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DE69616548D1 - Polyaminosäuren-metallkomplexe und ihre anwendung in diagnostischer bilderzeugung - Google Patents

Polyaminosäuren-metallkomplexe und ihre anwendung in diagnostischer bilderzeugung

Info

Publication number
DE69616548D1
DE69616548D1 DE69616548T DE69616548T DE69616548D1 DE 69616548 D1 DE69616548 D1 DE 69616548D1 DE 69616548 T DE69616548 T DE 69616548T DE 69616548 T DE69616548 T DE 69616548T DE 69616548 D1 DE69616548 D1 DE 69616548D1
Authority
DE
Germany
Prior art keywords
pct
image generation
metal complexes
acid metal
polyamino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69616548T
Other languages
English (en)
Other versions
DE69616548T2 (de
Inventor
Dominique Meyer
Olivier Rousseaux
Michel Schaefer
Christian Simonot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUERBET VILLEPINTE
Original Assignee
GUERBET VILLEPINTE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GUERBET VILLEPINTE filed Critical GUERBET VILLEPINTE
Application granted granted Critical
Publication of DE69616548D1 publication Critical patent/DE69616548D1/de
Publication of DE69616548T2 publication Critical patent/DE69616548T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
DE69616548T 1995-06-29 1996-06-25 Polyaminosäuren-metallkomplexe und ihre anwendung in diagnostischer bilderzeugung Expired - Lifetime DE69616548T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9507860A FR2736051B3 (fr) 1995-06-29 1995-06-29 Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
PCT/FR1996/000992 WO1997001359A2 (fr) 1995-06-29 1996-06-25 Complexes metalliques de polyaminooxydes et leur utilisation en imagerie diagnostique

Publications (2)

Publication Number Publication Date
DE69616548D1 true DE69616548D1 (de) 2001-12-06
DE69616548T2 DE69616548T2 (de) 2002-07-18

Family

ID=9480531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616548T Expired - Lifetime DE69616548T2 (de) 1995-06-29 1996-06-25 Polyaminosäuren-metallkomplexe und ihre anwendung in diagnostischer bilderzeugung

Country Status (21)

Country Link
US (1) US5886158A (de)
EP (1) EP0835140B1 (de)
JP (1) JPH11508550A (de)
KR (1) KR19990028556A (de)
CN (1) CN1074934C (de)
AT (1) ATE207762T1 (de)
AU (1) AU708180B2 (de)
BR (1) BR9609519A (de)
CA (1) CA2222697A1 (de)
CZ (1) CZ414197A3 (de)
DE (1) DE69616548T2 (de)
EA (1) EA000378B1 (de)
FR (1) FR2736051B3 (de)
HU (1) HUP9900449A3 (de)
IL (1) IL122621A0 (de)
NO (1) NO976098L (de)
NZ (1) NZ312720A (de)
PL (1) PL325531A1 (de)
SK (1) SK282197B6 (de)
TR (1) TR199701716T1 (de)
WO (1) WO1997001359A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772025B1 (fr) 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
KR100309386B1 (ko) * 1999-08-04 2001-09-26 이계안 파트타임 4륜구동차량의 자동절환식 차동장치
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
KR101193686B1 (ko) * 2005-08-29 2012-10-22 니혼앗짜쿠단시세이소 가부시키가이샤 전기 커넥터 및 액정 표시 장치
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US20140170125A1 (en) 2011-08-10 2014-06-19 Digna Biotech, S.L. Use of cardiotrophin-1 for the treatment of kidney diseases
WO2017165841A1 (en) 2016-03-25 2017-09-28 Nanoprobes, Inc. Iodine-based particles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8916782D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5116599A (en) * 1989-07-31 1992-05-26 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
DE69425572T2 (de) * 1993-06-02 2001-04-26 Bracco Spa Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel

Also Published As

Publication number Publication date
EA000378B1 (ru) 1999-06-24
FR2736051A1 (fr) 1997-01-03
JPH11508550A (ja) 1999-07-27
SK173797A3 (en) 1998-06-03
HUP9900449A3 (en) 2001-05-28
MX9710380A (es) 1998-07-31
SK282197B6 (sk) 2001-12-03
WO1997001359A2 (fr) 1997-01-16
EP0835140B1 (de) 2001-10-31
TR199701716T1 (xx) 1998-04-21
BR9609519A (pt) 1999-02-23
AU708180B2 (en) 1999-07-29
EP0835140A2 (de) 1998-04-15
PL325531A1 (en) 1998-08-03
CN1074934C (zh) 2001-11-21
KR19990028556A (ko) 1999-04-15
CA2222697A1 (fr) 1997-01-16
CZ414197A3 (cs) 1998-03-18
EA199800101A1 (ru) 1998-08-27
HUP9900449A2 (hu) 1999-06-28
CN1189778A (zh) 1998-08-05
NZ312720A (en) 1999-04-29
DE69616548T2 (de) 2002-07-18
IL122621A0 (en) 1998-08-16
US5886158A (en) 1999-03-23
ATE207762T1 (de) 2001-11-15
NO976098L (no) 1998-02-27
AU6461696A (en) 1997-01-30
FR2736051B3 (fr) 1997-09-26
NO976098D0 (no) 1997-12-29
WO1997001359A3 (fr) 1997-05-22

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Legal Events

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