[go: up one dir, main page]

DE602004023924D1 - Ease-hemmer - Google Patents

Ease-hemmer

Info

Publication number
DE602004023924D1
DE602004023924D1 DE602004023924T DE602004023924T DE602004023924D1 DE 602004023924 D1 DE602004023924 D1 DE 602004023924D1 DE 602004023924 T DE602004023924 T DE 602004023924T DE 602004023924 T DE602004023924 T DE 602004023924T DE 602004023924 D1 DE602004023924 D1 DE 602004023924D1
Authority
DE
Germany
Prior art keywords
present
compounds
formula
relates
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004023924T
Other languages
English (en)
Inventor
Suanne Nakajima
Ying Sun
Datong Tang
Gouyou Xu
Brian Porter
Yat Sun Or
Zhe Wang
Zhenwei Miao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enanta Pharmaceuticals Inc
Original Assignee
Enanta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharmaceuticals Inc filed Critical Enanta Pharmaceuticals Inc
Publication of DE602004023924D1 publication Critical patent/DE602004023924D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602004023924T 2003-04-18 2004-04-16 Ease-hemmer Expired - Lifetime DE602004023924D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41875903A 2003-04-18 2003-04-18
PCT/US2004/011841 WO2004093798A2 (en) 2003-04-18 2004-04-16 Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors

Publications (1)

Publication Number Publication Date
DE602004023924D1 true DE602004023924D1 (en) 2009-12-17

Family

ID=33309537

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004023924T Expired - Lifetime DE602004023924D1 (en) 2003-04-18 2004-04-16 Ease-hemmer

Country Status (15)

Country Link
EP (2) EP2143727B1 (de)
JP (2) JP4778893B2 (de)
KR (1) KR101031825B1 (de)
CN (1) CN1788006A (de)
AT (1) ATE447573T1 (de)
AU (2) AU2004231987C1 (de)
CA (1) CA2522561C (de)
CY (1) CY1109748T1 (de)
DE (1) DE602004023924D1 (de)
DK (1) DK1615613T3 (de)
ES (2) ES2535147T3 (de)
PL (1) PL1615613T3 (de)
PT (1) PT1615613E (de)
SI (1) SI1615613T1 (de)
WO (1) WO2004093798A2 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
RU2006113880A (ru) 2003-09-26 2007-11-20 Шеринг Корпорейшн (US) Макроциклические ингибиторы сериновой протеиназы ns3 вируса гепатита с
BRPI0506945A (pt) 2004-01-30 2007-06-12 Medivir Ab inibidores de serina protease ns-3 de hcv
CN1938332B (zh) 2004-02-04 2011-10-19 沃泰克斯药物股份有限公司 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂
KR20120091276A (ko) 2004-02-20 2012-08-17 베링거 인겔하임 인터내셔날 게엠베하 바이러스 폴리머라제 억제제
MX2007004783A (es) * 2004-10-21 2007-05-11 Pfizer Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan.
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7608592B2 (en) 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
NZ565059A (en) * 2005-07-25 2011-08-26 Intermune Inc Novel macrocyclic inhibitors of hepatitus C virus replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1915378A4 (de) 2005-08-12 2009-07-22 Boehringer Ingelheim Int Viren-polymerasehemmer
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US20070281884A1 (en) * 2006-06-06 2007-12-06 Ying Sun Macrocyclic oximyl hepatitis C protease inhibitors
PE20080992A1 (es) * 2006-06-26 2008-08-06 Enanta Pharm Inc Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c
WO2008008776A2 (en) 2006-07-11 2008-01-17 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2054388A4 (de) 2006-08-17 2009-10-28 Boehringer Ingelheim Int Virale polymerasehemmer
US20080107623A1 (en) * 2006-11-01 2008-05-08 Bristol-Myers Squibb Company Inhibitors of Hepatitis C Virus
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) * 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN101568543B (zh) * 2006-11-16 2012-06-06 百时美施贵宝公司 大环肽作为丙型肝炎病毒抑制剂
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EA200900969A1 (ru) * 2007-01-08 2010-02-26 Феномикс Корпорейшн Макроциклические ингибиторы протеазы гепатита с
NZ582096A (en) * 2007-06-29 2012-05-25 Gilead Sciences Inc Antiviral compounds that inhibit hepatitis c virus (hcv)
SG182979A1 (en) 2007-06-29 2012-08-30 Gilead Sciences Inc Antiviral compounds
AR067180A1 (es) * 2007-06-29 2009-09-30 Gilead Sciences Inc Compuestos antivirales
WO2009018657A1 (en) 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
MX2010006210A (es) 2007-12-05 2010-08-10 Enanta Pharm Inc Inhibidores de serina proteasa de hcv de tripeptido fluorado.
CA2708324C (en) 2007-12-19 2013-03-05 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
TW200936131A (en) * 2008-02-04 2009-09-01 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2300491B1 (de) 2008-05-29 2016-01-06 Bristol-Myers Squibb Company Inhibitoren des hepatitis-c-virus
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
AU2012201327B2 (en) * 2008-09-11 2014-06-26 Abbvie Ireland Unlimited Company Macrocyclic hepatitis C serine protease inhibitors
UY32099A (es) * 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20100173837A1 (en) 2009-01-07 2010-07-08 Scynexis, Inc. Dosing forms and regimens comprising 3-[(r)-2-(n,n-dimethylamino)ethylthio-sar]-4-(gammahydroxymethylleucine)cyclosporine
EP2417134B1 (de) 2009-04-08 2017-05-17 Idenix Pharmaceuticals LLC. Macrocyclische serinproteaseinhibitoren
CA2761650C (en) 2009-05-13 2015-05-26 Enanta Pharmaceuticals, Inc. Macrocyclic compounds as hepatitis c virus inhibitors
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
WO2011017389A1 (en) 2009-08-05 2011-02-10 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
MX2012003500A (es) * 2009-09-28 2012-08-01 Intermune Inc Nuevos inhibidores macrocíclicos de la replicación de virus de la hepatitis c.
EP3020723A1 (de) 2010-09-21 2016-05-18 Enanta Pharmaceuticals, Inc. Makrozyklische, prolin basierte hcv-serinproteasehemmer
US20120101032A1 (en) * 2010-10-22 2012-04-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
KR20140003521A (ko) 2010-12-30 2014-01-09 이난타 파마슈티칼스, 인코포레이티드 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
US8937041B2 (en) 2010-12-30 2015-01-20 Abbvie, Inc. Macrocyclic hepatitis C serine protease inhibitors
WO2012109398A1 (en) 2011-02-10 2012-08-16 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
EA025560B1 (ru) 2012-10-19 2017-01-30 Бристол-Майерс Сквибб Компани Ингибиторы вируса гепатита с
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (de) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Inhibitoren des hepatitis-c-virus
JP2016505011A (ja) * 2013-01-10 2016-02-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎の治療用の大環状ベンゾフランおよびアザベンゾフラン化合物
JP6342922B2 (ja) 2013-03-07 2018-06-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
AU2014244232B2 (en) 2013-03-13 2019-05-02 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
EP2970335B1 (de) 2013-03-15 2019-05-08 Gilead Sciences, Inc. Makrocyclische und bicyclische hemmer des hepatitis-c-virus
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
EP2899207A1 (de) 2014-01-28 2015-07-29 Amikana.Biologics Neues Verfahren zum Testen von HCV-Proteasehemmung
US11066416B2 (en) 2016-02-04 2021-07-20 The Johns Hopkins University Rapafucin derivative compounds and methods of use thereof
AU2017213630B2 (en) 2016-02-04 2022-05-12 The Johns Hopkins University Rapaglutins, novel inhibitors of GLUT and use thereof
JP7022069B2 (ja) 2016-02-04 2022-02-17 ザ・ジョンズ・ホプキンス・ユニバーシティ ラパドシン（Ｒａｐａｄｏｃｉｎｓ）、受動拡散型ヌクレオシド輸送体１阻害剤及びその使用
EP3678683A4 (de) 2017-09-07 2021-07-14 Fog Pharmaceuticals, Inc. Mittel zur modulierung von ?-catenin-funktionen und verfahren dafür
WO2021067405A1 (en) * 2019-10-01 2021-04-08 The Johns Hopkins University Neuroprotective compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931141A2 (de) * 1996-09-27 1999-07-28 Merck & Co., Inc. Detergens-freie hepatitis c-protease.
US5861297A (en) 1996-09-27 1999-01-19 Merck & Co., Inc. Detergent-free hepatitis C protease
DK1003775T3 (da) * 1997-08-11 2005-05-30 Boehringer Ingelheim Ca Ltd Hepatitis C-inhibitorpeptider
DK1066247T3 (da) * 1998-03-31 2007-04-02 Vertex Pharma Inhibitorer af serinproteaser, især hepatitis C virus NS3 protease
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6086469A (en) * 1998-10-29 2000-07-11 Dec International, Inc. Method and means for conveying and processing an extruded sausage strand
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition

Also Published As

Publication number Publication date
HK1140214A1 (en) 2010-10-08
PL1615613T3 (pl) 2010-04-30
AU2004231987C1 (en) 2010-09-30
EP2143727A1 (de) 2010-01-13
ES2535147T3 (es) 2015-05-06
ES2335887T3 (es) 2010-04-06
WO2004093798A3 (en) 2005-12-08
CN1788006A (zh) 2006-06-14
EP1615613A2 (de) 2006-01-18
AU2004231987B2 (en) 2009-11-19
ATE447573T1 (de) 2009-11-15
JP2007525455A (ja) 2007-09-06
AU2010200619A1 (en) 2010-03-11
AU2004231987A1 (en) 2004-11-04
HK1083337A1 (en) 2006-06-30
SI1615613T1 (sl) 2010-03-31
PT1615613E (pt) 2010-02-09
EP1615613A4 (de) 2007-02-14
JP4778893B2 (ja) 2011-09-21
JP2011178781A (ja) 2011-09-15
AU2010200619B2 (en) 2013-11-07
EP1615613B1 (de) 2009-11-04
CA2522561C (en) 2012-07-17
KR101031825B1 (ko) 2011-04-29
DK1615613T3 (da) 2010-03-22
EP2143727B1 (de) 2015-01-21
CY1109748T1 (el) 2014-09-10
WO2004093798A2 (en) 2004-11-04
KR20050123170A (ko) 2005-12-29
CA2522561A1 (en) 2004-11-04

Similar Documents

Publication Publication Date Title
DE602004023924D1 (en) Ease-hemmer
WO2004113365A3 (en) Hepatitis c serine protease tri-peptide inhibitors
WO2005007681A3 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
TW200510391A (en) Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
WO2005037860A3 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
WO2005077969A3 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
WO2008002924A3 (en) Quinoxalinyl macrocyclic hepatitis c virus serine protease inhibitors
MX2010006209A (es) Derivados de quinoxalinilo.
WO2008022006A3 (en) Arylalkoxyl hepatitis c virus protease inhibitors
WO2004072243A3 (en) Macrocyclic hepatitis c serine protease inhibitors
MX2010006210A (es) Inhibidores de serina proteasa de hcv de tripeptido fluorado.
WO2007143694A3 (en) Macrocyclic oximyl hepatitis c protease inhibitors
WO2009053828A3 (en) P3 hydroxyamino macrocyclic hepatitis c serine protease inhibitors
UA102677C2 (uk) Хіноксалінвмісні сполуки як інгібітори вірусу гепатиту с
WO2008021956A3 (en) Acylaminoheteroaryl hepatitis c virus protease inhibitors
WO2008019266A3 (en) Acyclic, pyridazinone-derived hepatitis c serine protease inhibitors
ATE349463T1 (de) Verbrückte bizyklische serinproteaseinhibitoren
WO2008021871A3 (en) Triazolyl acyclic hepatitis c serine protease inhibitors
WO2008019303A3 (en) Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors
WO2005035525A3 (en) 2-amido-4-aryloxy-1-carbonylpyrrolidine derivatives as inhibitors of serine proteases, particularly hcv ns3-ns4a protease
WO2008021960A3 (en) Triazolyl macrocyclic hepatitis c serine protease inhibitors
WO2009076166A3 (en) Oximyl hcv serine protease inhibitors
MX2010006518A (es) Inhibidores de serina proteasa de hepatitis c de oximil macrociclica.
EP1441720B8 (de) Hemmer von serin-protease, insbesondere von hepatitis-c-virus-ns3-ns4a-protease, mit einem kondensierten ringsystem
MX2010010276A (es) Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition