DE69033986D1 - Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den Untereinheiten - Google Patents
Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den UntereinheitenInfo
- Publication number
- DE69033986D1 DE69033986D1 DE69033986T DE69033986T DE69033986D1 DE 69033986 D1 DE69033986 D1 DE 69033986D1 DE 69033986 T DE69033986 T DE 69033986T DE 69033986 T DE69033986 T DE 69033986T DE 69033986 D1 DE69033986 D1 DE 69033986D1
- Authority
- DE
- Germany
- Prior art keywords
- uncharged
- phosphorus
- subunit
- chiral
- subunits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 title abstract 2
- 239000011574 phosphorus Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- MHCMWGPPLOSCJY-UHFFFAOYSA-N 4-$l^{1}-azanylmorpholine Chemical compound [N]N1CCOCC1 MHCMWGPPLOSCJY-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Saccharide Compounds (AREA)
- Polyamides (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45405789A | 1989-12-20 | 1989-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69033986D1 true DE69033986D1 (de) | 2002-08-14 |
| DE69033986T2 DE69033986T2 (de) | 2003-03-13 |
Family
ID=23803120
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69033986T Expired - Lifetime DE69033986T2 (de) | 1989-12-20 | 1990-12-20 | Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den Untereinheiten |
| DE69034213T Expired - Lifetime DE69034213T2 (de) | 1989-12-20 | 1990-12-20 | Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69034213T Expired - Lifetime DE69034213T2 (de) | 1989-12-20 | 1990-12-20 | Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP0962463B1 (de) |
| JP (2) | JP3398378B2 (de) |
| KR (1) | KR0167574B1 (de) |
| AT (2) | ATE220407T1 (de) |
| AU (1) | AU655164B2 (de) |
| CA (1) | CA2069869C (de) |
| DE (2) | DE69033986T2 (de) |
| WO (1) | WO1991009033A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405938A (en) * | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5166315A (en) * | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| AU7135498A (en) * | 1997-04-17 | 1998-11-11 | Antivirals Inc. | Method of treating restenosis by antisense targeting of cmv |
| US20010024783A1 (en) * | 1999-01-29 | 2001-09-27 | Avi Biopharma, Inc. | Non-invasive method for detecting target RNA |
| KR20010102992A (ko) * | 1999-01-29 | 2001-11-17 | 추후보정 | 표적 ｒｎａ를 검출하는 비-침입적 방법 |
| US6875747B1 (en) | 1999-05-24 | 2005-04-05 | Avi Bio Pharma, Inc. | Antisense to c-myc for treatment of polycystic kidney disease |
| JP2003500418A (ja) * | 1999-05-24 | 2003-01-07 | エイブイアイ バイオファーマ， インコーポレイテッド | 多発性嚢胞腎疾患の処置のためのｃ−ｍｙｃに対するアンチセンス |
| ATE393221T1 (de) | 1999-11-29 | 2008-05-15 | Avi Biopharma Inc | Gegen bakterielle 16s und 23s rrnas gerichtete ungeladene antisense oligonukleotide und deren verwendungen |
| AU781676B2 (en) * | 2000-01-04 | 2005-06-02 | Avi Biopharma, Inc. | Antisense antibacterial cell division composition and method |
| WO2006085973A2 (en) | 2004-07-02 | 2006-08-17 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| DK2024499T3 (da) * | 2006-05-10 | 2018-01-29 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske intersubunit-koblinger |
| EP2207779B1 (de) * | 2007-11-15 | 2014-04-09 | Sarepta Therapeutics, Inc. | Verfahren zur synthese von morpholino-oligomeren |
| AU2013202731B2 (en) * | 2010-05-28 | 2016-04-21 | Sarepta Therapeutics, Inc. | Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups |
| EP2576574A2 (de) * | 2010-05-28 | 2013-04-10 | Sarepta Therapeutics, Inc. | Oligonucleotidanaloga mit modifizierten interuntereinheitenkopplungen und/oder entständigen gruppen |
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| LT2623507T (lt) | 2010-09-30 | 2017-01-25 | Nippon Shinyaku Co., Ltd. | Morfolino nukleorūgšties darinys |
| KR102271212B1 (ko) | 2011-11-18 | 2021-07-01 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 기능적으로-변형된 올리고뉴클레오티드 및 이의 서브유니트 |
| AU2012360702C1 (en) | 2011-12-28 | 2018-09-20 | National Center Of Neurology And Psychiatry | Antisense nucleic acid |
| EA031110B1 (ru) | 2012-03-20 | 2018-11-30 | Сарепта Терапьютикс, Инк. | Конъюгаты бороновых кислот олигонуклеотидных аналогов |
| DK3015467T3 (da) | 2013-05-24 | 2025-02-10 | Ajinomoto Kk | Morpholino-oligonukleotidfremstillingsfremgangsmåde |
| SMT201900169T1 (it) | 2014-03-12 | 2019-05-10 | Nippon Shinyaku Co Ltd | Acido nucleico antisenso |
| TWI721461B (zh) | 2014-06-17 | 2021-03-11 | 日商日本新藥股份有限公司 | 反義核酸 |
| EP3208277A4 (de) * | 2014-10-14 | 2018-06-13 | Ajinomoto Co., Inc. | Morpholin-oligonukleotid-herstellungsverfahren |
| CN113717239B (zh) | 2015-01-21 | 2024-12-24 | 味之素株式会社 | 沉淀促进剂以及使用其的沉淀方法 |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| PL3351633T3 (pl) | 2015-09-15 | 2020-11-02 | Nippon Shinyaku Co., Ltd. | Antysensowny kwas nukleinowy |
| US10563199B2 (en) | 2015-09-16 | 2020-02-18 | Nippon Shinyaku Co., Ltd. | Antisense nucleic acid for treating amyotrophy |
| AU2017330276B2 (en) * | 2016-09-20 | 2022-01-20 | The Regents Of The University Of Colorado, A Body Corporate | Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry |
| WO2019216433A1 (ja) | 2018-05-10 | 2019-11-14 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| CA3101321A1 (en) | 2018-06-26 | 2020-01-02 | Nippon Shinyaku Co., Ltd. | Composition comprising antisense oligonucleotide and use thereof for treatment of duchenne muscular dystrophy |
| GB201821269D0 (en) | 2018-12-28 | 2019-02-13 | Nippon Shinyaku Co Ltd | Myostatin signal inhibitor |
| EP4059944A4 (de) | 2019-11-13 | 2024-04-10 | Nippon Shinyaku Co., Ltd. | Verfahren zur herstellung einer oligonukleidsäureverbindung |
| JP7669280B2 (ja) | 2019-11-13 | 2025-04-28 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| JPWO2021125311A1 (de) | 2019-12-19 | 2021-06-24 | ||
| AU2020411964A1 (en) | 2019-12-26 | 2022-06-16 | National Center Of Neurology And Psychiatry | Antisense nucleic acid that induces skipping of exon 50 |
| BR112022017066A2 (pt) | 2020-02-28 | 2022-11-16 | Nippon Shinyaku Co Ltd | Ácido nucleico antissentido indutor de salto do éxon 51 |
| EP4320138A1 (de) | 2021-04-09 | 2024-02-14 | Bachem Holding AG | Pseudofestphase-schutzgruppe und verfahren zur synthese von oligonukleotiden und oligonukleotidkonjugaten |
| AU2022266379A1 (en) | 2021-04-28 | 2023-11-09 | Nippon Shinyaku Co., Ltd. | Method for producing oligonucleic acid compound |
| JPWO2022239863A1 (de) | 2021-05-13 | 2022-11-17 | ||
| AU2022279820A1 (en) | 2021-05-28 | 2023-12-14 | Sumitomo Pharma Co., Ltd. | Antisense nucleic acid |
| EP4361269A1 (de) | 2021-06-23 | 2024-05-01 | Nippon Shinyaku Co., Ltd. | Kombination von antisense-oligomeren |
| KR20240035502A (ko) | 2021-07-08 | 2024-03-15 | 니뽄 신야쿠 가부시키가이샤 | 신독성 경감제 |
| CN118434424A (zh) | 2021-07-08 | 2024-08-02 | 日本新药株式会社 | 析出抑制剂 |
| WO2023282344A1 (ja) | 2021-07-08 | 2023-01-12 | 日本新薬株式会社 | 腎毒性軽減剤 |
| EP4389893A4 (de) | 2021-08-21 | 2025-09-10 | Takeda Pharmaceuticals Co | Peptid-wirkstoff-konjugat, das an den menschlichen transferrin-rezeptor bindet |
| KR20240129006A (ko) | 2021-12-27 | 2024-08-27 | 니뽄 신야쿠 가부시키가이샤 | 올리고 핵산 화합물의 제조 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0216860B1 (de) * | 1985-03-15 | 1992-10-28 | SUMMERTON, James | Stereoregulare polynukleotiden bindende polymere |
-
1990
- 1990-12-20 JP JP50289191A patent/JP3398378B2/ja not_active Expired - Lifetime
- 1990-12-20 EP EP99109726A patent/EP0962463B1/de not_active Expired - Lifetime
- 1990-12-20 WO PCT/US1990/007563 patent/WO1991009033A1/en active IP Right Grant
- 1990-12-20 AU AU71642/91A patent/AU655164B2/en not_active Expired
- 1990-12-20 KR KR1019920701479A patent/KR0167574B1/ko not_active Expired - Lifetime
- 1990-12-20 AT AT99109726T patent/ATE220407T1/de not_active IP Right Cessation
- 1990-12-20 EP EP91902085A patent/EP0506830B1/de not_active Expired - Lifetime
- 1990-12-20 DE DE69033986T patent/DE69033986T2/de not_active Expired - Lifetime
- 1990-12-20 CA CA002069869A patent/CA2069869C/en not_active Expired - Lifetime
- 1990-12-20 DE DE69034213T patent/DE69034213T2/de not_active Expired - Lifetime
- 1990-12-20 AT AT91902085T patent/ATE312834T1/de not_active IP Right Cessation
-
2001
- 2001-06-13 JP JP2001179272A patent/JP2002167441A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR920703584A (ko) | 1992-12-18 |
| EP0506830A4 (en) | 1993-01-07 |
| AU7164291A (en) | 1991-07-18 |
| DE69034213D1 (de) | 2006-01-19 |
| DE69034213T2 (de) | 2006-08-24 |
| EP0962463A1 (de) | 1999-12-08 |
| EP0506830B1 (de) | 2005-12-14 |
| DE69033986T2 (de) | 2003-03-13 |
| JP3398378B2 (ja) | 2003-04-21 |
| WO1991009033A1 (en) | 1991-06-27 |
| CA2069869C (en) | 1995-12-19 |
| KR0167574B1 (ko) | 1999-01-15 |
| JP2002167441A (ja) | 2002-06-11 |
| CA2069869A1 (en) | 1991-06-21 |
| ATE312834T1 (de) | 2005-12-15 |
| ATE220407T1 (de) | 2002-07-15 |
| EP0506830A1 (de) | 1992-10-07 |
| AU655164B2 (en) | 1994-12-08 |
| EP0962463B1 (de) | 2002-07-10 |
| JPH05504563A (ja) | 1993-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |