DE602008004245D1 - Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten - Google Patents

Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten

Info

Publication number: DE602008004245D1
Authority: DE; Germany
Prior art keywords: alpha; hydroxy; production; improved method; opiates
Prior art date: 2007-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

DE602008004245T

Other languages

English (en)

Inventor

Christopher W Grote

Peter X Wang

Tao Jiang

Gary L Cantrell

Frank W Moser

Catherine E Thomasson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mallinckrodt Inc

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-04

Filing date

2008-05-02

Publication date

2011-02-10

2008-05-02 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2011-02-10 Publication of DE602008004245D1 publication Critical patent/DE602008004245D1/de

Status Active legal-status Critical Current

2028-05-03 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE602008004245T 2007-05-04 2008-05-02 Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten Active DE602008004245D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US91596207P	2007-05-04	2007-05-04
US94905507P	2007-07-11	2007-07-11
PCT/US2008/062413 WO2008137672A1 (en)	2007-05-04	2008-05-02	Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates

Publications (1)

Publication Number	Publication Date
DE602008004245D1 true DE602008004245D1 (de)	2011-02-10

Family

ID=39561936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602008004245T Active DE602008004245D1 (de)	2007-05-04	2008-05-02	Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten

Country Status (10)

Country	Link
US (3)	US7985858B2 (de)
EP (3)	EP2152715B1 (de)
JP (1)	JP2009534472A (de)
AT (1)	ATE493416T1 (de)
AU (3)	AU2008207580B2 (de)
CA (1)	CA2637610A1 (de)
DE (1)	DE602008004245D1 (de)
ES (2)	ES2407033T3 (de)
MX (1)	MX2008013842A (de)
WO (1)	WO2008137672A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9040726B2 (en) *	2007-03-06	2015-05-26	Mallinckrodt Llc	Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
WO2010017573A1 (en)	2008-08-11	2010-02-18	Tasmanian Alkaloids Pty Limited	PROCESS FOR MAKING MORPHINAN-6α-OLS
NZ592005A (en) *	2008-09-30	2013-03-28	Mallinckrodt Llc	Process for the preparation of a N-alkylated ketomorphinan by selective catalytiC hydrogen transfer reduction
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102803267A (zh) *	2009-06-11	2012-11-28	马林克罗特有限公司	通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备
EP2440561B1 (de) *	2009-06-11	2014-04-30	Mallinckrodt LLC	Reduktive aminierung von 6-keto-normorphinanen durch katalytischen wasserstofftransfer
WO2011009020A2 (en)	2009-07-16	2011-01-20	Mallinckrodt Inc.	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
GB0914338D0 (en)	2009-08-17	2009-09-30	Johnson Matthey Plc	Improved process
EP2483349B1 (de)	2009-10-02	2017-01-25	Dow Global Technologies LLC	Thermoplastisches vulkanisat mit blockzusammensetzungen
CA2936749C (en) *	2010-06-11	2019-07-09	Joshua R. Giguere	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013529595A (ja)	2010-06-11	2013-07-22	ローズテクノロジーズ	第３級アミンのｎ−脱アルキル化方法
WO2012025944A2 (en) *	2010-08-27	2012-03-01	Usv Limited	Sitagliptin, salts and polymorphs thereof
JP5685046B2 (ja) *	2010-10-14	2015-03-18	高砂香料工業株式会社	光学純度低下防止方法
US9296699B2 (en)	2011-06-09	2016-03-29	Mallinckrodt Llc	Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
US9896402B2 (en)	2011-11-04	2018-02-20	Takasago International Corporation	Method for preventing decrease in optical purity
ES2622342T3 (es) *	2012-02-08	2017-07-06	Mallinckrodt Llc	Proceso en un solo recipiente para producir 6-hidroxilo nal-opiáceos
MX370344B (es) *	2013-11-01	2019-12-10	SpecGx LLC	Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas.
PL3065743T3 (pl) *	2013-11-07	2019-12-31	SpecGx LLC	Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich
US9701687B2 (en) *	2014-05-05	2017-07-11	Noramco, Inc.	Process for the preparation of opioid compounds
US9701688B2 (en) *	2014-05-05	2017-07-11	Noramco, Inc.	Process for the preparation of opioid compounds
GB201719667D0 (en) *	2017-11-27	2018-01-10	Johnson Matthey Plc	Process
US11505556B2 (en)	2017-12-12	2022-11-22	Xalud Therapeutics, Inc.	Halogenated derivatives of morphinans and uses thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US182692A (en) *		1876-09-26		Improvement in washing-machines
US2772270A (en) *	1954-10-21	1956-11-27	M J Lewenstein	14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
US2722270A (en) *	1954-12-13	1955-11-01	Bongiorno Leonard	Spark responsive safety starting control for oil burners
US4089855A (en) *	1976-04-23	1978-05-16	Cornell Research Foundation, Inc.	Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby
EP0034480A3 (de)	1980-02-14	1982-01-13	Grigg, Ronald Ernest	Alkylierung von Aminen
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4443605A (en) *	1982-07-30	1984-04-17	Miles Laboratories, Inc.	7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
US4775759A (en) *	1984-11-27	1988-10-04	The United States Of America As Represented By The Department Of Health And Human Services	Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT)
US4673679A (en) *	1986-05-14	1987-06-16	E. I. Du Pont De Nemours And Company	Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US5668285A (en) *	1986-10-31	1997-09-16	The United States Of America As Represented By The Department Of Health And Human Services	Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US4912114A (en) *	1988-03-18	1990-03-27	Sandoz Ltd.	Morphinan derivatives
US5208338A (en) *	1991-06-14	1993-05-04	The United States Of America As Represented By The Department Of Health & Human Services.	Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
DE4132159A1 (de) *	1991-09-27	1993-04-01	Boehringer Ingelheim Kg	14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5808091A (en) *	1991-10-29	1998-09-15	Bracco International B.V.	Rhenium and technetium complexes containing a hypoxia localizing moiety
DE69507697T2 (de) *	1994-05-31	1999-06-10	Mallinckrodt Chemical, Inc., Chesterfield, Mo.	Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält
WO1997020789A1 (fr) *	1995-12-06	1997-06-12	Japan Science And Technology Corporation	Procede de preparation de composes optiquement actifs
DE19548399A1 (de)	1995-12-22	1997-06-26	Basf Ag	Rutheniumkomplexe mit einem chiralen, zweizähnigen Phosphinoxazolin-Liganden zur enantioselektiven Transferhydrierung von prochiralen Ketonen
GB9616253D0 (en) *	1996-08-01	1996-09-11	Johnson Matthey Plc	Preparation of narcotic analgesics
PT102006B (pt)	1997-05-19	2000-06-30	Hovione Sociedade Quimica S A	Novo processo de preparacao de azitromicina
GB9821067D0 (en) *	1998-09-29	1998-11-18	Zeneca Ltd	Transfer hydrogenation process
MXPA05010316A (es) *	2003-03-26	2005-11-17	Pharmacia & Upjohn Co Llc	Procedimiento para producir alcoholes y aminas enriquecidos enantiomericamente.
US20060182692A1 (en) *	2003-12-16	2006-08-17	Fishburn C S	Chemically modified small molecules
SK286047B6 (sk) *	2004-04-13	2008-01-07	Zentiva, A. S.	Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
WO2006008562A1 (en)	2004-07-23	2006-01-26	Pliva-Istrazivanje I Razvoj D.O.O.	Process
GB0421687D0 (en)	2004-09-30	2004-11-03	Johnson Matthey Plc	Preparation of opiate analgesics
WO2006052710A1 (en)	2004-11-05	2006-05-18	Rensselaer Polytechnic Institute	4-hydroxybenzomorphans

2008
- 2008-05-02 CA CA002637610A patent/CA2637610A1/en not_active Abandoned
- 2008-05-02 MX MX2008013842A patent/MX2008013842A/es not_active Application Discontinuation
- 2008-05-02 EP EP08747498A patent/EP2152715B1/de active Active
- 2008-05-02 EP EP10000185.8A patent/EP2189460B1/de active Active
- 2008-05-02 AT AT08747498T patent/ATE493416T1/de not_active IP Right Cessation
- 2008-05-02 ES ES10000184T patent/ES2407033T3/es active Active
- 2008-05-02 WO PCT/US2008/062413 patent/WO2008137672A1/en active Application Filing
- 2008-05-02 DE DE602008004245T patent/DE602008004245D1/de active Active
- 2008-05-02 EP EP10000184A patent/EP2180000B1/de active Active
- 2008-05-02 JP JP2009513489A patent/JP2009534472A/ja not_active Withdrawn
- 2008-05-02 ES ES10000185.8T patent/ES2468415T3/es active Active
- 2008-05-02 AU AU2008207580A patent/AU2008207580B2/en active Active
- 2008-05-02 US US12/444,421 patent/US7985858B2/en active Active
2009
- 2009-12-03 US US12/630,192 patent/US8524904B2/en active Active
- 2009-12-03 US US12/630,171 patent/US8273888B2/en active Active
2010
- 2010-01-18 AU AU2010200188A patent/AU2010200188B2/en active Active
- 2010-01-18 AU AU2010200191A patent/AU2010200191B2/en active Active

Also Published As

Publication number	Publication date
AU2010200191B2 (en)	2012-02-09
WO2008137672A1 (en)	2008-11-13
CA2637610A1 (en)	2008-11-04
EP2189460A1 (de)	2010-05-26
US20100081818A1 (en)	2010-04-01
US8524904B2 (en)	2013-09-03
US7985858B2 (en)	2011-07-26
US8273888B2 (en)	2012-09-25
ES2468415T3 (es)	2014-06-16
AU2010200188A1 (en)	2010-02-04
AU2010200188B2 (en)	2012-02-02
US20100041888A1 (en)	2010-02-18
JP2009534472A (ja)	2009-09-24
AU2008207580B2 (en)	2011-04-14
EP2180000A1 (de)	2010-04-28
US20100113788A1 (en)	2010-05-06
EP2180000B1 (de)	2013-03-27
EP2189460B1 (de)	2014-04-23
ES2407033T3 (es)	2013-06-11
EP2152715B1 (de)	2010-12-29
AU2010200191A1 (en)	2010-02-04
AU2008207580A1 (en)	2009-11-19
EP2152715A1 (de)	2010-02-17
ATE493416T1 (de)	2011-01-15
MX2008013842A (es)	2009-03-06

Publication	Publication Date	Title
DE602008004245D1 (de)	2011-02-10	Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten
DE502006009032D1 (de)	2011-04-14	Verfahren zur herstellung von glycerincarbonat
EP2271586A4 (de)	2012-02-22	Verfahren zur herstellung von kohlenstoffnanostrukturen
EP2423291A4 (de)	2012-09-26	1-menthyl-(3r-)3-hydroxybutanoat, verfahren zu seiner herstellung und zusammensetzung damit zur stimulation der sinne
DE602007004008D1 (de)	2010-02-11	Verfahren zur Erzeugung von Wasserstoffgas aus Borohydrid
EP2277045A4 (de)	2012-09-19	Verfahren zur herstellung von nanodrahtanordnungen
EP2032709A4 (de)	2012-02-08	System zur herstellung von methan aus co2
EP2181962A4 (de)	2010-11-24	Verfahren und vorrichtung zur erzeugung von wasserstoff und rückgewinnung von kohlendioxid
EP2264232A4 (de)	2011-09-14	Kohlefaser-vorläufer, kohlefaser und verfahren zu ihrer herstellung
EP2107943A4 (de)	2011-08-31	Katalysatorsysteme für die tetramerisierung von ethylen und verfahren zur herstellung von 1-octen damit
DE602006011469D1 (de)	2010-02-11	Verfahren zur herstellung und verwendung eines selektiven hydrierungkatalysators
EP2170785A4 (de)	2015-04-15	Verfahren zur herstellung von hydrofluorolefinen
ATE523479T1 (de)	2011-09-15	Verfahren zur herstellung von cyclohexylbenzen
EP2322674A4 (de)	2016-11-30	Verfahren zur herstellung von orientiertem cu-haltigen si-stahl
CO6450635A2 (es)	2012-05-31	Método de depurar sulfuro de hidrógeno de una corriente de hidrocarburos
DE602006003393D1 (de)	2008-12-11	Verfahren zur Herstellung von Synthesegas durch Dampfreformieren und partielle Oxidation
DE602006018429D1 (de)	2011-01-05	Verfahren zur herstellung von verschlüssen
EP2265438A4 (de)	2015-09-02	Vorrichtung zur herstellung von wellpappe
ATE480531T1 (de)	2010-09-15	Verfahren zur herstellung von benzopyran-2- olderivaten
PL2384239T3 (pl)	2013-04-30	Sposób regeneracji zawierającego tlenek rutenu katalizatora utleniania chlorowodoru
ATE528260T1 (de)	2011-10-15	Verbessertes verfahren zur herstellung von blausäure durch katalytische dehydratisierung von gasförmigem formamid - direktheizung
EP2412679A4 (de)	2012-08-29	Verfahren zur herstellung von regeneriertem wasser und system zur herstellung von regeneriertem wasser
EP2128153A4 (de)	2010-12-01	Verfahren zur herstellung von oxidiertem zyklischem phenolsulfid
ATE514666T1 (de)	2011-07-15	Verfahren zur herstellung von ethen
EP2172420A4 (de)	2012-10-24	System zur erzeugung von wasserstoff, brennstoffzellensystem und verfahren zum betreiben des systems zur erzeugung von wasserstoff