DE69723728D1 - Totalsynthese des amino hip analogen von didemnin a - Google Patents

Totalsynthese des amino hip analogen von didemnin a

Info

Publication number: DE69723728D1
Authority: DE; Germany
Prior art keywords: didemnin; total synthesis; amino; hip analog; analog
Prior art date: 1996-10-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69723728T

Other languages

English (en)

Other versions

DE69723728T2 (de

Inventor

L Rinehart

J Sanborn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Illinois at Urbana Champaign

Original Assignee

University of Illinois at Urbana Champaign

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-24

Filing date

1997-10-24

Publication date

2003-08-28

1997-10-24 Application filed by University of Illinois at Urbana Champaign filed Critical University of Illinois at Urbana Champaign

2003-08-28 Application granted granted Critical

2003-08-28 Publication of DE69723728D1 publication Critical patent/DE69723728D1/de

2004-06-03 Publication of DE69723728T2 publication Critical patent/DE69723728T2/de

2017-10-25 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

XQZOGOCTPKFYKC-VSZULPIASA-N (2r)-n-[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]-4-methyl-2-(m Chemical compound C([C@H]1C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](CC(C)C)NC)C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N1C)C(C)C)O)[C@@H](C)CC)C1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-VSZULPIASA-N 0.000 title abstract 3
-1 AMINO Chemical class 0.000 title 1
238000006257 total synthesis reaction Methods 0.000 title 1
108010061297 didemnins Proteins 0.000 abstract 2
XQZOGOCTPKFYKC-UHFFFAOYSA-N epididemnin A1 Natural products CN1C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(C(C)C)OC(=O)CC(O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C1CC1=CC=C(OC)C=C1 XQZOGOCTPKFYKC-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Transplantation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Catalysts (AREA)

DE69723728T 1996-10-24 1997-10-24 Totalsynthese des amino hip analogen von didemnin a Expired - Fee Related DE69723728T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2910996P	1996-10-24	1996-10-24
US29109P		1996-10-24
PCT/US1997/019211 WO1998017302A1 (en)	1996-10-24	1997-10-24	Total synthesis of the amino hip analogue of didemnin a

Publications (2)

Publication Number	Publication Date
DE69723728D1 true DE69723728D1 (de)	2003-08-28
DE69723728T2 DE69723728T2 (de)	2004-06-03

Family

ID=21847275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69723728T Expired - Fee Related DE69723728T2 (de)	1996-10-24	1997-10-24	Totalsynthese des amino hip analogen von didemnin a

Country Status (11)

Country	Link
US (1)	US6380156B1 (de)
EP (1)	EP0956033B1 (de)
JP (1)	JP2001504814A (de)
AT (1)	ATE245435T1 (de)
AU (1)	AU726146B2 (de)
CA (1)	CA2269878A1 (de)
DE (1)	DE69723728T2 (de)
DK (1)	DK0956033T3 (de)
ES (1)	ES2202644T3 (de)
PT (1)	PT956033E (de)
WO (1)	WO1998017302A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
JP2003535048A (ja)	2000-04-07	2003-11-25	ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア	タマンダリンおよびジデムニン同族体およびそれらの作成および使用法
US6509315B1 (en)	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
GB0016148D0 (en) *	2000-06-30	2000-08-23	Pharma Mar Sa	Synthetic methods for aplidine and new antitiumoral derivatives
GB0103750D0 (en) *	2001-02-15	2001-04-04	Pharma Mar Sa	Synthetic methods for aplidine and new antitumoral derivatives methods of making and using them
NZ525196A (en)	2000-10-12	2004-09-24	Pharma Mar S	Treatment of cancers by aplidine in conjunction with a myoprotector
KR20060002778A (ko)	2003-03-12	2006-01-09	파르마 마르, 에스.에이.	개선된 항종양 치료
SI1603584T1 (sl)	2003-03-12	2009-02-28	Dana Farber Cancer Inst Inc	Aplidin za zdravljenje multiple mieloma
US8030279B2 (en)	2003-03-21	2011-10-04	The Trustees Of The University Of Pennsylvania	Tamandarin analogs and fragments thereof and methods of making and using
DE102004051025A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Substituierte Nonadepsipeptide
DE102004051024A1 (de) *	2004-10-20	2006-04-27	Bayer Healthcare Ag	Heterocyclyl-substituierte Nonadepsipeptide
DE102004051023A1 (de) *	2004-10-20	2006-05-04	Bayer Healthcare Ag	Desoxo-Nonadepsipeptide
DE102004053410A1 (de) *	2004-11-05	2006-05-11	Bayer Healthcare Ag	Cyclische Nonadepsipeptidamide
DE102006003443A1 (de) *	2006-01-25	2007-07-26	Aicuris Gmbh & Co. Kg	Asparagin-10-substituierte Nonadepsipeptide
RU2481853C2 (ru)	2006-02-28	2013-05-20	Фарма Мар, С.А.	Улучшенные способы лечения опухолей
DE102006018080A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Lysobactinamide
DE102006018250A1 (de) *	2006-04-13	2007-10-18	Aicuris Gmbh & Co. Kg	Verfahren zum Herstellen von cyclischen Depsipeptiden
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
KR20250007021A (ko)	2017-06-09	2025-01-13	추가이 세이야쿠 가부시키가이샤	N-치환 아미노산을 포함하는 펩타이드의 합성 방법
WO2020111238A1 (ja) *	2018-11-30	2020-06-04	中外製薬株式会社	ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法

1997
- 1997-10-24 EP EP97946294A patent/EP0956033B1/de not_active Expired - Lifetime
- 1997-10-24 DE DE69723728T patent/DE69723728T2/de not_active Expired - Fee Related
- 1997-10-24 AT AT97946294T patent/ATE245435T1/de not_active IP Right Cessation
- 1997-10-24 WO PCT/US1997/019211 patent/WO1998017302A1/en active IP Right Grant
- 1997-10-24 DK DK97946294T patent/DK0956033T3/da active
- 1997-10-24 JP JP51964998A patent/JP2001504814A/ja not_active Ceased
- 1997-10-24 US US09/284,905 patent/US6380156B1/en not_active Expired - Fee Related
- 1997-10-24 CA CA002269878A patent/CA2269878A1/en not_active Abandoned
- 1997-10-24 PT PT97946294T patent/PT956033E/pt unknown
- 1997-10-24 ES ES97946294T patent/ES2202644T3/es not_active Expired - Lifetime
- 1997-10-24 AU AU51495/98A patent/AU726146B2/en not_active Ceased

Also Published As

Publication number	Publication date
DE69723728T2 (de)	2004-06-03
EP0956033A4 (de)	2000-06-21
EP0956033A1 (de)	1999-11-17
AU5149598A (en)	1998-05-15
WO1998017302A1 (en)	1998-04-30
CA2269878A1 (en)	1998-04-30
ES2202644T3 (es)	2004-04-01
US6380156B1 (en)	2002-04-30
PT956033E (pt)	2003-10-31
ATE245435T1 (de)	2003-08-15
AU726146B2 (en)	2000-11-02
DK0956033T3 (da)	2003-10-06
EP0956033B1 (de)	2003-07-23
JP2001504814A (ja)	2001-04-10

Publication	Publication Date	Title
DE69723728D1 (de)	2003-08-28	Totalsynthese des amino hip analogen von didemnin a
EA199700117A1 (ru)	1997-12-30	Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов
EP0982988A4 (de)	2000-04-05	Im wesentlichen reines zonulin als physiologischer modulator von "tight junctions" bei säugern
MY121543A (en)	2006-02-28	Preparation of 3,4,4-trisubstituted-piperidinyl-n- alkylcarboxylates and intermediates
TR200001603T2 (tr)	2000-10-23	Yeni bileşikler
LV12350A (lv)	1999-09-20	Heptapeptida oksitocina analogi
CA2104909A1 (en)	1994-03-04	Decahydroisoquinolines as excitatory amino acid receptor antagonists
TR200001012T2 (tr)	2000-09-21	Yeni ariloksi-alkil-dialkilaminler.
MY138258A (en)	2009-05-29	Growth hormone secretagogues
PL309282A1 (en)	1995-10-02	Application of 2-amino-6-n-propyl-amino- 4,5,6,7-tetrahydrobenzothiasole (pramipexol) as an antidepressant
KR0180256B1 (en)	1999-04-01	Bpc peptides, their preparation and use
BG102589A (en)	1999-09-30	3-azetidinylalkylpiperidines or -pyrrolidines as tachykin antagonists
PL340165A1 (en)	2000-11-20	Novel substituted dimeric compounds, method of obtaining them and pharmacological preparations containing such compounds
EP0973518A4 (de)	2004-05-26	Semisynthetisches verfahren zur herstellung von didemninanalogen
CA2213609A1 (fr)	1998-03-02	Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie
MX9709398A (es)	1998-07-31	N-aril-1,2,4-triazolin-5-onas.
EP0339549A3 (de)	1991-01-16	Tyr-Peptid-Analoge
NZ217007A (en)	1988-06-30	Peptide derivative which inhibits proteases, preparation and pharmaceutical composition
EP0749320A4 (de)	1997-06-18	Fibrin spezifischer antikörper zur verwendung als antithrombose agenz
BG103649A (en)	2000-06-30	Method for the preparation of eprosartan
BG103650A (en)	2000-06-30	Method for the preparation of eprosartan
NZ330464A (en)	2000-04-28	Methods for the preparation of biphenyl isoxazole sulfonamides
BG101722A (en)	1998-03-31	New cumarine derivatives, methods for their preparation and application
TW371661B (en)	1999-10-11	Novel intermediates and their use to prepare N,N'-bridged bisindolylmaleimides
PT837677E (pt)	2006-08-31	Derivados hexa-hidroxibifenilo bromados

Legal Events

Date	Code	Title	Description
2004-08-19	8364	No opposition during term of opposition
2008-08-14	8339	Ceased/non-payment of the annual fee