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DE69638061D1 - Onkogenische mutanten des genes tsg101 - Google Patents

Onkogenische mutanten des genes tsg101

Info

Publication number
DE69638061D1
DE69638061D1 DE69638061T DE69638061T DE69638061D1 DE 69638061 D1 DE69638061 D1 DE 69638061D1 DE 69638061 T DE69638061 T DE 69638061T DE 69638061 T DE69638061 T DE 69638061T DE 69638061 D1 DE69638061 D1 DE 69638061D1
Authority
DE
Germany
Prior art keywords
gene
construct
region sequence
copy
antisense rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69638061T
Other languages
English (en)
Inventor
Li Stanford
Cohen Stanford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R UNIVERSITY
Original Assignee
R UNIVERSITY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/670,274 external-priority patent/US5891668A/en
Application filed by R UNIVERSITY filed Critical R UNIVERSITY
Priority claimed from PCT/US1996/018828 external-priority patent/WO1997018333A1/en
Application granted granted Critical
Publication of DE69638061D1 publication Critical patent/DE69638061D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69638061T 1995-11-16 1996-11-15 Onkogenische mutanten des genes tsg101 Expired - Lifetime DE69638061D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US685695P 1995-11-16 1995-11-16
US08/585,758 US5679523A (en) 1995-11-16 1996-01-16 Method for concurrent disruption of expression of multiple alleles of mammalian genes
US08/670,274 US5891668A (en) 1996-01-16 1996-06-13 Mammalian tumor susceptibility genes and their uses
PCT/US1996/018828 WO1997018333A1 (en) 1995-11-16 1996-11-15 Disruption of expression of multiple alleles of mammalian genes

Publications (1)

Publication Number Publication Date
DE69638061D1 true DE69638061D1 (de) 2009-12-10

Family

ID=26676150

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69638061T Expired - Lifetime DE69638061D1 (de) 1995-11-16 1996-11-15 Onkogenische mutanten des genes tsg101

Country Status (4)

Country Link
US (1) US5679523A (de)
AT (1) ATE447042T1 (de)
DE (1) DE69638061D1 (de)
DK (1) DK0877819T3 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892016A (en) * 1997-01-23 1999-04-06 Incyte Pharmaceuticals Human tumor suppressor
CA2250830A1 (en) 1996-06-26 1997-12-31 Binhai Zheng Chromosomal rearrangement by insertion of two recombination substrates
US6855545B1 (en) * 1996-10-04 2005-02-15 Lexicon Genetics Inc. Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US7332338B2 (en) 1996-10-04 2008-02-19 Lexicon Pharmaceuticals, Inc. Vectors for making genomic modifications
US20040072243A1 (en) * 1996-10-11 2004-04-15 Lexicon Genetics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6228579B1 (en) 1997-11-14 2001-05-08 San Diego State University Foundation Method for identifying microbial proliferation genes
AU2678999A (en) 1998-02-13 1999-08-30 Genetrace Systems, Inc. Use of ribozymes for functionating genes
US6436707B1 (en) * 1998-03-27 2002-08-20 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
US6808921B1 (en) 1998-03-27 2004-10-26 Lexicon Genetics Incorporated Vectors for gene mutagenesis and gene discovery
US6893838B1 (en) * 1998-04-07 2005-05-17 Genetics Institute Llc DADD, death activator death domain protein
US6720139B1 (en) 1999-01-27 2004-04-13 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation in Escherichia coli
WO2000056874A1 (en) * 1999-03-25 2000-09-28 Massachusetts Institute Of Technology Retroviral vectors and methods for production and use thereof
US6890726B1 (en) 1999-04-06 2005-05-10 Oklahoma Medical Research Foundation Method for selecting recombinase variants with altered specificity
WO2000065027A2 (en) 1999-04-28 2000-11-02 Genetics Institute, Inc. Human gil-19/ae289 proteins and polynucleotides encoding same
WO2001034810A2 (en) 1999-11-09 2001-05-17 Elitra Pharmaceuticals, Inc. Genes essential for microbial proliferation
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
WO2001049728A2 (en) * 2000-01-06 2001-07-12 Protegene Inc. HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
US6750379B2 (en) * 2000-03-09 2004-06-15 Dekalb Genetics Corporation Homologous recombination-mediated transgene alterations in plants
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
NZ525607A (en) 2000-12-22 2005-05-27 Aurox Llc Methods for cloning mammals using reprogrammed donor chromatin or donor cells
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US6943025B2 (en) * 2001-01-10 2005-09-13 Children's Medical Center Corporation Method for identifying genes involved in cell proliferation
US20030104410A1 (en) * 2001-03-16 2003-06-05 Affymetrix, Inc. Human microarray
US7494767B2 (en) * 2001-05-21 2009-02-24 Functional Genetics, Inc. Assay for TSG101 as inhibitors of HIV production
US20030082596A1 (en) * 2001-08-08 2003-05-01 Michael Mittmann Methods of genetic analysis of probes: test3
AU2002330151A1 (en) * 2001-09-27 2003-04-07 Functional Genetics, Inc. Methods and compositions for generating homozygous mutations
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20030170694A1 (en) * 2001-12-21 2003-09-11 Daniel Wall Stabilized nucleic acids in gene and drug discovery and methods of use
AU2003241359A1 (en) * 2002-05-06 2003-11-11 Functional Genetics, Inc. Mammalian genes involed in rapamycin resistance and tumorgenesis: annexin xiii genes
AU2003265525A1 (en) * 2002-08-15 2004-03-19 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
US20060099676A1 (en) * 2002-08-15 2006-05-11 Limin Li Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
US20040052161A1 (en) * 2002-09-17 2004-03-18 Steven Liao Mechanical clock having wireless manipulation and adjustment function
AU2003290689A1 (en) * 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
US7314750B2 (en) 2002-11-20 2008-01-01 Affymetrix, Inc. Addressable oligonucleotide array of the rat genome
US7250289B2 (en) * 2002-11-20 2007-07-31 Affymetrix, Inc. Methods of genetic analysis of mouse
US20040259125A1 (en) * 2003-02-26 2004-12-23 Omni Genetics, Inc. Methods, systems and apparatus for identifying genetic differences in disease and drug response
EP1678307A1 (de) * 2003-09-30 2006-07-12 Lexicon Genetics Incorporated Verfahren und zusammensetzungen zur definition der genfunktion
CA2563064A1 (en) * 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US8129334B2 (en) 2006-03-31 2012-03-06 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory
US20080176962A1 (en) * 2006-08-09 2008-07-24 Cohen Stanley N Methods and compositions for identifying cellular genes exploited by viral pathogens
EP2078075B1 (de) * 2006-10-30 2015-09-02 Eli Lilly and Company Verbesserte antikörperproduktion durch rhgp (random homozygous gene pertubation)
EP2360182A1 (de) 2006-11-13 2011-08-24 Functional Genetics, Inc. Therapeutisches Targeting von Escort-Proteinen
AU2010203755A1 (en) * 2009-01-06 2010-07-15 Eli Lilly And Company Random Homozygous Gene Perturbation (RHGP) with thermal asymmetric interlaced (TAIL)-PCR
US10127295B2 (en) * 2009-06-05 2018-11-13 Microsoft Technolofy Licensing, Llc Geographic co-location service for cloud computing

Also Published As

Publication number Publication date
US5679523A (en) 1997-10-21
ATE447042T1 (de) 2009-11-15
DK0877819T3 (da) 2010-03-15

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