DE60203995D1 - Triazoloverbindungen als mmp-inhibitoren - Google Patents

Triazoloverbindungen als mmp-inhibitoren

Info

Publication number: DE60203995D1
Authority: DE; Germany
Prior art keywords: bindings; triazole; mmp inhibitors; mmp; inhibitors
Prior art date: 2001-02-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60203995T

Other languages

English (en)

Other versions

DE60203995T2 (de

Inventor

Charles Andrianjara

Henry Jacobelli

Bernard Gaudilliere

Francine Breuzard

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-14

Filing date

2002-02-11

Publication date

2005-06-09

2002-02-11 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2005-06-09 Publication of DE60203995D1 publication Critical patent/DE60203995D1/de

2005-09-22 Application granted granted Critical

2005-09-22 Publication of DE60203995T2 publication Critical patent/DE60203995T2/de

2022-02-12 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE60203995T 2001-02-14 2002-02-11 Triazoloverbindungen als mmp-inhibitoren Expired - Fee Related DE60203995T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US26875701P	2001-02-14	2001-02-14
PCT/EP2002/001961 WO2002064595A1 (en)	2001-02-14	2002-02-11	Triazolo compounds as mmp inhibitors
US268757P		2009-06-16

Publications (2)

Publication Number	Publication Date
DE60203995D1 true DE60203995D1 (de)	2005-06-09
DE60203995T2 DE60203995T2 (de)	2005-09-22

Family

ID=23024335

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60203995T Expired - Fee Related DE60203995T2 (de)	2001-02-14	2002-02-11	Triazoloverbindungen als mmp-inhibitoren

Country Status (15)

Country	Link
US (1)	US6849637B2 (de)
EP (1)	EP1362048B1 (de)
JP (1)	JP2004521908A (de)
AR (1)	AR032677A1 (de)
AT (1)	ATE294805T1 (de)
BR (1)	BR0207270A (de)
CA (1)	CA2437588A1 (de)
DE (1)	DE60203995T2 (de)
ES (1)	ES2239216T3 (de)
HN (1)	HN2002000038A (de)
MX (1)	MXPA03007249A (de)
PA (1)	PA8539501A1 (de)
PE (1)	PE20020885A1 (de)
SV (1)	SV2002000875A (de)
WO (1)	WO2002064595A1 (de)

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MXPA03004926A (es) *	2001-02-14	2005-02-14	Warner Lambert Co	Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
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WO2004006914A1 (en) *	2002-07-17	2004-01-22	Warner-Lambert Company Llc	Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
EP1530467A2 (de) *	2002-07-17	2005-05-18	Warner-Lambert Company LLC	Pharmazeutische zusammensetzungen enthaltend allosterische karbonsäure-inhibitor von matrix-metalloproteinase-13 und celecoxib oder valdecoxib
AU2003247024A1 (en) *	2002-07-17	2004-02-02	Warner-Lambert Company Llc	Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
JP2006502113A (ja) *	2002-07-17	2006-01-19	ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー	マトリックス・メタロプロテイナーゼ−１３アロステリック阻害剤と、セレコキシブ又はバルデコキシブでないシクロオキシゲナーゼ−２選択的阻害剤との複合体
WO2004014365A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Phthalimide derivatives as matrix metalloproteinase inhibitors
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AU2003250466A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
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PA8578101A1 (es) *	2002-08-13	2004-05-07	Warner Lambert Co	Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
WO2004014908A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Heterobicylcic metalloproteinase inhibitors
CA2497656A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
WO2004014880A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Chromone derivatives as matrix metalloproteinase inhibitors
AU2003250470A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidinone fused bicyclic metalloproteinase inhibitors
AU2003249540A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Fused bicyclic metalloproteinase inhibitors
WO2004014867A2 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Matrix metalloproteinase inhibitors and methods for identification of lead compounds
WO2004014354A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	1,6-fused uracil derivatives as matrix metalloproteinase inhibitors
AU2003249531A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
EP1530472A1 (de) *	2002-08-13	2005-05-18	Warner-Lambert Company LLC	Isochinolin-derivate als matrix-metalloproteinase-hemmer
US20040142950A1 (en) *	2003-01-17	2004-07-22	Bunker Amy Mae	Amide and ester matrix metalloproteinase inhibitors
CA2572324A1 (en) *	2003-07-02	2005-01-13	Warner-Lambert Company Llc	Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
WO2005016926A1 (en) *	2003-08-19	2005-02-24	Warner-Lambert Company Llc	Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
US20060247231A1 (en) *	2003-12-18	2006-11-02	Warner-Lambert Company Llc	Amide and ester matrix metalloproteinase inhibitors
US20070155738A1 (en)	2005-05-20	2007-07-05	Alantos Pharmaceuticals, Inc.	Heterobicyclic metalloprotease inhibitors
CN101238127A (zh) *	2005-05-20	2008-08-06	艾伦托斯制药控股公司	嘧啶或三嗪稠合的二环金属蛋白酶抑制剂
US7795877B2 (en) *	2006-11-02	2010-09-14	Current Technologies, Llc	Power line communication and power distribution parameter measurement system and method
US20080176870A1 (en) *	2006-11-20	2008-07-24	Bert Nolte	Heterobicyclic metalloprotease inhibitors
US8193182B2 (en)	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX2010007419A (es)	2008-01-04	2010-11-12	Intellikine Inc	Ciertas entidades quimicas, composiciones y metodos.
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AR084824A1 (es)	2011-01-10	2013-06-26	Intellikine Inc	Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
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US6747147B2 (en) *	2002-03-08	2004-06-08	Warner-Lambert Company	Oxo-azabicyclic compounds
AU2002249275A1 (en)	2002-03-08	2003-09-22	Warner-Lambert Company Llc	Oxo azabicyclic compounds
US6894057B2 (en) *	2002-03-08	2005-05-17	Warner-Lambert Company	Oxo-azabicyclic compounds
US20040006077A1 (en) *	2002-06-25	2004-01-08	Bernard Gaudilliere	Thiazine and oxazine derivatives as MMP-13 inhibitors
WO2004000321A1 (en)	2002-06-25	2003-12-31	Warner-Lambert Company Llc	Thiazine and oxazine derivatives as mmp-13 inhibitors for treating arthritis
WO2004014384A2 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors

2002
- 2002-02-08 PA PA20028539501A patent/PA8539501A1/es unknown
- 2002-02-11 WO PCT/EP2002/001961 patent/WO2002064595A1/en active IP Right Grant
- 2002-02-11 ES ES02702366T patent/ES2239216T3/es not_active Expired - Lifetime
- 2002-02-11 JP JP2002564526A patent/JP2004521908A/ja not_active Abandoned
- 2002-02-11 AT AT02702366T patent/ATE294805T1/de not_active IP Right Cessation
- 2002-02-11 DE DE60203995T patent/DE60203995T2/de not_active Expired - Fee Related
- 2002-02-11 MX MXPA03007249A patent/MXPA03007249A/es unknown
- 2002-02-11 EP EP02702366A patent/EP1362048B1/de not_active Expired - Lifetime
- 2002-02-11 CA CA002437588A patent/CA2437588A1/en not_active Abandoned
- 2002-02-11 BR BR0207270-0A patent/BR0207270A/pt not_active IP Right Cessation
- 2002-02-13 AR ARP020100471A patent/AR032677A1/es not_active Application Discontinuation
- 2002-02-13 SV SV2002000875A patent/SV2002000875A/es not_active Application Discontinuation
- 2002-02-13 PE PE2002000115A patent/PE20020885A1/es not_active Application Discontinuation
- 2002-02-13 HN HN2002000038A patent/HN2002000038A/es unknown
- 2002-02-14 US US10/075,654 patent/US6849637B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2239216T3 (es)	2005-09-16
MXPA03007249A (es)	2005-02-14
PA8539501A1 (es)	2002-09-30
DE60203995T2 (de)	2005-09-22
WO2002064595A1 (en)	2002-08-22
JP2004521908A (ja)	2004-07-22
US20020151558A1 (en)	2002-10-17
PE20020885A1 (es)	2002-10-26
AR032677A1 (es)	2003-11-19
BR0207270A (pt)	2004-02-10
EP1362048A1 (de)	2003-11-19
EP1362048B1 (de)	2005-05-04
SV2002000875A (es)	2002-10-04
HN2002000038A (es)	2002-09-05
ATE294805T1 (de)	2005-05-15
CA2437588A1 (en)	2002-08-22
US6849637B2 (en)	2005-02-01

Publication	Publication Date	Title
DE60203995D1 (de)	2005-06-09	Triazoloverbindungen als mmp-inhibitoren
ATE493406T1 (de)	2011-01-15	Hydantoinderivate als mmp-inhibitoren
CY2015028I1 (el)	2016-07-27	Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης
ATE363284T1 (de)	2007-06-15	Triazol-verbindungen als protein-kinase- inhibitoren
PT1370553E (pt)	2006-09-29	Inibidores de rhoquinase
ATE452891T1 (de)	2010-01-15	Pyrimidopyrimidone als kinaseinhibitoren
ATE397925T1 (de)	2008-07-15	Cis-imidazoline als mdm2-hemmer
ATE286049T1 (de)	2005-01-15	Pyridazinonaldose reductase inhibitoren
NO20041293L (no)	2004-05-27	Alkyn-aryl-fosfodiesterase-4-inhibitorer
DK1358165T3 (da)	2009-05-11	Imidazolderivater
DE60218138D1 (de)	2007-03-29	Rho-kinase inhibitoren
DE60119776D1 (de)	2006-06-22	Pyrazolverbindungen als protein-kinase-inhibitoren
NO20034032D0 (no)	2003-09-11	Metallproteinase-inhibitorer
ATE411306T1 (de)	2008-10-15	Biarylsulfonamide als mmp-inhibitoren
DE60140368D1 (de)	2009-12-17	Substitutuierte imidazole als tafia inhibitoren
DE60203529D1 (de)	2005-05-04	Indolderivate als cox-ii-inhibitoren
DK1272488T3 (da)	2006-07-17	Tri-aryl-substitueret ethan-PDE4-inhibitorer
NO20034921D0 (no)	2003-11-04	Skibinding
DE60009260D1 (de)	2004-04-29	Thiopyranderivate as mmp-inhibitoren
DE60229669D1 (de)	2008-12-11	X-2 inhibitoren
DE60104977D1 (de)	2004-09-23	Glucosamine enthaltende Neutrophilfunktionshemmer
DE60226715D1 (de)	2008-07-03	Monoamin-aufnahme-inhibitor
DE50213467D1 (de)	2009-05-28	Skibindung
ITTV20010070A0 (it)	2001-05-31	Struttura di pattino
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