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DE112017003142T8 - Messung der Aktivität der LP-PLA2 - Google Patents

Messung der Aktivität der LP-PLA2 Download PDF

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Publication number
DE112017003142T8
DE112017003142T8 DE112017003142.7T DE112017003142T DE112017003142T8 DE 112017003142 T8 DE112017003142 T8 DE 112017003142T8 DE 112017003142 T DE112017003142 T DE 112017003142T DE 112017003142 T8 DE112017003142 T8 DE 112017003142T8
Authority
DE
Germany
Prior art keywords
measurement
pla2 activity
pla2
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE112017003142.7T
Other languages
English (en)
Other versions
DE112017003142T5 (de
Inventor
Shinichi Sakasegawa
Saki Yamaura
Daisuke Sugimori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAGASE DIAGNOSTICS CO., LTD., JP
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Publication of DE112017003142T5 publication Critical patent/DE112017003142T5/de
Application granted granted Critical
Publication of DE112017003142T8 publication Critical patent/DE112017003142T8/de
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01004—Phospholipase A2 (3.1.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G01N2333/92—Triglyceride splitting, e.g. by means of lipase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE112017003142.7T 2016-06-22 2017-06-15 Messung der Aktivität der LP-PLA2 Active DE112017003142T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-123707 2016-06-22
JP2016123707 2016-06-22
PCT/JP2017/022051 WO2017221795A1 (ja) 2016-06-22 2017-06-15 Ｌｐ－ＰＬＡ２活性の測定

Publications (2)

Publication Number Publication Date
DE112017003142T5 DE112017003142T5 (de) 2019-03-21
DE112017003142T8 true DE112017003142T8 (de) 2019-08-08

Family

ID=60784072

Family Applications (1)

Application Number Title Priority Date Filing Date
DE112017003142.7T Active DE112017003142T8 (de) 2016-06-22 2017-06-15 Messung der Aktivität der LP-PLA2

Country Status (5)

Country Link
US (1) US10900063B2 (de)
JP (1) JP6691212B2 (de)
CN (1) CN109563536B (de)
DE (1) DE112017003142T8 (de)
WO (1) WO2017221795A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110462037A (zh) * 2017-01-30 2019-11-15 学校法人日本医科大学 腺相关病毒(aav)衣壳蛋白的突变体
JP7131008B2 (ja) * 2018-03-23 2022-09-06 東洋紡株式会社 アスコルビン酸オキシダーゼの安定化方法
CN114295567B (zh) * 2021-12-30 2024-01-16 青岛汉唐生物科技有限公司 一种磷脂酶a2检测试剂盒及其制备方法
AU2024206259A1 (en) 2023-01-03 2025-07-17 Baker Heart and Diabetes Institute Ether of phosphatidylcholine and phosphatidylethanolamine, their lyso-forms and mixture thereof for use in the treatment of a disease or disorder caused by a deficiency in plasmalogens

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3036883B2 (ja) 1991-05-24 2000-04-24 株式会社シノテスト 血小板活性化因子アセチルヒドロラーゼ活性の測定法
JPH05168498A (ja) 1991-12-24 1993-07-02 Asahi Chem Ind Co Ltd カルシウムイオン測定用組成物
JPH05317056A (ja) 1992-01-22 1993-12-03 Takeda Chem Ind Ltd コリンオキシダーゼをコードするｄｎａおよびその用途
JPH0759597A (ja) 1993-08-23 1995-03-07 Shinotesuto:Kk 血小板活性化因子アセチルヒドロラーゼ活性測定方法
JP3693302B2 (ja) 1994-06-17 2005-09-07 旭化成ファーマ株式会社 カルシウムイオン測定方法および組成物
JP4220603B2 (ja) 1998-12-02 2009-02-04 アルフレッサファーマ株式会社 血小板活性化因子アセチルヒドロラーゼ活性の測定方法
JP4621927B2 (ja) * 2000-07-07 2011-02-02 アルフレッサファーマ株式会社 リゾリン脂質の測定方法
JP2004159531A (ja) 2002-11-11 2004-06-10 Azwell Inc リゾホスホリパーゼｄ活性測定方法
US20070077614A1 (en) 2003-04-01 2007-04-05 Wolfert Robert L Uses of lp-pla2 in combination to assess coronary risk
PT1633864E (pt) 2003-05-28 2010-06-24 Glaxo Group Ltd Ensaio de actividade de lp-pla2 de alta produtividade
US20070166777A1 (en) 2004-04-16 2007-07-19 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
US20130236450A1 (en) 2010-04-30 2013-09-12 Joan Montaner Methods Using Lipoprotein-Associated Phospholipase A2 in an Acute Care Setting
JP2012210179A (ja) 2011-03-31 2012-11-01 Asahi Kasei Pharma Kk エーテル型リン脂質の測定方法
JP6185466B2 (ja) * 2012-07-12 2017-08-23 学校法人帝京大学 認知機能検査法、及びそのキット
US20150086998A1 (en) 2013-09-24 2015-03-26 Thomas D. Schaal Value-assigned solutions of lipoprotein-associated phospholipase a2 having a long shelf-life
US20150160229A1 (en) 2013-12-06 2015-06-11 Thomas D. Schaal Methods for detection of heart failure
WO2015123598A1 (en) 2014-02-14 2015-08-20 Diadexus, Inc. Biomarkers for cardiovascular disease
JP2016123707A (ja) 2014-12-26 2016-07-11 佐藤　清 投げ輪及び輪受けに名札を付けた輪投げの用具

Also Published As

Publication number Publication date
JPWO2017221795A1 (ja) 2019-01-17
US20200002744A1 (en) 2020-01-02
CN109563536A (zh) 2019-04-02
US10900063B2 (en) 2021-01-26
DE112017003142T5 (de) 2019-03-21
CN109563536B (zh) 2022-08-02
JP6691212B2 (ja) 2020-04-28
WO2017221795A1 (ja) 2017-12-28

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Legal Events

Date Code Title Description
R012 Request for examination validly filed
R081 Change of applicant/patentee

Owner name: ASAHI KASEI PHARMA CORP., JP

Free format text: FORMER OWNER: ASAHI KASEI PHARMA CORPORATION, TOKYO, JP

R082 Change of representative

Representative=s name: BOETERS & LIECK, DE

R081 Change of applicant/patentee

Owner name: ASAHI KASEI PHARMA CORP., JP

Free format text: FORMER OWNERS: ASAHI KASEI PHARMA CORPORATION, TOKYO, JP; NATIONAL UNIVERSITY CORPORATION FUKUSHIMA UNIVERSITY, FUKUSHIMA, JP

R082 Change of representative

Representative=s name: BOETERS & LIECK, DE

R016 Response to examination communication
R081 Change of applicant/patentee

Owner name: NAGASE DIAGNOSTICS CO., LTD., JP

Free format text: FORMER OWNER: ASAHI KASEI PHARMA CORP., TOKIO/TOKYO, JP