[go: up one dir, main page]

DE69832197D1 - Rantes mutanten und deren therapeutische verwendungen - Google Patents

Rantes mutanten und deren therapeutische verwendungen

Info

Publication number
DE69832197D1
DE69832197D1 DE69832197T DE69832197T DE69832197D1 DE 69832197 D1 DE69832197 D1 DE 69832197D1 DE 69832197 T DE69832197 T DE 69832197T DE 69832197 T DE69832197 T DE 69832197T DE 69832197 D1 DE69832197 D1 DE 69832197D1
Authority
DE
Germany
Prior art keywords
rantes
therapeutic uses
rantes mutants
mutants
wild
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69832197T
Other languages
English (en)
Other versions
DE69832197T2 (de
Inventor
Paolo Lusso
Simona Polo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAN RAFFAELE CENTRO FOND
Original Assignee
SAN RAFFAELE CENTRO FOND
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI972865 external-priority patent/IT1297015B1/it
Priority claimed from IT98MI001866 external-priority patent/IT1302012B1/it
Application filed by SAN RAFFAELE CENTRO FOND filed Critical SAN RAFFAELE CENTRO FOND
Application granted granted Critical
Publication of DE69832197D1 publication Critical patent/DE69832197D1/de
Publication of DE69832197T2 publication Critical patent/DE69832197T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69832197T 1997-12-23 1998-12-21 Rantes-mutanten und therapeutische anwendungen davon Expired - Lifetime DE69832197T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITMI972865 1997-12-23
ITMI972865 IT1297015B1 (it) 1997-12-23 1997-12-23 Mutanti di rantes e loro applicazioni terapeutiche
ITMI981866 1998-08-07
IT98MI001866 IT1302012B1 (it) 1998-08-07 1998-08-07 Derivati di rantes e loro applicazioni terapeutiche.
PCT/EP1998/008354 WO1999033989A2 (en) 1997-12-23 1998-12-21 Rantes mutants and therapeutic applications thereof

Publications (2)

Publication Number Publication Date
DE69832197D1 true DE69832197D1 (de) 2005-12-08
DE69832197T2 DE69832197T2 (de) 2006-05-24

Family

ID=26331556

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69832216T Expired - Lifetime DE69832216T2 (de) 1997-12-23 1998-12-21 RANTES-Mutanten und therapeutische Anwendungen davon
DE69832197T Expired - Lifetime DE69832197T2 (de) 1997-12-23 1998-12-21 Rantes-mutanten und therapeutische anwendungen davon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69832216T Expired - Lifetime DE69832216T2 (de) 1997-12-23 1998-12-21 RANTES-Mutanten und therapeutische Anwendungen davon

Country Status (10)

Country Link
US (2) US6608177B1 (de)
EP (2) EP1431391B1 (de)
JP (1) JP4323094B2 (de)
AT (2) ATE308617T1 (de)
AU (1) AU2415599A (de)
CA (1) CA2316447C (de)
DE (2) DE69832216T2 (de)
DK (2) DK1040191T3 (de)
ES (2) ES2247738T3 (de)
WO (1) WO1999033989A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
UA77950C2 (en) * 2000-10-04 2007-02-15 Applied Research Systems Use of mutants of cc chemokines for treatment of multiple sclerosis
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
ES2320743T3 (es) 2001-12-17 2009-05-28 Laboratoires Serono Sa Mutantes de quimiocina que actuan como antagonistas de quimiocinas.
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
ATE319471T1 (de) * 2002-04-04 2006-03-15 Applied Research Systems Chemokin-muntanten mit verbesserter oraler bioverfügbarkeit
EP1723178A4 (de) 2004-03-12 2007-12-12 Human Genome Sciences Inc Humaner g-protein-chemokinrezeptor (ccr5) hdgnr10
EP2360182A1 (de) * 2006-11-13 2011-08-24 Functional Genetics, Inc. Therapeutisches Targeting von Escort-Proteinen
ES2453592T3 (es) 2007-08-02 2014-04-08 Novimmune Sa Anticuerpos anti-RANTES y métodos de uso de los mismos
WO2019229615A1 (en) 2018-05-28 2019-12-05 Université De Genève Methods of inhibiting cerebral inflammation
WO2025172252A1 (en) * 2024-02-15 2025-08-21 Novo Nordisk A/S Protracted ccr5 antagonists and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017935A2 (en) * 1994-12-08 1996-06-13 Glaxo Group Limited Rantes peptide and fragments and compositions comprising it for treatment of inflammation
FR2748938B1 (fr) * 1996-05-22 1998-07-31 Pasteur Institut Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
EP0972043A1 (de) * 1996-09-25 2000-01-19 British Biotech Pharmaceuticals Limited Mutanten von humanem rantes, die keine aggregate bilden können

Also Published As

Publication number Publication date
CA2316447C (en) 2009-07-28
EP1431391A2 (de) 2004-06-23
EP1431391A3 (de) 2004-10-06
DE69832197T2 (de) 2006-05-24
DK1040191T3 (da) 2005-12-19
DE69832216T2 (de) 2006-05-24
ATE308617T1 (de) 2005-11-15
WO1999033989A3 (en) 1999-08-26
JP4323094B2 (ja) 2009-09-02
CA2316447A1 (en) 1999-07-08
ES2247475T3 (es) 2006-03-01
AU2415599A (en) 1999-07-19
DE69832216D1 (de) 2005-12-08
ATE308616T1 (de) 2005-11-15
US7164000B2 (en) 2007-01-16
US20030216549A1 (en) 2003-11-20
US6608177B1 (en) 2003-08-19
WO1999033989A2 (en) 1999-07-08
EP1040191B1 (de) 2005-11-02
ES2247738T3 (es) 2006-03-01
EP1431391B1 (de) 2005-11-02
EP1040191A2 (de) 2000-10-04
DK1431391T3 (da) 2005-12-19
JP2002507388A (ja) 2002-03-12

Similar Documents

Publication Publication Date Title
ATE185602T1 (de) Verändertes menschliches il-6
DE69731373D1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
ATE211467T1 (de) 4-amino-derivate der mycophenolsäure mit immun suppressiver wirkung
TR200002773T2 (tr) Alzheimer tedavisi için smilagenin ve anzurogenin-D ve bunların kullanımı.
NO911624L (no) Farmasoeytiske forbindelser.
PH31441A (en) 5.Substituted derivatives of mycophenolic acid.
DE69832197D1 (de) Rantes mutanten und deren therapeutische verwendungen
DE69033703D1 (de) Nichtglykosyliertes fgf-4 und dieses enthaltende präparate
DE69324826D1 (de) Gegen Papillomaviren wirksame 2',5'-OLIGOADENYLAT-2',3'-CYCLOPHOSPHATE und 2',5'-OLIGOADENYLATE
ES2177625T3 (es) Citoquina cc-1 humana circulante.
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ATE210126T1 (de) 4-amino-6-substituierte mycophenolsäurederivate mit immunsuppressiver wirkung
ATE186731T1 (de) Anomere fluorribosylamine
IT1244880B (it) Formulazioni di amminoacidi liofilizzati contenenti glutammina, loro preparazione ed uso nell'alimentazione parenterale
FR2710244B3 (fr) Composition diététique à base d'acides aminés essentiels.
BR9704964A (pt) Uso de sulbutiamina para obter composições farmacêuticas úteis no tratamento de algumas pertubações psicomotoras e psico-intelectuais
SE8802323D0 (sv) 8alfa-acylaminoergoline, its preparation and pharmaceutical compositions containing it
IT8840172A0 (it) Procedimento e mezzi per l'impressione in rilievo di tessuti, o pelli e simili
IT8722543V0 (it) Cerotto, in particolare per l'impiego in corrispondenza di zone articolari.
ATE106088T1 (de) Peptide und deren verwendung in der therapie.
Palani Professor Dr. N. Subbu Reddiar's contributions for the enrichment of Tamil
ES2127133A1 (es) Utilizacion de derivados 2,5-dihidroxibencenosulfonicos para la fabricacion de medicamentos destinados al tratamiento y a la prevencion de la enfermedad de alzheimer.
IT1230707B (it) Pirimidine 2 4 disostituite loro preparazione ed impieghi terapeutici.
ITRM920079A1 (it) Manufatto per l'allargamento di banchine stradali e procedimento di posa in opera.
ITRM930343A0 (it) Proteine ricombinanti, vettori per l'espressione e loro usi.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition