DE69711883D1 - Verfahren zur herstellung von narcotischen analgetika - Google Patents
Verfahren zur herstellung von narcotischen analgetikaInfo
- Publication number
- DE69711883D1 DE69711883D1 DE69711883T DE69711883T DE69711883D1 DE 69711883 D1 DE69711883 D1 DE 69711883D1 DE 69711883 T DE69711883 T DE 69711883T DE 69711883 T DE69711883 T DE 69711883T DE 69711883 D1 DE69711883 D1 DE 69711883D1
- Authority
- DE
- Germany
- Prior art keywords
- analges
- narcotic
- producing
- hydromorphone
- hydrocodone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000003533 narcotic effect Effects 0.000 title abstract 2
- 241001535291 Analges Species 0.000 title 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 abstract 1
- 229960000240 hydrocodone Drugs 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 abstract 1
- 229960001410 hydromorphone Drugs 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9616253.2A GB9616253D0 (en) | 1996-08-01 | 1996-08-01 | Preparation of narcotic analgesics |
| PCT/GB1997/001977 WO1998005667A1 (en) | 1996-08-01 | 1997-07-18 | Preparation of narcotic analgesics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69711883D1 true DE69711883D1 (de) | 2002-05-16 |
| DE69711883T2 DE69711883T2 (de) | 2002-10-31 |
Family
ID=10797912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69711883T Expired - Lifetime DE69711883T2 (de) | 1996-08-01 | 1997-07-18 | Verfahren zur herstellung von narcotischen analgetika |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5847142A (de) |
| EP (1) | EP0915884B1 (de) |
| JP (2) | JP4316674B2 (de) |
| CN (1) | CN1105721C (de) |
| AT (1) | ATE215955T1 (de) |
| AU (1) | AU3629197A (de) |
| DE (1) | DE69711883T2 (de) |
| DK (1) | DK0915884T3 (de) |
| ES (1) | ES2175438T3 (de) |
| GB (1) | GB9616253D0 (de) |
| MY (1) | MY117858A (de) |
| PL (1) | PL186307B1 (de) |
| TW (1) | TW396157B (de) |
| WO (1) | WO1998005667A1 (de) |
| ZA (1) | ZA976853B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9616253D0 (en) * | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
| ATE500257T1 (de) * | 1999-11-09 | 2011-03-15 | Abbott Lab | Hydromorphinonzusammensetzungen |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CN103405431B (zh) * | 2002-05-17 | 2016-04-13 | 台湾J药品有限公司 | 阿片和阿片样化合物及其用途 |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| RU2215741C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения |
| RU2215742C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов |
| AU2004319925B2 (en) * | 2002-11-11 | 2010-12-09 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| WO2005047291A1 (en) * | 2002-11-11 | 2005-05-26 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7323565B2 (en) * | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7399858B2 (en) * | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| SK286047B6 (sk) * | 2004-04-13 | 2008-01-07 | Zentiva, A. S. | Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu |
| US6946556B1 (en) | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
| US7348430B2 (en) * | 2005-01-21 | 2008-03-25 | Acura Pharmaceuticals, Inc. | Production of opioid analgesics |
| AU2006229734A1 (en) | 2005-03-28 | 2006-10-05 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| WO2006138020A2 (en) * | 2005-06-16 | 2006-12-28 | Mallinckrodt Inc. | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
| US7399859B1 (en) | 2007-02-06 | 2008-07-15 | Cody Laboratories Inc. | Method for catalytic preparation of hydromorphone and hydrocodone |
| CA2637610A1 (en) * | 2007-05-04 | 2008-11-04 | Mallinckrodt Inc. | Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
| US7999104B2 (en) | 2007-06-29 | 2011-08-16 | Brock University | Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| JP2010533719A (ja) * | 2007-07-17 | 2010-10-28 | マリンクロッド・インコーポレイテッド | 還元的アミノ化によるｎ−アルキル化オピエートの調製 |
| NZ592005A (en) | 2008-09-30 | 2013-03-28 | Mallinckrodt Llc | Process for the preparation of a N-alkylated ketomorphinan by selective catalytiC hydrogen transfer reduction |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| WO2010118275A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of saturated ketone morphinan compounds |
| WO2010118274A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of 6-keto, 3-alkoxy morphinans |
| US8293907B2 (en) * | 2009-04-09 | 2012-10-23 | Mallinckrodt Inc. | Preparation of saturated ketone morphinan compounds by catalytic isomerization |
| CN102803267A (zh) * | 2009-06-11 | 2012-11-28 | 马林克罗特有限公司 | 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备 |
| EP2440561B1 (de) * | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Reduktive aminierung von 6-keto-normorphinanen durch katalytischen wasserstofftransfer |
| SI2506712T1 (sl) | 2009-12-04 | 2019-06-28 | Alkermes Pharma Ireland Limited, | Derivati morfinana za zdravljenje prevelikega odmerka mamil |
| CA2936749C (en) | 2010-06-11 | 2019-07-09 | Joshua R. Giguere | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| US8703950B2 (en) | 2010-07-02 | 2014-04-22 | Johnson Matthey Public Limited Co. | Low ABUK oxycodone, its salts and methods of making same |
| ES2708726T3 (es) * | 2010-07-08 | 2019-04-10 | Alkermes Pharma Ireland Ltd | Proceso para la síntesis de morfinanos sustituidos |
| DK2608670T3 (en) | 2010-08-23 | 2019-02-11 | Alkermes Pharma Ireland Ltd | METHOD OF TREATING ANTI-SOCIETY-INDICATED WEIGHT RISE |
| CN103619847A (zh) | 2011-05-06 | 2014-03-05 | 布鲁克大学 | 通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法 |
| US9296699B2 (en) | 2011-06-09 | 2016-03-29 | Mallinckrodt Llc | Reductive amination of 6-keto morphinans by catalytic hydrogen transfer |
| CA2845187A1 (en) | 2011-09-08 | 2013-03-14 | Peter X. Wang | Production of alkaloids without the isolation of intermediates |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| NZ631018A (en) | 2013-05-24 | 2017-12-22 | Alkermes Pharma Ireland Ltd | Morphan and morphinan analogues, and methods of use |
| WO2014190271A2 (en) | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limted | Methods for treating depressive symptoms |
| GB201313211D0 (en) | 2013-07-24 | 2013-09-04 | Cambrex Karlskoga Ab | New process |
| EP3255051A1 (de) | 2016-06-09 | 2017-12-13 | Siegfried AG | Trägerbasierter metallkatalysator für die herstellung von hydrocodon und hydromorphon |
| US10081636B2 (en) | 2016-07-08 | 2018-09-25 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates |
| WO2022101444A1 (en) | 2020-11-12 | 2022-05-19 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
| EP4244226A1 (de) | 2020-11-13 | 2023-09-20 | Ferrer Internacional, S.A. | Synthese einer hydromorphonbase |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2654756A (en) * | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US2628962A (en) * | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
| US2715626A (en) * | 1950-07-05 | 1955-08-16 | Merck & Co Inc | Process of preparing dihydrocodeinone |
| FR1290174A (fr) * | 1961-01-25 | 1962-04-13 | S E M P A Chemie | Préparation de la codéïnone à partir de la thébaïne |
| GB9616253D0 (en) * | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
-
1996
- 1996-08-01 GB GBGB9616253.2A patent/GB9616253D0/en active Pending
-
1997
- 1997-04-03 US US08/825,744 patent/US5847142A/en not_active Expired - Lifetime
- 1997-07-18 JP JP50769898A patent/JP4316674B2/ja not_active Expired - Lifetime
- 1997-07-18 EP EP97932926A patent/EP0915884B1/de not_active Expired - Lifetime
- 1997-07-18 DK DK97932926T patent/DK0915884T3/da active
- 1997-07-18 AT AT97932926T patent/ATE215955T1/de active
- 1997-07-18 DE DE69711883T patent/DE69711883T2/de not_active Expired - Lifetime
- 1997-07-18 WO PCT/GB1997/001977 patent/WO1998005667A1/en active IP Right Grant
- 1997-07-18 ES ES97932926T patent/ES2175438T3/es not_active Expired - Lifetime
- 1997-07-18 PL PL97331525A patent/PL186307B1/pl unknown
- 1997-07-18 AU AU36291/97A patent/AU3629197A/en not_active Abandoned
- 1997-07-18 CN CN97198338A patent/CN1105721C/zh not_active Expired - Lifetime
- 1997-07-24 TW TW086110548A patent/TW396157B/zh active
- 1997-07-28 MY MYPI97003431A patent/MY117858A/en unknown
- 1997-07-31 ZA ZA9706853A patent/ZA976853B/xx unknown
-
2009
- 2009-03-12 JP JP2009059906A patent/JP2009161557A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MY117858A (en) | 2004-08-30 |
| JP2009161557A (ja) | 2009-07-23 |
| EP0915884A1 (de) | 1999-05-19 |
| ES2175438T3 (es) | 2002-11-16 |
| GB9616253D0 (en) | 1996-09-11 |
| CN1105721C (zh) | 2003-04-16 |
| PL331525A1 (en) | 1999-07-19 |
| WO1998005667A1 (en) | 1998-02-12 |
| JP2001500846A (ja) | 2001-01-23 |
| JP4316674B2 (ja) | 2009-08-19 |
| DE69711883T2 (de) | 2002-10-31 |
| CN1231667A (zh) | 1999-10-13 |
| EP0915884B1 (de) | 2002-04-10 |
| ATE215955T1 (de) | 2002-04-15 |
| PL186307B1 (pl) | 2003-12-31 |
| AU3629197A (en) | 1998-02-25 |
| DK0915884T3 (da) | 2002-07-01 |
| US5847142A (en) | 1998-12-08 |
| ZA976853B (en) | 1998-02-11 |
| TW396157B (en) | 2000-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69711883D1 (de) | Verfahren zur herstellung von narcotischen analgetika | |
| ATA100687A (de) | Verfahren zur herstellung von eisen | |
| DE69618485D1 (de) | Verfahren zur herstellung von epoxidierungskatalysatoren | |
| DE69119587D1 (de) | Verfahren zur herstellung von tagatose | |
| ATE223383T1 (de) | Verfahren zur herstellung von 3-haloalkyl-1h- pyrazole | |
| DE69619237D1 (de) | Verfahren zur herstellung von n-phosphonomethyliminodiessigesäure. | |
| DE69722210D1 (de) | Verfahren zur herstellung einer mischung von sterin-estern | |
| DE59509924D1 (de) | Verfahren zur Herstellung von verbrückten Halbsandwichkomplexen | |
| DE3675239D1 (de) | Verfahren zur herstellung von aminopropylalkoxysilanen. | |
| ATE271070T1 (de) | Verfahren zur herstellung eines metallocen- katalysatorsystems | |
| DE19881314D2 (de) | Verfahren und Vorrichtung zur Herstellung einer verteilten Wellenwicklung | |
| AT399722B (de) | Verfahren zur herstellung von mevinolin | |
| DE3773872D1 (de) | Verfahren zur herstellung ungesaettigter carboxylate. | |
| ATE166348T1 (de) | Verfahren zur herstellung von 4,6- dichlorpyrimidinen | |
| DE3874700D1 (de) | Verfahren zur herstellung von aminoxid. | |
| ATE212035T1 (de) | Verfahren zur herstellung von 17-estern von | |
| DE69521266D1 (de) | Verfahren zur herstellung von 9-amino camptothecin | |
| DE69023328D1 (de) | Verfahren zur herstellung von glycin. | |
| DE69713323D1 (de) | Verfahren zur herstellung von octahydrofluoren-metallkomplexen | |
| DE68916022D1 (de) | Verfahren zur herstellung von wasserstoffgas. | |
| DE69712869D1 (de) | Verfahren zur herstellung einer mischung von epsilon-caprolactam, 6-aminocapronsäure sowie von 6-aminocapronamid | |
| ATE242218T1 (de) | Verfahren zur herstellung von imidazolinderivaten | |
| DE68916805D1 (de) | Verfahren zur herstellung von tocopherolen. | |
| ATA95587A (de) | Verfahren zur herstellung von glucosylmoranolin | |
| DE69810863D1 (de) | Behandlung von (Fluoroaryl)boranverbindung und Verfahren zur Herstellung einer Kohlenwasserstofflösung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |