruding channel 211, this slightly protruding (channel 211) does not affect the adhesion between the absorbent element 100 and the elastic disc. In some embodiments, the elastomeric disk 203 is still disposed in the recessed region 212 of the retainer disk 207, with the elastomeric disk surface 205 being on the same surface as the retainer disk edge surface 202 of the retainer disk (as shown in FIG. 3), and the conduits 211 similarly protrude upward from the elastomeric disk surface 205 and the retainer disk edge surface 202 of the retainer disk 207. As shown in fig. 10, in an alternative way, the recess area 212 of the fixing plate 207 may be deeper, and when the elastic plate 203 is fixed in the recess area, and the opening 204 of the pipe 211 is located at the same horizontal position as the surface 205 of the fixing plate 207, for example, the pipe is 2 mm higher than the surface 205 of the elastic plate 203, a2 mm deep depression 289 is formed in the recess area of the fixing plate, and when glue is applied, one or 2 drops of glue 701 are directly added into the depression, and when the glue is pressed to a thickness of substantially 1.5-2 mm, one end 102 of the water absorbing element may be directly contacted with the elastic plate 203. as explained above, although the absorbent member is hard and rigid, it is not 100% rigid and is not deformed or compressed, especially if made of materials like polypropylene sponge (PP), polyvinyl alcohol sponge PVA, polypropylene, etc., which, even when dry, are slightly resilient, as regards 1-2mm compression, so that when one end 102 of the absorbent member is released from the resilient disc 203 and the disc rim surface 202 of the disc 207, the glue has a thin layer of approximately 1-1.5, and the protruding channel 211 is slightly allowed to enter the absorbent member, thereby allowing other areas of one end 102 of the absorbent member 100 to be in contact with the glue and adhere to the disc 207, and in addition, since the protruding channel 211 is slightly allowed to enter the absorbent member, the one end 301 of the indicator strip 300 is more tightly in contact with one end 102 of the absorbent member 100. In order to make the absorbent member more precisely glued to the holding pan 207, a relatively rough surface may be formed on the surface 205 of the resilient pan, or a rough surface may be formed on a portion of the edge surface of the holding pan, so that the absorbent member is more firmly fixed to the holding pan 207.

In the above embodiment, the absorbent members may be bonded by glue when materials are used which are relatively stiff when dry and soft after absorption of water. However, if the material is soft but less stiff for both dry and water absorbent, it is difficult to adhere with glue, such as melamine foam, sponge, etc. Thus, as shown in figures 8-9, 11,12, in some embodiments, the utility model provides a collector comprising a cavity 501 in the collector, the cavity having a cavity 502 defined by a bottom 504 and a side wall 503, a water absorbing element 400 disposed in the space, a portion of the water absorbing element being disposed in the cavity 502, and a resilient securing member 801 disposed in the space, the resilient securing member contacting a surface of the absorbing element on one side and an inner surface of the side wall 503 on the other side, the absorbing element being secured in the cavity by the force of the resilient member. The resilient member may be of any shape and the cavity may be provided in the holding pan 207, although in some embodiments it may be connected to a rod-like structure 500 at the bottom of the cavity 504, the rod-like structure comprising a channel 501, the channel 501 being in communication with the cavity 501, and if an indicator strip 300 is provided in the channel 501, one end 301 of the indicator strip being in contact with one end 402 of the absorbent member. The elastic fixing element is adopted, and the elastic fixing element is compressed by the elastic fixing element or has the natural property of resilience after receiving external force, or has the capability of recovering to the original position after receiving external force, so that when the elastic fixing element is assembled, the absorbing element can be firstly positioned in the cavity 502, a gap is arranged between the absorbing element and the cavity, then the elastic element is plugged into the gap, generally the width of the elastic element is larger than the width of the gap, the elastic element is necessarily compressed when being plugged into the elastic element, and once the external force is released after the elastic element is compressed, acting force can be applied between the absorbing element and the inner surface of the side wall 503 of the cavity 501, so that the absorbing element is fixed in the cavity. In some embodiments, the elastic member has a pair 901,902 of elastic members on either side of the absorbent member, and when the absorbent member itself is flexible, such as melamine foam, the material described in CA3167464 of the patent application is incorporated by reference as part of the present utility model. The absorbent element 400 will shrink in the direction of the opposing force by the two elastic elements (fig. 12, when the absorbent element is not dry, but the elastic elements also need to be inserted into the cavity 502, so that the absorbent element 400 is still fixed in the cavity 502 by means of the interaction force of the elastic elements (with the force of pressing against the absorbent element, as indicated by the arrows), whereby the absorbent element is fixed to the collector, in such a way that the step of applying glue is omitted.

Of course, if the absorbent member is composed of a material that is rigid when dry and softens when wet, it is also possible to secure the absorbent member with an elastic member, such as shown in FIG. 11, the absorbent member 400 is secured in the cavity by means of two elastic members 801,802 that are jammed in the cavity 501, and dry in this case, in such a way that a stiff absorbent member is secured when dry, which would otherwise have a force to return to the center when it softens after absorbing liquid (without fully returning to a normal state when dry), so that when the absorbent member softens, the two elastic members continue to have the ability to compress against the absorbent member, partially shrinking (as illustrated in FIG. 11), yet still allow the absorbent member to be secured in the cavity 501 without falling off.

The elastic element can be a spring, a silica gel plug, a rubber plug and other similar materials, can not be compressed, has a restoring action in a natural state when the external force disappears, and has an acting force when the external force cannot restore in the natural state. These materials may also be implemented as elastic disks or elastic fixing blocks.

Analyte substance

Examples of analytes that can be used in the present utility model include small molecule substances, including drugs (e.g., drugs of abuse). "drug of abuse" (DOA) refers to the use of drugs (typically acting to paralyze nerves) in non-medical destinations. Abuse of these drugs can lead to physical and mental impairment, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black americans, white amphetamine tablets, dextroamphetamine tablets, beans); methamphetamine MET (crank, methamphetamine, crystal, speed), barbiturates BAR (such as Valium, roche Pharmaceuticals, nutley, new Jersey), sedatives (i.e. sleep aids), lysergic diethylamide (LSD), inhibitors (downers, goofballs, barbs, blue devils, yellow jackets, hypnotic), tricyclic antidepressants (TCA, imipramine, amitriptyline and doxepin), dimethoxymethylaniline MDMA, phencyclidine (PCP), tetrahydrocannabinol (THC, pot, rope, hash, weed, etc.), opiates (i.e. morphine MOP or opium, cocaine COC, heroin, hydroxydihydrocodeinone), anxiolytics and sedatives, the anxiolytics being a class of drugs which are mainly used to relieve anxiety, stress, fear, stabilize mood, and have hypnotic effects, including benzodiazepines BZO (benzodiazepines), atypical BZ, diazepines, benzodiazepines 23, BZ, benzodiazepine, oxazine derivatives, oxamic derivatives, heterocyclic derivatives, such as the derivatives of the class of the heterocyclic classes, such as the oxamic acid, the heterocyclic derivatives of the oxamic acid derivatives, the heterocyclic derivatives, such as the oxamic derivatives, the derivatives, such as the oxydol, the derivatives, etc. The detection device can also be used for detecting medical application and is easy to take excessive medicines, such as tricyclic antidepressants (promethazine or analogues), acetaminophen and the like. These drugs are metabolized into small molecular substances after being absorbed by the human body, and these small molecular substances exist in body fluids such as blood, urine, saliva, sweat, etc. or some body fluids exist in these small molecular substances.

For example, analytes to be detected with the present utility model include, but are not limited to, creatinine, bilirubin, nitrite, proteins (non-specific), hormones (e.g., human chorionic gonadotropin, progestin, follicular stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial substances (e.g., proteins or carbohydrate substances directed against specific bacteria, such as e.g., E.coli 0157: H7, staphylococci, salmonella, clostridium, campylobacter, L. Unicytogenes, vibrio, or Cactus) and substances associated with physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemistry analysis can be tested using lateral flow testing in combination with the device of the present utility model. Any analyte may be detected using a suitable detection element or test element of the present utility model. Preferably, the utility model is used for detecting drug small molecules in saliva and urine. Preferably, small molecule substances such as viruses and bacteria in saliva, throat or nasal fluids can be detected. Or white blood cells, red blood cells, urobilinogen, urinary vitamin c, urinary crystals, urine specific gravity, urine albumin, urinary ketone bodies, urine colony count, urine pH value and nitrous acid in the liquid sample. For example, white blood cells, red blood cells, urobilinogen, urinary vitamin c, urinary crystals, urine specific gravity, urinary albumin, urinary ketone bodies, urinary colony count, urine pH, and the content of nitrous acid in a urine sample.

The method for testing the analyzed substances in the urine can be used for immunization or chemical method. The chemical method is adopted for testing, namely chemical substances are processed on the water absorbing material, when specific analyzed substances are contained in urine, a certain amount of chemical substances can be generated on the water absorbing material, the water absorbing material is colored by the colored substances, whether the analyzed substances exist or are probably exist in the urine sample can be known by comparing the color substances with a standard colorimetric card, and the higher the general color is, the higher the content of the analyzed substances is. For example, when nitrous acid is tested, an aromatic amino sulfonamide diazonium is treated on the test area and the compound reacts with nitrous acid to form a diazonium compound that reacts with 2,3, 4-tetrahydrobenzo (h) quinolin-3-phenol to form a pink colored substance that precipitates on the test area to allow the test area to appear pink. The leucocytes in the urine contain esterases, which catalyze the hydrolysis of privately owned pyrrole amino acid esters, releasing 3-hydroxy-5-phenylpyrrole. This pyrrole then reacts with the diazonium salt to form a purple color. This reaction was used to test the content or amount of leukocytes in urine.

All patents and publications mentioned in the specification are indicative of those of ordinary skill in the art to which this utility model pertains and which may be applied. All patents and publications cited herein are hereby incorporated by reference to the same extent as if each individual publication were specifically and individually indicated to be incorporated by reference. The utility model described herein may be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. For example, the terms "comprising," "consisting essentially of," and "consisting of," in each example herein, may be replaced with the remaining 2 terms of one of the two. The terms and expressions which have been employed herein are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described, but it is recognized that various modifications are possible within the scope of the utility model and of the claims.

Claims (15)

1. A liquid sample collector, the collector comprising:

The device comprises a liquid sample, an absorbing element for absorbing the liquid sample, a fixing disk for fixing the absorbing element, and a rod connected with the fixing disk, wherein the rod comprises a channel, the channel is used for containing an indication strip for indicating whether the liquid is sufficient or a test element for testing the analyzed substance in the liquid sample, and the channel comprises an outlet which is in fluid communication with the fixing disk.

2. The collector of claim 1, wherein said mounting plate has a resilient tab secured thereto, said resilient tab having said outlet, one end of the absorbent member contacting said resilient tab when the absorbent member is secured to the mounting plate.

3. The collector of claim 2, wherein the elastic sheet surface and one end of the absorbing element comprise a layer of glue, and the absorbing element is adhered to the fixing disc through the glue.

4. A collector according to claim 3 wherein when the channel-containing rod contains an indicator or test element, one end of the indicator or test strip is in contact with one end of the absorbent element through the outlet.

5. The collector of claim 4 wherein said outlet of said flexible sheet extends outwardly to form a channel through which said indicator strip contacts one end of said absorbent member.

6. The collector of claim 5 wherein said glue is distributed over the surface of said flexible sheet around the conduit and not across the outlet of the flexible sheet.

7. The collector of claim 1, wherein the holding pan has a cavity with an open bottom and side walls, the opening of the channel is provided in the bottom of the cavity, one end of the absorbent member is located in the cavity, and an elastic fixing member is provided around the absorbent member, and the absorbent member is fixed in the cavity by the elastic fixing member.

8. The collector of claim 7, wherein the number of elastic fixing members is two, and the elastic fixing members are disposed around the absorbing member, thereby fixing the absorbing member in the cavity.

9. The collector of claim 8, wherein the absorbing member is a cylinder, and the elastic fixing member is a ring-shaped rubber or latex, and the absorbing member is fixed in the cavity on the fixing plate by interaction force of the ring-shaped elastic rubber or latex with the absorbing element and the inner surface of the side wall.

10. The collector of claim 9, wherein the rod channel includes an indicator strip having one end in contact with one end of the absorbent member.

11. The collector of claim 1, wherein the fluid sample is saliva, urine, sputum or nasal secretion.

12. The collector of claim 1, wherein said absorbent member comprises polyester, sponge, cotton, filter paper.

13. The collector of claim 1, wherein said absorbent member is rigid and substantially non-compressively deformable when dry and compressively deformable when wet.

14. The collector of claim 1, wherein said absorbent member is in a soft compressible state both when dry and when absorbing liquid.

15. The collector of claim 1, wherein said absorbent member is comprised of polypropylene sponge (PP), polyvinyl alcohol sponge PVA, polypropylene or melamine foam.