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DE19638870B4 - Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel - Google Patents

Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel Download PDF

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Publication number
DE19638870B4
DE19638870B4 DE19638870A DE19638870A DE19638870B4 DE 19638870 B4 DE19638870 B4 DE 19638870B4 DE 19638870 A DE19638870 A DE 19638870A DE 19638870 A DE19638870 A DE 19638870A DE 19638870 B4 DE19638870 B4 DE 19638870B4
Authority
DE
Germany
Prior art keywords
methanol
tubulysin
compound
tubulysins
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE19638870A
Other languages
German (de)
English (en)
Other versions
DE19638870A1 (de
Inventor
Hans Prof. Dr. Reichenbach
Gerhard Prof. Dr. Höfle
Florenz Dr. Sasse
Heinrich Steinmetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum Fuer Infektionsforschung De GmbH
Original Assignee
HELMHOLTZ INFEKTIONSFORSCHUNG
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HELMHOLTZ INFEKTIONSFORSCHUNG, Helmholtz Zentrum fuer Infektionsforschung HZI GmbH filed Critical HELMHOLTZ INFEKTIONSFORSCHUNG
Priority to DE19638870A priority Critical patent/DE19638870B4/de
Priority to PCT/EP1997/005095 priority patent/WO1998013375A1/fr
Priority to AU45550/97A priority patent/AU4555097A/en
Publication of DE19638870A1 publication Critical patent/DE19638870A1/de
Application granted granted Critical
Publication of DE19638870B4 publication Critical patent/DE19638870B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19638870A 1996-09-23 1996-09-23 Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel Expired - Lifetime DE19638870B4 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19638870A DE19638870B4 (de) 1996-09-23 1996-09-23 Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel
PCT/EP1997/005095 WO1998013375A1 (fr) 1996-09-23 1997-09-17 Composes a effet antimycotique et cytostatique, leur procede de production, agents contenant ces composes et dsm 11 092
AU45550/97A AU4555097A (en) 1996-09-23 1997-09-17 Compounds with antimycotic and cytostatic effect, preparation method, agent containing these compounds and dsm 11 092

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19638870A DE19638870B4 (de) 1996-09-23 1996-09-23 Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel

Publications (2)

Publication Number Publication Date
DE19638870A1 DE19638870A1 (de) 1998-03-26
DE19638870B4 true DE19638870B4 (de) 2009-05-14

Family

ID=7806530

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19638870A Expired - Lifetime DE19638870B4 (de) 1996-09-23 1996-09-23 Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel

Country Status (3)

Country Link
AU (1) AU4555097A (fr)
DE (1) DE19638870B4 (fr)
WO (1) WO1998013375A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7750164B2 (en) 1996-12-03 2010-07-06 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
JP5042444B2 (ja) 2002-03-22 2012-10-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 癌の処置におけるヘミアスタリン誘導体およびその利用法
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
WO2004005326A2 (fr) * 2002-07-09 2004-01-15 Morphochem Aktiengellschaft Fu Conjugues de tubulysine
US7816377B2 (en) * 2002-07-09 2010-10-19 R&D-Biopharmaceuticals Gmbh Tubulysin analogues
DE60310916T2 (de) 2002-08-23 2007-11-15 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
DE10241152A1 (de) * 2002-09-05 2004-03-18 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Tubulysin-Biosynthese-Gene
DE10254439A1 (de) 2002-11-21 2004-06-03 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Tubulysine, Herstellungsverfahren und Tubulysin-Mittel
EP2532673A3 (fr) 2007-05-10 2014-01-08 R & D Biopharmaceuticals Gmbh Dérivés de tubulysine
EP2181101A2 (fr) * 2007-07-20 2010-05-05 Helmholtz-Zentrum für Infektionsforschung GmbH Analogues de la tubulysine d
IT1394860B1 (it) 2009-07-22 2012-07-20 Kemotech S R L Composti farmaceutici
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
EP2322537A1 (fr) 2009-11-12 2011-05-18 R & D Biopharmaceuticals Gmbh Inhibiteurs de tubuline
EP2499152B1 (fr) 2009-11-12 2016-06-29 TUBE Pharmaceuticals GmbH Inhibiteurs de tubuline
EP2409983A1 (fr) 2010-07-19 2012-01-25 Leibniz-Institut für Pflanzenbiochemie (IPB) Analogues de la tubulysine
CA2837840C (fr) 2011-06-10 2020-08-04 Mersana Therapeutics, Inc. Conjugues de medicament-proteine-polymere
PT2872157T (pt) 2012-07-12 2020-04-30 Hangzhou Dac Biotech Co Ltd Conjugados de moléculas de ligação celular com agentes citotóxicos
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
WO2014093394A1 (fr) 2012-12-10 2014-06-19 Mersana Therapeutics, Inc. Conjugués protéine-polymère-médicament
US9872918B2 (en) 2012-12-12 2018-01-23 Mersana Therapeutics, Inc. Hydroxyl-polymer-drug-protein conjugates
AU2014216539B2 (en) 2013-02-14 2017-03-23 Bristol-Myers Squibb Company Tubulysin compounds, methods of making and use
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
CN112826940A (zh) * 2014-11-11 2021-05-25 杭州多禧生物科技有限公司 细胞毒素分子同细胞结合受体分子的共轭体
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
TWI852735B (zh) 2015-12-04 2024-08-11 美商思進公司 四級胺化妥布賴森(tubulysin)化合物之結合物
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
KR102459469B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
WO2020022892A1 (fr) 2018-07-24 2020-01-30 Rijksuniversiteit Groningen Dérivés de tubulysine et leurs procédés de préparation
CN114040778A (zh) 2019-06-29 2022-02-11 杭州多禧生物科技有限公司 一种细胞结合分子-Tubulysin衍生物偶联物及其制备方法
EP3862023A1 (fr) 2020-02-05 2021-08-11 Hangzhou DAC Biotech Co, Ltd Conjugués de molécules de liaison cellulaire à des agents cytotoxiques
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013094A1 (fr) * 1991-12-24 1993-07-08 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Archazolides, leur procede de fabrication et agents les renfermant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013094A1 (fr) * 1991-12-24 1993-07-08 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Archazolides, leur procede de fabrication et agents les renfermant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE JOURNAL OF ANTIBIOTICS, VOL. 48, 1995, 21-25 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7750164B2 (en) 1996-12-03 2010-07-06 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
USRE41990E1 (en) 1996-12-03 2010-12-07 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US8481575B2 (en) 1996-12-03 2013-07-09 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof

Also Published As

Publication number Publication date
AU4555097A (en) 1998-04-17
WO1998013375A1 (fr) 1998-04-02
DE19638870A1 (de) 1998-03-26

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH, DE

8364 No opposition during term of opposition
R071 Expiry of right