[go: up one dir, main page]

DE69634581D1 - Antibakterielle Cephalosporine - Google Patents

Antibakterielle Cephalosporine

Info

Publication number
DE69634581D1
DE69634581D1 DE69634581T DE69634581T DE69634581D1 DE 69634581 D1 DE69634581 D1 DE 69634581D1 DE 69634581 T DE69634581 T DE 69634581T DE 69634581 T DE69634581 T DE 69634581T DE 69634581 D1 DE69634581 D1 DE 69634581D1
Authority
DE
Germany
Prior art keywords
cephalosporins
antibacterial
antibacterial cephalosporins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634581T
Other languages
English (en)
Other versions
DE69634581T2 (de
Inventor
Gerd Ascher
Johannes Ludescher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nabriva Therapeutics AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT79495A external-priority patent/AT402820B/de
Priority claimed from AT99295A external-priority patent/AT402821B/de
Priority claimed from AT69896A external-priority patent/AT403283B/de
Priority claimed from AT73396A external-priority patent/AT403284B/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE69634581D1 publication Critical patent/DE69634581D1/de
Application granted granted Critical
Publication of DE69634581T2 publication Critical patent/DE69634581T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
    • A01N3/02—Keeping cut flowers fresh chemically
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C05F11/10—Fertilisers containing plant vitamins or hormones
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/20—Liquid fertilisers
    • C05G5/23—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/40—Bio-organic fraction processing; Production of fertilisers from the organic fraction of waste or refuse

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69634581T 1995-05-11 1996-05-10 Antibakterielle Cephalosporine Expired - Lifetime DE69634581T2 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
AT79495A AT402820B (de) 1995-05-11 1995-05-11 Organische verbindungen
AT79495 1995-05-11
AT99295A AT402821B (de) 1995-06-12 1995-06-12 Organische verbindungen
AT99295 1995-06-12
AT69896A AT403283B (de) 1996-04-17 1996-04-17 3-methylimino-3-cephemderivate
AT69896 1996-04-17
AT73396 1996-04-23
AT73396A AT403284B (de) 1996-04-23 1996-04-23 3-methylimino-3-cephemderivate

Publications (2)

Publication Number Publication Date
DE69634581D1 true DE69634581D1 (de) 2005-05-12
DE69634581T2 DE69634581T2 (de) 2006-02-09

Family

ID=27421316

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69634581T Expired - Lifetime DE69634581T2 (de) 1995-05-11 1996-05-10 Antibakterielle Cephalosporine
DE69626389T Expired - Lifetime DE69626389T2 (de) 1995-05-11 1996-05-10 Antibakterielle cephalosporinverbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69626389T Expired - Lifetime DE69626389T2 (de) 1995-05-11 1996-05-10 Antibakterielle cephalosporinverbindungen

Country Status (29)

Country Link
US (2) US6531465B1 (de)
EP (2) EP0824535B1 (de)
JP (2) JPH11506429A (de)
KR (1) KR100451336B1 (de)
CN (1) CN1142937C (de)
AR (1) AR001931A1 (de)
AT (2) ATE292637T1 (de)
AU (1) AU712814B2 (de)
BR (1) BR9608517A (de)
CA (1) CA2219656C (de)
CO (1) CO4750666A1 (de)
CY (1) CY2445B1 (de)
CZ (1) CZ352997A3 (de)
DE (2) DE69634581T2 (de)
DK (1) DK0824535T3 (de)
ES (1) ES2193246T3 (de)
HU (1) HUP9801387A3 (de)
IL (2) IL118221A (de)
MX (1) MX9708696A (de)
NO (1) NO326126B1 (de)
NZ (1) NZ308518A (de)
PE (1) PE8398A1 (de)
PL (1) PL193133B1 (de)
PT (1) PT824535E (de)
RU (1) RU2183212C2 (de)
SK (1) SK284962B6 (de)
TW (1) TW452579B (de)
WO (1) WO1996035692A1 (de)
ZA (1) ZA963758B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405180B (de) * 1997-04-01 1999-06-25 Biochemie Gmbh Neue derivate von substituierten 3-cephem-4-carbonsäurederivaten und verfahren zu deren herstellung
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
RU2201933C2 (ru) * 1997-04-01 2003-04-10 Биохеми Гезельшафт Мбх Антибактериальные замещенные 7-ациламино-3-(метилгидразоно)метилцефалоспорины, способ их получения, фармацевтические композиции на их основе, промежуточные соединения и способ лечения заболеваний, вызванных микроорганизмами
AT406772B (de) * 1998-03-23 2000-08-25 Biochemie Gmbh Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung
WO2001027103A1 (en) 1999-10-08 2001-04-19 Smithkline Beecham Corporation Fab i inhibitors
KR100739830B1 (ko) * 2001-03-23 2007-07-13 주식회사 하원제약 세파로스포린 유도체의 제조방법
US7049310B2 (en) * 2001-04-06 2006-05-23 Affinium Pharmaceuticals, Inc. Fab I inhibitors
AR040545A1 (es) * 2002-07-15 2005-04-13 Sandoz Ag Cefalosporinas
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
ES2515101T3 (es) * 2004-06-04 2014-10-29 Debiopharm International Sa Derivados de acrilamida como agentes antibióticos
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (de) * 2006-07-20 2017-06-14 Debiopharm International SA Acrylamidderivate als fab-i-inhibitoren
EP3255045A1 (de) 2007-02-16 2017-12-13 Debiopharm International SA Salze, prodrugs und polymorphe von fab i-inhibitoren
NZ702695A (en) 2012-06-19 2015-10-30 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
SG11201807067YA (en) 2016-02-26 2018-09-27 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
MA54009B1 (fr) 2019-02-14 2022-10-31 Debiopharm Int Sa Formulation d'afabicine et son procédé de préparation
AU2020293635B2 (en) 2019-06-14 2025-05-29 Debiopharm International S.A. Medicament and use thereof for treating bacterial infections involving biofilm
TW202126664A (zh) 2019-09-06 2021-07-16 奧地利商納畢瓦治療有限責任公司 鐵載體頭孢菌素共軛物及其用途
CN110590814A (zh) * 2019-09-29 2019-12-20 天津力生制药股份有限公司 一种生产头孢唑林钠产生的二聚体杂质的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2333263A1 (de) * 1972-07-07 1974-01-24 Ciba Geigy Ag 7 beta-amino-3-oximinomethyl-cephem-4carbonsaeureverbindungen und verfahren zu ihrer herstellung
JPS5417030B2 (de) 1972-12-06 1979-06-27
DE2262500A1 (de) * 1972-12-20 1973-07-05 Lilly Co Eli 3-oxyiminomethylcephalosporinverbindungen
US4053469A (en) 1973-02-28 1977-10-11 Shionogi & Co., Ltd. Intermediates for the preparation of 7-acylamino-3-oxyiminomethyl-3-cephem-4-carboxylic acids
JPS49109391A (de) 1973-02-28 1974-10-17
JPS49124091A (de) * 1973-03-30 1974-11-27
JPS5013389A (de) * 1973-06-08 1975-02-12
JPS5093989A (de) * 1973-10-25 1975-07-26
JPS5076085A (de) * 1973-10-31 1975-06-21
JPS5083391A (de) * 1973-11-28 1975-07-05
JPS5715597B2 (de) * 1973-12-20 1982-03-31
JPS50131982A (de) * 1974-04-05 1975-10-18
US4101658A (en) 1975-06-04 1978-07-18 Shionogi & Co., Ltd. Antibacterial hydrazono cephalosporins
JPS5283865A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd Cephalosporin derivatives
JPS5470294A (en) * 1977-11-09 1979-06-05 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4258181A (en) * 1978-09-05 1981-03-24 American Cyanamid Company Substituted 9,10-anthracenebishydrazones
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
RU1831484C (ru) * 1988-06-06 1993-07-30 Фудзисава Фармасьютикал Ко, ЛтД Способ получени цефемовых соединений или их солей
US6693095B2 (en) * 1997-04-01 2004-02-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates

Also Published As

Publication number Publication date
US20030191105A1 (en) 2003-10-09
TW452579B (en) 2001-09-01
PL323233A1 (en) 1998-03-16
MX9708696A (es) 1998-08-30
JPH11506429A (ja) 1999-06-08
EP1221446A1 (de) 2002-07-10
ATE292637T1 (de) 2005-04-15
NO975151D0 (no) 1997-11-10
ZA963758B (en) 1997-11-10
CA2219656A1 (en) 1996-11-14
NO326126B1 (no) 2008-09-29
CN1186494A (zh) 1998-07-01
SK284962B6 (sk) 2006-03-02
CO4750666A1 (es) 1999-03-31
CN1142937C (zh) 2004-03-24
KR100451336B1 (ko) 2005-01-17
WO1996035692A1 (en) 1996-11-14
ATE233268T1 (de) 2003-03-15
BR9608517A (pt) 1999-06-08
NZ308518A (en) 2000-01-28
IL118221A0 (en) 1996-09-12
RU2183212C2 (ru) 2002-06-10
DE69626389D1 (de) 2003-04-03
KR19990014669A (ko) 1999-02-25
HUP9801387A2 (hu) 1999-01-28
CZ352997A3 (cs) 1998-02-18
SK150397A3 (en) 1998-03-04
DE69626389T2 (de) 2003-10-09
EP0824535B1 (de) 2003-02-26
PE8398A1 (es) 1998-03-13
US6531465B1 (en) 2003-03-11
CA2219656C (en) 2008-08-19
IL118221A (en) 2004-06-01
IL132532A (en) 2003-06-24
CY2445B1 (en) 2004-11-12
HUP9801387A3 (en) 2000-12-28
EP0824535A1 (de) 1998-02-25
US7317101B2 (en) 2008-01-08
PT824535E (pt) 2003-07-31
AR001931A1 (es) 1997-12-10
AU712814B2 (en) 1999-11-18
DK0824535T3 (da) 2003-06-02
NO975151L (no) 1997-11-10
DE69634581T2 (de) 2006-02-09
ES2193246T3 (es) 2003-11-01
PL193133B1 (pl) 2007-01-31
EP1221446B1 (de) 2005-04-06
AU5818496A (en) 1996-11-29
JP2007023046A (ja) 2007-02-01
HK1008993A1 (en) 1999-05-21

Similar Documents

Publication Publication Date Title
BR9507267A (pt) Antibióticos de cefalosporina
ATE292637T1 (de) Antibakterielle cephalosporine
BR9609989A (pt) Compostos de benzilaminopiperidina substituídos
ID16345A (id) Senyawa-senyawa heterosiklik
DE69519421D1 (de) Kodiergerät
DE69633213D1 (de) Drehwinkelgeber
FI963761L (fi) Kefalosporiinin synteesi
DE69618015D1 (de) Cephalosporinantibiotika
NO963805D0 (no) Cefalosporinderivater
EE9800172A (et) Ühendid
NO974170D0 (no) Polyazacykloalkan-forbindelser
FI973500L (fi) 3-pyrrolidylideeni-2-oni-kefalosporiinien johdannaiset
DE69618709D1 (de) Interferenz-Lärmkontrolleanordnung
KR960013362A (ko) 항균제
SI0824535T1 (en) Antibacterial cephalosporins
MA23677A1 (fr) Derives de la cephalosporine
ITMI941228A0 (it) Nuove cefalosporine
BR9603734A (pt) Derivados de cefalosporina
NO952527D0 (no) Antibiotika
SE9502559D0 (sv) Novel compounds
NO920017L (no) Cefalosporinderivater
NO934078D0 (no) Cefalosporinderivater
ITMI950031A0 (it) Composti dibenzoalchilenici
BR1100842A (pt) Compostos

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NABRIVA THERAPEUTICS FORSCHUNG GMBH, WIEN, AT

8327 Change in the person/name/address of the patent owner

Owner name: NABRIVA THERAPEUTICS AG, WIEN, AT

8330 Complete renunciation