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DE60216310D1 - Substituierte 4-phenyl-4-(1h-imidazol-2-yl)-piperidinderivate zur verringerung von ischämischer schädigung - Google Patents

Substituierte 4-phenyl-4-(1h-imidazol-2-yl)-piperidinderivate zur verringerung von ischämischer schädigung

Info

Publication number
DE60216310D1
DE60216310D1 DE60216310T DE60216310T DE60216310D1 DE 60216310 D1 DE60216310 D1 DE 60216310D1 DE 60216310 T DE60216310 T DE 60216310T DE 60216310 T DE60216310 T DE 60216310T DE 60216310 D1 DE60216310 D1 DE 60216310D1
Authority
DE
Germany
Prior art keywords
imidazole
phenyl
substituted
ischemic injury
piperidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216310T
Other languages
English (en)
Other versions
DE60216310T2 (de
Inventor
Eduard Janssens
Elisabeth Leenaerts
Willem Flameng
Francisco Javi Fernandez-Gadea
Antonio Gomez-Sanchez
Frans Meert
J Borgers
Paul Joannes Ludovic Herijgers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE60216310D1 publication Critical patent/DE60216310D1/de
Application granted granted Critical
Publication of DE60216310T2 publication Critical patent/DE60216310T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60216310T 2001-10-15 2002-10-10 Substituierte 4-phenyl-4-(1h-imidazol-2-yl)-piperidinderivate zur verringerung von ischämischer schädigung Expired - Lifetime DE60216310T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203927 2001-10-15
EP01203927 2001-10-15
PCT/EP2002/011371 WO2003039440A2 (en) 2001-10-15 2002-10-10 Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage

Publications (2)

Publication Number Publication Date
DE60216310D1 true DE60216310D1 (de) 2007-01-04
DE60216310T2 DE60216310T2 (de) 2007-06-21

Family

ID=8181081

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216310T Expired - Lifetime DE60216310T2 (de) 2001-10-15 2002-10-10 Substituierte 4-phenyl-4-(1h-imidazol-2-yl)-piperidinderivate zur verringerung von ischämischer schädigung

Country Status (26)

Country Link
US (1) US7390822B2 (de)
EP (1) EP1438049B1 (de)
JP (1) JP4418676B2 (de)
KR (1) KR100967599B1 (de)
CN (1) CN1283252C (de)
AR (1) AR036800A1 (de)
AT (1) ATE345799T1 (de)
AU (1) AU2002363369B2 (de)
BR (1) BR0213325A (de)
CA (1) CA2462374C (de)
CY (1) CY1106335T1 (de)
DE (1) DE60216310T2 (de)
EA (1) EA007657B1 (de)
ES (1) ES2276980T3 (de)
HR (1) HRP20040325A2 (de)
HU (1) HUP0402332A3 (de)
IL (1) IL161347A0 (de)
MX (1) MXPA04003480A (de)
MY (1) MY139586A (de)
NO (1) NO20041681L (de)
NZ (1) NZ531733A (de)
PL (1) PL370371A1 (de)
PT (1) PT1438049E (de)
UA (1) UA75980C2 (de)
WO (1) WO2003039440A2 (de)
ZA (1) ZA200402816B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
CL2004000754A1 (es) * 2003-04-11 2005-02-25 Janssen Pharmaceutica Nv Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central.
WO2005005478A2 (en) * 2003-07-02 2005-01-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled opioid receptor; delta 1 (oprd1)
WO2005015242A1 (en) * 2003-08-06 2005-02-17 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled opioid receptor kappa 1 (opkr1)
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
KR20100114018A (ko) 2007-11-30 2010-10-22 바이엘 쉐링 파마 악티엔게젤샤프트 헤테로아릴-치환된 피페리딘
DE102009014484A1 (de) 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009056387B9 (de) * 2009-10-30 2020-05-07 Osram Opto Semiconductors Gmbh Kantenemittierender Halbleiterlaser mit einem Phasenstrukturbereich zur Selektion lateraler Lasermoden
EP3697410B1 (de) 2017-10-19 2024-12-18 Teijin Pharma Limited Benzimidazolderivate und ihre verwendungen
CN113209294B (zh) * 2020-02-05 2023-06-13 复旦大学 Dor激动剂在制备对抗肾脏纤维化药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2213000A1 (en) 1995-03-06 1996-09-12 Interneuron Pharmaceuticals, Inc. Reduction of infarct volume using citicoline
ATE306546T1 (de) 1996-08-23 2005-10-15 Ludwig Inst Cancer Res Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d)
IL132537A0 (en) 1997-04-25 2001-03-19 Collateral Therapeutics Truncated vegf-related proteins
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
GB2332373A (en) * 1997-12-19 1999-06-23 Merck & Co Inc Treatment of coronary and/or peripheral ischemia using an antithrombotic agent and an angiogenesis promoter
DE69925036T2 (de) * 1998-12-19 2006-01-26 Janssen Pharmaceutica N.V. Spiro verbindungen mit antihistaminischer aktivität
EP1038872A1 (de) * 1999-02-22 2000-09-27 Pfizer Products Inc. 4-Phenyl-4-heteroarylpiperdine Derivate als Opioid-Rezeptorligande
US6297256B1 (en) * 1999-06-15 2001-10-02 Neurogen Corporation Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
ATE347549T1 (de) * 2001-10-15 2006-12-15 Janssen Pharmaceutica Nv Neue substituierte 4-phenyl-4-(1h-imidazo-2-yl)- piperidin-derivate und ihre anwendung als selective delta-opioid-agonisten
FR2831166B1 (fr) 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
CA2462374C (en) 2011-01-18
KR100967599B1 (ko) 2010-07-05
EA007657B1 (ru) 2006-12-29
US7390822B2 (en) 2008-06-24
WO2003039440A2 (en) 2003-05-15
US20050004170A1 (en) 2005-01-06
NO20041681L (no) 2004-04-23
CA2462374A1 (en) 2003-05-15
CN1568186A (zh) 2005-01-19
JP2005507943A (ja) 2005-03-24
NZ531733A (en) 2006-04-28
MXPA04003480A (es) 2004-07-30
AR036800A1 (es) 2004-10-06
UA75980C2 (en) 2006-06-15
EA200400547A1 (ru) 2004-10-28
EP1438049B1 (de) 2006-11-22
HRP20040325A2 (en) 2005-04-30
HUP0402332A3 (en) 2009-07-28
KR20050035120A (ko) 2005-04-15
PL370371A1 (en) 2005-05-16
PT1438049E (pt) 2007-02-28
IL161347A0 (en) 2004-09-27
CN1283252C (zh) 2006-11-08
ATE345799T1 (de) 2006-12-15
DE60216310T2 (de) 2007-06-21
ES2276980T3 (es) 2007-07-01
BR0213325A (pt) 2004-10-13
AU2002363369B2 (en) 2008-08-21
HK1072562A1 (en) 2005-09-02
EP1438049A2 (de) 2004-07-21
WO2003039440A3 (en) 2003-12-18
CY1106335T1 (el) 2011-10-12
ZA200402816B (en) 2005-06-29
MY139586A (en) 2009-10-30
JP4418676B2 (ja) 2010-02-17
HUP0402332A2 (hu) 2005-02-28

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