DE102006008770A1 - Use of hydroxymatairesinol for the preparation of cosmetic or dermatological preparations for the prophylaxis and treatment of inflammatory skin conditions - Google Patents

Abstract

Use of hydroxymatairesinol for the production of cosmetic or dermatological preparations for the treatment, care and prophylaxis of sensitive skin and / or for the treatment and prophylaxis of erythematous symptoms.

Description

The The present invention relates to the use of the flavonoid hydroxymatairesinol for the preparation of cosmetic or dermatological preparations for the treatment, care and prophylaxis of sensitive skin and erythematous phenomena.

Furthermore The invention relates to preparations with extremely low so-called "stinging potential".

The Problem "sensitive Skin "concerns one growing number of adults and children. With Sensitive Skin you get a combination of different symptoms, like hyperreactive and intolerant skin. But also atopic skin can be subsumed under it become. These skin conditions are often referred to by those affected, not quite correct, as "allergic" skin. Although an allergic disease to symptoms of sensitive skin to lead can, the appearance is "sensitive Skin "not up Allergic limited.

The Skin, especially the epidermis, is considered a barrier organ of the human Organism in particular external influences among words. Represented according to today's scientific understanding the skin is an immunological organ that acts as an immunocompetent peripheral Compartment has its own role in inductive, effective and regulative Immune processes of the whole organism plays.

The Epidermis is rich in nerves and nerve endings such as Vater-Pacini lamellar bodies, Merkel cell neurite complexes and free nerve endings for Pain, cold, heat sensation and itching equipped.

at People with sensitive, sensitive or vulnerable skin can one labeled "stinging" (hurting, burning, hurting) neurosensory phenomenon to be watched. This "sensitive Skin "is different basically from "dry skin" with thickened and indurated Horn layers.

typical Stinging reactions in sensitive skin are redness, Tensing and burning of the skin as well as itching.

When neurosensory phenomenon is the itching in atopic skin, as well as itching in skin diseases.

"Stinging" phenomena can be considered as cosmetically treated disorders be considered. Severe itching, especially in atopy severe skin itching can also be more severe dermatological disorder be designated.

typical, associated with the terms "stinging" or "sensitive skin", disturbing neurosensory phenomena are skin redness, Tingling, tingling, tightening and burning of the skin and itching. she can by stimulating environmental conditions e.g. Massage, surfactant action, Weather effect as Sun, cold, Dryness, but also damp heat, thermal radiation and UV radiation, e.g. the sun, to be evoked.

In "Journal of the Society of Cosmetic Chemists "28, P.197 - 209 (May 1977) describe P.J.Frosch and A. M. Kligman a method for appraisal of the "stinging potential" administered topically Substances. As positive substances, here e.g. Lactic acid and Pyruvic acid used. When measuring by this method but were also amino acids, in particular Glycine, detected as neurosensory active (such substances are called "stinger").

To So far, such sensitivity has been completely different individually different substances. This means, A person who experiences "stinging effects" when in contact with a substance will most likely experience repeatedly at each additional contact. The contact with other "stingers" can just as well without any reaction.

Lots more or less sensitive people have even when using some deodorizing or antiperspirant preparations under erythematous Skin symptoms to suffer.

Erythematous skin symptoms also occur as side effects in certain skin diseases or irregularities on. For example, the typical skin rash is the appearance the acne regularly more or less reddened.

It So was the object of the present invention, the disadvantages of the prior art.

Especially should contain active substances and preparations containing such active substances, for cosmetic and dermatological treatment and / or prophylaxis erythematous, inflammatory, allergic or autoimmune-reactive phenomena, in particular Dermatoses, but also the appearance of the "Stinging" provided become.

According to the invention this solved tasks by the use of hydroxymatairesinol for the production of cosmetic or dermatological preparations for treatment, Care and prophylaxis of sensitive skin and / or treatment and prophylaxis of erythematous Phenomena.

at Use of cosmetic or topical dermatological preparations with an effective content of hydroxymatairesinol is an effective Treatment, but also a prophylaxis of inflammatory skin conditions - including the atopic eczema possible. Cosmetic or topical dermatological preparations with a effective content of hydroxymatairesinol but also serve in surprising Way to soothe sensitive or irritated skin.

Hydroxymatairesinol is characterized by the following chemical structure:

hydroxymatairesinol is a so-called lignan. Lignans are dimers of Phenylpropane derivatives that over the C-2 atom of the propane chain are linked together (2,2'-linkage). These are mostly colorless, crystalline, poorly volatile compounds without smell and striking taste. They arise as connections of plant secondary metabolism probably by radical-oxidative coupling of two phenylpropane derivatives.

hydroxymatairesinol as such occurs in the spruce (Picea abies) and is for example available after Procedures as described by Eklund, Lindholm, Mikkola, Smeda, Lehtilä and Söholm in Essay "Synthesis of (-) - matairesinol, (-) - enterolactone, and (-) - enterodiol from the natural lignan hydroxymatairesinol "in Org.Lett.2003, 5, pp. 491-493 become.

Advantageous is hydroxymatairesinol in cosmetic or dermatological preparations used, a content of 0.0005 - 50.0 wt .-%, in particular 0.01 - 20.0 Wt .-%, corresponding to, based on the total weight of the composition.

The cosmetic according to the invention and / or dermatological formulations may be composed as usual and for the treatment of the skin and / or the hair in the sense of a dermatological treatment or a treatment in terms of nourishing cosmetics. she can but also used in make-up products in decorative cosmetics or in cosmetic and dermatological cleansing products.

If the cosmetic or dermatological preparation is a solution or lotion, the solvents used can be: water or aqueous solutions, furthermore oils, such as triglycerides of capric or caprylic acid, but preferably castor oil, fats, waxes and other natural and synthetic Fat bodies, preferably esters of fatty acids with alcohols of low C number, for example with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids, but also alcohols, diols or polyols of low C number, and their ethers , preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products.

Especially Mixtures of the abovementioned solvents are used, such as with alcoholic solvents Water may be an advantageous additional component.

cosmetic and dermatological preparations according to the invention, also e.g. To protect the skin from UV rays, can take various forms present as e.g. usually For this Type of preparations are used. So they can e.g. a solution, a Emulsion of the water-in-oil (W / O) type or of the oil-in-water type (O / W), or a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W), oil-in-water-in-oil (O / W / O), a gel, a hydrodispersion, a lamellar phase, a liquid isotropic Solution phase, a micellar phase, a solid or dispersed one or more times hexagonal phase, a solid or dispersed one or more times cubic phase, a lyotropic phase, a crystalline phase, a solid pen or aerosol.

The active ingredients according to the invention can also particularly advantageous in microemulsions, for example as in German Offenlegungsschrift DE-195 9 079, used become.

The oil phase of preparations according to the invention is chosen favorably from the group of saturated esters and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then chosen advantageous are from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, Isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, Isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, Erucyl oleate, erucyl erucate and synthetic, semisynthetic and natural Mixtures of such esters, e.g. Jojoba oil.

Further can the oil phase chosen favorably are from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ether, the group of saturated or unsaturated, branched or unbranched alcohols, as well as the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 C-atoms. The fatty acid triglycerides can for example, advantageously chosen are selected from the group of synthetic, semi-synthetic and natural oils, e.g. Olive oil, Sunflower oil, Soybean oil, Peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like more.

Also any mixtures of such oil and wax components are advantageous in the sense of the present Use invention.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C _12-15 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 -alkyl benzoate and isotridecyl isononanoate and mixtures of C _12-15 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.

From The hydrocarbons are paraffin oil, squalane and squalene advantageous to be used in the sense of the present invention.

Advantageous can the oil phase also have a content of cyclic or linear silicone oils or Completely from such oils although it is preferred, except the silicone oil or silicone oils additional Content of other oil phase components to use.

Advantageously, cyclomethicone (octamethylcyclotetrasiloxane) is used as the invention Silicone oil used. However, other silicone oils are also advantageous for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Especially also advantageous are mixtures of cyclomethicone and isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

Advantageous is the content of the oil phase between 1 and 50% by weight, based on the total weight of the preparations, preferably 2.5-30 Wt .-%, particularly preferably 5 - 15 wt .-%.

to Application are the cosmetic and / or dermatological according to the invention Formulations in the for Cosmetics and dermatological usual Applied to the skin and / or hair in sufficient quantity.

The following examples are the embodiments of the present Illustrate inventions.

Claims (2)

Use of hydroxymatairesinol for the preparation of cosmetic or dermatological preparations for treatment, Care and prophylaxis of sensitive skin and / or treatment and prophylaxis of erythematous Phenomena. Use according to claim 1, characterized that hydroxymatairesinol used in cosmetic or dermatological preparations, a content of 0.0005 - 50.0 Wt .-%, in particular 0.01 - 20.0 Wt .-%, corresponding to, based on the total weight of the composition.