DE69813868D1 - Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten - Google Patents

Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten

Info

Publication number: DE69813868D1
Authority: DE; Germany
Prior art keywords: mitogeneses; cytokines; inhibition; immune responses; pathological immune
Prior art date: 1997-11-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69813868T

Other languages

English (en)

Other versions

DE69813868T2 (de

Inventor

A Horwitz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Southern California USC

Original Assignee

University of Southern California USC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-05

Filing date

1998-11-05

Publication date

2003-05-28

1998-11-05 Application filed by University of Southern California USC filed Critical University of Southern California USC

2003-05-28 Application granted granted Critical

2003-05-28 Publication of DE69813868D1 publication Critical patent/DE69813868D1/de

2004-03-04 Publication of DE69813868T2 publication Critical patent/DE69813868T2/de

2018-11-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
230000001575 pathological effect Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
108010002350 Interleukin-2 Proteins 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000016784 immunoglobulin production Effects 0.000 abstract 1
210000005087 mononuclear cell Anatomy 0.000 abstract 1
210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69813868T 1997-11-05 1998-11-05 Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten Expired - Lifetime DE69813868T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6450797P	1997-11-05	1997-11-05
US64507P		1997-11-05
PCT/US1998/023584 WO1999025366A1 (en)	1997-11-05	1998-11-05	Use of cytokines and mitogens to inhibit pathological immune responses

Publications (2)

Publication Number	Publication Date
DE69813868D1 true DE69813868D1 (de)	2003-05-28
DE69813868T2 DE69813868T2 (de)	2004-03-04

Family

ID=22056456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69813868T Expired - Lifetime DE69813868T2 (de)	1997-11-05	1998-11-05	Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten

Country Status (11)

Country	Link
US (1)	US6228359B1 (de)
EP (1)	EP1028738B1 (de)
JP (1)	JP4309047B2 (de)
AT (1)	ATE238061T1 (de)
AU (1)	AU747767B2 (de)
CA (1)	CA2309115C (de)
DE (1)	DE69813868T2 (de)
DK (1)	DK1028738T3 (de)
ES (1)	ES2198774T3 (de)
PT (1)	PT1028738E (de)
WO (1)	WO1999025366A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6358506B1 (en) *	1997-11-05	2002-03-19	University Of Southern California	Use of cytokines and mitogens to inhibit pathological immune responses
US20030157057A1 (en) *	1999-05-05	2003-08-21	Horwitz David A.	Methods for the induction of professional and cytokine-producing regulatory T cells
US6803036B1 (en)	1998-03-03	2004-10-12	University Of Southern California	Use of cytokines, cells and mitogens to inhibit graft versus host disease
DE69941113D1 (de)	1998-03-03	2009-08-27	Univ Southern California	Zytokinen und mitogenen um "graft-versus-host disease" zu verhindern
WO2000066158A2 (en) *	1999-05-05	2000-11-09	University Of Southern California	Use of cytokines and mitogens to inhibit pathological immune responses
DE60042210D1 (de) *	1999-09-01	2009-06-25	Univ Southern California	Verwendung von cytokinen, zellen und mitogene zur hemmung der graft-versus-host krankheit
AU2007202534B2 (en) *	2000-04-11	2011-06-09	University Of Southern California	A method to prevent graft rejection using TGF-beta to induce T suppressor cells
EP1274833B1 (de) *	2000-04-11	2010-03-10	University Of Southern California	Methode zur verhinderung der transplantatabstossung unter verwendung von tgf-beta zur induktion von t-suppressorzellen
AU2002364230B2 (en) *	2001-12-21	2008-05-01	University Of Southern California	Methods for the induction of professional and cytokine-producing regulatory cells
US20050202010A1 (en) *	2003-08-29	2005-09-15	Giroir Brett P.	Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor
WO2011133808A1 (en)	2010-04-22	2011-10-27	University Of Southern California	Methods and compositions for expanding and stabilizing natural regulatory t cells
WO2013050529A2 (en)	2011-10-06	2013-04-11	European Molecular Biology Laboratory	Use of igf-1 in the modulation of treg cell activity and the treatment and prevention of autoimmune disorders or diseases
JP2014530360A (ja)	2011-10-07	2014-11-17	バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒＨｅａｌｔｈｃａｒｅＳＡ	診断マーカーとしてのｏｘＭＩＦ
US20150110738A1 (en)	2012-05-04	2015-04-23	University Of Southern California	Methods and compositions for generating and using allogeneic suppressor cells
GB201421716D0 (en) *	2014-12-05	2015-01-21	King S College London	Cell expansion procedure

1998
- 1998-11-05 AT AT98957605T patent/ATE238061T1/de active
- 1998-11-05 US US09/186,771 patent/US6228359B1/en not_active Expired - Lifetime
- 1998-11-05 AU AU13827/99A patent/AU747767B2/en not_active Ceased
- 1998-11-05 CA CA2309115A patent/CA2309115C/en not_active Expired - Fee Related
- 1998-11-05 WO PCT/US1998/023584 patent/WO1999025366A1/en active IP Right Grant
- 1998-11-05 JP JP2000520799A patent/JP4309047B2/ja not_active Expired - Fee Related
- 1998-11-05 DK DK98957605T patent/DK1028738T3/da active
- 1998-11-05 EP EP98957605A patent/EP1028738B1/de not_active Expired - Lifetime
- 1998-11-05 PT PT98957605T patent/PT1028738E/pt unknown
- 1998-11-05 ES ES98957605T patent/ES2198774T3/es not_active Expired - Lifetime
- 1998-11-05 DE DE69813868T patent/DE69813868T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU747767B2 (en)	2002-05-23
ATE238061T1 (de)	2003-05-15
CA2309115A1 (en)	1999-05-27
DE69813868T2 (de)	2004-03-04
CA2309115C (en)	2010-10-19
PT1028738E (pt)	2003-08-29
WO1999025366A1 (en)	1999-05-27
EP1028738B1 (de)	2003-04-23
JP4309047B2 (ja)	2009-08-05
JP2001523443A (ja)	2001-11-27
US6228359B1 (en)	2001-05-08
EP1028738A1 (de)	2000-08-23
DK1028738T3 (da)	2003-08-11
AU1382799A (en)	1999-06-07
ES2198774T3 (es)	2004-02-01

Publication	Publication Date	Title
DE69813868D1 (de)	2003-05-28	Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten
ES2099158T3 (es)	1997-05-16	Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo.
DE69929681D1 (de)	2006-04-13	Mesenchymale stammzellen für die prävention und behandlung von immunantworten bei transplantationen
DE3751470D1 (de)	1995-09-21	Pentigetide zur Behandlung von nicht-IgE-vermittelten entzündlichen Erkrankungen.
DE69435270D1 (de)	2010-04-01	Verwendung der neurotoxischen Komponente von Botulinum Toxin zur Behandlung spastischer Muskeln
ATE279181T1 (de)	2004-10-15	Verwendung von 5ht-6 antagonisten zur behandlung adhd
NZ294446A (en)	1999-07-29	Stem cell proliferation inhibitors, haemoglobin chains used for the treatment of autoimmune diseases.
DE69014030D1 (de)	1994-12-15	Mittel für die Verhütung und Behandlung von Diarrhöe.
ES2149888T3 (es)	2000-11-16	3-(3,4-dioxifenil)-pirrolidinas como inhibidores de la fosfodiesterasa de tipo iv para el tratamiento de enfermedades inflamatorias.
ATE190357T1 (de)	2000-03-15	Schnelles verfahren fur die dns sequenzierung und diagnostische anwendungen
DE3779149D1 (de)	1992-06-25	Galanthamin oder dessen analoge zur behandlung der alzheimerschen krankheit.
IL143748A0 (en)	2002-04-21	Substituted aryl or heteroarylamides having retinoid-like biological activity
EP0702566A4 (de)	1997-02-26	Inhibition des migrations-inhibitions-faktors in der behandlung von krankheiten bei denen eine cytokin-vermittelte toxizität eine rolle spielt
IT8121396A0 (it)	1981-04-28	Procedimento per il trattamento, in particolare per la rigenerazione di olio usato.
DE69920205D1 (de)	2004-10-21	Verwendung von metall-proteinase-inhibitoren, um das wachstum der haare oder körperhaare zu induzieren und/oder zu stimulieren und/oder den haarausfall zu verlangsamen
FR2491334B1 (de)	1983-09-23
ATE53302T1 (de)	1990-06-15	Mittel zur behandlung von wunden.
DE60039863D1 (de)	2008-09-25	Verwendung von zytokinen und mitogenen zur inhibierung von pathologischen immunantworten
DE3686019D1 (de)	1992-08-20	Die verwendung von nitrofurantoin zur behandlung und verhuetung von magen-darmkrankheiten.
ATE123942T1 (de)	1995-07-15	5-aryl-3h-1,2,4-triazol-3-one und ihre verwendung als antikonvulsiva.
DE69936779D1 (de)	2007-09-20	Verwendung von ngali nussöl zur behandlung/linderung der arthritisschmerzen und anderer ähnlichen störungen
IT8323342A0 (it)	1983-10-18	Impianto per il trattamento dei rifiuti e dei fanghi biologici.
DE3378979D1 (en)	1989-02-23	1-acyl-3-pyridylmethylguanidines and their use as antihypertensive agents
DE3769497D1 (de)	1991-05-29	Mittel zur bekaempfung von phytopathogenen mikroben.
DE69012883D1 (de)	1994-11-03	Methode für die Behandlung von Abgas.

Legal Events

Date	Code	Title	Description
2004-05-19	8364	No opposition during term of opposition