DE69619530D1 - Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität - Google Patents

Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität

Info

Publication number: DE69619530D1
Authority: DE; Germany
Prior art keywords: growth; humor; inhibiting activity; pct; somatostatin analogs
Prior art date: 1995-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69619530T

Other languages

English (en)

Other versions

DE69619530T2 (de

Inventor

Romano Deghenghi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ardana Bioscience Ltd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-28

Filing date

1996-07-17

Publication date

2002-04-04

1996-07-17 Application filed by Individual filed Critical Individual

2002-04-04 Publication of DE69619530D1 publication Critical patent/DE69619530D1/de

2002-08-08 Application granted granted Critical

2002-08-08 Publication of DE69619530T2 publication Critical patent/DE69619530T2/de

2016-07-18 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

230000002401 inhibitory effect Effects 0.000 title abstract 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Toxicology (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Food Science & Technology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DE69619530T 1995-07-28 1996-07-17 Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität Expired - Fee Related DE69619530T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95MI001670A IT1277391B1 (it)	1995-07-28	1995-07-28	Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
PCT/EP1996/003149 WO1997005167A1 (en)	1995-07-28	1996-07-17	Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone

Publications (2)

Publication Number	Publication Date
DE69619530D1 true DE69619530D1 (de)	2002-04-04
DE69619530T2 DE69619530T2 (de)	2002-08-08

Family

ID=11372091

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69619530T Expired - Fee Related DE69619530T2 (de)	1995-07-28	1996-07-17	Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität

Country Status (14)

Country	Link
US (1)	US5962409A (de)
EP (1)	EP0842193B1 (de)
JP (1)	JPH11510147A (de)
KR (1)	KR100321448B1 (de)
AT (1)	ATE213742T1 (de)
AU (1)	AU6700996A (de)
BR (1)	BR9609801A (de)
CA (1)	CA2227980A1 (de)
DE (1)	DE69619530T2 (de)
DK (1)	DK0842193T3 (de)
ES (1)	ES2171704T3 (de)
IT (1)	IT1277391B1 (de)
PT (1)	PT842193E (de)
WO (1)	WO1997005167A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6579967B1 (en)	1999-12-14	2003-06-17	The Salk Institute For Biological Studies	Receptor-selective somatostatin analogs
GB0018891D0 (en)	2000-08-01	2000-09-20	Novartis Ag	Organic compounds
US7019109B2 (en) *	2001-03-16	2006-03-28	The Salk Institute For Bilogical Studies	SSTR1-selective analogs
US20040121407A1 (en) *	2002-09-06	2004-06-24	Elixir Pharmaceuticals, Inc.	Regulation of the growth hormone/IGF-1 axis
CN1317031C (zh) *	2005-09-14	2007-05-23	上海第二医科大学附属新华医院	增强实体肿瘤细胞化疗敏感性的高效混合制剂
CA2629245C (en) *	2005-11-21	2016-07-12	Novartis Ag	Neuroendocrine tumor treatment
EP2752425A4 (de) *	2011-09-04	2015-04-22	Glytech Inc	Glykosyliertes polypeptid und arzneimittelzusammensetzung mit diesem polypeptid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
US4904642A (en) *	1985-09-12	1990-02-27	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
GR862206B (en) *	1985-09-12	1986-12-31	Univ Tulane	Therapeutic somatostatin analogs
IT1240643B (it) *	1990-05-11	1993-12-17	Mediolanum Farmaceutici Spa	Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
HU207104B (en) *	1991-01-25	1993-03-01	Biosignal Kutato Fejlesztoe Kf	Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
EP0588905A1 (de) *	1991-06-03	1994-03-30	Mallinckrodt Medical, Inc.	Radioaktiv markierte somatostatinderivate, ihre herstellung und verwendung
JPH07500259A (ja) *	1991-06-06	1995-01-12	ソマネチックス　コーポレイション	光学式大脳酸素濃度計

1995
- 1995-07-28 IT IT95MI001670A patent/IT1277391B1/it active IP Right Grant
1996
- 1996-07-17 US US08/983,363 patent/US5962409A/en not_active Expired - Fee Related
- 1996-07-17 ES ES96927035T patent/ES2171704T3/es not_active Expired - Lifetime
- 1996-07-17 WO PCT/EP1996/003149 patent/WO1997005167A1/en active IP Right Grant
- 1996-07-17 PT PT96927035T patent/PT842193E/pt unknown
- 1996-07-17 AU AU67009/96A patent/AU6700996A/en not_active Abandoned
- 1996-07-17 EP EP96927035A patent/EP0842193B1/de not_active Expired - Lifetime
- 1996-07-17 JP JP9507186A patent/JPH11510147A/ja not_active Ceased
- 1996-07-17 KR KR1019980700622A patent/KR100321448B1/ko not_active Expired - Fee Related
- 1996-07-17 DE DE69619530T patent/DE69619530T2/de not_active Expired - Fee Related
- 1996-07-17 CA CA002227980A patent/CA2227980A1/en not_active Abandoned
- 1996-07-17 AT AT96927035T patent/ATE213742T1/de not_active IP Right Cessation
- 1996-07-17 BR BR9609801A patent/BR9609801A/pt not_active IP Right Cessation
- 1996-07-17 DK DK96927035T patent/DK0842193T3/da active

Also Published As

Publication number	Publication date
ITMI951670A1 (it)	1997-01-28
ITMI951670A0 (it)	1995-07-28
HK1008225A1 (en)	1999-05-07
DE69619530T2 (de)	2002-08-08
KR19990035961A (ko)	1999-05-25
KR100321448B1 (ko)	2002-07-31
PT842193E (pt)	2002-06-28
IT1277391B1 (it)	1997-11-10
CA2227980A1 (en)	1997-02-13
DK0842193T3 (da)	2002-04-29
US5962409A (en)	1999-10-05
BR9609801A (pt)	1999-07-06
AU6700996A (en)	1997-02-26
JPH11510147A (ja)	1999-09-07
EP0842193B1 (de)	2002-02-27
ATE213742T1 (de)	2002-03-15
WO1997005167A1 (en)	1997-02-13
ES2171704T3 (es)	2002-09-16
EP0842193A1 (de)	1998-05-20

Publication	Publication Date	Title
DE69401204D1 (de)	1997-01-30	Gonadotropin enthaltende gefriergetrocknete troepfen
GR3023233T3 (en)	1997-07-30	Inhibitors of dipeptidyl-aminopeptidase type iv
GR3023511T3 (en)	1997-08-29	THE EFFECT OF N,N,N-TRIMETHYLSPHINGOSINE ON PROTEIN KINASE-C ACTIVITY; MELANOMA CELL GROWTH -i(IN VITRO); METASTATIC POTENTIAL -i(IN VIVO) AND HUMAN PLATELET AGGREGATION
BR9611175B1 (pt)	2009-01-13	compostos e composiÇÕes farmacÊuticas.
NO962664D0 (no)	1996-06-21	Forbindelser med veksthormonfrigjörende egenskaper
ATE364079T1 (de)	2007-06-15	Peptide mit gdp-austauschfaktorartiger wirkung, dafür kodierende nukleinsäuresequenzen, ihre herstellung und verwendung
ZA961364B (en)	1996-08-22	1-Aryl-2-acylamino-ethane compounds
ATE165827T1 (de)	1998-05-15	Herstellung von n-acetylneuraminsäure-derivaten
ES2131528T3 (es)	1999-08-01	Nuevos polipeptidos y su uso.
MY132550A (en)	2007-10-31	Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
DE69619530D1 (de)	2002-04-04	Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität
NO980296D0 (no)	1998-01-23	Forbedrede terapeutiske midler
MX9604762A (es)	1997-04-30	Nuevas sulfonamidas y procedimiento para su preparacion.
DE3765808D1 (de)	1990-12-06	Heterocyclische tetrahydro-3,4-diamin-n-n'-platin-komplexe.
AU6722498A (en)	1998-09-22	Disubstituted biphenyloxazolines
ATE247088T1 (de)	2003-08-15	Peptidverbindungen mit mmp- und tnf-hemmender wirkung
ES2097931T3 (es)	1997-04-16	Nueva proteina inhibidora de trombina a partir de chinches cazadoras.
ES2109373T3 (es)	1998-01-16	Nueva proteina inhibidora de trombina a partir de garrapatas.
MX9802268A (es)	1998-08-30	Nuevos derivados de la substancia pf1022 de ciclodepsipeptido.

Legal Events

Date	Code	Title	Description
2003-03-27	8364	No opposition during term of opposition
2004-01-29	8327	Change in the person/name/address of the patent owner	Owner name: ARDANA BIOSCIENCE LTD., EDINBURGH, GB
2004-01-29	8381	Inventor (new situation)	Inventor name: DEGHENGHI, ROMANO, S.-CERGUE, CH
2007-05-16	8339	Ceased/non-payment of the annual fee