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DE602005015834D1 - 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus - Google Patents

3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus

Info

Publication number
DE602005015834D1
DE602005015834D1 DE602005015834T DE602005015834T DE602005015834D1 DE 602005015834 D1 DE602005015834 D1 DE 602005015834D1 DE 602005015834 T DE602005015834 T DE 602005015834T DE 602005015834 T DE602005015834 T DE 602005015834T DE 602005015834 D1 DE602005015834 D1 DE 602005015834D1
Authority
DE
Germany
Prior art keywords
prolin
hepatitis
cyclopentyl
virus
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005015834T
Other languages
English (en)
Inventor
George F Njoroge
Srikanth Venkatraman
Ashok Arasappan
Francisco Velazquez
Viyyoor M Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE602005015834D1 publication Critical patent/DE602005015834D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE602005015834T 2004-02-27 2005-02-24 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus Expired - Lifetime DE602005015834D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54865504P 2004-02-27 2004-02-27
PCT/US2005/005778 WO2005087730A1 (en) 2004-02-27 2005-02-24 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease

Publications (1)

Publication Number Publication Date
DE602005015834D1 true DE602005015834D1 (de) 2009-09-17

Family

ID=34961939

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005015834T Expired - Lifetime DE602005015834D1 (de) 2004-02-27 2005-02-24 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus

Country Status (11)

Country Link
US (1) US7342041B2 (de)
EP (1) EP1737821B1 (de)
JP (1) JP2007525512A (de)
CN (1) CN1946692A (de)
AR (1) AR048413A1 (de)
AT (1) ATE438622T1 (de)
CA (1) CA2557307A1 (de)
DE (1) DE602005015834D1 (de)
ES (1) ES2328589T3 (de)
TW (1) TWI302835B (de)
WO (1) WO2005087730A1 (de)

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Also Published As

Publication number Publication date
JP2007525512A (ja) 2007-09-06
CN1946692A (zh) 2007-04-11
CA2557307A1 (en) 2005-09-22
EP1737821A1 (de) 2007-01-03
US20050197301A1 (en) 2005-09-08
US7342041B2 (en) 2008-03-11
ATE438622T1 (de) 2009-08-15
WO2005087730A1 (en) 2005-09-22
HK1095820A1 (en) 2007-05-18
AR048413A1 (es) 2006-04-26
TWI302835B (en) 2008-11-11
ES2328589T3 (es) 2009-11-16
EP1737821B1 (de) 2009-08-05
TW200536530A (en) 2005-11-16

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