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DE60230546D1 - Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe - Google Patents

Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe

Info

Publication number
DE60230546D1
DE60230546D1 DE60230546T DE60230546T DE60230546D1 DE 60230546 D1 DE60230546 D1 DE 60230546D1 DE 60230546 T DE60230546 T DE 60230546T DE 60230546 T DE60230546 T DE 60230546T DE 60230546 D1 DE60230546 D1 DE 60230546D1
Authority
DE
Germany
Prior art keywords
antimalarcinogenic
agents
quaternary ammonium
ammonium compounds
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60230546T
Other languages
English (en)
Inventor
Ivan Richards
Sue K Cammarata
Craig D Wegner
Michael Hawley
Mark P Warchol
Mark Kontny
Walter Morozowich
Karen P Kolbasa
Malcolm W Moon
Dominique Bonafoux
Sergey G Wolfson
Patrick J Lennon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60230546D1 publication Critical patent/DE60230546D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DE60230546T 2001-10-26 2002-10-25 Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe Expired - Lifetime DE60230546D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34893001P 2001-10-26 2001-10-26
US36197902P 2002-03-06 2002-03-06
US39152102P 2002-06-25 2002-06-25
PCT/US2002/034529 WO2003035599A1 (en) 2001-10-26 2002-10-25 Quarternary ammonium compounds and their use as antimuscarinic agents

Publications (1)

Publication Number Publication Date
DE60230546D1 true DE60230546D1 (de) 2009-02-05

Family

ID=27407868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60230546T Expired - Lifetime DE60230546D1 (de) 2001-10-26 2002-10-25 Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe

Country Status (16)

Country Link
US (2) US6890920B2 (de)
EP (1) EP1461306B1 (de)
JP (1) JP3981357B2 (de)
AT (1) ATE418534T1 (de)
BR (1) BR0206207A (de)
CA (1) CA2464223C (de)
CY (1) CY1109898T1 (de)
DE (1) DE60230546D1 (de)
DK (1) DK1461306T3 (de)
ES (1) ES2315425T3 (de)
MX (1) MXPA04003865A (de)
MY (1) MY130316A (de)
NO (1) NO20032938L (de)
PT (1) PT1461306E (de)
SG (1) SG168451A1 (de)
WO (1) WO2003035599A1 (de)

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EP0957073A1 (de) * 1998-05-12 1999-11-17 Schwarz Pharma Ag 3,3-Diphenylpropylaminderivate
WO2003035599A1 (en) * 2001-10-26 2003-05-01 Pharmacia & Upjohn Company Quarternary ammonium compounds and their use as antimuscarinic agents
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
DE60326709D1 (de) * 2002-04-29 2009-04-30 Supernus Pharmaceuticals Inc Pharmazeutische formulierungen mit verbesserter bioverfügbarkeit
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
EP1622606A1 (de) * 2003-04-15 2006-02-08 Pharmacia & Upjohn Company LLC Quaternäre ammonium verbindungen und ihre verwendung als antimuskarinische wirkstoffe
WO2004091597A2 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Method of treating irritable bowel syndrome (ibs)
JP2006523674A (ja) * 2003-04-18 2006-10-19 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 慢性閉塞性肺疾患（ｃｏｐｄ）のための組合せ治療法
EP1620389A1 (de) 2003-04-25 2006-02-01 Pharmacia & Upjohn Company LLC Halogen-substituierte 3,3-diphenylpropylamine (tolterodin) mit antimuscarinerger wirkung
US7410978B2 (en) * 2003-11-04 2008-08-12 Supernus Pharmaceuticals, Inc. Once daily dosage forms of trospium
EP1680100A4 (de) 2003-11-04 2012-08-08 Supernus Pharmaceuticals Inc Zusammensetzungen aus quartärem ammonium mit biologisch verfügbaren verstärkern
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
CA2551501C (en) * 2003-12-24 2012-05-29 Cipla Limited Tolterodine, compositions and uses thereof, and preparation of the same
JP2007530451A (ja) * 2004-03-11 2007-11-01 グラクソ　グループ　リミテッド 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
EP1838659B1 (de) * 2004-12-24 2015-07-15 LEK Pharmaceuticals d.d. Verfahren zur herstellung von n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamin
CA2653105A1 (en) * 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Novel medicament combinations for the treatment of respiratory diseases
EP1908502A1 (de) * 2006-10-02 2008-04-09 Koninklijke Philips Electronics N.V. Modulares Interaktivenfliesensystem
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
EP2114972A2 (de) * 2006-12-13 2009-11-11 Gilead Sciences, Inc. Monophosphate als gemeinsame prodrugs für muskarinrezeptorantagonisten und beta-agonisten für die behandlung von copd und chronischer bronchitis
CA2675942C (en) * 2007-02-23 2016-04-12 Theravance, Inc. Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
EP2146957B1 (de) 2007-04-24 2013-06-12 Theravance, Inc. Als antagonisten am muskarinrezeptor geeignete quaternäre ammoniumverbindungen
US20090246146A1 (en) * 2008-01-25 2009-10-01 Botond Banfi Halides in the treatment of pathogenic infection
EP2294077A1 (de) * 2008-06-10 2011-03-16 Gilead Sciences, Inc. Corticosteroid-verknüpfte beta-agonisten-verbindungen für therapeutische zwecke
WO2010010464A2 (en) * 2008-07-21 2010-01-28 Actavis Group Ptc Ehf Fesoterodine substantially free of dehydroxy impurity
JP5801997B2 (ja) 2009-07-07 2015-10-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物
CN110845357B (zh) * 2019-11-22 2022-09-30 华东理工大学 季铵盐型酰肼化合物及由其制备的季铵盐型腙类化合物与应用
EP4171525A1 (de) 2020-06-26 2023-05-03 Mylan Pharma UK Limited Formulierungen mit 5-[3-(3-hydroxyphenoxy)azetidin-1-yl!-5-methyl-2,2-diphenylhexanamid

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AU7971394A (en) 1993-10-08 1995-05-04 Sepracor, Inc. Method for treating urinary incontinence using optically pure s-terodiline
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KR20000057548A (ko) 1996-12-13 2000-09-25 알프레드 엘. 미첼슨 광학적 전송물질 및 결합재
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PE20020547A1 (es) * 2000-10-24 2002-06-12 Upjohn Co Uso de la tolterodina en tratamientos del asma
WO2002035245A1 (en) 2000-10-26 2002-05-02 Koninklijke Philips Electronics N.V. Electronic device
WO2003035599A1 (en) * 2001-10-26 2003-05-01 Pharmacia & Upjohn Company Quarternary ammonium compounds and their use as antimuscarinic agents
EP1622606A1 (de) * 2003-04-15 2006-02-08 Pharmacia & Upjohn Company LLC Quaternäre ammonium verbindungen und ihre verwendung als antimuskarinische wirkstoffe
EP1620389A1 (de) * 2003-04-25 2006-02-01 Pharmacia & Upjohn Company LLC Halogen-substituierte 3,3-diphenylpropylamine (tolterodin) mit antimuscarinerger wirkung

Also Published As

Publication number Publication date
PT1461306E (pt) 2009-04-01
WO2003035599A1 (en) 2003-05-01
NO20032938D0 (no) 2003-06-26
US6890920B2 (en) 2005-05-10
ATE418534T1 (de) 2009-01-15
EP1461306B1 (de) 2008-12-24
SG168451A1 (en) 2011-02-28
MY130316A (en) 2007-06-29
US20050148672A1 (en) 2005-07-07
CA2464223C (en) 2009-05-26
US20030158176A1 (en) 2003-08-21
ES2315425T3 (es) 2009-04-01
JP2005524605A (ja) 2005-08-18
NO20032938L (no) 2003-08-25
JP3981357B2 (ja) 2007-09-26
BR0206207A (pt) 2003-12-23
DK1461306T3 (da) 2009-03-09
US7439397B2 (en) 2008-10-21
CA2464223A1 (en) 2003-05-01
CY1109898T1 (el) 2014-09-10
MXPA04003865A (es) 2004-07-08
EP1461306A1 (de) 2004-09-29

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