DE69703449D1 - Neuroaktive peptide - Google Patents
Neuroaktive peptideInfo
- Publication number
- DE69703449D1 DE69703449D1 DE69703449T DE69703449T DE69703449D1 DE 69703449 D1 DE69703449 D1 DE 69703449D1 DE 69703449 T DE69703449 T DE 69703449T DE 69703449 T DE69703449 T DE 69703449T DE 69703449 D1 DE69703449 D1 DE 69703449D1
- Authority
- DE
- Germany
- Prior art keywords
- neuroactive peptides
- specific identification
- neuroactive
- peptides
- nmda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/649,272 US5763393A (en) | 1996-05-17 | 1996-05-17 | Neuroactive peptides |
| PCT/US1997/008667 WO1997043306A1 (en) | 1996-05-17 | 1997-05-16 | Neuroactive peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69703449D1 true DE69703449D1 (de) | 2000-12-07 |
| DE69703449T2 DE69703449T2 (de) | 2001-06-07 |
Family
ID=24604116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69703449T Expired - Fee Related DE69703449T2 (de) | 1996-05-17 | 1997-05-16 | Neuroaktive peptide |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5763393A (de) |
| EP (2) | EP1077217A3 (de) |
| JP (1) | JP2000501746A (de) |
| AT (1) | ATE197307T1 (de) |
| AU (1) | AU3209097A (de) |
| CA (1) | CA2255659C (de) |
| DE (1) | DE69703449T2 (de) |
| DK (1) | DK0914331T3 (de) |
| ES (1) | ES2153671T3 (de) |
| GR (1) | GR3035227T3 (de) |
| PT (1) | PT914331E (de) |
| WO (1) | WO1997043306A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2413974A1 (en) * | 2000-06-22 | 2001-12-27 | Nyxis Neurotherapies, Inc. | Neuroactive peptides for treatment of hypoxia and related conditions |
| WO2003010540A1 (en) * | 2001-07-25 | 2003-02-06 | Nyxis Neurotherapies, Inc. | Method of identifying nmda-related agent |
| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| EP3488856A1 (de) | 2009-10-05 | 2019-05-29 | Northwestern University | Glyx zur verwendung zur behandlung von depression oder angstzuständen |
| KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| EP2542254B1 (de) | 2010-02-11 | 2018-09-26 | Northwestern University | Nmda-rezeptor-agonisten und ihre verwendungen |
| KR20140043078A (ko) | 2011-04-27 | 2014-04-08 | 노오쓰웨스턴 유니버시티 | 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 |
| US8798716B1 (en) | 2011-11-03 | 2014-08-05 | Solstice Corporation | Fiducial markers and related methods |
| US8974365B2 (en) | 2012-11-25 | 2015-03-10 | Steven Richard Devore Best | Treatment of thalamocortical dysrhythmia |
| ES2751138T3 (es) | 2013-01-22 | 2020-03-30 | Vistagen Therapeutics Inc | Formas de dosificación y usos terapéuticos de la L-4-cloroquinurenina |
| BR112015018094A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor nmda de espiro-lactama e usos dos mesmos |
| EP2951186B1 (de) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam-nmda-rezeptormodulatoren und verwendungen davon |
| MX2015009786A (es) | 2013-01-29 | 2015-12-11 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| US9828384B2 (en) | 2013-01-29 | 2017-11-28 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| KR20150110787A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| GB201319437D0 (en) * | 2013-11-04 | 2013-12-18 | Nanomerics Ltd | Delivery of drugs |
| RU2716164C2 (ru) | 2014-04-25 | 2020-03-06 | Наурекс, Инк. | Стабильные композиции нейроактивных пептидов |
| CA2955196A1 (en) * | 2014-07-24 | 2016-01-28 | M. Amin Khan | N-methyl-d-aspartate receptor modulators and methods of making and using same |
| UA123623C2 (uk) | 2014-08-14 | 2021-05-05 | Наурекс, Інк. | Способи лікування депресії із застосуванням модуляторів nmda |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| JP6823083B2 (ja) | 2016-05-19 | 2021-01-27 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| CN109843889B (zh) | 2016-08-01 | 2022-03-15 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda调节剂和使用其的方法 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ－ラクタムｎｍｄａ受容体修飾因子およびその使用 |
| IL264496B (en) | 2016-08-01 | 2022-09-01 | Aptinyx Inc | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
| US11299495B2 (en) | 2016-08-01 | 2022-04-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| EP3706734A1 (de) | 2017-11-10 | 2020-09-16 | Naurex Inc. | Verfahren zur verabreichung von nmda-rezeptor-agonisten |
| EP3720464A1 (de) | 2017-12-05 | 2020-10-14 | Naurex Inc. | Kombination aus nmda-rezeptormodulatoren (rapastinel) zur verwendung in kombinierter behandlung (schlaf und zns-störung ) |
| CA3089561A1 (en) | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854217A (en) * | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| US5428069A (en) * | 1993-01-11 | 1995-06-27 | The United States Of America As Represented By The Department Of Health & Human Services | Treating cognition with, aminocyclopropanecarboxylic derivatives |
| JPH07101999A (ja) * | 1993-10-06 | 1995-04-18 | Hagiwara Yoshihide | 抗癌ヒトモノクローナル抗体に対する抗イデイオタイプ抗体のアミノ酸配列およびそれをコードするｄｎａ塩基配列 |
-
1996
- 1996-05-17 US US08/649,272 patent/US5763393A/en not_active Expired - Lifetime
-
1997
- 1997-05-16 DE DE69703449T patent/DE69703449T2/de not_active Expired - Fee Related
- 1997-05-16 JP JP9541206A patent/JP2000501746A/ja not_active Ceased
- 1997-05-16 AU AU32090/97A patent/AU3209097A/en not_active Abandoned
- 1997-05-16 EP EP00118013A patent/EP1077217A3/de not_active Withdrawn
- 1997-05-16 AT AT97927691T patent/ATE197307T1/de not_active IP Right Cessation
- 1997-05-16 CA CA002255659A patent/CA2255659C/en not_active Expired - Lifetime
- 1997-05-16 ES ES97927691T patent/ES2153671T3/es not_active Expired - Lifetime
- 1997-05-16 DK DK97927691T patent/DK0914331T3/da active
- 1997-05-16 WO PCT/US1997/008667 patent/WO1997043306A1/en active IP Right Grant
- 1997-05-16 EP EP97927691A patent/EP0914331B1/de not_active Expired - Lifetime
- 1997-05-16 PT PT97927691T patent/PT914331E/pt unknown
-
1998
- 1998-06-08 US US09/105,799 patent/US6107271A/en not_active Expired - Fee Related
-
2001
- 2001-01-11 GR GR20010400043T patent/GR3035227T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE197307T1 (de) | 2000-11-15 |
| EP1077217A3 (de) | 2004-01-02 |
| GR3035227T3 (en) | 2001-04-30 |
| JP2000501746A (ja) | 2000-02-15 |
| US5763393A (en) | 1998-06-09 |
| EP0914331B1 (de) | 2000-11-02 |
| PT914331E (pt) | 2001-04-30 |
| CA2255659C (en) | 2005-03-15 |
| WO1997043306A1 (en) | 1997-11-20 |
| DE69703449T2 (de) | 2001-06-07 |
| DK0914331T3 (da) | 2001-02-12 |
| AU3209097A (en) | 1997-12-05 |
| EP0914331A1 (de) | 1999-05-12 |
| CA2255659A1 (en) | 1997-11-20 |
| ES2153671T3 (es) | 2001-03-01 |
| US6107271A (en) | 2000-08-22 |
| EP1077217A2 (de) | 2001-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |