[go: up one dir, main page]

DE69607183D1 - Benzothiazolone-derivate - Google Patents

Benzothiazolone-derivate

Info

Publication number
DE69607183D1
DE69607183D1 DE69607183T DE69607183T DE69607183D1 DE 69607183 D1 DE69607183 D1 DE 69607183D1 DE 69607183 T DE69607183 T DE 69607183T DE 69607183 T DE69607183 T DE 69607183T DE 69607183 D1 DE69607183 D1 DE 69607183D1
Authority
DE
Germany
Prior art keywords
benzothiazolone derivatives
benzothiazolone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69607183T
Other languages
English (en)
Other versions
DE69607183T2 (de
Inventor
Victor Bonnert
Charles Brown
Alan Cage
Francis Ince
Garry Pairaudeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Astra Pharmaceuticals Ltd
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9518952.8A external-priority patent/GB9518952D0/en
Priority claimed from GBGB9614346.6A external-priority patent/GB9614346D0/en
Application filed by Astra Pharmaceuticals Ltd, Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceuticals Ltd
Publication of DE69607183D1 publication Critical patent/DE69607183D1/de
Application granted granted Critical
Publication of DE69607183T2 publication Critical patent/DE69607183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/04Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69607183T 1995-09-15 1996-09-12 Benzothiazolone-derivate Expired - Fee Related DE69607183T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9518952.8A GB9518952D0 (en) 1995-09-15 1995-09-15 Compounds
GBGB9614346.6A GB9614346D0 (en) 1996-07-10 1996-07-10 Benzothiazolone derivatives
PCT/GB1996/002247 WO1997010227A1 (en) 1995-09-15 1996-09-12 Benzothiazolone derivatives

Publications (2)

Publication Number Publication Date
DE69607183D1 true DE69607183D1 (de) 2000-04-20
DE69607183T2 DE69607183T2 (de) 2000-11-23

Family

ID=26307771

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69607183T Expired - Fee Related DE69607183T2 (de) 1995-09-15 1996-09-12 Benzothiazolone-derivate

Country Status (28)

Country Link
US (5) US5846989A (de)
EP (1) EP0850232B1 (de)
JP (1) JP3213327B2 (de)
KR (1) KR19990044674A (de)
CN (2) CN1073098C (de)
AR (1) AR004512A1 (de)
AT (1) ATE190610T1 (de)
AU (1) AU706094B2 (de)
BR (1) BR9610316A (de)
CA (1) CA2231003A1 (de)
CY (1) CY2227B1 (de)
CZ (1) CZ74098A3 (de)
DE (1) DE69607183T2 (de)
EE (1) EE03395B1 (de)
ES (1) ES2146901T3 (de)
GR (1) GR3033681T3 (de)
HU (1) HUP9802393A3 (de)
IL (4) IL141954A0 (de)
IS (1) IS4679A (de)
MY (1) MY113518A (de)
NO (1) NO310721B1 (de)
NZ (4) NZ318007A (de)
PL (1) PL325517A1 (de)
PT (1) PT850232E (de)
SK (1) SK282394B6 (de)
TR (1) TR199800457T2 (de)
TW (1) TW356468B (de)
WO (1) WO1997010227A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1559424A3 (de) * 1997-10-17 2009-11-11 Ark Therapeutics Limited Verwendung von Hemmern des Renin-Angiotensin-Systems
SE0004750D0 (sv) * 2000-12-19 2000-12-19 Astrazeneca Ab Novel formulation
PE20050130A1 (es) * 2002-08-09 2005-03-29 Novartis Ag Compuestos organicos
GB0218629D0 (en) * 2002-08-09 2002-09-18 Novartis Ag Organic compounds
ES2329586T3 (es) * 2003-11-21 2009-11-27 Theravance, Inc. Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
TW200738658A (en) * 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
CN101282950B (zh) * 2005-08-09 2012-09-12 阿斯利康(瑞典)有限公司 新颖的苯并噻唑酮衍生物
RU2415136C2 (ru) * 2005-08-09 2011-03-27 Астразенека Аб Новые производные бензотиазолона
TW200740781A (en) * 2005-08-29 2007-11-01 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
AU2007336074B2 (en) * 2006-12-20 2011-09-22 Astrazeneca Ab Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
MX2010013477A (es) 2008-06-18 2010-12-21 Astrazeneca Ab Derivados de benzoxazinona que actuan como agonistas de receptores adrenergicos beta2 para el tratamiento de trastornos respiratorios.
CA2727908A1 (en) * 2008-06-20 2009-12-23 Astrazeneca Ab Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
GB8426200D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
US4554287A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones
EP0180994A3 (de) * 1984-11-08 1987-09-23 Syntex (U.S.A.) Inc. Antihypertensive Dialkylaminoethylanilinderivate
DE3728695A1 (de) * 1987-08-25 1989-03-09 Schering Ag Neue benzimidazol-derivate
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
GB9211172D0 (en) * 1992-05-27 1992-07-08 Fisons Plc Compounds
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds

Also Published As

Publication number Publication date
NO310721B1 (no) 2001-08-20
AU706094B2 (en) 1999-06-10
IL141956A0 (en) 2002-03-10
JP3213327B2 (ja) 2001-10-02
IL123639A0 (en) 1998-10-30
US5977384A (en) 1999-11-02
MY113518A (en) 2002-03-30
JPH11512422A (ja) 1999-10-26
NZ332395A (en) 1999-02-25
KR19990044674A (ko) 1999-06-25
US5846989A (en) 1998-12-08
CN1356323A (zh) 2002-07-03
IL141954A0 (en) 2002-03-10
CN1202163A (zh) 1998-12-16
SK282394B6 (sk) 2002-01-07
HUP9802393A3 (en) 2000-01-28
SK29598A3 (en) 1999-01-11
NZ332397A (en) 1999-02-25
AR004512A1 (es) 1998-12-16
ES2146901T3 (es) 2000-08-16
IL123639A (en) 2002-04-21
EE03395B1 (et) 2001-04-16
CA2231003A1 (en) 1997-03-20
TR199800457T2 (xx) 1998-07-21
BR9610316A (pt) 1999-07-06
IS4679A (is) 1998-03-04
ATE190610T1 (de) 2000-04-15
CN1073098C (zh) 2001-10-17
AU6937196A (en) 1997-04-01
EP0850232A1 (de) 1998-07-01
PL325517A1 (en) 1998-08-03
US6080869A (en) 2000-06-27
GR3033681T3 (en) 2000-10-31
IL141955A0 (en) 2002-03-10
NZ332396A (en) 1999-02-25
NZ318007A (en) 1999-07-29
EP0850232B1 (de) 2000-03-15
CZ74098A3 (cs) 1998-08-12
CY2227B1 (en) 2003-04-18
EE9800069A (et) 1998-10-15
PT850232E (pt) 2000-08-31
DE69607183T2 (de) 2000-11-23
US5973167A (en) 1999-10-26
TW356468B (en) 1999-04-21
US6008365A (en) 1999-12-28
NO981104D0 (no) 1998-03-12
HK1008781A1 (en) 1999-05-21
NO981104L (no) 1998-05-14
MX9801963A (es) 1998-08-30
HUP9802393A2 (hu) 1999-04-28
WO1997010227A1 (en) 1997-03-20

Similar Documents

Publication Publication Date Title
DE69522717D1 (de) Chinazolinderivate
DE69611361D1 (de) Chinazolin-derivate
NO974103D0 (no) Arylsulfonylaminohydroksamsyre-derivater
DE69610698D1 (de) Chinazolin-derivate
PT833828E (pt) Derivados de rapamicina
NO952854D0 (no) 1-arylpyrimidin-derivater
DE59508427D1 (de) 3-aryl-4-hydroxy-delta 3 -dihydrothiophenon-derivate
BR9611834A (pt) Derivados de oximetóxi-3-aril-pirona
ATE199150T1 (de) Diphenylmethylenpiperidin-derivate
NO964667D0 (no) Purin-6-on-derivater
ATE190610T1 (de) Benzothiazolone-derivate
BR9509793A (pt) Derivados de tiofeneno
DE69601527D1 (de) Pyrrolylbenzimidazol-Derivate
ATA100695A (de) Prothrombin-derivate
PT856007E (pt) Derivados de ciclopeptidos
ATE240307T1 (de) Diarylalkenylamin-derivate
DE69627830D1 (de) Pyrazol-derivate
DE59607054D1 (de) 4-Amino-benzoylguanidin-Derivate
ATE177102T1 (de) Chromanderivate
DE59610106D1 (de) Fluorbenzylether-Derivate
DK0843675T3 (da) Aza-anthracyclinonderivater
BR9603508A (pt) Derivados de alquenil-benzoilguanidina
BR9506618A (pt) Derivados de difeniloxazolinas
FI955026A7 (fi) Alkyyli-5-metyylisulfonyylibentsoyyliguanidiinijohdannaisia
DE59607055D1 (de) 4-Mercapto-benzoylguanidin-Derivate

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee