DE60043189D1 - Öl, das Brassicastanol enthält - Google Patents
Öl, das Brassicastanol enthältInfo
- Publication number
- DE60043189D1 DE60043189D1 DE60043189T DE60043189T DE60043189D1 DE 60043189 D1 DE60043189 D1 DE 60043189D1 DE 60043189 T DE60043189 T DE 60043189T DE 60043189 T DE60043189 T DE 60043189T DE 60043189 D1 DE60043189 D1 DE 60043189D1
- Authority
- DE
- Germany
- Prior art keywords
- seeds
- transgenic plants
- brassicastanol
- sitostanol
- dna sequences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000009261 transgenic effect Effects 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 229930182558 Sterol Natural products 0.000 abstract 2
- 235000003702 sterols Nutrition 0.000 abstract 2
- LGJMUZUPVCAVPU-HRJGVYIJSA-N stigmastanol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]2(C)CC1 LGJMUZUPVCAVPU-HRJGVYIJSA-N 0.000 abstract 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
- VGSSUFQMXBFFTM-UHFFFAOYSA-N (24R)-24-ethyl-5alpha-cholestane-3beta,5,6beta-triol Natural products C1C(O)C2(O)CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 VGSSUFQMXBFFTM-UHFFFAOYSA-N 0.000 abstract 1
- ARYTXMNEANMLMU-UHFFFAOYSA-N 24alpha-methylcholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(C)C(C)C)C1(C)CC2 ARYTXMNEANMLMU-UHFFFAOYSA-N 0.000 abstract 1
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 abstract 1
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 abstract 1
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 abstract 1
- 108010028554 LDL Cholesterol Proteins 0.000 abstract 1
- LGJMUZUPVCAVPU-JFBKYFIKSA-N Sitostanol Natural products O[C@@H]1C[C@H]2[C@@](C)([C@@H]3[C@@H]([C@H]4[C@@](C)([C@@H]([C@@H](CC[C@H](C(C)C)CC)C)CC4)CC3)CC2)CC1 LGJMUZUPVCAVPU-JFBKYFIKSA-N 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 229940087168 alpha tocopherol Drugs 0.000 abstract 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- ARYTXMNEANMLMU-ATEDBJNTSA-N campestanol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]2(C)CC1 ARYTXMNEANMLMU-ATEDBJNTSA-N 0.000 abstract 1
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 abstract 1
- 235000000431 campesterol Nutrition 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- -1 sterol compounds Chemical class 0.000 abstract 1
- 150000003432 sterols Chemical class 0.000 abstract 1
- 229960000984 tocofersolan Drugs 0.000 abstract 1
- 229930003799 tocopherol Natural products 0.000 abstract 1
- 239000011732 tocopherol Substances 0.000 abstract 1
- 235000019149 tocopherols Nutrition 0.000 abstract 1
- 235000004835 α-tocopherol Nutrition 0.000 abstract 1
- 239000002076 α-tocopherol Substances 0.000 abstract 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12899599P | 1999-04-12 | 1999-04-12 | |
| PCT/US2000/009696 WO2000061771A2 (en) | 1999-04-12 | 2000-04-12 | Transgenic plants containing altered levels of sterol compounds and tocopherols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60043189D1 true DE60043189D1 (de) | 2009-12-03 |
Family
ID=22437998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60043189T Expired - Lifetime DE60043189D1 (de) | 1999-04-12 | 2000-04-12 | Öl, das Brassicastanol enthält |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7709666B2 (de) |
| EP (1) | EP1169462B1 (de) |
| CN (1) | CN1360637A (de) |
| AT (1) | ATE446370T1 (de) |
| AU (1) | AU4231600A (de) |
| BR (1) | BR0010597A (de) |
| CA (1) | CA2372120A1 (de) |
| DE (1) | DE60043189D1 (de) |
| HK (1) | HK1041608A1 (de) |
| MX (1) | MXPA01010304A (de) |
| WO (1) | WO2000061771A2 (de) |
Families Citing this family (56)
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|---|---|---|---|---|
| US6936289B2 (en) | 1995-06-07 | 2005-08-30 | Danisco A/S | Method of improving the properties of a flour dough, a flour dough improving composition and improved food products |
| EP1433852B1 (de) | 1997-04-09 | 2006-06-28 | Danisco A/S | Verwendung von Lipase zur Verbesserung von Teigen und Backwaren |
| US6541259B1 (en) | 1999-04-15 | 2003-04-01 | Calgene Llc | Nucleic acid sequences to proteins involved in isoprenoid synthesis |
| AU4498500A (en) | 1999-05-07 | 2000-11-21 | Board Of Regents Of The University And Community College System Of Nevada, The | Phytyl/prenyltransferase nucleic acids, polypeptides and uses thereof |
| WO2001031027A1 (en) * | 1999-10-27 | 2001-05-03 | Unilever N.V | Process for modifying plants |
| GB9925453D0 (en) * | 1999-10-27 | 1999-12-29 | Univ Bristol | Increasing isoprenoid biosynthesis |
| DE60132508T2 (de) * | 2000-01-31 | 2008-04-30 | Härting S.A. | Zusammensetzungen enthaltend Phytosterol- und Policosanolester von Fettsäuren zur Herabsetzung des Cholesterol- und Triglyceridspiegels |
| EP1272648A2 (de) * | 2000-04-14 | 2003-01-08 | Unilever N.V. | Verfahren zur veränderung von pflanzen |
| US6872815B1 (en) | 2000-10-14 | 2005-03-29 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| AU2001290522B2 (en) | 2000-08-07 | 2006-11-30 | Monsanto Technology Llc | Methyl-D-erythritol phosphate pathway genes |
| AU2002214048A1 (en) * | 2000-11-24 | 2002-06-03 | Harker, Mark | Process for increasing the level of sterols in plants |
| US6822142B2 (en) | 2001-01-05 | 2004-11-23 | Monsanto Company | Transgenic plants containing altered levels of steroid compounds |
| DE10111676A1 (de) * | 2001-03-09 | 2002-09-12 | Sungene Gmbh & Co Kgaa | Erhöhung des Vitamin-E-Gehalts in Organismen durch Erhöhung der Tyrosinaminotransferase-Aktivität |
| EP1950305A1 (de) | 2001-05-09 | 2008-07-30 | Monsanto Technology, LLC | Tyr-A-Gene und ihre Verwendung |
| JP2004533244A (ja) | 2001-05-09 | 2004-11-04 | モンサント テクノロジー リミテッド ライアビリティー カンパニー | ＴｙｒＡ遺伝子及びその使用法 |
| US7161061B2 (en) | 2001-05-09 | 2007-01-09 | Monsanto Technology Llc | Metabolite transporters |
| WO2002092799A2 (en) * | 2001-05-11 | 2002-11-21 | Bayer Aktiengesellschaft | Regulation of human steroid 5-alpha reductase-like protein |
| ATE362315T1 (de) | 2001-05-18 | 2007-06-15 | Danisco | Verfahren zur herstellung von teig mit einem enzym |
| CA2448881A1 (en) | 2001-06-04 | 2002-12-12 | Basf Plant Science Gmbh | Sugar and lipid metabolism regulators in plants ii |
| AU2002329759A1 (en) | 2001-08-17 | 2003-03-03 | Monsanto Technology Llc | Methyltransferase genes and uses thereof |
| ATE456657T1 (de) | 2001-10-25 | 2010-02-15 | Monsanto Technology Llc | Aromatische methyltransferasen und ihre verwendung |
| BRPI0308740B1 (pt) | 2002-03-19 | 2018-11-21 | Monsanto Technology Llc | molécula de ácido nucléico codificando uma homogentisato prenil transferase (“hpt”) e método de produzir planta tendo semente com nível de tocoferol aumentado |
| EP2216405A1 (de) | 2002-05-03 | 2010-08-11 | Monsanto Technology LLC | Saatspezifische USP-Promotoren zur Expression von Genen in Pflanzen |
| CN1681928A (zh) | 2002-08-05 | 2005-10-12 | 孟山都技术公司 | 生育酚生物合成相关基因及其用途 |
| FR2844142B1 (fr) * | 2002-09-11 | 2007-08-17 | Bayer Cropscience Sa | Plantes transformees a biosynthese de prenylquinones amelioree |
| MXPA05007653A (es) | 2003-01-17 | 2005-09-30 | Danisco | Metodo. |
| BRPI0411638A (pt) * | 2003-07-29 | 2006-08-29 | Unilever Nv | produto alimentìcio e métodos de preparação de uma formulação |
| GB0405637D0 (en) | 2004-03-12 | 2004-04-21 | Danisco | Protein |
| EP2267107A3 (de) | 2004-07-16 | 2011-05-25 | Danisco A/S | Lipolytisches Enzym Verwendungen davon in der Lebensmittelindustrie |
| CN101184844A (zh) * | 2005-03-30 | 2008-05-21 | 加拿大国家研究委员会 | 固醇酰基转移酶基因的鉴定 |
| AR053269A1 (es) * | 2005-05-16 | 2007-04-25 | Monsanto Technology Llc | Plantas y semillas de maiz con mejoramiento de asparagina y proteina |
| BRPI0616096A2 (pt) | 2005-09-20 | 2011-06-07 | Basf Plant Science Gmbh | polinucleotìdeo, vetor, célula hospedeira, método para a fabricação de um polipeptìdeo, polipeptìdeo, anticorpo, organismo não humano transgênico, e, métodos para a fabricação de um lipìdeo ou um ácido graxo, e para a fabricação de uma planta tendo uma quantidade modificada de um composto de armazenagem de semente |
| CN101453885B (zh) | 2006-03-28 | 2014-03-05 | 康乃尔研究基金会有限公司 | Nap基因在控制植物中叶子衰老中的应用 |
| AU2008259834B2 (en) * | 2007-06-01 | 2013-08-01 | Corbion Biotech, Inc. | Production of oil in microorganisms |
| EP3517622A1 (de) | 2008-11-28 | 2019-07-31 | Corbion Biotech, Inc. | Herstellung von massgeschneiderten ölen in heterotrophen mikroorganismen |
| CA2749187C (en) | 2009-01-16 | 2018-02-06 | Danisco A/S | Enzymatic generation of functional lipids from cereals or cereal bi-streams |
| EP2413715B1 (de) | 2009-03-31 | 2017-10-25 | DuPont Nutrition Biosciences ApS | Vermeidung der bräunung und der bildung von fehlgeruch während der solubilisierung von pflanzenzellwänden |
| WO2010122405A2 (en) * | 2009-04-23 | 2010-10-28 | Avesthagen Limited | A method for over expression of chemical constituents in plants |
| WO2011132197A1 (en) | 2010-04-20 | 2011-10-27 | Chetan Balar | An efficient compound for increasing reproductive growth in crop plants, vegetable plants, spices plants, flower and gardening plants thereof |
| ES2898678T3 (es) | 2010-05-28 | 2022-03-08 | Corbion Biotech Inc | Composiciones alimentarias que comprenden aceites a medida |
| BR112013011039A8 (pt) | 2010-11-03 | 2017-10-03 | Solazyme Inc | Óleos microbianos com pontos de escorrimento reduzidos, fluidos dielétricos produzidos dos mesmos, e métodos relacionados |
| BR112013019699A2 (pt) | 2011-02-02 | 2017-12-19 | Solazyme Inc | método de produção de um óleo natural, óleo natural, produto, célula recombinante, célula de microrganismo, e, alimento |
| AU2012253803A1 (en) | 2011-05-06 | 2013-12-05 | Terravia Holdings, Inc. | Genetically engineered microorganisms that metabolize xylose |
| EP2839018B1 (de) | 2012-04-18 | 2019-06-05 | Corbion Biotech, Inc. | Massgeschneiderte öle |
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| US9816079B2 (en) | 2013-01-29 | 2017-11-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US9567615B2 (en) | 2013-01-29 | 2017-02-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US9290749B2 (en) | 2013-03-15 | 2016-03-22 | Solazyme, Inc. | Thioesterases and cells for production of tailored oils |
| US9783836B2 (en) | 2013-03-15 | 2017-10-10 | Terravia Holdings, Inc. | Thioesterases and cells for production of tailored oils |
| JP6517196B2 (ja) | 2013-10-04 | 2019-05-22 | テラヴィア ホールディングス， インコーポレイテッド | 調整油 |
| WO2016007862A2 (en) | 2014-07-10 | 2016-01-14 | Solazyme, Inc. | Novel ketoacyl acp synthase genes and uses thereof |
| EP3660149A1 (de) | 2014-07-24 | 2020-06-03 | Corbion Biotech, Inc. | Variante thioesterasen und verfahren zur verwendung |
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| CN113174395B (zh) * | 2021-04-30 | 2022-06-24 | 中国烟草总公司郑州烟草研究院 | 与烟气苯酚释放量相关的突变基因dhq-sdh1 |
| US20240229052A1 (en) * | 2021-05-14 | 2024-07-11 | Canisius University | Methods and Compositions for Improving Carbon Accumulation in Plants |
| CN118755867B (zh) * | 2024-07-22 | 2025-02-07 | 广东省农业科学院作物研究所 | 一种检测甜玉米籽粒gamma-生育三烯酚含量的Zmhppd1基因及其应用 |
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| US5998396A (en) * | 1996-11-05 | 1999-12-07 | Riken Vitamin Co., Ltd. | Oil solubilized solutions and foods containing phytosterols and process for their production |
| WO1998045457A1 (en) * | 1996-12-26 | 1998-10-15 | Monsanto Company | Transgenic plants with modified sterol biosynthetic pathways |
| US6642434B1 (en) * | 1997-07-25 | 2003-11-04 | University Of Community College System Of Nevada | Transgenic plants with γ-tocopherol methyltransferase |
| JP2002517201A (ja) * | 1998-06-05 | 2002-06-18 | カルジーン エルエルシー | アシルＣｏＡ：コレステロールアシルトランスフェラーゼ関連核酸配列 |
| AU5250399A (en) * | 1998-08-03 | 2000-02-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona, The | Sterol methyltransferase gene |
| CA2340857A1 (en) * | 1998-08-25 | 2000-03-02 | University Of Nevada | Manipulation of tocopherol levels in transgenic plants |
| AU2163000A (en) * | 1998-12-03 | 2000-06-19 | E.I. Du Pont De Nemours And Company | Plan lecithin:cholesterol acyltransferases |
| WO2000032757A2 (en) * | 1998-12-03 | 2000-06-08 | E.I. Du Pont De Nemours And Company | Plant vitamin e biosynthetic enzymes |
| EP1033405A3 (de) * | 1999-02-25 | 2001-08-01 | Ceres Incorporated | DNS-fragmente mit bestimmter Sequenz und die dadurch kodierte Polypeptide |
| DE19931834A1 (de) * | 1999-07-09 | 2001-01-11 | Sungene Gmbh & Co Kgaa | Identifizierung und Überexpression einer DNA-Sequenz codierend für eine 2-Methyl-6-phytylhydrochinon-methyltransferase in Pflanzen |
-
2000
- 2000-04-12 CN CN00807669A patent/CN1360637A/zh active Pending
- 2000-04-12 MX MXPA01010304A patent/MXPA01010304A/es unknown
- 2000-04-12 WO PCT/US2000/009696 patent/WO2000061771A2/en active Application Filing
- 2000-04-12 AU AU42316/00A patent/AU4231600A/en not_active Abandoned
- 2000-04-12 DE DE60043189T patent/DE60043189D1/de not_active Expired - Lifetime
- 2000-04-12 CA CA002372120A patent/CA2372120A1/en not_active Abandoned
- 2000-04-12 EP EP00922076A patent/EP1169462B1/de not_active Expired - Lifetime
- 2000-04-12 AT AT00922076T patent/ATE446370T1/de not_active IP Right Cessation
- 2000-04-12 HK HK02103157.1A patent/HK1041608A1/zh unknown
- 2000-04-12 BR BR0010597-0A patent/BR0010597A/pt not_active IP Right Cessation
-
2004
- 2004-01-16 US US10/647,517 patent/US7709666B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1041608A1 (zh) | 2002-07-12 |
| AU4231600A (en) | 2000-11-14 |
| US20050102716A1 (en) | 2005-05-12 |
| MXPA01010304A (es) | 2002-05-06 |
| CN1360637A (zh) | 2002-07-24 |
| US7709666B2 (en) | 2010-05-04 |
| CA2372120A1 (en) | 2000-10-19 |
| ATE446370T1 (de) | 2009-11-15 |
| EP1169462B1 (de) | 2009-10-21 |
| WO2000061771A2 (en) | 2000-10-19 |
| WO2000061771A9 (en) | 2001-08-02 |
| BR0010597A (pt) | 2002-02-13 |
| EP1169462A2 (de) | 2002-01-09 |
| WO2000061771A3 (en) | 2001-07-05 |
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