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DE602006008641D1 - Herstellung und anwendung von tetrahydropyrrolo ä3, 2-cüpyridin-4-onderivaten zur behandlung von obesitas und psychiatrischen und neurologischen erkrankungen - Google Patents

Herstellung und anwendung von tetrahydropyrrolo ä3, 2-cüpyridin-4-onderivaten zur behandlung von obesitas und psychiatrischen und neurologischen erkrankungen

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Publication number
DE602006008641D1
DE602006008641D1 DE602006008641T DE602006008641T DE602006008641D1 DE 602006008641 D1 DE602006008641 D1 DE 602006008641D1 DE 602006008641 T DE602006008641 T DE 602006008641T DE 602006008641 T DE602006008641 T DE 602006008641T DE 602006008641 D1 DE602006008641 D1 DE 602006008641D1
Authority
DE
Germany
Prior art keywords
cypyridine
obesitas
tetrahydropyrrolo
psychiatric
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006008641T
Other languages
English (en)
Inventor
Leifeng Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37781800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006008641(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE602006008641D1 publication Critical patent/DE602006008641D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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DE602006008641T 2005-10-06 2006-10-05 Herstellung und anwendung von tetrahydropyrrolo ä3, 2-cüpyridin-4-onderivaten zur behandlung von obesitas und psychiatrischen und neurologischen erkrankungen Active DE602006008641D1 (de)

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR056560A1 (es) * 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1
JP5256047B2 (ja) * 2006-01-27 2013-08-07 シャンハイ ヘンルイ ファーマシューティカル カンパニー リミテッド ピロロ［３，２−ｃ］ピリジン−４−オン２−インドリノン（ｉｎｄｏｌｉｎｏｎｅ）プロテインキナーゼ阻害剤
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
AR065909A1 (es) * 2007-04-03 2009-07-08 Astrazeneca Ab Agentes terapeuticos 685
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
NZ587719A (en) * 2008-02-26 2012-04-27 Takeda Pharmaceutical Fused heterocyclic derivative and use thereof
EP2310372B1 (de) 2008-07-09 2012-05-23 Sanofi Heterocyclische Verbindungen, Verfahren zu ihrer Herstellung, Arzneimitteln mit diesen Verbindungen und ihre Verwendung
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
KR101273643B1 (ko) * 2010-10-12 2013-06-11 한국화학연구원 5,6-디하이드로-피롤로［3,4-ｂ］피리딘-7-온 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US9560630B2 (en) * 2011-08-12 2017-01-31 Qualcomm Incorporated Devices for reduced overhead paging
SI2964229T1 (sl) 2013-03-06 2020-02-28 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidin modulatorji receptorja histamina H4
EP3250567B1 (de) 2015-01-28 2019-10-30 Bayer Pharma Aktiengesellschaft 4h-pyrrolo[3,2-c]pyridin-4-on-derivate
WO2020074403A1 (en) * 2018-10-08 2020-04-16 Universität Zürich Appetite-modulating molecules
EP3921317B1 (de) 2019-02-07 2023-08-02 Bayer Aktiengesellschaft 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-on als csnk1-inhibitoren
US20210015762A1 (en) * 2019-07-16 2021-01-21 TRUETIVA, Inc. Compositions for treating obesity
KR20210103688A (ko) 2020-02-14 2021-08-24 (주) 디엔테크 오링용 고무조성물
EP4188551B1 (de) 2020-07-29 2024-12-18 Bayer Aktiengesellschaft Arylsubstituierte pyrrolopyridinone und ihre therapeutische verwendung
WO2022023337A1 (en) 2020-07-29 2022-02-03 Bayer Aktiengesellschaft Substituted pyrrolo-pyridinone derivatives and therapeutic uses thereof
CN115108895A (zh) * 2022-07-06 2022-09-27 四川东材科技集团成都新材料有限公司 一种1-(1-乙氧基乙氧基)-4-乙烯基苯的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
FR2714057B1 (fr) 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2758723B1 (fr) 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
HUP0204519A3 (en) 2000-03-23 2003-07-28 Solvay Pharm Bv 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, pharmaceutical compositions containing them and process for their preparations
DE60207744T2 (de) 2001-09-24 2006-08-03 Bayer Pharmaceuticals Corp., West Haven Verfahren zur herstellung von 1,5,6,7-tetrahydropyrrolo[3,2-c]derivaten zur behandlung der fettleibigkeit
GB0403780D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Therapeutic agents
ES2329915T3 (es) 2004-02-20 2009-12-02 Astrazeneca Ab Derivados de 1,5-difenilpirazol 3-sustituidos utiles como moduladores de cb1.
WO2005095354A1 (en) 2004-04-03 2005-10-13 Astrazeneca Ab Therapeutic agents
AR056560A1 (es) * 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1

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AU2006298530A1 (en) 2007-04-12
ECSP088413A (es) 2008-05-30
ES2329616T3 (es) 2009-11-27
ATE440099T1 (de) 2009-09-15
HK1122808A1 (en) 2009-05-29
KR20080058456A (ko) 2008-06-25
AR056560A1 (es) 2007-10-10
AU2006298530B2 (en) 2009-10-29
ZA200802946B (en) 2009-03-25
IL190025A0 (en) 2008-08-07
CA2624495A1 (en) 2007-04-12
CN101277957A (zh) 2008-10-01
BRPI0616653A2 (pt) 2011-06-28
US7875626B2 (en) 2011-01-25
RU2415856C2 (ru) 2011-04-10
US20080312269A1 (en) 2008-12-18
US7576095B2 (en) 2009-08-18
NO20081523L (no) 2008-07-02
TW200730525A (en) 2007-08-16
WO2007039740A3 (en) 2007-05-31
JP4277062B2 (ja) 2009-06-10
EP1937679B1 (de) 2009-08-19
US20080009513A1 (en) 2008-01-10
JP2009504722A (ja) 2009-02-05
UY29838A1 (es) 2007-05-31
EP1937679A2 (de) 2008-07-02
RU2008109185A (ru) 2009-11-20

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