DE60222790D1 - Dendrimere zur verwendung in gezielter verabreichung - Google Patents
Dendrimere zur verwendung in gezielter verabreichungInfo
- Publication number
- DE60222790D1 DE60222790D1 DE60222790T DE60222790T DE60222790D1 DE 60222790 D1 DE60222790 D1 DE 60222790D1 DE 60222790 T DE60222790 T DE 60222790T DE 60222790 T DE60222790 T DE 60222790T DE 60222790 D1 DE60222790 D1 DE 60222790D1
- Authority
- DE
- Germany
- Prior art keywords
- dendrimers
- targeted administration
- bioactive molecules
- molecules
- spleen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000412 dendrimer Substances 0.000 title abstract 3
- 230000000975 bioactive effect Effects 0.000 abstract 2
- 229920000736 dendritic polymer Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 210000002216 heart Anatomy 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
- A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
- C08L101/005—Dendritic macromolecules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0125216 | 2001-10-19 | ||
| GBGB0125216.2A GB0125216D0 (en) | 2001-10-19 | 2001-10-19 | Dendrimers for use in targeted delivery |
| PCT/GB2002/004706 WO2003033027A2 (en) | 2001-10-19 | 2002-10-17 | Dendrimers for use in targeted delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60222790D1 true DE60222790D1 (de) | 2007-11-15 |
| DE60222790T2 DE60222790T2 (de) | 2008-07-17 |
Family
ID=9924221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60222790T Expired - Lifetime DE60222790T2 (de) | 2001-10-19 | 2002-10-17 | Dendrimere zur verwendung in gezielter verabreichung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050019923A1 (de) |
| EP (1) | EP1436011B1 (de) |
| JP (1) | JP2005511533A (de) |
| AT (1) | ATE374625T1 (de) |
| CA (1) | CA2463974C (de) |
| DE (1) | DE60222790T2 (de) |
| GB (1) | GB0125216D0 (de) |
| WO (1) | WO2003033027A2 (de) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2547220T3 (es) * | 2004-04-20 | 2015-10-02 | Dendritic Nanotechnologies, Inc. | Polímeros dendríticos con amplificación y funcionalidad interior mejoradas |
| US7985424B2 (en) | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| MX2007010402A (es) * | 2005-04-20 | 2008-01-22 | Dendritic Nanotechnologies Inc | Polimeros dendriticos con amplificacion mejorada y funcionalidad interior. |
| JP2009501245A (ja) * | 2005-07-08 | 2009-01-15 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 修飾ポリ−（プロピレンイミン）デンドリマーおよびアニオン性生物活性因子のトランスフェクション剤としてのそれらの使用 |
| ES2265291B1 (es) * | 2005-07-22 | 2008-03-01 | Universidad De Alcala | Nuevos dendrimeros carbosilanos, su preparacion y sus usos. |
| EP1924256A1 (de) | 2005-09-14 | 2008-05-28 | Wisconsin Alumni Research Foundation | Zusammensetzung mit einem dendrimer und deren verwendung zur phosphatbindung |
| US8114393B2 (en) * | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| JP5264492B2 (ja) * | 2005-10-25 | 2013-08-14 | エボニック デグサ ゲーエムベーハー | 超分岐ポリマーを含有する調製物 |
| US9603941B2 (en) * | 2006-01-24 | 2017-03-28 | Minghui Chai | Method of preparing dendritic drugs |
| EP2049014A2 (de) * | 2006-07-18 | 2009-04-22 | Genzyme Corporation | Amindendrimere |
| US20090263346A1 (en) * | 2006-12-05 | 2009-10-22 | David Taft | Systems and methods for delivery of drugs |
| US8399007B2 (en) * | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
| US20100004124A1 (en) * | 2006-12-05 | 2010-01-07 | David Taft | Systems and methods for delivery of materials for agriculture and aquaculture |
| US20100210792A1 (en) | 2006-12-05 | 2010-08-19 | David Taft | Drug delivery |
| EP1982698A1 (de) * | 2007-04-18 | 2008-10-22 | Evonik Degussa GmbH | Präparate zur gesteuerten Freisetzung von bioaktiven Naturstoffen |
| WO2008137470A1 (en) * | 2007-05-01 | 2008-11-13 | Pgr-Solutions | Multi-chain lipophilic polyamines |
| US8114883B2 (en) * | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
| DE102008000290A1 (de) | 2008-02-13 | 2009-08-20 | Evonik Degussa Gmbh | Lagerstabile Produktsyteme für Prämixformulierungen |
| DE102008042923A1 (de) | 2008-10-17 | 2010-04-22 | Evonik Goldschmidt Gmbh | Präparate zur gesteuerten Freisetzung von Wirkstoffen |
| GB0903559D0 (en) | 2009-03-02 | 2009-04-08 | Univ London Pharmacy | Oral delivery of hydrophilic drugs to the brain |
| DE102009028255A1 (de) | 2009-08-05 | 2011-02-10 | Evonik Degussa Gmbh | Mikrostrukturierte multifunktionale anorganische Coating-Additive zur Vermeidung von Fouling (Biofilmbewuchs) bei aquatischen Anwendungen |
| WO2011017500A1 (en) * | 2009-08-06 | 2011-02-10 | The Trustees Of The University Of Pennsylvania | Amphiphilic janus-dendrimers |
| DE102009036767A1 (de) | 2009-08-08 | 2011-02-10 | Evonik Degussa Gmbh | Kompositpartikel für den Einsatz in der Mundhygiene |
| GB0918822D0 (en) | 2009-10-27 | 2009-12-09 | Univ Strathclyde | Targeted dendrimers |
| US8226985B2 (en) | 2010-01-28 | 2012-07-24 | International Business Machines Corporation | Surface modified nanoparticles, methods of their preparation, and uses thereof for gene and drug delivery |
| WO2012090223A1 (en) * | 2010-12-29 | 2012-07-05 | Indian Institute Of Science | Poly(ether imine) dendrimers and uses thereof |
| WO2014078399A1 (en) * | 2012-11-13 | 2014-05-22 | Baylor College Of Medicine | Multi-arm biodegradable polymers for nucleic acid delivery |
| SG10201912328UA (en) | 2012-12-12 | 2020-02-27 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
| CA2915845A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| CN105793425B (zh) | 2013-06-17 | 2021-10-26 | 布罗德研究所有限公司 | 使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用 |
| JP6738728B2 (ja) | 2013-06-17 | 2020-08-19 | ザ・ブロード・インスティテュート・インコーポレイテッド | 肝臓ターゲティングおよび治療のためのＣＲＩＳＰＲ−Ｃａｓ系、ベクターおよび組成物の送達および使用 |
| EP3470089A1 (de) | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Freisetzung, verwendung und therapeutische anwendungen der crispr-cas-systeme und zusammensetzungen für störungen und erkrankungen mittels partikelfreisetzungskomponenten |
| JP6712948B2 (ja) | 2013-12-12 | 2020-06-24 | ザ・ブロード・インスティテュート・インコーポレイテッド | 組成物、及びヌクレオチドリピート障害におけるｃｒｉｓｐｒ−ｃａｓ系の使用方法 |
| EP3080271B1 (de) | 2013-12-12 | 2020-02-12 | The Broad Institute, Inc. | Systeme, verfahren und zusammensetzungen zur sequenzmanipulation mit optimierten funktionellen crispr-cas-systemen |
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| RU2127125C1 (ru) * | 1994-03-07 | 1999-03-10 | Дзе Дау Кемикал Компани | Биологически активные и/или целевые дендримерные конъюгаты |
| US6221959B1 (en) * | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| DE10016881B4 (de) * | 2000-04-05 | 2006-06-01 | Qiagen Gmbh | Gezielte Transfektion von Zellen mittels biotinyliertem Dendrimer |
| WO2003001218A2 (en) * | 2001-06-25 | 2003-01-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Macromolecular imaging agents for liver imaging |
-
2001
- 2001-10-19 GB GBGB0125216.2A patent/GB0125216D0/en not_active Ceased
-
2002
- 2002-10-17 US US10/493,125 patent/US20050019923A1/en not_active Abandoned
- 2002-10-17 JP JP2003535829A patent/JP2005511533A/ja not_active Withdrawn
- 2002-10-17 DE DE60222790T patent/DE60222790T2/de not_active Expired - Lifetime
- 2002-10-17 AT AT02772526T patent/ATE374625T1/de not_active IP Right Cessation
- 2002-10-17 WO PCT/GB2002/004706 patent/WO2003033027A2/en active IP Right Grant
- 2002-10-17 CA CA2463974A patent/CA2463974C/en not_active Expired - Fee Related
- 2002-10-17 EP EP02772526A patent/EP1436011B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003033027A2 (en) | 2003-04-24 |
| WO2003033027A3 (en) | 2003-09-12 |
| EP1436011A2 (de) | 2004-07-14 |
| GB0125216D0 (en) | 2001-12-12 |
| JP2005511533A (ja) | 2005-04-28 |
| CA2463974C (en) | 2012-01-03 |
| CA2463974A1 (en) | 2003-04-24 |
| US20050019923A1 (en) | 2005-01-27 |
| EP1436011B1 (de) | 2007-10-03 |
| ATE374625T1 (de) | 2007-10-15 |
| DE60222790T2 (de) | 2008-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SCHOOL OF PHARMACY, UNIVERSITY OF LONDON, LOND, GB |